Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and A... by Bing Tan, Amélie Jaulin, Caroline Bund, Hassiba Outilaft, Corinne Wendling, Marie-Pierrette Chenard, Fabien Alpy, A. Ercüment Cicek, Izzie J. Namer, Catherine Tomasetto, Nassim Dali-Youcef

“…Of interest, MMP11 promotes Insulin-like Growth Factor-1 (IGF1)/protein kinase B (AKT)/Forkhead box protein O1 (FoxO1) signaling and is associated with a metabolic switch in the tumor, activation of the endoplasmic reticulum stress response, and an alteration in the mitochondrial unfolded protein response with decreased proteasome activity. …”
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Reproductive toxicity and preliminary mechanism of polystyrene nanoplastics in male mice by CHENG Ya, CHENG Ya, CHENG Ya, HAN Fei, LIANG Yuehui, LIANG Yuehui

“…Transmission electron microscopy displayed that mitochondrial swelling and endoplasmic reticulum expansion were observed in the cytoplasm of Leydig cells in 10 PS and 40 PS groups. …”
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Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells by Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai

“…Propofol translocated PKCδ and PKCη of nPKCs to the Golgi apparatus and endoplasmic reticulum, respectively. Propofol also induced the nuclear translocation of PKCζ of atypical PKCs or proteins other than PKCs, such that the protein concentration inside and outside the nucleus became uniform. …”
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Identification of Prognosis Associated microRNAs in HNSCC Subtypes Based on TCGA Dataset by Cintia M. Chamorro Petronacci, Abel García García, Elena Padín Iruegas, Berta Rivas Mundiña, Alejandro I. Lorenzo Pouso, Mario Pérez Sayáns

“…The most probable affected pathways based on miRNAs interaction levels were protein processing in endoplasmic reticulum, proteoglycans in cancer (<i>p</i> < 0.01), Hippo signaling pathway (<i>p </i>< 0.01), and Transforming growth factor-beta (TGF-beta) signaling pathway (<i>p</i> < 0.01). …”
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Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer by Adeline Dolly, Thierry Lecomte, Nicolas Tabchouri, Morgane Caulet, Nicolas Michot, Benjamin Anon, Romain Chautard, Yoann Desvignes, Mehdi Ouaissi, Gaëlle Fromont‐Hankard, Jean‐François Dumas, Stéphane Servais

“…Finally, our results show no dysfunction in lipid storage and endoplasmic reticulum homeostasis. Conclusions This clinical protocol brings unique data that provide new insight to mechanisms underlying muscle wasting in cancer cachexia. …”
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KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models by James D. West, Eric D. Austin, Elise M. Rizzi, Ling Yan, Harikrishna Tanjore, Amber L. Crabtree, Christy S. Moore, Gladson Muthian, Erica J. Carrier, David A. Jacobson, Rizwan Hamid, Peggy L. Kendall, Susan Majka, Anandharajan Rathinasabapathy

“…KCNK3 is expressed in several cell and tissue types on both membrane and endoplasmic reticulum and potentially plays a role in multiple pathological process associated with PAH. …”
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Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin by David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce

“…Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. …”
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Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq by Hongbiao Ran, Qiuya He, Yuting Han, Jikun Wang, Haibo Wang, Binglin Yue, Ming Zhang, Zhixin Chai, Xin Cai, Jincheng Zhong, Hui Wang

“…Chromatin immunoprecipitation coupled with high-throughput sequencing of H3K4ac (a known direct target of SIRT1) and high-throughput mRNA sequencing results revealed that SIRT1 may regulate intramuscular fat deposition via three potential new transcription factors (NRF1, NKX3.1, and EGR1) and four genes (MAPK1, RXRA, AGPAT1, and HADH) implicated in protein processing within the endoplasmic reticulum pathway and the MAPK signalling pathway in yaks. …”
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Effects of β-Nicotinamide Mononucleotide, Berberine, and Cordycepin on Lipid Droplet Content and Developmental Ability of Vitrified Bovine Oocytes by Xi Xu, Baigao Yang, Hang Zhang, Xiaoyi Feng, Haisheng Hao, Weihua Du, Huabin Zhu, Adnan Khan, Muhammad Zahoor Khan, Peipei Zhang, Xueming Zhao

“…This study analyzed the impact of β-nicotinamide mononucleotide (NMN), berberine (BER), or cordycepin (COR) on various aspects of bovine oocytes, including lipid droplet content and the expression levels of genes related to lipid synthesis in bovine oocytes, development ability, reactive oxygen species (ROS), apoptosis, and the expression levels of genes associated with endoplasmic reticulum (ER) stress, and mitochondrial function in vitrified bovine oocytes. …”
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Single-molecule force spectroscopy of protein-membrane interactions by Lu Ma, Yiying Cai, Yanghui Li, Junyi Jiao, Zhenyong Wu, Ben O'Shaughnessy, Pietro De Camilli, Erdem Karatekin, Yongli Zhang

“…Syts and E-Syts bind the plasma membrane via multiple C2 domains, bridging the plasma membrane with synaptic vesicles or endoplasmic reticulum to regulate membrane fusion or lipid exchange, respectively. …”
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Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye by Anuradha Venkatakrishnan Chimata, Hannah Darnell, Akanksha Raj, Madhuri Kango-Singh, Amit Singh

“…Abbreviations: hid: head involution defective; rpr: reaper; DIAP: Drosophila inhibitor of apoptosis proteins; RD genes: Retinal Determination genes; MF: Morphogenetic Furrow; PCD: Programmed cell death; ER: Endoplasmic reticulum; Wg: Wingless; JNK - c: Jun amino-terminal (NH2) Kinase; MAPKs – Mitogen: activated protein kinases; TNF: Tumor necrosis factor; Egr: Eiger; Wgn: Wengen; Tak 1: TGFβ activating kinase 1; JNKKK: JNK kinase kinase; Hep: Hemipterous; JNKK: JNK kinase; Bsk: Basket; Puc - Puckered; Pol II - RNA polymerase II; DNA: Deoxyribonucleic acid; TSS: Transcription start site; ESCs: Embryonic stem cells; Hop: Hopscotch; Dpp: Decapentaplegic; GAF: GAGA factor; M1BP: Motif 1 Binding Protein; ZAD: Zinc-associated domain; ZKSCAN3 - Zinc finger with a SCAN and a KRAB domain 3 (ZKSCAN3); UAS: Upstream activation sequence; ELAV: Embryonic lethal abnormal vision; RT qPCR: Real time quantitative polymerase chain reaction; LOF: Loss of function; GOF: Gain of function; GFP: Green fluorescent protein; WT: Wild-type; PBS: Phosphate buffered saline; PFA: Paraformaldehyde; PBST: Phosphate Buffered Saline with Triton X-100; β-GAL: Beta-galactosidase; DSHB: Developmental Studies Hybridoma Bank; CST: Cell Signaling Technologies; Dlg: Discs large; IgG: Immunoglobulin G; FITC: Fluorescein isothiocyanate; RNA: Ribonucleic acid; cDNA: Complementary DNA; Ct: cycle threshold; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; SAPK: Stress-activated protein kinases; HRP: Horse Radish Peroxidase; ROI: Region Of Interest; SEM: Standard Error of the Mean; CI: Confidence Intervals…”
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Lipid accumulation and oxidative stress in the crop tissues of male and female pigeons during incubation and chick-rearing periods by P. Xie, J.G. Zhu, L.X. Wang, Y. Liu, E.J. Diao, D.Q. Gong, T.W. Liu

“…Transmission electron microscopy analysis showed swollen mitochondria with disintegration of cristae and typical characteristics of endoplasmic reticulum stress in crop tissues at R1 compared with those at I4. …”
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Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib by Yusuke Yamashita, Shuhei Morita, Hiroki Hosoi, Hiroshi Kobata, Shohei Kishimoto, Tatsuya Ishibashi, Hiroyuki Mishima, Akira Kinoshita, Bradley J. Backes, Koh-Ichiro Yoshiura, Feroz R. Papa, Takashi Sonoki, Shinobu Tamura

“…Background: Inositol-requiring enzyme 1α (IRE1α), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). …”
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Effects of Coverlys TF150^® on the Photosynthetic Characteristics of Grape by Zhonghan Li, Enshun Jiang, Minghui Liu, Qinghua Sun, Zhen Gao, Yuanpeng Du

“…KEGG enrichment analysis showed the occurrence of protein processing in the endoplasmic reticulum. Plant hormone signal transduction and plant-pathogen interaction were identified as the metabolic pathways with the highest differential gene expression enrichment. …”
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YOD1 serves as a potential prognostic biomarker for pancreatic cancer by Zhishuo Zhang, Wenxia Zhao, Yiming Li, Yang Li, Hanzeng Cheng, Liyun Zheng, Xiaoyu Sun, Hao Liu, Rongguang Shao

“…Among them, the deubiquitinating enzyme YOD1, a member of the ovarian tumor domain protease (OTUs) subfamily, is involved in the regulation of endoplasmic reticulum (ER)-related degradation pathways. …”
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Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells by Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao

“…In response to endoplasmic reticulum (ER) stress in multiple tumor cells including GBM, the glucose-regulated protein 78 (GRP78) expression increases and the protein is partially translocated to the cell surface, while it is restricted to the cytoplasm and the nucleus in normal cells. …”
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Transcriptomics and metabolomics reveal the molecular and metabolic adaptation to heat stress in Manila clam Ruditapes philippinarum by Hao Jing, Hao Jing, Hao Jing, Liqing Zhou, Liqing Zhou, Yiqiang Gao, Yiqiang Gao, Yiqiang Gao, Zhihong Liu, Zhihong Liu, Biao Wu, Biao Wu, Xiujun Sun, Xiujun Sun, Kang Tu

“…The protein processing in endoplasmic reticulum may play the important roles in the stability of cell membrane structure during heat adaptation. …”
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LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases by Zining Li, Zining Li, Zining Li, Jialiang Gao, Jialiang Gao, Jialiang Gao, Di Sun, Di Sun, Di Sun, Qian Jiao, Qian Jiao, Qian Jiao, Jing Ma, Jing Ma, Jing Ma, Weilu Cui, Weilu Cui, Weilu Cui, Yuqing Lou, Yuqing Lou, Yuqing Lou, Fan Xu, Fan Xu, Fan Xu, Shanshan Li, Shanshan Li, Shanshan Li, Haixia Li, Haixia Li, Haixia Li

“…MEG3 directly or competitively binds with miRNA to participate in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, EMT and other processes. LncRNA MEG3 is mainly involved in malignant tumors, metabolic diseases, immune system diseases, cardiovascular and cerebrovascular diseases, etc., LncRNA MEG3 has a variety of pathological effects in cardiomyocytes, fibroblasts and endothelial cells and has great clinical application potential in the prevention and treatment of AS, MIRI, hypertension and HF. …”
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Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway by Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo, Yongmei Song

“…Abstract Background Hypoxia is one of most typical features in the tumor microenvironment of solid tumor and an inducer of endoplasmic reticulum (ER) stress, and HIF-1α functions as a key transcription factor regulator to promote tumor angiogenesis in the adaptive response to hypoxia. …”
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A network medicine approach to study comorbidities in heart failure with preserved ejection fraction by Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez, Rebecca T. Levinson

“…Based on the HFpEF comorbidity profile, we predicted and recovered gene candidates, including genes involved in fibrosis (COL3A1, LOX, SMAD9, PTHL), hypertrophy (GATA5, MYH7), oxidative stress (NOS1, GSST1, XDH), and endoplasmic reticulum stress (ATF6). Finally, predicted genes were significantly overrepresented in the murine transcriptomic disease signature providing additional plausibility for their relevance. …”
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