Comparative Study of the Myocardium of Patients from Four COVID-19 Waves by Lubov Borisovna Mitrofanova, Igor Aleksandrovich Makarov, Andrey Nikolaevich Gorshkov, Andrey Leonidovich Runov, Maxim Sergeevich Vonsky, Maria Mikhailovna Pisareva, Andrey Borisovich Komissarov, Taiana Alekseevna Makarova, Qingli Li, Tatiana Leonidovna Karonova, Alexandra Olegovna Konradi, Evgeny Vladimirovich Shlaykhto

“…Electron microscopy showed several single particles similar to SARS-CoV-2 virions on the surface of the endothelium of myocardial vessels. A comparison of the cardiovascular complication incidence between three waves revealed that the incidence of hemorrhage (48 vs. 24 vs. 17%), myocardial necrosis (18 vs. 11 vs. 4%), blood clots in the intramural arteries (12 vs. 7 vs. 0%), and myocarditis (19 vs. 1 vs. 6%) decreased over time, and CD8-T-killers appeared. …”
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Complement Factor H Inhibits Anti-Neutrophil Cytoplasmic Autoantibody-Induced Neutrophil Activation by Interacting With Neutrophils by Su-Fang Chen, Su-Fang Chen, Su-Fang Chen, Feng-Mei Wang, Feng-Mei Wang, Feng-Mei Wang, Zhi-Ying Li, Zhi-Ying Li, Zhi-Ying Li, Feng Yu, Feng Yu, Feng Yu, Min Chen, Min Chen, Min Chen, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao

“…Here, we investigated the role of FH in the process of ANCA-mediated activation of neutrophils and neutrophil–endothelium interaction. We demonstrated that FH bound to neutrophils by immunostaining and flow cytometry. …”
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Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular gra... by Sabrina Rohringer, Karl H. Schneider, Gabriela Eder, Pia Hager, Marjan Enayati, Barbara Kapeller, Herbert Kiss, Ursula Windberger, Bruno K. Podesser, Helga Bergmeister

“…The endothelium plays an important regulatory role for cardiovascular homeostasis. …”
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Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation by Stéphanie Chasseigneaux, Véronique Cochois-Guégan, Lucas Lecorgne, Murielle Lochus, Sophie Nicolic, Corinne Blugeon, Laurent Jourdren, David Gomez-Zepeda, Stefan Tenzer, Sylvia Sanquer, Valérie Nivet-Antoine, Marie-Claude Menet, Jean-Louis Laplanche, Xavier Declèves, Salvatore Cisternino, Bruno Saubaméa

“…Methods We used a combination of in vivo and in vitro experiments to assess the response of the brain endothelium in male rats that were fed ad libitum or fasted for one to three days. …”
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90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics by Daan Andel, Lotte van den Bent, Marnix Gerard Ernest Hendrik Lam, Maarten Leonard Johannes Smits, Isaac Quintus Molenaar, Joep de Bruijne, Miangela Marie Laclé, Onno Kranenburg, Inne Hildbrand Max Borel Rinkes, Jeroen Hagendoorn

“…Lymph vessel morphology was analyzed by two researchers using podoplanin, a protein that is expressed in lymphatic endothelium. In vivo liver lymph drainage of radioembolized livers was assessed using intraoperative liver lymphangiography (ILL): during liver surgery, patent blue dye was injected into the liver parenchyma, followed by inspection for staining of perihepatic lymph structures. …”
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New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension by Polina V. Alyabyeva, Olga V. Chastina, Marina M. Petrova, Natalia V. Lareva, Natalia P. Garganeeva, Galina A. Chumakova, Marina S. Cherniaeva, Natalia A. Shnayder

“…Reduced bioavailability of NO in the endothelium is an important precursor for impaired vasodilation and arterial hypertension (AH). …”
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The Inhibition of the FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-N... by Gabriela Morales-Guadarrama, Edgar A. Méndez-Pérez, Janice García-Quiroz, Euclides Avila, María J. Ibarra-Sánchez, José Esparza-López, Rocío García-Becerra, Fernando Larrea, Lorenza Díaz

“…Similarly, endothelial cells primed by TNBC cells showed an upregulation of proangiogenic molecules, including FGF, VEGFA, and several inflammatory cytokines. Endothelium-dependent TNBC-VM formation was prevented by AZD4547 or LY294002, strongly suggesting the involvement of the FGFR/PI3K/Akt axis in this process. …”
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Efeitos da atorvastatina, fluvastatina, pravastatina e simvastatina sobre a função endotelial, a peroxidação lipídica e a aterosclerose aórtica em coelhos hipercolesterolêmicos Eff... by Paulo Afonso Ribeiro Jorge, Eros Antonio de Almeida, Michiko R. Ozaki, Mariana Jorge, Adriano Carneiro

“…The MDA content was also significantly reduced in native and oxidized LDL, as well as in the arterial wall. Endothelium-dependent relaxation was significantly greater in the treated group compared with that in the hypercholesterolemic group. …”
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Characterization of Fruit Development, Antioxidant Capacity, and Potential Vasoprotective Action of Peumo (<i>Cryptocarya alba</i>), a Native Fruit of Chile by Mónika Valdenegro, Maricarmen Bernales, Marcela Knox, Raúl Vinet, Eduardo Caballero, Aníbal Ayala-Raso, Denisa Kučerová, Rohitesh Kumar, Jitka Viktorová, Tomáš Ruml, Carlos R. Figueroa, Lida Fuentes

“…Also, the assay of isolated rat aorta with endothelium-dependent relaxation damage demonstrated that the peumo extract induced vascular protection, depending on its concentration under a high glucose condition. …”
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أثر الداء السكري النمط 2 على ثخانة القرنية المركزية و خلايا بطانة القرنية by تيم درويش, يوسف سليمان, نوار سكاف

“… Purpose : To study the effect of diabetes type 2 on central corneal thickness and corneal endothelium  with respect to duration and glycemic control (level of glycosylated haemoglobin) Methods : The corneal endothelial structure and central corneal thickness (CCT) were investigated in 57 type II diabetic patients (114 eyes) and in 46 nondiabetic patients (92 eyes) aged between 40-60 years. …”
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Visualization of basement membranes by a nidogen-based fluorescent reporter in mice by Sugiko Futaki, Ayano Horimoto, Chisei Shimono, Naoko Norioka, Yukimasa Taniguchi, Hitomi Hamaoka, Mari Kaneko, Mayo Shigeta, Takaya Abe, Kiyotoshi Sekiguchi, Yoichi Kondo

“…In the retina, Nid1-mCherry fluorescence visualized the BMs of vascular endothelium and pericytes. In the developing retina, Nid1-mCherry fluorescence labeled the BM of the major central vessels; however, the BM fluorescence were hardly observed in the peripheral growing tips of the vascular network, despite the presence of endothelial BM. …”
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Case report: Microcirculatory leukocytes in a pediatric patient with severe SARS-CoV-2 pneumonia. Findings of leukocytes trafficking beyond the lungs by Gabriella Bottari, Can Ince, Valerio Confalone, Salvatore Perdichizzi, Chiara Casamento Tumeo, Joseph Nunziata, Stefania Bernardi, Francesca Calò Carducci, Laura Lancella, Paola Bernaschi, Cristina Russo, Cristina Russo, Carlo Federico Perno, Carlo Federico Perno, Corrado Cecchetti, Alberto Villani

“…It’s significant to underline how the patient didn’t show a contextual significant increase in inflammatory biomarkers or other clinical signs related to an inflammatory response, beyond the presence of severe hypoxic respiratory failure.ConclusionLeukocyte activation in multiple organs can occur at the endothelial lining of the microvasculature where a surge of pro-inflammatory mediators can result in accumulation of activated leukocytes and degradation of the endothelium. The introduction of a method to assess in a non-invasive, real-time manner the extent of inflammation in a patient with COVID19 could lead to potential clinical and therapeutic implications. …”
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Cellular activation pathways and interaction networks in vascularized composite allotransplantation by Leonard Knoedler, Leonard Knoedler, Samuel Knoedler, Samuel Knoedler, Adriana C. Panayi, Adriana C. Panayi, Catherine A. A. Lee, Sam Sadigh, Lioba Huelsboemer, Viola A. Stoegner, Viola A. Stoegner, Andreas Schroeter, Andreas Schroeter, Barbara Kern, Vikram Mookerjee, Christine G. Lian, Stefan G. Tullius, George F. Murphy, Bohdan Pomahac, Martin Kauke-Navarro

“…The fine line between tolerance and rejection of the graft is orchestrated by different cell types, including both donor and recipient-derived lymphocytes, macrophages, and other immune and donor-derived tissue cells (e.g., endothelium). Here, we delineate the role of different cell and tissue types during VCA rejection. …”
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Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model by Yu-Ting Song, Yan-Qing Li, Mao-Xuan Tian, Jun-Gen Hu, Xiu-Ru Zhang, Peng-Cheng Liu, Xiu-Zhen Zhang, Qing-Yi Zhang, Li Zhou, Long-Mei Zhao, Jesse Li-Ling, Hui-Qi Xie

“…In vivo experiment proved that the AC-SIS scaffold could promote rapid endothelium healing and smooth muscle regeneration. …”
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Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 by Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage

“…Given the potential pleiotropic effects of PCSK9 on the endothelium, beyond canonical effects on serum lipoproteins, both of which may influence sepsis outcomes, we sought to test the influence of PCSK9 LOF genotype on endothelial dysfunction. …”
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Coagulation Abnormalities in Renal Pathology of Chronic Kidney Disease: The Interplay between Blood Cells and Soluble Factors by Efthimia G. Pavlou, Hara T. Georgatzakou, Sotirios P. Fortis, Konstantina A. Tsante, Andreas G. Tsantes, Efrosyni G. Nomikou, Athanasia I. Kapota, Dimitrios I. Petras, Maria S. Venetikou, Effie G. Papageorgiou, Marianna H. Antonelou, Anastasios G. Kriebardis

“…The interaction of red blood cells with platelets, the thrombus, the endothelium, the soluble components of the coagulation pathways, and the contribution of extracellular vesicles on hemostasis as well as the identification of the unknown origin ADAMTS-13 inhibitor deserve further investigation in uremia.…”
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Development of high-speed two-photon microscopy for biological and medical applications by Kim, Ki Hean

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Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease by Okpala, Iheanyi, Ren, Hongmei, Ghebremeskel, Kebreab, Ugochukwu, Cynthia C., Ibegbulam, Obike, Crawford, Michael A.

“…Leukocyte adhesion to vascular endothelium contributes to vaso-occlusion and widespread organ damage in sickle cell disease (SCD). …”

Relationship between the structure, function and endothelial damage, and vascular ageing and the biopsychological situation in adults diagnosed with persistent COVID (BioICOPER stu... by Leticia Gómez-Sánchez, Leticia Gómez-Sánchez, Olaya Tamayo-Morales, Olaya Tamayo-Morales, Olaya Tamayo-Morales, Nuria Suárez-Moreno, Nuria Suárez-Moreno, Nuria Suárez-Moreno, Jesus F. Bermejo-Martín, Jesus F. Bermejo-Martín, Andrea Domínguez-Martín, Andrea Domínguez-Martín, Andrea Domínguez-Martín, José A. Martín-Oterino, José A. Martín-Oterino, José A. Martín-Oterino, José A. Martín-Oterino, José I. Martín-González, José I. Martín-González, José I. Martín-González, José I. Martín-González, David González-Calle, David González-Calle, David González-Calle, David González-Calle, Ángel García-García, Ángel García-García, Ángel García-García, Ángel García-García, Cristina Lugones-Sánchez, Cristina Lugones-Sánchez, Cristina Lugones-Sánchez, Susana González-Sánchez, Susana González-Sánchez, Susana González-Sánchez, Raquel Jiménez-Gómez, Raquel Jiménez-Gómez, Raquel Jiménez-Gómez, Luis García-Ortiz, Luis García-Ortiz, Luis García-Ortiz, Luis García-Ortiz, Luis García-Ortiz, Manuel A. Gómez-Marcos, Manuel A. Gómez-Marcos, Manuel A. Gómez-Marcos, Manuel A. Gómez-Marcos, Manuel A. Gómez-Marcos, Elena Navarro-Matías, Elena Navarro-Matías, Elena Navarro-Matías, ICOPER investigators group

“…Background: SARS-CoV-2 infection affects the vascular endothelium, which mediates the inflammatory and thrombotic cascade. …”
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Comparación de los niveles séricos de óxido nítrico y malondialdehído en pacientes con pie diabético con y sin infección by Hernández Arteaga M, Núñez R, Godoy N, Socarras E, González Z, Chávez J, Cano C, Bermúdez VSuárez G, Suárez G

“…Abstract: Pathogenesis of diabetic foot infections include polineuropathy, macro and microvascular disease and neutrophil functional deficit. Endothelium dependent vasodilatation related to Nitric Oxide (NO) production is compromised in diabetics predisposed to foot ulceration. …”
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