Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway by Zhang Yonghui, Zhang Haoyang, Mu Jinage, Han Meiyue, Cao Zhihao, Dong Feng, Wang Tingting, Pan Lian, Luo Wujing, Li Jiaxin, Liu Huan, Jin Lishan, Ding Wenxuan, Wei Yong, Deng Xuesong, Liu Dan, He Xiuzhen, Pang Yi, Mu Xiao, Wu Zhongjun, Chen Dilong

“…The results demonstrate that EB exerts anti-proliferative activity in hepatic carcinoma by blocking cell cycle arrest at S phase and inducing ferroptosis mediated by endoplasmic reticulum (ER) stress, as well as HO-1 activation. …”
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Novel insights on toxicology of ochratoxin A contaminated diets to skin: Residues, mucus disruption and barrier impairment in teleost model grass carp (Ctenopharyngodon idella) by Piao Zhao, Xin Liu, Wei-Dan Jiang, Pei Wu, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lu Zhang, Hai-Feng Mi, Lin Feng, Xiao-Qiu Zhou

“…Results were shown as follows in the skin: (1) OTA increased the mRNA abundances of uptake transporter proteins (e.g., OAT3) and decreased efflux transporter proteins (e.g., ABCG2), which caused the accumulation of OTA in the skin of grass carp. (2) OTA upregulated the gene expression related to ROS production by enhancing the NOX (1, 2, 4) signaling pathway and decreased the ability to ROS elimination with downregulation of GPx1 (a,b), Trx by inhibiting the PGC1-α/Nrf2 signaling pathway, which caused oxidative damage to the skin. (3) OTA exacerbated apoptosis in the skin by upregulating the expression of apoptosis-related proteins mediated by ways of endoplasmic reticulum stress and mitochondrial apoptosis. …”
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A comparative analysis of morphology, microstructure, and volatile metabolomics of leaves at varied developmental stages in Ainaxiang (Blumea balsamifera (Linn.) DC.) by Xiaolu Chen, Yanqun Li, Yuxin Pang, Yuxin Pang, Wanyun Shen, Wanyun Shen, Qilei Chen, Liwei Liu, Liwei Liu, Xueting Luo, Xueting Luo, Zhenxia Chen, Xingfei Li, Yulan Li, Yingying Zhang, Mei Huang, Chao Yuan, Dan Wang, Lingliang Guan, Yuchen Liu, Quan Yang, Hubiao Chen, Hong Wu, Fulai Yu

“…Ultra-microstructural examination revealed the involvement of chloroplasts, mitochondria, endoplasmic reticulum, and vacuoles in the synthesizing, transporting, and storing essential oils. …”
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Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD by Guangyong Sun, Yaning Wang, Lu Yang, Zihan Zhang, Yushang Zhao, Zongshan Shen, Xiaotong Han, Xiaonan Du, Hua Jin, Changying Li, Songlin Wang, Zhongtao Zhang, Dong Zhang

“…Mechanistically, melatonin receptor-independent BTG2-ATF4 signaling plays a role in the regulation of CCR3+ MoMF endoplasmic reticulum stress, survival, and inflammation. …”
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Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Sub... by Anthony H. Cincotta, Eugenio Cersosimo, Mariam Alatrach, Michael Ezrokhi, Christina Agyin, John Adams, Robert Chilton, Curtis Triplitt, Bindu Chamarthi, Nicholas Cominos, Ralph A. DeFronzo

“…Relative to pre-treatment status, 4 months of bromocriptine-QR therapy resulted in significant reductions of mRNA levels in PBMC endoplasmic reticulum stress-unfolded protein response effectors [<i>GRP78/BiP</i> (34%), <i>EIF2α</i> (32%), <i>ATF4</i> (29%), <i>XBP1</i> (25%), <i>PIN1</i> (14%), <i>BECN1</i> (23%)], oxidative stress response proteins [<i>OXR1</i> (31%), <i>NRF2</i> (32%), <i>NQO1</i> (39%), <i>SOD1</i> (52%), <i>CAT</i> (26%), <i>GPX1</i> (33%), <i>GPX4</i> (31%), <i>GCH1</i> (30%), <i>HMOX1</i> (40%)], mRNA levels of TLR pro-inflammatory pathway proteins [<i>TLR2</i> (46%), <i>TLR4</i> (20%), <i>GSK3β</i> (19%), <i>NFkB</i> (33%), <i>TXNIP</i> (18%), <i>NLRP3</i> (32%), <i>CCR2</i> (24%), <i>GCR</i> (28%)], mRNA levels of pro-inflammatory cellular receptor proteins <i>CCR2</i> and <i>GCR</i> by 24% and 28%, and adhesion molecule proteins <i>L-selectin</i> (35%) and <i>VCAM1</i> (24%). …”
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Cholesterol supplementation improved growth performance, cholesterol metabolism, and intestinal health of Pacific white shrimp (Litopenaeus vannamei) fed a low fishmeal diet by Xiaoyue Li, Yongkang Chen, Xin Chen, Shuang Zhang, Xiaohui Dong, Shuyan Chi, Junming Deng, Beiping Tan, Shiwei Xie

“…Cholesterol supplementation increased the height of the intestinal folds of shrimp fed the low fishmeal based-diets (P < 0.05), as well as improved the integrity of the mitochondria and the endoplasmic reticulum. Dietary cholesterol supplementation decreased the abundance of harmful bacteria phylum (Chlamydiae) and increased the abundance of beneficial bacteria genus (Pseudoalteromona, Rhodopirellula, and Ruegeria) compared with LFM group (P < 0.05). …”
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Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance by Nathalia R.V. Dragano, Edward Milbank, Roberta Haddad-Tóvolli, Pablo Garrido-Gil, Eva Nóvoa, Marcos F. Fondevilla, Valentina Capelli, Ariane Maria Zanesco, Carina Solon, Joseane Morari, Leticia Pires, Ánxela Estevez-Salguero, Daniel Beiroa, Ismael González-García, Olga Barca-Mayo, Carlos Diéguez, Ruben Nogueiras, José L. Labandeira-García, Elisabeth Rexen Ulven, Trond Ulven, Marc Claret, Licio A. Velloso, Miguel López

“…Results: Pharmacological stimulation of FFAR1, using central administration of its agonist TUG-905 in diet-induced obese mice, decreases body weight and is associated with increased energy expenditure, BAT thermogenesis and browning of subcutaneous WAT (sWAT), as well as reduced AMP-activated protein kinase (AMPK) levels, reduced inflammation, and decreased endoplasmic reticulum (ER) stress in the hypothalamus. As FFAR1 is expressed in distinct hypothalamic neuronal subpopulations, we used an AAV vector expressing a shRNA to specifically knockdown Ffar1 in proopiomelanocortin (POMC) neurons of the arcuate nucleus of the hypothalamus (ARC) of obese mice. …”
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Genome-wide analysis of the polyphenol oxidase gene family reveals that MaPPO1 and MaPPO6 are the main contributors to fruit browning in Musa acuminate by Fei Qin, Fei Qin, Fei Qin, Chunhua Hu, Tongxin Dou, Ou Sheng, Qiaosong Yang, Guiming Deng, Weidi He, Huijun Gao, Chunyu Li, Tao Dong, Ganjun Yi, Ganjun Yi, Fangcheng Bi, Fangcheng Bi

“…Furthermore, MaPPO1 and MaPPO7 localized in chloroplasts, and MaPPO6 was a chloroplast- and Endoplasmic Reticulum (ER)-localized protein, whereas MaPPO10 only localized in the ER. …”
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A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint by Kevin P. Guay, Roberta Ibba, J.L. Kiappes, Snežana Vasiljević, Francesco Bonì, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Juliane Brun, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Matteo De Rosa, Mario Milani, Carlos P. Modenutti, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi

“…Summary: Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). …”
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Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors by Bopei Cui, Lifang Song, Qian Wang, Kelei Li, Qian He, Xing Wu, Fan Gao, Mingchen Liu, Chaoqiang An, Qiushuang Gao, Chaoying Hu, Xiaotian Hao, Fangyu Dong, Jiuyue Zhou, Dong Liu, Ziyang Song, Xujia Yan, Jialu Zhang, Yu Bai, Qunying Mao, Xiaoming Yang, Zhenglun Liang

“…Here, we showed that viral infection triggered endoplasmic reticulum (ER) stress-related pro-apoptosis and autophagy signals, whereas repair for double-stranded DNA breaks (DSBs) contributed to cell survival which can be antagonized by inhibitor-induced cell death, manifesting exacerbated DSBs, apoptosis, and autophagy. …”
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Downregulation of PDIA3 inhibits gastric cancer cell growth through cell cycle regulation by Min Yang, Qianxiu Li, Huan Yang, Yifan Li, Lan Lu, Xu Wu, Yubin Liu, Wanping Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Yu Chen, Shuai Deng, Chi Hin Cho, Xiaobing Li, Mingxing Li

“…Objective: Protein disulfide isomerase A3 (PDIA3) promotes the correct folding of newly synthesized glycoproteins in the endoplasmic reticulum. PDIA3 is overexpressed in most tumors, and it may become a biomarker of cancer prognosis and immunotherapy. …”
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The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance by Rakhee Banerjee, Rakhee Banerjee, Rachel C. Hohe, Rachel C. Hohe, Shijie Cao, Shijie Cao, Bryan M. Jung, Bryan M. Jung, Anthony J. Horak, Iyappan Ramachandiran, Iyappan Ramachandiran, William J. Massey, William J. Massey, William J. Massey, Venkateshwari Varadharajan, Venkateshwari Varadharajan, Natalie I. Zajczenko, Natalie I. Zajczenko, Amy C. Burrows, Amy C. Burrows, Sumita Dutta, Sumita Dutta, Maryam Goudarzi, Maryam Goudarzi, Kala Mahen, Kala Mahen, Abigail Carter, Robert N. Helsley, Robert N. Helsley, Scott M. Gordon, Richard E. Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, J. Mark Brown, J. Mark Brown

“…Introduction:The Aster-C protein (encoded by the Gramd1c gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma membrane to the ER. …”
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A Dynamic Model of Cytosolic Calcium Concentration Oscillations in Mast Cells by Mingzhu Sun, Yingchen Li, Wei Yao

“…This model includes the cytoplasm (Cyt), endoplasmic reticulum (ER), mitochondria (Mt), and functional region (μd), formed by the ER and Mt, also with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mrow><mi>Ca</mi></mrow><mrow><mrow><mn>2</mn><mo>+</mo></mrow></mrow></msup></mrow></semantics></math></inline-formula> channels in these cellular compartments. …”
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Computational modelling of the biological and social factors of type 2 diabetes by Dutta, Pritha

“…Chronic hyperglycemia causes deterioration of beta-cell function through oxidative stress, endoplasmic reticulum (ER) stress, and cytokines. In this thesis, two computational models are proposed to study beta-cell dysfunction in T2D. …”
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2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton by Chuanxin Zhang, Xiaoyu Yin, Xueqi Dong, Mingze Shi, Yuxin Xu, Jiayin Gao, Jiawei Wang, Jinzhu Song, Boyang Liu, Keliang Wu

“…Gene Ontology (GO) analysis further revealed that DEGs were mainly enriched in mitochondrial functions, oxidative stress, cytoskeleton, endoplasmic reticulum (ER), Golgi and protein synthesis, DNA damage and apoptosis. …”
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Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection by Senzhao Zhang, Senzhao Zhang, Senzhao Zhang, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Ling Zhang, Yanling Yu, Shun Chen, Shun Chen, Shun Chen, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…NS1 is highly conserved among multiple flaviviruses and occurs in distinct forms, including a dimeric form within the endoplasmic reticulum, a cell-associated form on the plasma membrane, or a secreted hexameric form (sNS1) trafficked to the extracellular matrix. …”
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Effect of Electroacupuncture on Inflammation Response and Ferroptosis in Rats Modeling Postoperative Cognitive Dysfunction by QIN Xiaoyu, ZHANG Binsen, ZHANG Xiaojia, LU Xiaoting, LIU Hongxin, WANG Chunai

“…In 3 d and 7 d postoperative subgroups in model group, the structure of double nuclear membrane of cell nucleus was clear in the hippocampal field of vision, and the perinuclear space was not significantly widened, with irregular shape and uneven surface; the chromatin in the nucleus was concentrated and marginalized; a small amount of mitochondrial membranes in the cytoplasm were broken and the membrane structure disappeared; part of the endoplasmic reticulum expanded obviously; some myelin sheaths were broken and disorganized. …”
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Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model by Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu, Wenju Lu, Tengteng Zhao, Jian Wang, Yuqin Chen

“…Furthermore, sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), a marker of myocardial damage, was highly expressed in week 2 of SuHx-induced PH and had higher levels of expression of γ-H2AX at all timepoints, as well as higher levels of DDR-related proteins p-ATM and p53/p-p53 and p21 in week 4 and week 6. …”
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Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE by Wen Li, Lian-Xiang Luo, Qing-Qing Zhou, Hai-Biao Gong, Yuan-Yuan Fu, Chang-Yu Yan, E. Li, Jie Sun, Zhuo Luo, Zhao-Jun Ding, Qiong-Yi Zhang, Han-Lu Mu, Yun-Feng Cao, Shu-Hua Ouyang, Hiroshi Kurihara, Yi-Fang Li, Wan-Yang Sun, Min Li, Rong-Rong He

“…Our results agree with the recognized role of endoplasmic reticulum as the primary source for autophagosomal membranes. …”
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Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration by Guoqiang Li, Lijun Zhu, Mingwei Guo, Dongmei Wang, Meiyao Meng, Yinzhao Zhong, Zhijian Zhang, Yi Lin, Caizhi Liu, Jiawen Wang, Yahui Zhang, Yining Gao, Yuxiang Cao, Zhirui Xia, Jin Qiu, Yu Li, Shuang Liu, Haibing Chen, Wenyue Liu, Yu Han, Minghua Zheng, Xinran Ma, Lingyan Xu

“…Forkhead box protein A3 (FOXA3), a member of the forkhead box family, plays important roles in endoplasmic reticulum stress sensing, and lipid and glucose homoeostasis, yet its functions in liver regeneration are unknown. …”
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