Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity by Nan Cai, Xuanrong Chen, Jia Liu, Zheyao Wen, Siyin Wen, Wen Zeng, Shuo Lin, Yanming Chen, Guojun Shi, Longyi Zeng

“…Transcriptomic analysis of liver tissues indicated the lipogenesis and protein kinase RNA-like endoplasmic reticulum kinase (PERK)-unfolded protein response (UPR) pathway activations in GKA-treated HFD-fed mice. …”
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Minimally invasive injection of biomimetic Nano@Microgel for in situ ovarian cancer treatment through enhanced photodynamic reactions and photothermal combined therapy by Xiaodong Ma, Wenhui Zhou, Rong Zhang, Cancan Zhang, Jiaqi Yan, Jing Feng, Jessica M. Rosenholm, Tingyan Shi, Xian Shen, Hongbo Zhang

“…Moreover, we further conjugated an endoplasmic reticulum (ER) targeting ligand Tosyl Ethylenediamine (Ter) on the surface of Au-MSN NPs. …”
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Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patient... by Qiwei Wang, Xiaoshan Lin, Kunbei Lai, Yinghui Liu, Tingfeng Qin, Haowen Tan, Jing Li, Zhuoling Lin, Xulin Zhang, Xiaoyan Li, Haotian Lin, Weirong Chen

“…The observation of typical distended endoplasmic reticulum cisternae further supported the diagnosis of CLSD. …”
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Calcium signaling mediates proliferation of the precursor cells that give rise to the ciliated left-right organizer in the zebrafish embryo by Osama Abdel-Razek, Amanda Marzouk, Madison MacKinnon, Edward T. Guy, Sonny A. Pohar, Emily Zhushma, Junjie Liu, Isabel Sia, Jason J. Gokey, Hwee Goon Tay, Jeffrey D. Amack, Jeffrey D. Amack

“…Small molecule inhibitors of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) were found to reduce DFC mitosis. …”
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Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease by D. Chernyuk, M. Callens, M. Polozova, A. Gordeev, M. Chigriai, A. Rakovskaya, A. Ilina, E. Pchitskaya, C. Van den Haute, T. Vervliet, G. Bultynck, I. Bezprozvanny

“…In particular, increased Ca2+ release from endoplasmic reticulum-located Ca2+ channels, including inositol-1,4,5-trisphosphate type 1 receptors (IP3R1) and ryanodine receptors type 2 (RyR2), have been extensively reported. …”
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TaNF-YB11, a gene of NF-Y transcription factor family in Triticumaestivum, confers drought tolerance on plants via modulating osmolyte accumulation and reactive oxygen species home... by Ying-jia ZHAO, Yan-yang ZHANG, Xin-yang BAI, Rui-ze LIN, Gui-qing SHI, Ping-ping DU, Kai XIAO

“…TaNF-YB11 harbors the conserved domains specified by its NF-YB partners and targets the nucleus after the endoplasmic reticulum (ER) assortment. Yeast two-hybrid assay indicated the interactions of TaNF-YB11 with TaNF-YA2 and TaNF-YC3, two proteins encoded by genes in the NF-YA and NF-YC families, respectively. …”
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Nogo-A Is Critical for Pro-Inflammatory Gene Regulation in Myocytes and Macrophages by H. M. Arif Ullah, A. K. Elfadl, SunYoung Park, Yong Deuk Kim, Myung-Jin Chung, Ji-Yoon Son, Hyun-Ho Yun, Jae-Min Park, Jae-Hyuk Yim, Seung-Jun Jung, Young-Chul Choi, Jin-Hong Shin, Dae-Seong Kim, Jin-Kyu Park, Kyu-Shik Jeong

“…Additionally, experiments showed that endoplasmic reticulum (ER) stress marker, C/EBP homologous protein (CHOP), was upregulated in gastrocnemius muscle of a murine model of ALS. …”
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Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insuf... by Xiao Sun, Shuangshan Dong, Hiroki Kato, Jun Kong, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda

“…MFF silencing also caused mitochondrial Ca²⁺ accumulation through accelerated Ca²⁺ influx from the endoplasmic reticulum (ER) via the inositol 1,4,5-trisphosphate receptor. …”
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PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy by Jinfei Yang, Li Li, Chenrui Li, Wei Chen, Yan Liu, Shilu Luo, Chanyue Zhao, Yachun Han, Ming Yang, Hao Zhao, Na Jiang, Yiyun Xi, Chengyuan Tang, Juan Cai, Li Xiao, Huafeng Liu, Lin Sun

“…Abstract Autophagy of endoplasmic reticulum (ER-phagy) selectively removes damaged ER through autophagy-lysosome pathway, acting as an adaptive mechanism to alleviate ER stress and restore ER homeostasis. …”
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ER proteostasis regulators cell-non-autonomously control sleep by Taizo Kawano, Mitsuaki Kashiwagi, Mika Kanuka, Chung-Kuan Chen, Shinnosuke Yasugaki, Sena Hatori, Shinichi Miyazaki, Kaeko Tanaka, Hidetoshi Fujita, Toshiro Nakajima, Masashi Yanagisawa, Yoshimi Nakagawa, Yu Hayashi

“…Here, a forward genetic screen in C. elegans identifies 3 genes that strongly affect sleep amount: sel-1, sel-11, and mars-1. sel-1 and sel-11 encode endoplasmic reticulum (ER)-associated degradation components, whereas mars-1 encodes methionyl-tRNA synthetase. …”
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SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes by Katterine Salazar, Francisca Espinoza, Gustavo Cerda-Gallardo, Luciano Ferrada, Rocío Magdalena, Eder Ramírez, Viviana Ulloa, Natalia Saldivia, Ninoschka Troncoso, María José Oviedo, María José Barahona, Fernando Martínez, Francisco Nualart

“…SVCT2 was mainly observed in the cell membrane and endoplasmic reticulum; however, it was not detected in the mitochondria. …”
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Neuroprotective role of plumbagin on eye damage induced by high-sucrose diet in adult fruit fly Drosophila melanogaster by Elisabetta Catalani, Simona Del Quondam, Kashi Brunetti, Agnese Cherubini, Silvia Bongiorni, Anna Rita Taddei, Silvia Zecchini, Matteo Giovarelli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Davide Cervia

“…Likewise, plumbagin may act additively and/or synergistically inhibiting the mitochondrial-endoplasmic reticulum stress and unfolded protein response pathways, which prevented neuronal impairment and eye damage induced by reactive oxygen species. …”
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Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alc... by Kentaro Murakami, Yusuke Sasaki, Masato Asahiyama, Wataru Yano, Toshiaki Takizawa, Wakana Kamiya, Yoshihiro Matsumura, Motonobu Anai, Tsuyoshi Osawa, Jean-Charles Fruchart, Jamila Fruchart-Najib, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama, Toshiya Tanaka

“…In addition, combination treatment reduced expression levels of endoplasmic reticulum stress-related genes (<i>Ire1a</i>, <i>Grp78</i>, <i>Xbp1</i>, and <i>Phlda3</i>). …”
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Activation of NR1H3 attenuates the severity of septic myocardial injury by inhibiting NLRP3 inflammasome by Chao Deng, Qiong Liu, Huadong Zhao, Lu Qian, Wangrui Lei, Wenwen Yang, Zhenxing Liang, Ye Tian, Shaofei Zhang, Changyu Wang, Ying Chen, Yang Yang

“…NR1H3 knockout worsensed cardiac dysfunction and injury in mice subjected to cecal ligation and puncture (CLP), in association with exacerbated NLRP3‐mediated inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis‐related markers. …”
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Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds by Veronika Palušová, Tereza Renzová, Amandine Verlande, Tereza Vaclová, Michaela Medková, Linda Cetlová, Miroslava Sedláčková, Hana Hříbková, Iva Slaninová, Miriama Krutá, Vladimír Rotrekl, Hana Uhlířová, Aneta Křížová, Radim Chmelík, Pavel Veselý, Michaela Krafčíková, Lukáš Trantírek, Kay Oliver Schink, Stjepan Uldrijan

“…The induced disruption of the endolysosomal pathway not only disrupts mTORC1 signaling, but also renders melanoma cells sensitive to endoplasmic reticulum (ER) stress. Our findings identify new activities of pharmacologically relevant small molecule compounds and provide a biological rationale for the development of anti-melanoma therapeutics based on the pyridinyl imidazole core.…”
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Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and LipolysisSummary by Seol Hee Park, Wonhyo Seo, Ming-Jiang Xu, Bryan Mackowiak, Yuhong Lin, Yong He, Yaojie Fu, Seonghwan Hwang, Seung-Jin Kim, Yukun Guan, Dechun Feng, Liqing Yu, Richard Lehner, Suthat Liangpunsakul, Bin Gao

“…Results: Oral administration of a single dose of ethanol induced acute liver injury and hepatic endoplasmic reticulum (ER) stress in chow- or HFD-fed mice. …”
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The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression by Yunsheng Gao, Joy Birkelbach, Chengzhang Fu, Jennifer Herrmann, Herbert Irschik, Bernd Morgenstern, Kerstin Hirschfelder, Ruijuan Li, Youming Zhang, Rolf Jansen, Rolf Müller

“…The main component disorazole Z1 shows comparable activity in effectively killing cancer cells to disorazole A1 via binding to tubulin, which we show induces microtubule depolymerization, endoplasmic reticulum delocalization, and eventually apoptosis. …”
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Trends of mitochondrial changes in AD: a bibliometric study by Ruiyao Song, Yunchu Guo, Yu Fu, Hongling Ren, Hairong Wang, Hongting Yan, Yusong Ge, Yusong Ge

“…The hotpots of mitochondrial dysfunction in AD were as follows: “oxidative stress,” “amyloid-beta-protein,” “tau,” “apoptosis,” “inflammation,” “autophagy,” “precursor protein,” “endoplasmic-reticulum,” “dynamics” and “mitochondrial unfolded protein response.”ConclusionThis bibliometric analysis research will help readers rapidly identify current hotpots and milestone studies related to directions of interest in AD research.…”
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The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses by Kan Xing Wu, Thinesshwary Yogarajah, Marcus Wing Choy Loe, Parveen Kaur, Regina Ching Hua Lee, Chee Keng Mok, Yi Hao Wong, Patchara Phuektes, Li Sze Yeo, Vincent T.K. Chow, Yong Wah Tan, Justin Jang Hann Chu

“…Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories. …”
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Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress by Zhixin Liu, Yanan Fu, Yanping Huang, Feng Zeng, Jingjing Rao, Xiao Xiao, Xiaoguang Sun, Hao Jin, Jian Li, Jing Yang, Weixing Du, Long Liu

“…We show that ORF7a induces cell apoptosis by recruiting the prosurvival factor BclXL to the endoplasmic reticulum (ER) via the exposed C-terminal residues Lys117 and Lys119. …”
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