Characterizing the West Nile Virus's polyprotein from nucleotide sequence to protein structure – Computational tools by Mallari Praveen

“…Two proteins had signals for localization in the host endoplasmic reticulum. Non-structural (NS) 2A showed low protein disorder. …”
Get full text

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis by Mengyue You, Fan Wu, Meilin Gao, Mengyue Chen, Shu Zeng, Yang Zhang, Wei Zhao, Danyang Li, Li Wei, Xiong Z. Ruan, Yaxi Chen

“…SelenoproteinK (SelK), an endoplasmic reticulum (ER) - resident protein, possesses the property of mediate oxidation resistance and ER - associated protein degradation (ERAD) in several tissues. …”
Get full text

Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling... by I.-Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin, Po-Len Liu

“…Cardiac mitochondrial shape transition and damage, mitochondria-associated endoplasmic reticulum membrane (MAM) disruption, cardiac function change, caspase-mediated apoptosis pathway activation, and cardiac remodeling were examined using TEM, echocardiography, immunohistochemistry, and Western blot assay. …”
Get full text

The Protective Effects of Hydrogen Sulfide New Donor Methyl <i>S</i>-(4-Fluorobenzyl)-<i>N</i>-(3,4,5-Trimethoxybenzoyl)-<span style="font-variant: small-caps">l</span>-Cysteinate... by Jing Fan, Junxi Du, Zhongwei Zhang, Wenjing Shi, Binyan Hu, Jiaqin Hu, Yan Xue, Haipeng Li, Wenjin Ji, Jian Zhuang, Pengcheng Lv, Kui Cheng, Kun Chen

“…The levels of cleaved caspase-9 and cleaved caspase-3 were also reduced in the plasma. The endoplasmic reticulum stress (ERS) was decreased, which in turns the survival rate of nerve cells was increased, so that the ischemic injury of neurons was protected accordingly. …”
Get full text

Manpixiao Decoction Halted the Malignant Transformation of Precancerous Lesions of Gastric Cancer: From Network Prediction to In-Vivo Verification by Yuan Li, Yuan Li, Yuan Li, Tao Li, Jiena Chen, Haocheng Zheng, Yicong Li, Fuhao Chu, Fuhao Chu, Fuhao Chu, Sici Wang, Ping Li, Jie Lin, Zeqi Su, Xia Ding, Xia Ding

“…Network pharmacology results demonstrated that inflammation, immune responses, and angiogenesis might be associated with the efficacy of MPX in the treatment of PLGC, in which the PI3K-Akt, cellular senescence, P53 and protein processing in endoplasmic reticulum were involved. Then, we established a rat model of PLGC using a combination of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), sodium salicylate, irregular fasting, and ranitidine, and observed the effects after MPX treatment. …”
Get full text

TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer’s disease by Jessica Panes-Fernandez, Pamela A. Godoy, Javiera Gavilan, Oscar Ramírez-Molina, Carlos Felipe Burgos, Ana Marileo, Oscar Flores-Núñez, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yévenes, Carola Muñoz-Montesino, Jorge Fuentealba

“…AβTG2 induced an acute increase in intracellular Ca2+, miniature currents, and hiperexcitability, consistent with an increased mitochondrial Ca2+ overload, IP3R-VDAC tethering, and mitochondria-endoplasmic reticulum contacts (MERCs). AβTG2 also decreased neuronal viability and excitatory postsynaptic currents, reinforcing the idea of synaptic failure associated with MAMs dysregulation mediated by TG2. …”
Get full text

SARS-CoV-2: Ultrastructural Characterization of Morphogenesis in an In Vitro System by Debora Ferreira Barreto-Vieira, Marcos Alexandre Nunes da Silva, Ana Luisa Teixeira de Almeida, Arthur da Costa Rasinhas, Maria Eduarda Monteiro, Milene Dias Miranda, Fernando Couto Motta, Marilda M. Siqueira, Wendell Girard-Dias, Bráulio Soares Archanjo, Patricia T. Bozza, Thiago Moreno L. Souza, Suelen Silva Gomes Dias, Vinicius Cardoso Soares, Ortrud Monika Barth

“…Several ultrastructural changes were observed—such as syncytia formation, cytoplasmic membrane projections, lipid droplets accumulation, proliferation of double-membrane vesicles derived from the rough endoplasmic reticulum, and alteration of mitochondria. The entry of the virus into cells occurred through endocytosis. …”
Get full text

Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11 by Zixi Wang, Huaiyuan Zong, Weiwei Liu, Wei Lin, Anjiang Sun, Zhao Ding, Xu Chen, Xiaofeng Wan, Yanyan Liu, Zhongdong Hu, Hongbing Zhang, Hongwu Li, Yehai Liu, Dapeng Li, Sumei Zhang, Xiaojun Zha

“…However, the precise underlying mechanisms still need to be fully understood. Methods Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) expression in mTORC1-activated mouse embryonic fibroblasts, cancer cells, and laryngeal squamous cell carcinoma (LSCC) clinical samples was examined by quantitative real-time PCR (qRT–PCR), western blotting, immunofluorescence (IF), and immunohistochemistry. …”
Get full text

Mutation of <i>OsLPR3</i> Enhances Tolerance to Phosphate Starvation in Rice by Hao Ai, Xiuli Liu, Zhi Hu, Yue Cao, Nannan Kong, Feiyan Gao, Siwen Hu, Xing Shen, Xianzhong Huang, Guohua Xu, Shubin Sun

“…<i>Low Phosphate Root</i> (<i>LPR</i>) encodes a protein localized to the endoplasmic reticulum (ER) and cell wall. This gene plays a key role in responding to phosphate (Pi) deprivation, especially in remodeling the root system architecture (RSA). …”
Get full text

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis by Danyi Zou, Yimin Cai, Meng Jin, Ming Zhang, Yizhuo Liu, Shuoni Chen, Shuhui Yang, Heng Zhang, Xu Zhu, Chaoqun Huang, Ying Zhu, Xiaoping Miao, Yongchang Wei, Xiaojun Yang, Jianbo Tian, Jing Ni, Xuehong Zhang

“…The rs71630754 regulating the expression of endoplasmic reticulum aminopeptidase 1 (ERAP1) was significantly associated with the prognosis of CRC (additive model, hazard ratio [HR]: 1.43, 95% confidence interval [CI]: 1.08-1.88, P = 0.012). …”
Get full text

Imaging and Manipulation of Plasma Membrane Fatty Acid Clusters Using TOF-SIMS Combined Optogenetics by Chi Zhang, Kenji Kikushima, Mizuki Endo, Tomoaki Kahyo, Makoto Horikawa, Takaomi Matsudaira, Tatsuya Tanaka, Yusuke Takanashi, Tomohito Sato, Yutaka Takahashi, Lili Xu, Naoki Takayama, Ariful Islam, Md. Al Mamun, Takeaki Ozawa, Mitsutoshi Setou

“…By the optogenetic tool translocating the endoplasmic reticulum (ER), we were able to manipulate the distribution of PM FAs. …”
Get full text

Whole-Blood Gene Expression Profiles Associated with Mortality in Community-Acquired Pneumonia by Diego Viasus, Antonella F. Simonetti, Lara Nonell, Oscar Vidal, Yolanda Meije, Lucía Ortega, Magdalena Arnal, Marta Bódalo-Torruella, Montserrat Sierra, Alexander Rombauts, Gabriela Abelenda-Alonso, Gemma Blanchart, Carlota Gudiol, Jordi Carratalà

“…Similarly, GSEA identified seven positively enriched gene sets, associated with the oxidative stress, endoplasmic reticulum stress, oxidative phosphorylation, and angiogenesis pathways, in the patients who died. …”
Get full text

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin by Solène Denolly, Hongbo Guo, Miriam Martens, Anna Płaszczyca, Pietro Scaturro, Vibhu Prasad, Kessiri Kongmanas, Nuntaya Punyadee, Adisak Songjaeng, Dumrong Mairiang, Andreas Pichlmair, Panisadee Avirutnan, Ralf Bartenschlager

“…We show that ivermectin impairs folding and secretion of endoplasmic reticulum-luminal glycoproteins, including NS1. …”
Get full text

Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury by Yi Li, Hua-bin Wang, Jin-long Cao, Wen-jun Zhang, Hai-long Wang, Chang-hong Xu, Kun-peng Li, Yi Liu, Ji-rong Wang, Hua-lan Ha, Sheng-jun Fu, Li Yang

“…Abstract Background The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). …”
Get full text

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein by Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki

“…We found that RNF185 and the SARS-CoV-2 envelope co-localize to the endoplasmic reticulum (ER). Finally, we demonstrate that the depletion of RNF185 significantly increases SARS-CoV-2 viral titer in a cellular model. …”
Get full text

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…As previously shown in other cancer types, we demonstrated that the molecular mechanism of action of ABTL0812 in glioblastoma involves the inhibition of Akt/mTORC1 axis by overexpression of TRIB3, and the activation of endoplasmic reticulum (ER) stress/unfolded protein response (UPR). …”
Get full text

milR20 negatively regulates the development of fruit bodies in Pleurotus cornucopiae by Yuhui Qi, Yuhui Qi, Yuhui Qi, Chenyang Huang, Chenyang Huang, Chenyang Huang, Mengran Zhao, Mengran Zhao, Mengran Zhao, Xiangli Wu, Xiangli Wu, Xiangli Wu, Guangyu Li, Guangyu Li, Guangyu Li, Yingjie Zhang, Yingjie Zhang, Yingjie Zhang, Yingjie Zhang, Lijiao Zhang, Lijiao Zhang, Lijiao Zhang

“…Comparison of the DEGs and DEMs across the different development stages revealed that DEMs and its target DEGs involved in the mitogen-activated protein kinase (MAPK) signaling pathway, protein processing in endoplasmic reticulum, endocytosis, aminoacyl-tRNA biosynthesis, RNA transport, and other metabolism pathways, which may play important roles in the development of the fruit bodies of P. cornucopiae. …”
Get full text

Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection by Francesca Liccardo, Martyna Śniegocka, Claudia Tito, Alessia Iaiza, Tiziana Ottone, Mariadomenica Divona, Serena Travaglini, Maurizio Mattei, Rosella Cicconi, Selenia Miglietta, Giuseppe Familiari, Stefania Annarita Nottola, Vincenzo Petrozza, Luca Tamagnone, Maria Teresa Voso, Silvia Masciarelli, Francesco Fazi

“…FLT3-ITD is retained in the endoplasmic reticulum (ER) and generates intrinsic proteotoxic stress. …”
Get full text

Comparison of the Effects of Monounsaturated Fatty Acids and Polyunsaturated Fatty Acids on Liver Lipid Disorders in Obese Mice by Wen Liu, Min Zhu, Meng Gong, Wen Zheng, Xin Zeng, Qing Zheng, Xiaoyu Li, Fudong Fu, Yingyi Chen, Jingqiu Cheng, Zhiyong Rao, Yanrong Lu, Younan Chen

“…Particularly, oleic acid (OA) was superior to eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), and arachidonic acid (AA) in terms of its anti-apoptotic effect and inhibition of endoplasmic reticulum (ER) stress. In vivo, both olive-oil-enriched (HFD + OO) and fish-oil-enriched high-fat diets (HFD + FO) reduced hepatic steatosis and improved insulin sensitivity in obese mice. …”
Get full text

1-Nitropyrene disrupts testicular steroidogenesis via oxidative stress-evoked PERK-eIF2α pathway by Xiu-liang Li, Yu-lin Liu, Jia-yu Liu, Yan-yan Zhu, Xin-xin Zhu, Wei-wei Zhang, Jian Li, Ye Zhao, Ling-li Zhao, Cheng Zhang, Hua Wang, De-xiang Xu, Lan Gao

“…The present research found 4-phenylbutyric acid (4-PBA), an endoplasmic reticulum (ER) stress inhibitor, recovered 1-NP-induced ER stress and testosterone synthases reduction in TM3 cells. …”
Get full text