Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites by Eisenhaber, Birgit, Sinha, Swati, Jadalanki, Chaitanya K., Shitov, Vladimir A., Tan, Qiao Wen, Sirota, Fernanda L., Eisenhaber, Frank

“…Together with the available indirect experimental data, we conclude that the TMTCs are not only part of an O-mannosylation pathway in the endoplasmic reticulum of upper eukaryotes but, actually, they are the sought mannosyl-transferases.…”
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Destabilization of β cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes by Zheng, Xiaofeng, Ho, Calvin Qing Wei, Chua, Minni, Stelmashenko, Olga, Yeo, Xin Yi, Muralidharan, Sneha, Torta, Federico, Chew, Elaine Guo Yan, Lian, Michelle Mulan, Foo, Jia Nee, Jung, Sangyong, Wong, Sunny Hei, Tan, Nguan Soon, Tong, Nanwei, Rutter, Guy A., Wenk, Markus R., Silver, David L., Berggren, Per-Olof, Ali, Yusuf

“…This mechanism involves direct acylation of FIT2 cysteine residues, which then marks the FIT2 protein for endoplasmic reticulum (ER)-associated degradation. Loss of β cell FIT2 and LDs reduces insulin secretion, increases intracellular ceramides, stimulates ER stress, and exacerbates diet-induced diabetes in mice. …”
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PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma by Liu, Xiaoyu, Liu, Man, Wu, Haoran, Tang, Wenshu, Yang, Weiqin, Chan, Thomas T. H., Zhang, Lingyun, Chen, Shufen, Xiong, Zhewen, Liang, Jianxin, Si-Tou, Willis Wai-Yiu, Shu, Ting, Li, Jingqing, Cao, Jianquan, Zhong, Chengpeng, Sun, Hanyong, Kwong, Tsz Tung, Leung, Howard H. W., Wong, John, Lai, Paul Bo-San, To, Ka-Fai, Xiang, Tingxiu, Sung, Joseph Jao Yiu, Chan, Stephen Lam, Zhou, Jingying, Cheng, Alfred Sze-Lok

“…Results: We uncovered over-expression of protein phosphatase 1 regulatory subunit 15A (PPP1R15A), a myeloid cell-enriched endoplasmic reticulum stress modulator, in human M-MDSCs that correlated with poor prognosis and ICB non-responsiveness in patients with HCC. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Iminosugars, which inhibit N-linked glycan processing enzymes such as endoplasmic reticulum alpha-glucosidase I and II of the glycoprotein quality control pathway, constituted one of the two most promising groups of drugs in this antiviral cellular screen that have not entered clinical trials yet.…”

Blood glucose response and cellular changes associated with andrographolide treatment in insulin-resistant mice by Abdulameer, Hanaa Abdulabbas

“…Importantly, this result were attended with a significant (p<O.05) tissues healing sings (increased in some and large size rough endoplasmic reticulum, increased secretory granules of pancreas tissue and increased the number of mitochondria in the HFA50 group and least extent the HFA2Sgroup compared to the CP group. …”
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Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases by Carolina Ferreira, Carolina Ferreira, Carolina Ferreira, Carolina Ferreira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Helena Sá, Helena Sá, Helena Sá, João Malva, João Malva, João Malva, João Malva, Miguel Castelo-Branco, Miguel Castelo-Branco, Miguel Castelo-Branco, Flávio Reis, Flávio Reis, Flávio Reis, Flávio Reis, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana

“…Third, polyphenols interfere with the assembly of NLR family pyrin domain containing 3 (NLRP3) in endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis and autophagosome-lysosome fusion. …”
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Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms by Nisakorn Yodsanit, Takuro Shirasu, Yitao Huang, Li Yin, Zain Husain Islam, Alexander Christopher Gregg, Alessandra Marie Riccio, Runze Tang, Eric William Kent, Yuyuan Wang, Ruosen Xie, Yi Zhao, Mingzhou Ye, Jingcheng Zhu, Yi Huang, Nicholas Hoyt, Mengxue Zhang, John A. Hossack, Morgan Salmon, K. Craig Kent, Lian-Wang Guo, Shaoqin Gong, Bowen Wang

“…In this study, we made an exciting finding that PERK, the endoplasmic reticulum (ER) stress Protein Kinase R-like ER Kinase, is a potent driver of SMC degeneration and hence a potential therapeutic target. …”
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Acute exposure of triclocarban affects early embryo development in mouse through disrupting maternal-to-zygotic transition and epigenetic modifications by Zhi-Ming Ding, Shang-Ke Wang, Shou-Xin Zhang, Yang-Wu Chen, Yong-Sheng Wang, Sheng-Ji Yang, Yun-Xia Cao, Yi-Liang Miao, Li-Jun Huo

“…GO and KEGG analysis revealed that the enriched genes were mainly involved in redox processes, RNA synthesis, DNA damage, apoptosis, mitochondria, endoplasmic reticulum, Golgi apparatus, cytoskeleton, peroxisome, RNA polymerase, and other components or processes. …”
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TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages by Jingjing Huang, Huayang Pan, Jing Sun, Jiaming Wu, Qiyue Xuan, Jinge Wang, Shanjia Ke, Shounan Lu, Zihao Li, Zhigang Feng, Yongliang Hua, Qingan Yu, Bing Yin, Baolin Qian, Menghua Zhou, Yanan Xu, Miaoyu Bai, Yingmei Zhang, Yaohua Wu, Yong Ma, Hongchi Jiang, Wenjie Dai

“…Abstract Background The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which are affected by transmembrane proteins localized in the ER membrane. …”
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Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion by C. Binsch, D. M. Barbosa, G. Hansen-Dille, M. Hubert, S. M. Hodge, M. Kolasa, K. Jeruschke, J. Weiß, C. Springer, S. Gorressen, J. W. Fischer, M. Lienhard, R. Herwig, S. Börno, B. Timmermann, A. L. Cremer, H. Backes, A. Chadt, H. Al-Hasani

“…Tbc1d4-deficiency results in elevated cardiac endoplasmic reticulum (ER)-stress response, increased deposition of ECM and aggravated cardiac damage following MI. …”
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Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules by Izabela Lenart, Izabela Lenart, Izabela Lenart, Linh-Huyen Truong, Linh-Huyen Truong, Dinh Dung Nguyen, Dinh Dung Nguyen, Olga Rasiukienė, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Kirsty McHugh, Branca I. Pereira, Branca I. Pereira, Branca I. Pereira, Balraj S. Maan, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou, Antony N. Antoniou

“…When stably expressed, a pMHC SCT incorporating HLA-B27 HC formed chaperone-bound homodimers within the endoplasmic reticulum (ER). A series of HLA-B27 SCT substitution mutations revealed that the F pocket and antigen binding groove regions of the HLA-B27 HC defined the folding and dimerisation of the single chain complex, independently of the peptide sequence. …”
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Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice by Beatriz López-Cauce, Beatriz López-Cauce, Beatriz López-Cauce, Marta Puerto, Marta Puerto, Juan José García, Manuel Ponce-Alonso, Federico Becerra-Aparicio, Rosa del Campo, Isabel Peligros, María J. Fernández-Aceñero, Yésica Gómez-Navarro, José M. Lara, José Miranda-Bautista, José Miranda-Bautista, Ignacio Marín-Jiménez, Ignacio Marín-Jiménez, Rafael Bañares, Rafael Bañares, Rafael Bañares, Luis Menchén, Luis Menchén, Luis Menchén

“…Expression of inflammatory and adhesion molecules in the colon was explored by qPCR as Mucin-2 (MUC-2) and molecules involved in goblet cell maturation Interleukin-18 (IL-18) and WAP Four-Disulfide Core Domain 2 (WFDC2), the endoplasmic reticulum stress markers X-box-binding protein (Xbp-1) and Reticulon-4B (RTN-4B). …”
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Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response by Antonio Jesús Ruiz-Malagón, Laura Hidalgo-García, María Jesús Rodríguez-Sojo, José Alberto Molina-Tijeras, Federico García, Patricia Diez-Echave, Teresa Vezza, Patricia Becerra, Juan Antonio Marchal, Eduardo Redondo-Cerezo, Martin Hausmann, Gerhard Rogler, José Garrido-Mesa, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, Julio Gálvez

“…Moreover, tigecycline induced apoptosis through extrinsic, intrinsic and endoplasmic reticulum pathways converging on an increase of CASP7 levels. …”
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Intrahepatic transcriptomics reveals gene signatures in chronic hepatitis B patients responded to interferon therapy by Ning Li, Kangkang Yu, Minhui Dong, Jinyu Wang, Feifei Yang, Haoxiang Zhu, Jie Yu, Jingshu Yang, Wentao Xie, Bidisha Mitra, Richeng Mao, Feizhen Wu, Haitao Guo, Jiming Zhang

“…The data also indicate that IFNα may influence the production of viral antigens associated with endoplasmic reticulum. Collectively, the intrahepatic transcriptome analyses in this study enriched our understanding of IFN-mediated antiviral effects in CHB patients and provided novel insights into the development of potential strategies to improve IFNα therapy.…”
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BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy by Sandra Donkervoort, Niklas Krause, Mykola Dergai, Pomi Yun, Judith Koliwer, Svetlana Gorokhova, Janelle Geist Hauserman, Beryl B Cummings, Ying Hu, Rosemarie Smith, Prech Uapinyoying, Vijay S Ganesh, Partha S Ghosh, Kristin G Monaghan, Seby L Edassery, Pia E Ferle, Sarah Silverstein, Katherine R Chao, Molly Snyder, Sara Ellingwood, Diana Bharucha‐Goebel, Susan T Iannaccone, Matteo Dal Peraro, A Reghan Foley, Jeffrey N Savas, Véronique Bolduc, Dirk Fasshauer, Carsten G Bönnemann, Michael Schwake

“…Abstract BET1 is required, together with its SNARE complex partners GOSR2, SEC22b, and Syntaxin‐5 for fusion of endoplasmic reticulum‐derived vesicles with the ER‐Golgi intermediate compartment (ERGIC) and the cis‐Golgi. …”
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ATPase Activity of the Subcellular Fractions of Colorectal Cancer Samples under the Action of Nicotinic Acid Adenine Dinucleotide Phosphate by Ivan Kushkevych, Mykola Bychkov, Solomiia Bychkova, Márió Gajdács, Romana Merza, Monika Vítězová

“…We tested the effect of NAADP on the activity of Na⁺/K⁺ ATPase; Ca²⁺ ATPase of endoplasmic reticulum (EPR) and plasma membrane (PM) and basal ATPase activity. …”
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Pharmacokinetics, absorption and transport mechanism for ginseng polysaccharides by Juanhong Zhang, Jiaxin He, Jumin Huang, Xuefeng Li, Xiaoqing Fan, Wenbin Li, Guofan Wu, Chun Xie, Xing-Xing Fan, Junmin Zhang, Xiaojun Yao, Rong Wang, Elaine Lai-Han Leung

“…Both are transported lysosomally mediated to the endoplasmic reticulum (ER) and then enter the nucleus through the ER, thus completing the process of intracellular uptake and transportation. …”
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Distribution of ELOVL4 in the Developing and Adult Mouse Brain by David M. Sherry, David M. Sherry, David M. Sherry, Blake R. Hopiavuori, Blake R. Hopiavuori, Megan A. Stiles, Megan A. Stiles, Negar S. Rahman, Negar S. Rahman, Kathryn G. Ozan, Ferenc Deak, Ferenc Deak, Ferenc Deak, Martin-Paul Agbaga, Martin-Paul Agbaga, Martin-Paul Agbaga, Martin-Paul Agbaga, Martin-Paul Agbaga, Robert E. Anderson, Robert E. Anderson, Robert E. Anderson, Robert E. Anderson, Robert E. Anderson

“…ELOVL4 was widely expressed in a region- and cell type-specific manner, and was restricted to cell bodies, consistent with its known localization to endoplasmic reticulum. ELOVL4 labeling was most prominent in gray matter, although labeling also was present in some cells located in white matter. …”
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A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma by Xifei Jiang, Wenjia Deng, Siyao Tao, Zheng Tang, Yuehong Chen, Mengxin Tian, Ting Wang, Chenyang Tao, Yize Li, Yuan Fang, Congying Pu, Jun Gao, Xiaomin Wang, Weifeng Qu, Xiameng Gai, Zhenbin Ding, Yixian Fu, Ying Zheng, Siyuwei Cao, Jian Zhou, Min Huang, Weiren Liu, Jun Xu, Jia Fan, Yinghong Shi

“…Mechanistically, MLKL is required for maintaining the endoplasmic reticulum (ER)-mitochondrial Mg2+ dynamics in HCC cells. …”
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<i>ZmFAR1</i> and <i>ZmABCG26</i> Regulated by microRNA Are Essential for Lipid Metabolism in Maize Anther by Yilin Jiang, Ziwen Li, Xinze Liu, Taotao Zhu, Ke Xie, Quancan Hou, Tingwei Yan, Canfang Niu, Shaowei Zhang, Mengbing Yang, Rongrong Xie, Jing Wang, Jinping Li, Xueli An, Xiangyuan Wan

“…Notably, ZmABCG26 proteins are localized in the endoplasmic reticulum (ER), chloroplast/plastid, and plasma membrane. …”
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