A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging by Laura Beth Payne, Hanaa Abdelazim, Maruf Hoque, Audra Barnes, Zuzana Mironovova, Caroline E. Willi, Jordan Darden, Clifton Houk, Meghan W. Sedovy, Scott R. Johnstone, John C. Chappell

“…Visualizing fluorescently labeled sPDGFRβ transcripts revealed a spatial distribution corresponding to murine brain pericytes alongside cerebrovascular endothelium. Soluble PDGFRβ protein was detected throughout the brain parenchyma in distinct regions, such as along the lateral ventricles, with signals also found more broadly adjacent to cerebral microvessels consistent with pericyte labeling. …”
Get full text

Bacteroides vulgatus alleviates dextran sodium sulfate-induced colitis and depression-like behaviour by facilitating gut-brain axis balance by Xing Wu, Xing Wu, Jiahao Xu, Jiahao Xu, Jingbo Li, Minzi Deng, Zhaohua Shen, Kai Nie, Weiwei Luo, Weiwei Luo, Chao Zhang, Chao Zhang, Kejia Ma, Kejia Ma, Xuejie Chen, Xuejie Chen, Xiaoyan Wang, Xiaoyan Wang, Xiaoyan Wang

“…By increasing the expression of the tight junction protein claudin-5 in the vascular endothelium of the BBB, B. vulgatus and 4-HPAA play critical roles in gut–brain communication.ConclusionB. vulgatus and B. vulgatus-derived 4-HPAA ameliorated intestinal inflammation and relieved depressive symptoms through the gut–brain axis. …”
Get full text

Serum Syndecan-1 levels in patients with immunoglobulin A vasculitis in children by Xinyi Jia, Zhenya Zhu, Jing Miao, Linqian Zhang, Xiaobing Li, Yunguang Bao, Mizu Jiang

“…Conclusions: SDC-1 serum levels may mirror vascular endothelium injury and mucosal damage in IgAV. Its applicability as a surrogate biomarker in IgAV remains to be determined.…”
Get full text

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion by Tarek A. M. Almabrouk, Tarek A. M. Almabrouk, Anna D. White, Azizah B. Ugusman, Azizah B. Ugusman, Dominik S. Skiba, Dominik S. Skiba, Omar J. Katwan, Omar J. Katwan, Husam Alganga, Husam Alganga, Tomasz J. Guzik, Tomasz J. Guzik, Rhian M. Touyz, Ian P. Salt, Simon Kennedy

“…Vascular responses were measured in endothelium-denuded aortic rings with or without attached PVAT. …”
Get full text

MECHANISMS OF CYTOKINE STORM DEVELOPMENT IN COVID-19 AND NEW POTENTIAL TARGETS OF PHARMACOTHERAPY by V. I. Petrov, A. A. Amosov, A. S. Gerasimenko, O. V. Shatalova, A. V. Ponomareva, A. N. Akinchits, I. S. Kulakova, V. S. Gorbatenko

“…Proinflammatory cytokines are potent inducers of the HAS 2 gene in the endothelium, which encodes the membrane enzymes of hyaluronate synthase. …”
Get full text

Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke by Shuaiwei Wang, Lauriane de Fabritus, Praveen Ashok Kumar, Yves Werner, Minglu Ma, Dan Li, Carole Siret, Milesa Simic, Bin Li, Yann M. Kerdiles, Lei Hou, Ralf Stumm, Serge A. van de Pavert

“…Their migration route via chemokine CXCL12 was studied by using different genetic mouse models, in which we induced deletion of Cxcl12 within the blood–brain barrier endothelium, or its receptor, Cxcr4, in the ILCs. The functional role of the ILCs was subsequently established using the beam-walk sensorimotor test. …”
Get full text

Regulation of CD163 Receptor in Patients with Abdominal Aortic Aneurysm and Associations with Antioxidant Enzymes HO-1 and NQO1 by Bianca Hamann, Anna Klimova, Felicia Klotz, Frieda Frank, Christian Jänichen, Marvin Kapalla, Pamela Sabarstinski, Steffen Wolk, Henning Morawietz, David M. Poitz, Anja Hofmann, Christian Reeps

Get full text

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model o... by Sarah Easson, Radha Dutt Singh, Liam Connors, Taylor Scheidl, Larissa Baker, Anshul Jadli, Hai-Lei Zhu, Jennifer Thompson

“…In a mouse model of low dose BPS exposure, NO-mediated endothelial function was assessed in pressurized microvessels by inducing endothelium-dependent dilation in the presence or absence of L-NAME. …”
Get full text

Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism by Xiaoqing Yan, Yue Su, Xia Fan, Hui Chen, Zixian Lu, Zijuan Liu, Yingjian Li, Mei Yi, Guigui Zhang, Chunjie Gu, Kai Wang, Jiamin Wu, Da Sun, Yikai Zhang, Chi Zhang, Xiaozhen Dai, Chao Zheng

“…The impairment in endothelial progenitor cell (EPC) functions results in dysregulation of vascular homeostasis and dysfunction of the endothelium under diabetic conditions. Improving EPC function has been considered as a promising strategy for ameliorating diabetic vascular complications. …”
Get full text

<i>Piper tectoniifolium</i> Kunth: A New Natural Source of the Bioactive Neolignan (−)-Grandisin by André M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimarães, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pâmella Dourila N. Souza, David William Provance, José Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo

“…In vascular reactivity tests, it was shown that the grandisin purified from botanical extracts presented an endothelium-dependent vasorelaxant effect with an IC₅₀ of 9.8 ± 1.22 μM and around 80% relaxation at 30 μM. …”
Get full text

Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke by Jean-Claude Barthelemy, Jean-Claude Barthelemy, Vincent Pichot, Vincent Pichot, David Hupin, David Hupin, David Hupin, Mathieu Berger, Mathieu Berger, Mathieu Berger, Sébastien Celle, Sébastien Celle, Lytissia Mouhli, Lytissia Mouhli, Magnus Bäck, Magnus Bäck, Jean-René Lacour, Frederic Roche, Frederic Roche

“…In support of these observations, a compensatory neurostimulation has already proved beneficial on endothelium function. The available data on stroke predictions from ANS is based on many long-term stroke cohorts. …”
Get full text

Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy by Ivica Premuzic Mestrovic, Ivan Maria Smoday, Luka Kalogjera, Ivan Krezic, Helena Zizek, Hrvoje Vranes, Vlasta Vukovic, Katarina Oroz, Ivan Skorak, Ivan Brizic, Klaudija Hriberski, Luka Novosel, Ivana Kavelj, Ivan Barisic, Lidija Beketic Oreskovic, Slavica Zubcic, Sanja Strbe, Tomislav Mestrovic, Predrag Pavic, Mario Staresinic, Anita Skrtic, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric

“…In this syndrome, as in similar syndromes with permanent occlusion of major vessels, peripheral and central, and other similar noxious procedures that severely disable endothelium function, the stable gastric pentadecapeptide BPC 157-collateral pathways activation, was a resolving therapy. …”
Get full text

Показники дисфункції ендотелію у хворих на хронічну критичну ішемію нижніх кінцівок = Endothelial dysfunction indicators in patients with chronic critical limb ischemia... by S. K.T. Goni

“…It is shown that regardless of the stage of ischemia and the presence of diabetes in patients who were investigated, breach of vasomotor endothelial function (according to the level of endothelin-1), increased proliferative activity of endothelium (according to the level of VEGF), a violation of hemostatic (according to the level of fibrinogen) and proinflammatory endothelial function (based on C-reactive protein) was shown. …”
Get full text

Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction by Wanessa M.C. Awata, Juliano V. Alves, Rafael M. Costa, Ariane Bruder-Nascimento, Shubhnita Singh, Gabriela S. Barbosa, Carlos Renato Tirapelli, Thiago Bruder-Nascimento

“…Results: Ethanol induced aortic hypercontractility in an endothelium-dependent manner. PGC1α (a marker of biogenesis), Mfn2, (an essential protein for mitochondria fusion), as well as Pink-1 and Parkin (markers of mitophagy), were reduced in aortas from ethanol-treated mice. …”
Get full text

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation by Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu

“…Vascular glycocalyx coating on the endothelium would be damaged and caused endothelial dysfunction in the inflammatory microenvironment, which was the initial factor of morbidity of many vascular diseases, such as atherosclerosis (AS). …”
Get full text

IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis by Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam, Pierre Meyer, Eric Flatter, Marie-Christine Birling, Jagadeesh Bayry, Jagadeesh Bayry, Mei Li

“…Using a hapten fluorescein isothiocyanate (FITC)-induced allergic contact dermatitis (ACD) mouse model, we show that basophils in FITC-treated IL-3-knockout mice are defective in crossing the vascular endothelium to enter the inflamed skin. By generating mice in which IL-3 is selectively ablated in T cells, we further demonstrate that IL-3 produced by T cells mediates basophil extravasation. …”
Get full text

Platelet derived exosomes disrupt endothelial cell monolayer integrity and enhance vascular inflammation in dengue patients by Sayali Vedpathak, Archana Sharma, Sonali Palkar, Varsha R. Bhatt, Vishwanath Chandrashekhar Patil, Arjun L. Kakrani, AkhileshChandra Mishra, Deepak Bhosle, Vidya A. Arankalle, Shubham Shrivastava

“…Activation status of platelets and interaction of platelets with endothelium contribute towards dengue disease pathogenesis. …”
Get full text

Comparison effect of high-intensity interval training and moderate intensity continuous training on vascular function in a mouse model of lower extremity peripheral artery disease by Slobodan Kojic, Steeve Menetrey, Karima Bouzourène, Lucia Mazzolai, Anne-Christine Peyter, Nathalie Rosenblatt-Velin, Grégoire P. Millet, Maxime Pellegrin

“…Vascular reactivity was assessed by measuring vasoconstrictor responses to phenylephrine as well as endothelium-dependent and -independent vasodilator responses to acetylcholine and DEA-NONOate, respectively, in isolated aortic rings. …”
Get full text

A novel OSA-related model of intermittent hypoxia in endothelial cells under flow reveals pronounced inflammatory pathway activation by Martin B. Müller, Martin B. Müller, Clemens Stihl, Annika Schmid, Simon Hirschberger, Simon Hirschberger, Rea Mitsigiorgi, Rea Mitsigiorgi, Martin Holzer, Martin Patscheider, Bernhard G. Weiss, Christoph Reichel, Christoph Reichel, Max Hübner, Max Hübner, Bernd Uhl, Bernd Uhl

“…Hence, we established a novel in vitro model for deciphering OSA-elicited effects on the vascular endothelium. First data obtained in this model point to the endothelial activation of pro-inflammatory rather than hypoxia-associated pathways in OSA. …”
Get full text

Renal Denervation Helps Preserve the Ejection Fraction by Preserving Endocardial-Endothelial Function during Heart Failure by Sathnur Pushpakumar, Mahavir Singh, Yuting Zheng, Oluwaseun E. Akinterinwa, Sri Prakash L. Mokshagundam, Utpal Sen, Dinesh K. Kalra, Suresh C. Tyagi

“…It should be noted that others have demonstrated a role of vascular endothelium in preserving the ejection by cell therapy intervention. …”
Get full text