Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats by Qi Li, Bo Wang, Kai-Wen Lin, Tang Deng, Qi-Feng Huang, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Nan Li, Yang Yi, Ji-Chao Peng, Yue Huang, Jin Qian, Xiao-Ran Liu

“…The mechanism of the protective effects of AH2QDS may be linked to reduction in cellular oxidative stress, PQ content of renal tissue, inflammatory injury, endoplasmic reticulum stress, and apoptosis. AH2QDS may play a role in the treatment of PQ poisoning by upregulating the expression of the apelin-APJ.…”
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Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish by Qianwen Ding, Qianwen Ding, Chenyao Lu, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhen Zhang, Zhigang Zhou

“…Hepatic proteins with increased succinylation levels were enriched in oxidative phosphorylation while proteins with decreased succinylation levels were enriched in the processes of protein processing and transport in the endoplasmic reticulum. Finally, fish fed the S0.15 diet had a higher abundance of Proteobacteria but a lower abundance of Fusobacteria and Cetobacterium. …”
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A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish by Jillian L. Ellis, Kimberley J. Evason, Changwen Zhang, Makenzie N. Fourman, Jiandong Liu, Nikolay Ninov, Marion Delous, Benoit Vanhollebeke, Ian Fiddes, Jessica P. Otis, Yariv Houvras, Steven A. Farber, Xiaolei Xu, Xueying Lin, Didier Y. R. Stainier, Chunyue Yin

“…The mutation altered Furinb localization and caused endoplasmic reticulum (ER) stress. The cystic phenotype could be suppressed by treatment with the ER stress inhibitor 4‐phenylbutyric acid and exacerbated by treatment with the ER stress inducer tunicamycin. …”
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MicroRNA expression profile of chicken jejunum in different time points Eimeria maxima infection by Endashaw Jebessa, Endashaw Jebessa, Endashaw Jebessa, Semiu Folaniyi Bello, Semiu Folaniyi Bello, Lijin Guo, Lijin Guo, Merga Daba Tuli, Olivier Hanotte, Olivier Hanotte, Qinghua Nie, Qinghua Nie

“…J7C, the KEGG pathway was significantly enriched, including metabolic pathways, protein processing in the endoplasmic reticulum, ubiquitin-mediated proteolysis, and FoxO signaling pathway. …”
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Potential Anti-<i>Candida albicans</i> Mechanism of Trichoderma Acid from <i>Trichoderma spirale</i> by Wei Ye, Yuchan Chen, Weimin Zhang, Taomei Liu, Yuping Liu, Mengran Li, Saini Li, Liqiong Xu, Hongxin Liu

“…Our results revealed that mitochondrial membrane potential, endoplasmic reticulum, ribosomes in the mitochondria, and cell walls were disrupted in TA-treated <i>C. albicans</i>, leading to the accumulation of ROS. …”
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Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands by Irene Marginedas-Freixa, Cora L. Alvarez, Martina Moras, Claude Hattab, Guillaume Bouyer, Arnaud Chene, Sophie D. Lefevre, Caroline Le Van Kim, Frederic Bihel, Pablo J. Schwarzbaum, Mariano A. Ostuni

“…TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic reticulum. The design of specific tools is necessary to determine the molecular associations and functions of TSPO, which remain controversial nowadays. …”
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Subcellular positioning during cell division and cell plate formation in maize by Lindy A. Allsman, Marschal A. Bellinger, Vivian Huang, Matthew Duong, Alondra Contreras, Andrea N. Romero, Benjamin Verboonen, Sukhmani Sidhu, Xiaoguo Zhang, Holly Steinkraus, Aimee N. Uyehara, Stephanie E. Martinez, Rosalie M. Sinclair, Gabriela Salazar Soriano, Beatrice Diep, Dawson Byrd V., Alexander Noriega, Georgia Drakakaki, Anne W. Sylvester, Carolyn G. Rasmussen

“…This dynamic process requires coordinated movement and arrangement of the cytoskeleton and organelles.MethodsHere we use live-cell markers to track the dynamic reorganization of microtubules, nuclei, endoplasmic reticulum, and endomembrane compartments during division and the formation of the cell plate in maize leaf epidermal cells.ResultsThe microtubule plus-end localized protein END BINDING1 (EB1) highlighted increasing microtubule dynamicity during mitosis to support rapid changes in microtubule structures. …”
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A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury by Ramani Soundararajan, Helena Hernández-Cuervo, Helena Hernández-Cuervo, Timothy M Stearns, Anthony J Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi, Narasaiah Kolliputi

“…Genetic deletion of the mitochondrial A-kinase anchoring protein 1 (Akap1) in mice resulted in mitochondrial damage, Endoplasmic reticulum (ER) stress, increased expression of mitophagy proteins and pro-inflammatory cytokines, exacerbating hyperoxia-induced Acute Lung Injury (HALI).Objective: Despite a strong causal link between mitochondrial dysfunction and HALI, the mechanisms governing the disease progression at the transcriptome level is unknown.Methods: In this study, RNA sequencing (RNA-seq) analysis was carried out using the lungs of Akap1 knockout (Akap1−/−) mice exposed to normoxia or 48 h of hyperoxia followed by quantitative real time PCR and Ingenuity pathway analysis (IPA). …”
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Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays by Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson, Ruth J Napier, Jonathan N Pruneda, Hugo J Bellen

“…Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated with developmental and epileptic encephalopathy 44 (DEE44), an autosomal recessive disorder characterized by early-onset encephalopathy, movement abnormalities, global developmental delay, intellectual disability, and seizures. …”
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Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive <i>Trichomonas vaginalis</i> Strains Identified Distinct Genes and Pathways Associated with Drug Res... by Po-Jung Huang, Ching-Yun Huang, Yu-Xuan Li, Yi-Chung Liu, Lichieh-Julie Chu, Yuan-Ming Yeh, Wei-Hung Cheng, Ruei-Ming Chen, Chi-Ching Lee, Lih-Chyang Chen, Hsin-Chung Lin, Shu-Fang Chiu, Wei-Ning Lin, Ping-Chiang Lyu, Petrus Tang, Kuo-Yang Huang

“…Functional enrichment analysis revealed that purine and pyrimidine metabolisms were suppressed in MTZ-S parasites upon drug treatment, whereas the endoplasmic reticulum-associated degradation (ERAD) pathway, proteasome, and ubiquitin-mediated proteolysis were strikingly activated, highlighting the novel pathways responsible for drug-induced stress. …”
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Identification of Age-associated Proteins and Functional Alterations in Human Retinal Pigment Epithelium by Xiuxiu Jin, Jingyang Liu, Weiping Wang, Jiangfeng Li, Guangming Liu, Ruiqi Qiu, Mingzhu Yang, Meng Liu, Lin Yang, Xiaofeng Du, Bo Lei

“…In older hRPE cells, apoptotic signaling-related pathways were up-regulated, and endoplasmic reticulum organization was down-regulated both in the intracellular and secreted proteomes. …”
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Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions by Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz, María M. Malagón

“…During lipid droplet biogenesis, Rab34 translocates from the Golgi to endoplasmic reticulum-related compartments and then reaches the surface of adipocyte lipid droplets. …”
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Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus by Sarah Al-Beltagi, Cristian Alexandru Preda, Leah V. Goulding, Joe James, Juan Pu, Paul Skinner, Zhimin Jiang, Belinda Lei Wang, Jiayun Yang, Ashley C. Banyard, Kenneth H. Mellits, Pavel Gershkovich, Christopher J. Hayes, Jonathan Nguyen-Van-Tam, Ian H. Brown, Jinhua Liu, Kin-Chow Chang

“…We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca²⁺ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. …”
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<i>N</i>-Glycan on the Non-Consensus N-X-C Glycosylation Site Impacts Activity, Stability, and Localization of the Sd^a Synthase B4GALNT2 by Virginie Cogez, Dorothée Vicogne, Céline Schulz, Lucie Portier, Giulia Venturi, Jérôme de Ruyck, Mathieu Decloquement, Marc F. Lensink, Guillaume Brysbaert, Fabio Dall’Olio, Sophie Groux-Degroote, Anne Harduin-Lepers

“…Furthermore, we observed that the mutant SF-B4GALNT2 was partially mislocalized in the endoplasmic reticulum, whereas the mutant LF-B4GALNT2 was still localized in the Golgi and post-Golgi vesicles. …”
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Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation by Trang Thi Minh Nguyen, Rudy Gadet, Marine Lanfranchi, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Frédéric Saudou, Nikolay Popgeorgiev, Germain Gillet

“…We generated a mouse model, referred to as ER-xL, in which Bcl-xL is absent in the mitochondria, yet present in the endoplasmic reticulum. Unlike bclx knockout mice that died at E13.5, ER-xL mice survived embryonic development but died post-partum because of altered feeding behavior. …”
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HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway by Yunzhi Liu, Qishan Xu, Fan Deng, Zhuojun Zheng, Jialiang Luo, Ping Wang, Jia Zhou, Xiao Lu, Liyun Zhang, Zhengliang Chen, Qifan Zhang, Qingyun Chen, Daming Zuo

“…Mechanically, HERC2 coupled with the endoplasmic reticulum (ER)-resident protein tyrosine phosphatase 1B (PTP1B) and limited PTP1B translocation from ER to ER-plasma membrane junction, which ameliorated the inhibitory role of PTP1B in Janus kinase 2 (JAK2) phosphorylation. …”
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The <i>Arabidopsis</i> J-Protein AtDjC5 Facilitates Thermotolerance Likely by Aiding in the ER Stress Response by Ting-Ting Shen, Lin Wang, Chun-Huan Shang, Yi-Cai Zhen, Yu-Lu Fang, Li-Li Wei, Ting Zhou, Jiao-Teng Bai, Bing Li

“…AtDjC5 was found to localize to the endoplasmic reticulum. The expression of the <i>AtDjC5</i> gene was induced by heat and TM (an ER stress inducer) treatment. …”
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CircDOCK7 facilitates the proliferation and adipogenic differentiation of chicken abdominal preadipocytes through the gga-miR-301b-3p/ACSL1 axis by Weihua Tian, Ye Liu, Wenhui Zhang, Ruixue Nie, Yao Ling, Bo Zhang, Hao Zhang, Changxin Wu

“…Chicken ACSL1 protein is localized in the endoplasmic reticulum and mitochondria of chicken abdominal preadipocytes and acts as an adipogenesis accelerator. …”
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Rosiglitazone Reverses Inflammation in Epididymal White Adipose Tissue in Hormone-Sensitive Lipase-Knockout Mice by Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O. Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R. Pieber

“…Here, we investigated if and to what extent HSL loss contributes to endoplasmic reticulum (ER) stress and adipose tissue inflammation in Hsl knockout mice. …”
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Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis by Jiahui Ni, Lijie Zhang, Guize Feng, Weilian Bao, Yirui Wang, Yuran Huang, Tongqing Chen, Jieli Chen, Xinyue Cao, Keyuan You, Sheng Tan, Thomas Efferth, Hong Li, Bo Li, Xiaoyan Shen, Yan You

“…The binding of VA to CA9 causes insulin-induced gene-2 (INSIG2) to interact with stromal interaction molecule 1 (STIM1), rather than SREBP cleavage-activating protein (SCAP), leading to the translocation of SCAP-SREBP1 from the endoplasmic reticulum (ER) to the Golgi apparatus for cleavage into mature SREBP1. …”
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