Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury by Rong Tang, Peng Jin, Chanjuan Shen, Wei Lin, Leilin Yu, Xueling Hu, Ting Meng, Linlin Zhang, Ling Peng, Xiangcheng Xiao, Peter Eggenhuizen, Joshua D. Ooi, Xueqin Wu, Xiang Ding, Yong Zhong, Jinjiao Li, Yuanyuan Ji

“…Furthermore, PT highly expressed DEGs enriched in endoplasmic reticulum stress, autophagy, and retinoic acid-inducible gene I (RIG-I) signaling. …”
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Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages by Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther, Noam Zelcer

“…Transcriptional profiling of LXR-activated macrophages identified the gene encoding transmembrane protein 86a (TMEM86a), an integral endoplasmic reticulum protein, as a previously uncharacterized sterol-regulated gene. …”
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Maize ZmBES1/BZR1-3 and -9 Transcription Factors Negatively Regulate Drought Tolerance in Transgenic <i>Arabidopsis</i> by Wenqi Feng, Yuan Liu, Yang Cao, Yiran Zhao, Hongwanjun Zhang, Fuai Sun, Qingqing Yang, Wanchen Li, Yanli Lu, Xuecai Zhang, Fengling Fu, Haoqiang Yu

“…The DEGs of <i>ZmBES1/BZR1-3</i> gene’s expressing lines were mainly associated with oxidative stress response and amino acid metabolic process and enriched in phenylpropanoid biosynthesis and protein processing in the endoplasmic reticulum. But the DEGs of the <i>ZmBES1/BZR1-9</i> gene’s expressing lines were predominantly annotated with water deprivation, extracellular stimuli, and jasmonic acid and enriched in phenylpropanoid biosynthesis and plant hormone signal transduction. …”
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The dynamic equilibrium between the protective and toxic effects of matrine in the development of liver injury: a systematic review and meta-analysis by Weiyi Feng, Weiyi Feng, Weiyi Feng, Te-chan Kao, Te-chan Kao, Te-chan Kao, Jiajie Jiang, Jiajie Jiang, Jiajie Jiang, Xinyu Zeng, Xinyu Zeng, Shuang Chen, Shuang Chen, Jinhao Zeng, Jinhao Zeng, Jinhao Zeng, Yu Chen, Yu Chen, Yu Chen, Xiao Ma, Xiao Ma

“…Matrine could alter Ca2+ homeostasis in liver injury via multiple pathways, including the SREBP1c/SCAP, Notch/RBP-J/HES1, IκK/NF-κB, and Cul3/Rbx1/Keap1/Nrf2.Conclusion: Matrine has bidirectional effects on the liver at doses ranging from 10 to 69.1 mg/kg by influencing Ca2+ homeostasis in the cytoplasm, endoplasmic reticulum, Golgi apparatus, and mitochondria.Systematic review registration:https://inplasy.com/, identifier INPLASY202340114…”
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Molecular insights into the responses of barley to yellow mosaic disease through transcriptome analysis by Mengna Zhang, Yi Hong, Juan Zhu, Yuhan Pan, Hui Zhou, Chao Lv, Baojian Guo, Feifei Wang, Rugen Xu

“…Significant enrichments in peptidase complex and protein processing in endoplasmic reticulum were clustered through Gene ontology and KEGG analysis. …”
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The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation by Lifen Xu, Yuxia Zhou, Guifang Wang, Li Bo, Bangming Jin, Lujun Dai, Qinli Lu, Xueni Cai, Laying Hu, Lu Liu, Yixuan Wu, Xuebing Chang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Lingling Liu, Mingjun Shi, Tuanlao Wang, Bing Guo

“…Abstract Impaired protein N-glycosylation leads to the endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). …”
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TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia by Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan

“…This ADP hypersensitivity, driven by increased expression of P2Y12 and P2Y13 receptors, results in greater release of Ca2+ from the endoplasmic reticulum stores, which triggers sustained Ca2+ influx through Orai channels and alters cell motility in TREM2 KO microglia. …”
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Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model by Luciano Cardoso Santos, Jeane Martinha dos Anjos Cordeiro, Maria Clara da Silva Galrão Cunha, Bianca Reis Santos, Luciana Santos de Oliveira, Adriana Lopes da Silva, Erikles Macêdo Barbosa, Raquel Vieira Niella, Gustavo José Cota de Freitas, Daniel de Assis Santos, Rogéria Serakides, Natália de Melo Ocarino, Stephanie Carvalho Borges, Mário Sérgio Lima de Lavor, Juneo Freitas Silva

“…Testis samples were collected for enzymatic, immunohistochemical and/or gene evaluation of mediators of oxidative stress (TBARs, lipid hydroperoxides (LOOH), ROS, peroxynitrite, SOD, CAT and GPX), endoplasmic reticulum stress (GRP78, ATF6, PERK, CHOP, HO-1 and sXBP1) and antiapoptocytes (BCL-2). …”
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Palmitate-Induced Cardiac Lipotoxicity Is Relieved by the Redox-Active Motif of SELENOT through Improving Mitochondrial Function and Regulating Metabolic State by Carmine Rocca, Anna De Bartolo, Rita Guzzi, Maria Caterina Crocco, Vittoria Rago, Naomi Romeo, Ida Perrotta, Ernestina Marianna De Francesco, Maria Grazia Muoio, Maria Concetta Granieri, Teresa Pasqua, Rosa Mazza, Loubna Boukhzar, Benjamin Lefranc, Jérôme Leprince, Maria Eugenia Gallo Cantafio, Teresa Soda, Nicola Amodio, Youssef Anouar, Tommaso Angelone

“…Given the fundamental role of the endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection and for the regulation of glucose metabolism, we took advantage of a small peptide (PSELT), derived from the SELENOT redox-active motif, to uncover the mechanisms through which PSELT could protect cardiomyocytes against lipotoxicity. …”
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Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER by Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa

“…AldB, a glycolytic enzyme, was associated with reduced insulin secretion via mitochondrial dysfunction and impaired calcium release from the endoplasmic reticulum (ER). Taken together, our findings provide a new mechanism of β-cell dysfunction by UCP2 and AldB. …”
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Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy by Pamela Bella, Andrea Farini, Stefania Banfi, Daniele Parolini, Noemi Tonna, Mirella Meregalli, Marzia Belicchi, Silvia Erratico, Pasqualina D'Ursi, Fabio Bianco, Mariella Legato, Chiara Ruocco, Clementina Sitzia, Simone Sangiorgi, Chiara Villa, Giuseppe D'Antona, Luciano Milanesi, Enzo Nisoli, PierLuigi Mauri, Yvan Torrente

“…Remarkably, anti‐IGF2R induced CD20 phosphorylation, leading to the activation of sarcoplasmic/endoplasmic reticulum Ca2+‐ATPase (SERCA) and removal of intracellular Ca2+. …”
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The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN by Stefan Tillmann, Kathrin Olschok, Sarah K. Schröder, Marlena Bütow, Julian Baumeister, Milena Kalmer, Vera Preußger, Barbora Weinbergerova, Kim Kricheldorf, Jiri Mayer, Blanka Kubesova, Zdenek Racil, Martina Wessiepe, Jörg Eschweiler, Susanne Isfort, Tim H. Brümmendorf, Walter Becker, Mirle Schemionek, Ralf Weiskirchen, Steffen Koschmieder, Nicolas Chatain

“…Mechanistically, we identified endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) as a main driver of LCN2 expression in BCR-ABL- and JAK2V617F-positive 32D cells. …”
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Characterization of Chromatin Accessibility in Fetal Bovine Chondrocytes by Qi Zhang, Qian Li, Yahui Wang, Yapeng Zhang, Ruiqi Peng, Zezhao Wang, Bo Zhu, Lingyang Xu, Xue Gao, Yan Chen, Huijiang Gao, Junwei Hu, Cong Qian, Minghao Ma, Rui Duan, Junya Li, Lupei Zhang

“…The KEGG analysis enriched endoplasmic reticulum protein processing signal pathway, TGF-β signaling pathway and cell cycle pathway, which are closely related to protein synthesis and processing during cell proliferation. …”
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A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets by Francisca F. Almeida, Sara Tognarelli, Antoine Marçais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zöller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. Chiocchetti, Sophie Ugolini, Marco J. Herold, Wei Shi, Joachim Koch, Alexander Steinle, Eric Vivier, Thierry Walzer, Gabrielle T. Belz, Evelyn Ullrich

“…This Ncr1 C14R mutation impairs NKp46 surface expression resulting in destabilization of Ncr1 and accumulation of NKp46 in the endoplasmic reticulum. Loss of stable NKp46 expression impaired the maturation of NKp46+ ILCs and altered the expression of TRAIL and T-bet in ILC1 and ILC3, respectively.…”
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Ethanol-induced ceramide production causes neuronal apoptosis by increasing MCL-1S-mediated ER-mitochondria contacts by Jae Ryong Lim, Chang Woo Chae, Ji Yong Park, Young Hyun Jung, Jee Hyeon Yoon, Min Jeong Kim, Hyun Jik Lee, Gee Euhn Choi, Ho Jae Han

“…Our results demonstrated that the interaction of MCL-1S with the inositol 1, 4, 5-trisphosphate receptor (IP3R) increases calcium release from the endoplasmic reticulum (ER) and then activated ER-bound inverted formin 2 (INF2). …”
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Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies by Weijie Xie, Ping Zhou, Yifan Sun, Xiangbao Meng, Ziru Dai, Guibo Sun, Xiaobo Sun

“…Our summarized review and analysis show that the pharmacological effects of and mechanisms underlying ginsenoside Rg1 activity against cerebral ischemia and reperfusion injury mainly involve 4 sets of mechanisms: anti-oxidant activity and associated apoptosis via the Akt, Nrf2/HO-1, PPAR&#947;/HO-1, extracellular regulated protein kinases (ERK), p38, and c-Jun N-terminal kinase (JNK) pathways (or mitochondrial apoptosis pathway) and the caspase-3/ROCK1/MLC pathway; anti-inflammatory and immune stimulatory-related activities that involve apoptosis or necrosis via MAPK pathways (the JNK1/2 + ERK1/2 and PPAR&#947;/HO-1 pathways), endoplasmic reticulum stress (ERS), high mobility group protein1 (HMGB1)-induced TLR2/4/9 and receptor for advanced glycation end products (RAGE) pathways, and the activation of NF-&#954;B; neurological cell cycle, proliferation, differentiation, and regeneration via the MAPK pathways (JNK1/2 + ERK1/2, PI3K-Akt/mTOR, PKB/Akt and HIF-1&#945;/VEGF pathways); and energy metabolism and the regulation of cellular ATP levels, the blood-brain barrier and other effects via N-methyl-D-aspartic acid (NMDA) receptors, ERS, and AMP/AMPK-GLUT pathways. …”
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Comparative analysis of SARS-CoV-2 variants Alpha (B.1.1.7), Gamma (P.1), Zeta (P.2) and Delta (B.1.617.2) in Vero-E6 cells: ultrastructural characterization of cytopathology and r... by Debora Ferreira Barreto Vieira, Derick Mendes Bandeira, Marcos Alexandre Nunes da Silva, Ana Luisa Teixeira de Almeida, Mia Araújo, Ana Beatriz Machado, Luis Fernando Lopez Tort, Valéria Pereira Nacife, Marilda M. Siqueira, Fernando Couto Motta, Alex Pauvolid-Corrêa, Ortrud Monika Barth

“…Ultrastructural analyses showed that all variants of SARS-CoV-2 altered the structure and function of mitochondria, nucleus, and rough endoplasmic reticulum of cells. Monolayers infected with the Delta variant showed the highest number of modified cells and the greatest statistically significant differences compared to those of other variants. …”
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Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy by Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis

“…The purpose of this study is to clarify the impact of long-term BJ nutraceutical intervention on cellular mechanisms that govern hepatic lipid homeostasis, namely autophagy and endoplasmic reticulum (ER) stress, in a rat model of prediabetes. …”
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Blockade of oncogenic notch1 with the new serca inhibitor cad204520 in t-cell acute lymphoblastic leukemia by M. Marchesini, A. Gherli, A. Montanaro, C. Sorrentino, L. Pagliaro, C. Rompietti, S. Kitara, F. Rizzi, D. Stilli, R. La Starza, C. Mecucci, K. Stegmaier, A.M. Lund Winter, P. Sportoletti, M. Bublitz, W. Dalby-Brown, G. Roti

“…The discovery of the P-type ATPase Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) as a bidirectional modulator of oncogenic NOTCH1 suggests an innovative approach for treating T-cell Acute Lymphoblastic Leukemia (T-ALL). …”
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PeHVA22 gene family in passion fruit (Passiflora edulis): initial characterization and expression profiling diversity by Zhimin Hou, Jianxiang Liang, Jianxiang Liang, Xinkai Cai, Jingting Lin, Xiaomei Wang, Ruoyu Liu, Lin Lu, Gaifeng Chai, Chang An, Shengzhen Chen, Yuan Qin, Yuan Qin, Ping Zheng, Ping Zheng

“…Here, six HVA22 genes were firstly identified in passion fruit genome and all predicted to be localized within the endoplasmic reticulum. Phylogenetic analyses showed that all PeHVA22s were divided into four subgroups. …”
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