Neuroprotective properties of taurine by Marcin Cieślak, Aleksandra Karmańska, Julia Kaźmierczak-Barańska, Magdalena Korycka, Bolesław Karwowski

“…Its deficiency blocks the synthesis of taurine-modified leucine tRNA (τm5U-tRNALeu), which results in inhibition of the synthesis of NADH-ubiquinone oxidoreductase, improper functioning of complex I of the respiratory chain and increase in oxidative stress. Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases and can lead to neuronal apoptosis. …”
Get full text

Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses wit... by Yujing Shao, Wenrui Zhen, Fangshen Guo, Zeqiong Hu, Kaichen Zhang, Linhua Kong, Yuming Guo, Zhong Wang

“…While alanine, asparate and glutamate metabolism; MAPK signal pathway-yeast; ubiquine and other terpenoid-quinore biosynthesis, protein processing in endoplasmic reticulum; as well as glutathione metabolism were suppressed by E. faecium NCIMB 11181 addition. …”
Get full text

Autophagy gene-dependent intracellular immunity triggered by interferon-γ by Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E. Sullender, L. David Sibley, Herbert W. Virgin

“…Furthermore, we found that perturbation of UFMylation pathway components led to more robust IFNγ-induced inhibition of norovirus via regulation of endoplasmic reticulum (ER) stress. Enhancing or inhibiting these dynamic cellular components could serve as a strategy to control intracellular pathogens and maintain an effective immune response.…”
Get full text

FXR, a Key Regulator of Lipid Metabolism, Is Inhibited by ER Stress-Mediated Activation of JNK and p38 MAPK in Large Yellow Croakers (<i>Larimichthys crocea</i>) Fed High Fat Diets by Jianlong Du, Xiaojun Xiang, Dan Xu, Junzhi Zhang, Wei Fang, Wei Xu, Kangsen Mai, Qinghui Ai

“…Furthermore, the findings revealed that endoplasmic reticulum (ER)-stress-induced-activation of JNK and P38 MAPK participated in the reduction of FXR induced by high-fat diets. …”
Get full text

Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma by Pongkorpsakol P, Yimnual C, Satianrapapong W, Worakajit N, Kaewin S, Saetang P, Rukachaisirikul V, Muanprasat C

“…Mechanistically, nornidulin (10 μM) suppressed Cl− currents induced by ionomycin (a Ca2+-specific ionophore), thapsigargin (an inhibitor of the endoplasmic reticulum Ca2+ ATPase), and Eact (a putative TMEM16A activator) without interfering with intracellular Ca2+ ([Ca2+]i) levels. …”
Get full text

Engineering a carbohydrate-binding module to increase the expression level of glucoamylase in Pichia pastoris by Lige Tong, Huoqing Huang, Jie Zheng, Xiao Wang, Yingguo Bai, Xiaolu Wang, Yuan Wang, Tao Tu, Bin Yao, Xing Qin, Huiying Luo

“…Meanwhile, the expression of genes related to the unfolded protein responses (UPR) in the endoplasmic reticulum (ER) did not differ significantly between the mutants and wild type. …”
Get full text

The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP⁺ by Zhaozhong Liao, Zunshuang Gong, Zhe Wang, Weiyan Yang, Wenjing Liu, Lin Hou, Xiaokun Liu, Junnan Hua, Bin Wang, Ning Li

“…This work aims to investigate the involvement of TMEM166, an endoplasmic-reticulum-localized autophagy-regulating protein, in the process of PD-associated oxidative stress through the classic cellular PD model of neuroblastoma SH-SY5Y cells exposed to 1-methyl-4-phenylpyridinium (MPP⁺). …”
Get full text

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein... by Po-Chun Hsieh, Po-Chun Hsieh, Chung-Kan Peng, Guan-Ting Liu, Guan-Ting Liu, Chan-Yen Kuo, I-Shiang Tzeng, Ming-Chieh Wang, Chou-Chin Lan, Chou-Chin Lan, Chou-Chin Lan, Kun-Lun Huang, Kun-Lun Huang

“…BackgroundLipopolysaccharide (LPS)-induced acute lung injury (ALI) induces endoplasmic reticulum stress, unfolded protein response (UPR), apoptosis, and inflammation. …”
Get full text

Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models by Su, Linhui Julie, Auluck, Pavan K., Outeiro, Tiago Fleming, Yeger-Lotem, Esti, Kritzer, Joshua A., Tardiff, Daniel F., Bell, George W., Fraenkel, Ernest, Lindquist, Susan, Strathearn, Katherine E., Liu, Fang, Cao, Songsong, Hamamichi, Shusei, Hill, Kathryn J., Caldwell, Kim A., Cooper, Antony A., Caldwell, Guy A., McCaffery, J. Michael, Rochet, Jean-Christophe

“…Unlike our previous strain, genetic suppression of endoplasmic reticulum (ER)-to-Golgi trafficking alone does not suppress α-syn toxicity in this strain. …”
Get full text
Get full text
Get full text

Mapping the interactions between the NS4B and NS3 proteins of dengue virus by Zou, Jing, Lee, Le Tian, Wang, Qing Yin, Xie, Xuping, Lu, Siyan, Yau, Yin Hoe, Yuan, Zhiming, Geifman Shochat, Susana, Kang, Congbao, Lescar, Julien, Shi, Pei-Yong

“…Flavivirus RNA synthesis is mediated by a multiprotein complex associated with the endoplasmic reticulum membrane, named the replication complex (RC). …”
Get full text
Get full text

Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding t... by Su, Chinh Tran-To, Sinha, Swati, Eisenhaber, Birgit, Eisenhaber, Frank

“…Background: The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal propeptide with a defined sequence signal. …”
Get full text

Characterization of candidate proteins involved in calreticulin-dependent invasion using breast cancer tissue biopsies by Noudehi, Zahra Yekta Moghaddam

“…CRT is a high-capacity calcium-binding protein found in the endoplasmic reticulum (ER) lumen and has been implicated in a variety of functions outside of the ER, including cell adhesion and integrin-dependent calcium signaling. …”
Get full text

Advanced Cell Biology / by Reece, Shelia, author 648683

Get full text

Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model by Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Erikles Macedo Barbosa, Letícia Dias Mendonça, Emilly Oliveira Santos, Isabella Oliveira de Macedo, Mário Sergio Lima de Lavor, Raphael Escorsim Szawka, Rogeria Serakides, Juneo Freitas Silva

“…Feto-placental development, placental histomorphometry, and expression levels of growth factors (VEGF, PLGF, IGF1, IGF2, and GLUT1), hormonal (Dio2) and inflammatory mediators (TNFα, IL10, and IL6), markers of hypoxia (HIF1α) and oxidative damage (8-OHdG), antioxidant enzymes (SOD1, Cat, and GPx1), and endoplasmic reticulum stress mediators (ATF4, GRP78, and CHOP) were evaluated on day 18 of gestation. …”
Get full text

A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production by Amandine Gautier-Stein, Julien Chilloux, Maud Soty, Bernard Thorens, Christophe Place, Carine Zitoun, Adeline Duchampt, Lorine Da Costa, Fabienne Rajas, Christophe Lamaze, Gilles Mithieux

“…According to textbooks, glucose is produced in the endoplasmic reticulum by glucose-6-phosphatase (G6Pase) and then exported in the blood by the glucose transporter GLUT2. …”
Get full text

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization by Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo

“…However, the precise role of ER stress effector IRE1α, encoded by endoplasmic reticulum to nucleus signaling 1 (ERN1), in skeletal development remains unknown. …”
Get full text

ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking by Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Vin-Cent Wu, Gwo-Tsann Chuang, Yi-Cheng Chang, Lee-Ming Chuang

“…In the RRBP1-knockdown Calu-6 cells, a human renin-producing cell line, transmission electron and confocal microscopy revealed that renin was primarily retained in the endoplasmic reticulum and was unable to efficiently target the Golgi apparatus for secretion. …”
Get full text

<i>GhCYP710A1</i> Participates in Cotton Resistance to Verticillium Wilt by Regulating Stigmasterol Synthesis and Plasma Membrane Stability by Li Huang, Guiming Li, Qiaoling Wang, Qian Meng, Fan Xu, Qian Chen, Fang Liu, Yulin Hu, Ming Luo

“…The GhCYP710A1 has the conservative domain that is essential for sterol C22-desaturase in plant and is highly expressed in root and stem, and its subcellular location is in the endoplasmic reticulum. The ectopic expression of <i>GhCYP710A1</i> gene promoted the synthesis of stigmasterol in <i>Arabidopsis</i>. …”
Get full text

Severe spinal cord hypoplasia due to a novel ATAD3A compound heterozygous deletion by Tomohiro Ebihara, Taro Nagatomo, Yohei Sugiyama, Tomoko Tsuruoka, Yoshiteru Osone, Masaru Shimura, Makiko Tajika, Keiko Ichimoto, Yuki Naruke, Nana Akiyama, Sze Chern Lim, Yukiko Yatsuka, Kazuhiro R. Nitta, Yoshihito Kishita, Takuya Fushimi, Atsuko Okazaki, Akira Ohtake, Yasushi Okazaki, Kei Murayama

“…The ATAD3A protein is essential for normal interaction between mitochondria and endoplasmic reticulum and is important for mitochondrial biosynthesis. …”
Get full text

Norketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells via a Ca²⁺-Regulated ERK1/2-Acti... by Jhe-Wei Lin, Yi-Chun Lin, Jui-Ming Liu, Shing-Hwa Liu, Kai-Min Fang, Ren-Jun Hsu, Chun-Fa Huang, Kai-Yao Chang, Kuan-I Lee, Kai-Chih Chang, Chin-Chuan Su, Ya-Wen Chen

“…NK exposure of cells also triggered the expression of endoplasmic reticulum (ER) stress-related proteins including GRP78, CHOP, XBP-1, ATF-4 and -6, caspase-12, PERK, eIF-2α, and IRE-1. …”
Get full text