Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice by Boying Zhao, Jiang Yu, Yuan Luo, Ming Xie, Can Qu, Qiong Shi, Xiaowen Wang, Xingji Zhao, Lingwen Kong, Yu Zhao, Yongzheng Guo

“…Meanwhile, S100A9 knockout improved endothelium-dependent vasodilatation and endothelial continuity in aged mice. …”
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Abstract Number ‐ 110: Case Report of Glue Embolism Complication after Lingual Artery Embolization and Rescue Thrombectomy by Jose M Morales, David Kimball, Charles Beaman, Naoki Kaneko, May Nour, Geoffrey Colby, Satoshi Tateshima, Viktor Szeder, Reza Jahan, Gary R Duckwiler

“…•After successful retrieval of the glue material, there was residual stenosis of unclear etiology, possibly due to denuded endothelium, dissection, or residual glue promoting in‐situ thrombosis. …”
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Vascular Remodeling Markers in Patients with Essential Arterial Hypertension Depending on Presence of Type 2 Diabetes Mellitus by Yu. A. Danilogorskaya, E. A. Zheleznykh, E. A. Privalova, Yu. N. Belenkov, A. A. Shchendrigina, M. V. Kozhevnikova, G. A. Shakaryants, V. Y. Zektser, A. S. Lishuta, I. S. Ilgisonis

“…ELISA was used for determining the level of humoral markers of endothelium dysfunction and vascular bed remodeling: metalloproteinase 9, metalloproteinase 9 inhibitor, E-selectin, endothelin, transforming growth factor (TGF-β1), endothelial growthfactor A.Results. …”
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Adipocytes in the Uterine Wall during Experimental Healing and in Cesarean Scars during Pregnancy by Natalia Tikhonova, Andrey P. Milovanov, Valentina V. Aleksankina, Ilyas A. Kulikov, Tatiana V. Fokina, Andrey P. Aleksankin, Tamara N. Belousova, Ludmila M. Mikhaleva, Natalya V. Niziaeva

“…The uterine wall was evaluated in gross and histological sections using morphometry, histochemistry (hematoxylin and eosin stain, Mallory stain), and immunohistochemistry for FABP4 (adipocyte markers), CD68, CD163, CD206 (macrophages), CD 34 (endothelium), cytokeratin 8 (epithelium), aSMA (smooth muscle cells). …”
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Different procedures combined with Toric intraocular lens implantation on age-related hard nuclear cataract by Yi Dong, Biao Wei, Yan Zhao

“…The incidence of postoperative complications in small-incision group was lower than that in phacoemulsification group(3.9% vs. 17.3%, P<0.05).CONCLUSION: Small-incision split nuclear technique in horizontal space combined with Toric IOL implantation can significantly improve visual acuity and astigmatism in patients with age-related cataract, with slight damage to corneal endothelium and tear film function.…”
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Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation by M. Smimmo, V. Casale, G.M. Casillo, E. Mitidieri, R. d'Emmanuele di Villa Bianca, I. Bello, A. Schettino, R. Montanaro, V. Brancaleone, C. Indolfi, G. Cirino, A. Di Lorenzo, M. Bucci, E. Panza, V. Vellecco

“…In vivo treatment with the H2S donor Erucin ameliorates vascular dysfunction observed in db/db mice without impacting eNOS, further highlighting a specific action on smooth muscle component rather than the endothelium. Analyzing the NO signaling pathway in db/db mice aortas, reduced cGMP levels were detected, implicating a defective sGC/cGMP signaling. …”
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Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response- a translational research sub-study of the REZOLVE (ANZGOG-1101) clinical trial by Bonnita Werner, Katrin M Sjoquist, David Espinoza, Sonia Yip, Garry Chang, Michelle M Cummins, Linda Mileshkin, Sumitra Ananda, Catherine Shannon, Michael Friedlander, Kristina Warton, Caroline E. Ford

“…Standard and methylation-specific PCRs were performed to measure 3 biomarkers: total cfDNA (Alu), tumour-derived cfDNA (ctDNA, methylated IFFO1 promoter) and endothelium-derived cfDNA (ec-cfDNA, unmethylated CDH5 promoter). …”
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Platelet‐derived lipids promote insulin secretion of pancreatic β cells by Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara

“…Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. …”
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Preoperative surgeon evaluation of corneal endothelial status: the Viability Control of Human Endothelial Cells before Keratoplasty (V-CHECK) study protocol by Yalin Zheng, Francesco Aiello, Vito Romano, Luigi Fontana, Mohit Parekh, Stephen B Kaye, Diego Ponzin, Stefano Ferrari, Sorcha Ní Dhubhghaill, Vincenzo Scorcia, Kunal A Gadhvi, Hannah J Levis, Francesco Semeraro, Alessandro Ruzza, Lamis Baydoun, Björn Bachmann, Stefano Calza, Matteo Airaldi, Mor M Dickman, Antonello Moramarco, Marina Rodriguez Calvo de Mora, Carlos Rocha de Lossada, Pietro Viola

“…Donor corneal tissues are routinely screened for endothelial damage before shipment; however, surgical teams have currently no means of assessing the overall viability of corneal endothelium immediately prior to transplantation. The aim of this study is to validate a preoperative method of evaluating the endothelial health of donor corneal tissues, to assess the proportion of tissues deemed suitable for transplantation by the surgeons and to prospectively record the clinical outcomes of a cohort of patients undergoing keratoplasty in relation to preoperatively defined endothelial viability.Methods and analysis In this multicentre cohort study, consecutive patients undergoing keratoplasty (perforating keratoplasty, Descemet stripping automated endothelial keratoplasty (DSAEK), ultra-thin DSAEK (UT-DSAEK) or Descemet membrane endothelial keratoplasty) will be enrolled and followed-up for 1 year. …”
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Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial by Jacopo Sabbatinelli, Patrick Orlando, Roberta Galeazzi, Sonia Silvestri, Ilenia Cirilli, Fabio Marcheggiani, Phiwayinkosi V. Dludla, Angelica Giuliani, Anna Rita Bonfigli, Laura Mazzanti, Fabiola Olivieri, Roberto Antonicelli, Luca Tiano

“…In this randomized, double-blind, single-center trial (ANZCTR number ACTRN12619000436178) we aimed to investigate changes in endothelium-dependent vasodilation induced by ubiquinol, the reduced form of coenzyme Q10 (CoQ10), in healthy subjects with moderate dyslipidemia. …”
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Cardiorenal disturbances in perimenopausal women by S. N. Tolstov, V. B. Mychka, I. A. Salov, Yu. V. Prokhorova, V. A. Vyshivanyuk

“…Non-invasive assessment of endothelial vasoregulatory function involved the measurement of brachial artery (BA) endothelium-dependent vasodilatation (EDVD) in the reactive hyperemia test (RHT). …”
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Paricalcitol Improves the Angiopoietin/Tie-2 and VEGF/VEGFR2 Signaling Pathways in Adriamycin-Induced Nephropathy by Amanda Lima Deluque, Beatriz Magalhães Oliveira, Cláudia Silva Souza, Ana Lívia Dias Maciel, Heloísa Della Coletta Francescato, Cleonice Giovanini, Lucas Ferreira de Almeida, Francisco José Albuquerque de Paula, Roberto Silva Costa, José Antunes-Rodrigues, Terezila Machado Coimbra

“…This study aimed to evaluate the effect of paricalcitol treatment on renal endothelial toxicity in a model of CKD induced by ADR in rats and explore mechanisms involved in EC maintenance by eNOS/NO, angiopoietins (Angs)/endothelium cell-specific receptor tyrosine kinase (Tie-2, also known as TEK) and vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) axis. …”
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Obesity and Hyperandrogenemia in Polycystic Ovary Syndrome: Clinical Implications by Mardia López-Alarcón, Víctor Saúl Vital-Reyes, Eduardo Almeida-Gutiérrez, Jorge Maldonado-Hernández, Salvador Flores-Chávez, Juan Manuel Domínguez-Salgado, José Vite-Bautista, David Cruz-Martínez, Aly S. Barradas-Vázquez, Ricardo Z’Cruz-López

“…The clinical biomarkers of alterations related to glucose (glucose, insulin, and clamp-derived glucose disposal − <i>M</i>), liver (aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase), and endothelium (arginine, asymmetric dymethylarginine, carotid intima-media thickness, and flow-mediated dilation) metabolism were measured; participants were categorized into four groups according to their obesity (OB) and hyperandrogenemia (HA) status as follows: Healthy (no-HA, lean), HA (HA, lean), OB (no-HA, OB), and HAOB (HA, OB). …”
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Use of polyclonal antibodies in brain-dead donors in kidney transplantation by D. O. Kuzmin, V. A. Manukovsky, S. F. Bagnenko, O. N. Reznik, A. N. Ananiev, O. A. Vorobyeva, S. L. Vorobyev, D. V. Gogolev, V. S. Daineko, A. A. Kutenkov, N. A. Chichagova, I. V. Uliankina

“…The objective of this study is to develop a therapeutic strategy for protecting grafts in order to improve the efficiency of kidney transplantation (KT) using polyclonal antibodies (pAbs) through elimination of activated forms of neutrophils, chemo- and cytokines from the donor’s bloodstream, and a decrease in the level of expression of adhesion molecules on the renal vascular endothelium at the pre-transplant stage.Materials and methods. …”
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Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice by Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens

“…Furthermore, αCTLA4 treatment induced endothelial activation, characterized by increased ICAM1 expression in the aortic endothelium. In the aortic arch, which mainly contained early atherosclerotic lesions at this time point, αCTLA4 treatment induced a 2.0-fold increase in the plaque area. …”
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The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr^−/− Mice with Obesity by Undral Munkhsaikhan, Young In Kwon, Amal M. Sahyoun, María Galán, Alexis A. Gonzalez, Karima Ait-Aissa, Ammaar H. Abidi, Adam Kassan, Modar Kassan

“…After treatment with lomitapide, the endothelium function of the thoracic aorta (47.7 ± 6.3% vs. 80.7 ± 3.1%) and mesenteric resistance artery (66.4 ± 4.3% vs. 79.5 ± 4.6%) was improved in the group of LDLr⁻/⁻ mice on HFD. …”
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Features and Comparative Characteristics of Fucosylated Glycans Expression in Endothelial Glycocalyx of Placental Terminal Villi in Patients with Preeclampsia Treated with Differen... by Marina M. Ziganshina, Galina V. Kulikova, Kamilla T. Muminova, Alexander I. Shchegolev, Ekaterina L. Yarotskaya, Zulfiya S. Khodzhaeva, Gennady T. Sukhikh

“…Their effect on the endothelium of placental vessels has not yet been studied. …”
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Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner by Mark Richards, Emmanuel Nwadozi, Sagnik Pal, Pernilla Martinsson, Mika Kaakinen, Marleen Gloger, Elin Sjöberg, Katarzyna Koltowska, Christer Betsholtz, Lauri Eklund, Sofia Nordling, Lena Claesson-Welsh

“…Here, we focus on organs with continuous endothelium to identify structural and functional in vivo characteristics of the EC barrier. …”
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LOCALIZATION OF AQUAPORIN-1 IN THE SMALL AND LARGE INTESTINES OF GEESE (Anser anser) by Ebru Karadag Sari, Buket Bakir, Gizem Fidan Arslan, Sevda Elis Yildiz

“…Consequently, with this study, Aquaporin-1 immunoreactivity was detected in the crypt epithelial cells, smooth muscle cells, and vascular endothelium of the small intestines of geese. Lokalizacija akvaporina-1 v tankem in debelem črevesu pri goseh (Anser anser) Izvleček: Akvaporini so selektivni vodni kanali za prenos vode skozi celične membrane in imajo pomembno vlogo v vseh celicah. …”
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Results of posterior lamellar femto-keratoplasty using two different lasers by B. E. Malyugin, A. N. Pashtaev, N. F. Shilova, K. N. Kuzmichev, K. I. Katmakov

“…Statistical analysis showed highest safety of transplanted endothelium in the 1st group at 1-year observation period.…”
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