The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB by Xia Fei, Jiaqi Huang, Fei Li, Yuejue Wang, Zhehua Shao, Lingling Dong, Yinfang Wu, Boran Li, Xue Zhang, Baihui Lv, Yun Zhao, Qingyu Weng, Kaijun Chen, Min Zhang, Shiyi Yang, Chao Zhang, Min Zhang, Wen Li, Songmin Ying, Qiming Sun, Zhihua Chen, Huahao Shen

“…SREBP cleavage-activating protein (Scap) and sterol regulatory element-binding protein 1 (SREBP1) form a super complex with inhibitors of NF-κB α (IκBα) to associate NF-κB close to the endoplasmic reticulum (ER). Upon lipopolysaccharide (LPS) stimulation, Scap transports the complex to the Golgi apparatus, where SREBP1 is cleaved by site-1 protease (S1P)/S2P, liberating IκBα for IκB kinase (Ikk)-mediated phosphorylation and subsequent activation of NF-κB. …”
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CRISPR screen identifies the role of RBBP8 in mediating unfolded protein response induced liver damage through regulating protein synthesis by Heting Wang, Xuya Pan, Xiaoxin Xiang, Yang Zhang, Jianning Chen, Shiyi Wen, Jin Wang, Rong Gao, Jifeng Yang, Yaping Zhi, Siying Wen, Yubao Zheng, Ting Li, Heying Ai, Xuemin He, Yan Lu, Yanhua Zhu, Chunliang Li, Yanming Chen, Guojun Shi

“…Abstract Unfolded protein response (UPR) maintains the endoplasmic reticulum (ER) homeostasis, survival, and physiological function of mammalian cells. …”
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Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress by Xiuyu Wang, Xing Ma, Yue Zeng, Lingbo Xu, Minghao Zhang

“…Abstract To provide a theoretical basis for the prevention and treatment of atherosclerosis (As), the current study aimed to investigate the mechanism underlying the effect of homocysteine (Hcy) on inducing the lipid deposition and foam cell formation of the vascular smooth muscle cell (VSMC) via C1q/Tumor necrosis factor-related protein9 (CTRP9) promoter region Hypermethylation negative regulating endoplasmic reticulum stress (ERs). Therefore, apolipoprotein E deficient (ApoE−/−) mice were randomly divided into the control [ApoE−/− + normal diet (NC)] and high methionine [ApoE−/− + (normal diet supplemented with 1.7% methionine (HMD)] groups (n = 6 mice/group). …”
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Inclusion body fibromatosis by Elgiva Iangngap, Mayur Parkhi, Aravind Sekar, Parmod Kumar, Uma Nahar Saikia

“…Ultrastructurally, the inclusions correspond to localized collections of non-membrane-bound, granular fibrillary material contiguous with the rough endoplasmic reticulum. These inclusions show strong immunoreactivity with actin and anti-calponin-1 antibody (inclusion containing calponin 1 as its possible content) but an occasional weak expression for caldesmon (the reason is still unknown). …”
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Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease by Jane I. Grove, Peggy C.K. Lo, Nick Shrine, Julian Barwell, Louise V. Wain, Martin D. Tobin, Andrew M. Salter, Aditi N. Borkar, Sara Cuevas-Ocaña, Neil Bennett, Catherine John, Ioanna Ntalla, Gabriela E. Jones, Christopher P. Neal, Mervyn G. Thomas, Helen Kuht, Pankaj Gupta, Vishwaraj M. Vemala, Allister Grant, Adeolu B. Adewoye, Kotacherry T. Shenoy, Leena K. Balakumaran, Edward J. Hollox, Nicholas R.F. Hannan, Guruprasad P. Aithal

“…Cytoplasmic triglyceride accumulation in HLCs triggered endoplasmic reticulum stress, secretion of pro-inflammatory mediators, and production of reactive oxygen species. …”
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EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence by Jeremie Gautheron, Christophe Morisseau, Wendy K Chung, Jamila Zammouri, Martine Auclair, Genevieve Baujat, Emilie Capel, Celia Moulin, Yuxin Wang, Jun Yang, Bruce D Hammock, Barbara Cerame, Franck Phan, Bruno Fève, Corinne Vigouroux, Fabrizio Andreelli, Isabelle Jeru

“…Functional analyses revealed that these variants led to the protein aggregation within the endoplasmic reticulum and to a loss of its hydrolysis activity. …”
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Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy by Jiancheng Huang, Jiancheng Huang, Jiancheng Huang, Jiancheng Huang, Meng Chen, Meng Chen, Meng Chen, Yu Liang, Yu Liang, Yu Liang, Yu Liang, Yuxiang Hu, Yuxiang Hu, Yuxiang Hu, Yuxiang Hu, Weiyi Xia, Weiyi Xia, Weiyi Xia, Weiyi Xia, Yihan Zhang, Yihan Zhang, Yihan Zhang, Yihan Zhang, Chen Zhao, Chen Zhao, Chen Zhao, Chen Zhao, Lianqun Wu, Lianqun Wu, Lianqun Wu, Lianqun Wu

“…In addition, metabolites-gene analysis illustrated that cholesterol metabolism was involved in the pathogenesis of TAO. Endoplasmic reticulum stress-related genes (ATF6, PERK, and IRE1α) expressions were higher in TAO orbital tissues than in control orbital tissues verified by western blot. …”
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Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut by Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden

“…While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the metabolic consequences of chronic ER stress on the pathophysiology of IBD remain unclear. …”
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Tumor necrosis factor-α reduces adiponectin production by decreasing transcriptional activity of peroxisome proliferator-activated receptor-γ in calf adipocytes by Hao Yu, Xinxing Gao, Qilai Ge, Wenjun Tai, Xue Hao, Qi Shao, Zhiyuan Fang, Meng Chen, Yuxiang Song, Wenwen Gao, Guowen Liu, Xiliang Du, Xinwei Li

“…Quantification of mRNA abundance of endoplasmic reticulum (ER)/Golgi resident chaperones involved in adiponectin assembly revealed that ER protein 44 (ERP44), ER oxidoreductase 1α (ERO1A), and disulfide bond-forming oxidoreductase A-like protein (GSTK1) were downregulated in TNF-α-treated adipocytes, while 78-kDa glucose-regulated protein and Golgi-localizing γ-adaptin ear homology domain ARF binding protein-1 were unaltered. …”
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A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells by Xiao Ling Li, Lőrinc Pongor, Wei Tang, Sudipto Das, Bruna R Muys, Matthew F Jones, Sarah B Lazar, Emily A Dangelmaier, Corrine CR Hartford, Ioannis Grammatikakis, Qinyu Hao, Qinyu Sun, Aaron Schetter, Jennifer L Martindale, BinWu Tang, Lisa M Jenkins, Ana I Robles, Robert L Walker, Stefan Ambs, Raj Chari, Svetlana A Shabalina, Myriam Gorospe, S Perwez Hussain, Curtis C Harris, Paul S Meltzer, Kannanganattu V Prasanth, Mirit I Aladjem, Thorkell Andresson, Ashish Lal

“…The epitope-tagged and endogenous FORCP protein predominantly localizes to the endoplasmic reticulum (ER). In response to ER stress, FORCP depletion results in decreased apoptosis. …”
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Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease by Jia-Hui Chen, Na Xu, Lei Qi, Hao-Hao Yan, Fang-Yan Wan, Feng Gao, Chuanhai Fu, Chunlei Cang, Boxun Lu, Guo-Qiang Bi, Ai-Hui Tang

“…This modulation depends on lysosomal Ca2+ release, which further promotes endoplasmic reticulum (ER) entry into spines. Importantly, optogenetically restoring lysosomal density in dendrites rescues the synaptic plasticity deficit in hippocampal slices of CAG-140 mice. …”
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Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis by Ping Zhang, Chaoting Zhou, Xueying Ren, Qiangan Jing, Yan Gao, Chen Yang, Yuhuan Shen, Yi Zhou, Wanye Hu, Feifan Jin, Haifeng Xu, Lingyan Yu, Yingchao Liu, Xiangmin Tong, Yanchun Li, Ying Wang, Jing Du

“…Herein, we found DSF/Cu induces endoplasmic reticulum stress with disrupted ER structures, increased Ca2+ level and activated expression of ATF4. …”
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FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases by Wei Shen, Modan Yang, Hao Chen, Chiyu He, Huigang Li, Xinyu Yang, Jianyong Zhuo, Zuyuan Lin, Zhihang Hu, Di Lu, Xiao Xu

“…Liver diseases are worldwide problems closely associated with various stresses, such as endoplasmic reticulum stress. The exact interplay between stress and liver diseases remains unclear. …”
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Effect of dietary oxidized fish oil on liver function in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus) by Shuisheng Long, Xiaohui Dong, Hao Liu, Xiaobo Yan, Beiping Tan, Shuang Zhang, Shuyan Chi, Qihui Yang, Hongyu Liu, Yuanzhi Yang, Haitao Zhang

“…Oxidized fish oil caused damage to the liver microstructure, including mitochondria, nucleoli, endoplasmic reticulum, and lipid droplets. The liver mainly functions as a metabolic process under oxidative stress. …”
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Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice by Chen Li, Marie F. Kiefer, Sarah Dittrich, Roberto E. Flores, Yueming Meng, Na Yang, Sascha Wulff, Sabrina Gohlke, Manuela Sommerfeld, Sylvia J. Wowro, Konstantin M. Petricek, Dominic Dürbeck, Leonard Spranger, Knut Mai, Holger Scholz, Tim J. Schulz, Michael Schupp

“…Objective: Retinol saturase (RetSat) is an endoplasmic reticulum-localized oxidoreductase highly expressed in organs involved in lipid metabolism such as white (WAT) and brown adipose tissue (BAT). …”
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Identification of molecular pathways associated with Newcastle disease virus (AF2240) persistent infection in urothelial cell carcinoma by Ahmad, Umar

“…Based on PPI network analysis, the bridges were found mainly from pathways of p53 signaling, ECM-receptor interaction, and TGF-beta signaling by the upregulated mRNAs, to the antigen processing and presentation, protein processing in endoplasmic reticulum, complement and coagulation cascades by the downregulated mRNAs in NDV persistent TCCSUPPi cells. …”
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A neurohistological study of the sensori-motor cortex by Sloper, J, Sloper, J. J.

“…In addition to their high density of axosomatic synapses, they have abundant cytoplasm full of organelles and usually containing stacks of endoplasmic reticulum. Their dendrites similarly receive a high density of asymmetric and symmetrical synapses and contain prominent organelles and have a moderately varicose shape. …”

Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy by Shujin Li, Mu Yang, Rulian Zhao, Li Peng, Wenjing Liu, Xiaoyan Jiang, Yunqi He, Erkuan Dai, Lin Zhang, Yeming Yang, Yi Shi, Peiquan Zhao, Zhenglin Yang, Xianjun Zhu

“…Endoplasmic reticulum (ER) membrane protein complex (EMC) is required for the co-translational insertion of newly synthesized multi-transmembrane proteins. …”
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Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders by Yi Zhang, Liwei Chen, Ye Xuan, Lina Zhang, Wen Tian, Yangyang Zhu, Jinghui Wang, Xinyu Wang, Jin Qiu, Jian Yu, Mengyang Tang, Zhen He, Hong Zhang, Si Chen, Yun Shen, Siyi Wang, Rong Zhang, Lingyan Xu, Xinran Ma, Yunfei Liao, Cheng Hu

“…Mechanistically, the reduction of iron overload in AgRP neurons inhibits AgRP neuron activity; improves insulin and leptin sensitivity; and inhibits iron-induced oxidative stress, endoplasmic reticulum stress, nuclear factor κB signaling, and suppression of cytokine signaling 3 expression. …”
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Expression profile analysis of LncRNAs and mRNAs in pre-receptive endometrium of women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer by Xiuhua Xu, Aimin Yang, Pengxiang Tian, Kun Zhang, Yuanyuan Liu, Yizhuo Wang, Ziwei Wang, Yanjing Wu, Zhiming Zhao, Qian Li, Baojun shi, Xianghua Huang, Gui-min Hao

“…Bioinformatics analysis showed that differentially expressed genes (DEGs) involved KEGG pathway were tyrosine metabolism, PI3K-Akt pathway, metabolic pathway, Jak-STAT pathway, pyruvate metabolism, protein processing in endoplasmic reticulum, oxidative phosphorylation and proteasome. …”
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