The Wheat Bax Inhibitor-1 Protein Interacts with an Aquaporin TaPIP1 and Enhances Disease Resistance in Arabidopsis by Pan-Pan Lu, Pan-Pan Lu, Tai-Fei Yu, Tai-Fei Yu, Wei-Jun Zheng, Ming Chen, Yong-Bin Zhou, Yong-Bin Zhou, Jun Chen, You-Zhi Ma, Ya-Jun Xi, Zhao-Shi Xu

“…Bax inhibitor-1 (BI-1) is an endoplasmic reticulum (ER)-resident cell death suppressor evolutionarily conserved in eukaryotes. …”
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Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation by Sylvia Torres-Odio, Jana Key, Hans-Hermann Hoepken, Júlia Canet-Pons, Lucie Valek, Bastian Roller, Michael Walter, Blas Morales-Gordo, David Meierhofer, Patrick N. Harter, Michel Mittelbronn, Irmgard Tegeder, Suzana Gispert, Georg Auburger

“…Later, highly significant networks of ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing occurred. Finally, an enrichment of neuroinflammation factors appeared, together with profiles of bacterial invasion and MAPK signaling changes—while mitophagy had minor significance. …”
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Mitochondrial Calcium Nanoregulators Reverse the Macrophage Proinflammatory Phenotype Through Restoring Mitochondrial Calcium Homeostasis for the Treatment of Osteoarthritis by Lei X, Tan G, Wang Y, Chen L, Cao Y, Si B, Zhen Z, Li B, Jin Y, Wang W, Jin F

“…The optimal METP NP concentration was further applied, and the endoplasmic reticulum (ER) and cytoplasm calcium levels were detected. …”
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Quantitative Lipid Profiling Reveals Major Differences between Liver Organoids with Normal Pi*M and Deficient Pi*Z Variants of Alpha-1-antitrypsin by Sara Pérez-Luz, Jaanam Lalchandani, Nerea Matamala, Maria Jose Barrero, Sara Gil-Martín, Sheila Ramos-Del Saz, Sarai Varona, Sara Monzón, Isabel Cuesta, Iago Justo, Alberto Marcacuzco, Loreto Hierro, Cristina Garfia, Gema Gomez-Mariano, Sabina Janciauskiene, Beatriz Martínez-Delgado

“…According to transcriptomic analysis, Pi*ZZ organoids possess many alterations in genes and cellular processes of lipid metabolism with a specific impact on the endoplasmic reticulum, mitochondria, and peroxisome dysfunction. …”
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Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis by Mariane Spudeit Dal Pizzol, Adriana Mércia Guaratini Ibelli, Maurício Egídio Cantão, Francelly Geralda Campos, Haniel Cedraz de Oliveira, Jane de Oliveira Peixoto, Lana Teixeira Fernandes, Fernando de Castro Tavernari, Marcos Antônio Zanella Morés, Ana Paula Almeida Bastos, Mônica Corrêa Ledur

“…The WS vs control contrast had two unique pathways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant. …”
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GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes by Jayashree Jena, Luis Miguel García-Peña, Eric T Weatherford, Alex Marti, Sarah H Bjorkman, Kevin Kato, Jivan Koneru, Jason H Chen, Randy J Seeley, E Dale Abel, Renata O Pereira

“…To determine alternative mediators of this phenotype, we performed transcriptome analysis, which revealed increased levels of growth differentiation factor 15 (GDF15), along with increased protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) levels in BAT. To investigate whether ATF4 induction was mediated by PERK and evaluate the contribution of GDF15 to the resistance to DIO, we selectively deleted PERK or GDF15 in OPA1 BKO mice. …”
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TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics by Elena Senís, Miriam Esgleas, Sonia Najas, Verónica Jiménez-Sábado, Camilla Bertani, Marta Giménez-Alejandre, Alba Escriche, Jorge Ruiz-Orera, Marta Hergueta-Redondo, Mireia Jiménez, Albert Giralt, Paolo Nuciforo, M. Mar Albà, M. Mar Albà, Héctor Peinado, Daniel del Toro, Leif Hove-Madsen, Magdalena Götz, María Abad

“…At the subcellular level, pTUNAR is a transmembrane protein that localizes in the endoplasmic reticulum and interacts with the calcium transporter SERCA2. pTUNAR overexpression reduces cytoplasmatic calcium, consistent with a possible role of pTUNAR as an activator of SERCA2. …”
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Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells by Muhammad Saad Khilji, Pouya Faridi, Erika Pinheiro-Machado, Carolin Hoefner, Tina Dahlby, Ritchlynn Aranha, Søren Buus, Morten Nielsen, Justyna Klusek, Thomas Mandrup-Poulsen, Kirti Pandey, Anthony W. Purcell, Michal T. Marzec

“…We have shown that loss of the proinsulin chaperone glucose-regulated protein (GRP) 94 from the endoplasmic reticulum (ER) leads to mishandling of proinsulin, ER stress, and activation of the immunoproteasome. …”
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation by Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly

“…Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. …”
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Jacalin-related lectin 45 (OsJRL45) isolated from ‘sea rice 86’ enhances rice salt tolerance at the seedling and reproductive stages by Qinmei Gao, Xiaolin Yin, Feng Wang, Congzhi Zhang, Feicui Xiao, Hongyan Wang, Shuchang Hu, Weihao Liu, Shiqi Zhou, Liangbi Chen, Xiaojun Dai, Manzhong Liang

“…OsJRL45 showed high expression level in leaves, and the corresponding protein mainly localized to the endoplasmic reticulum. The knockout mutant and overexpression lines of OsJRL45 revealed that OsJRL45 positively regulates the salt tolerance of rice plants at all growth stages. …”
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Curcumin ameliorates H₂O₂-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells by Cao Zhaohui, Wu Zhuan, Duan Tingting, Tang Cifei, Huang Di, Hu Xiaobo

“…Oxidative stress and endoplasmic reticulum (ER) stress play crucial roles in pancreatic β cell destruction, leading to the development and progression of type 1 diabetes mellitus (T1DM). …”
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Neuronal p58^IPK Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension by Todd McLaughlin, Jinli Wang, Liyun Jia, Fuguo Wu, Yaqin Wang, Joshua J. Wang, Xiuqian Mu, Sarah X. Zhang

“…p58^IPK is a multifaceted endoplasmic reticulum (ER) chaperone and a regulator of eIF2α kinases involved in a wide range of cellular processes including protein synthesis, ER stress response, and macrophage-mediated inflammation. …”
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Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic HepatitisSummary by Yuan Li, Joy X. Jiang, Weiguo Fan, Sarah R. Fish, Suvarthi Das, Parul Gupta, Gergely Mozes, Lorand Vancza, Sutapa Sarkar, Koshi Kunimoto, Dongning Chen, Hyesuk Park, Dahn Clemens, Alexey Tomilov, Gino Cortopassi, Natalie J. Török

“…In vivo, Shc-dependent induction, and, in hepatocytes, a p46Shc-dependent increase in pre-apoptotic proteins Bax/Bak, caspase 8, BAP31 cleavage, and membrane translocation of CRT/endoplasmic reticulum-resident protein 57 were seen. Idebenone protected against alcohol-mediated liver injury. …”
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A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport by Ruth Cruz-Cosme, Jiantao Zhang, Jiantao Zhang, Dongxiao Liu, Vidhyanand Mahase, Bhargava Teja Sallapalli, Peixi Chang, Yanjin Zhang, Shaolei Teng, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Qiyi Tang

“…Upon synthesis, it is transported from endoplasmic reticulum, Golgi apparatus to plasma membrane and subcellular endomembranes including endosomes and lysosomes. …”
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Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1 by Wenfeng Ren, Zilong Xu, Yating Chang, Fei Ju, Hongning Wu, Zhiqi Liang, Min Zhao, Naizhen Wang, Yanhua Lin, Chenhang Xu, Shengming Chen, Yipeng Rao, Chaolong Lin, Jianxin Yang, Pingguo Liu, Jun Zhang, Chenghao Huang, Ningshao Xia

“…Mechanistically, OTUB2 directly interacts with PD-L1 to disrupt the ubiquitination and degradation of PD-L1 in the endoplasmic reticulum. Genetic deletion of OTUB2 markedly decreases the expression of PD-L1 proteins on the tumor cell surface, resulting in increased tumor cell sensitivity to CD8+ T-cell-mediated cytotoxicity. …”
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Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats by Gaia Papini, Giulia Furini, Marco Matteucci, Vanessa Biemmi, Valentina Casieri, Nicole Di Lascio, Giuseppina Milano, Lucia Rosa Chincoli, Francesco Faita, Lucio Barile, Vincenzo Lionetti

“…SFN-F-EXOs counteract angiotensin II (AngII)-induced hypertrophy and apoptosis in murine HL-1 cardiomyocytes enhancing SERCA2a (sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a) levels more effectively than F-EXOs. …”
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Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands by Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester

“…The nicotinic iDrugSnFRs detect their drug partners in solution, as well as at the plasma membrane (PM) and in the endoplasmic reticulum (ER) of cell lines and mouse hippocampal neurons. …”
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MicroRNA expression profiles of stress susceptibility and resilience in the prelimbic and infralimbic cortex of rats after single prolonged stress by Gengdi Huang, Gengdi Huang, Javed Iqbal, Javed Iqbal, Dan Shen, Yan-xue Xue, Mei Yang, Mei Yang, Mei Yang, Mei Yang, Mei Yang, Xiaojian Jia, Xiaojian Jia, Xiaojian Jia

“…In the PL cortex, results indicated that the DEmiRs were enriched exclusively in the cellular component level of the endoplasmic reticulum lumen in the comparison between resilient and control rats. …”
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Genome-wide identification and analysis of the CNGC gene family in upland cotton under multiple stress conditions by Joy Nyangasi Kirungu, Richard Odongo Magwanga, Margaret Linyerera Shiraku, Erick Okuto, Xiaoyan Cai, Yanchao Xu, Yuqing Hou, Stephen Gaya Agong’, Kunbo Wang, Yuhong Wang, Zhongli Zhou, Fang Liu

“…The majority of CNGC proteins were localized in the endoplasmic reticulum, nucleus, and plasma membrane. Gene expression analysis revealed the up-regulation of Gh_A01G0520 (CNGC4) and Gh_D13G1974 (CNGC5) across various forms of abiotic stresses. …”
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Allantoate Amidohydrolase OsAAH is Essential for Preharvest Sprouting Resistance in Rice by Ting Xie, Wenling Hu, Jiaxin Shen, Jiangyu Xu, Zeyuan Yang, Xinyi Chen, Peiwen Zhu, Mingming Chen, Sunlu Chen, Hongsheng Zhang, Jinping Cheng

“…OsAAH protein was localized to the endoplasmic reticulum, with a function of hydrolyzing allantoate in vitro. …”
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