Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma by S. John Liu, Stephen T. Magill, Harish N. Vasudevan, Stephanie Hilz, Javier E. Villanueva-Meyer, Sydney Lastella, Vikas Daggubati, Jordan Spatz, Abrar Choudhury, Brent A. Orr, Benjamin Demaree, Kyounghee Seo, Sean P. Ferris, Adam R. Abate, Nancy Ann Oberheim Bush, Andrew W. Bollen, Michael W. McDermott, Joseph F. Costello, David R. Raleigh

“…Keywords: brain tumor, cancer, DNA methylation, C11orf95-RELA, ependymoma, epigenomics, exome sequencing, magnetic resonance imaging, RNA sequencing, SETD2…”
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Nutrient regulation of the islet epigenome controls adaptive insulin secretion by Matthew Wortham, Fenfen Liu, Austin R. Harrington, Johanna Y. Fleischman, Martina Wallace, Francesca Mulas, Medhavi Mallick, Nicholas K. Vinckier, Benjamin R. Cross, Joshua Chiou, Nisha A. Patel, Yinghui Sui, Carolyn McGrail, Yesl Jun, Gaowei Wang, Ulupi S. Jhala, Roland Schüle, Orian S. Shirihai, Mark O. Huising, Kyle J. Gaulton, Christian M. Metallo, Maike Sander

“…Overall, these studies revealed that adaptive insulin secretion involves Lsd1-mediated coupling of nutrient state to regulation of the islet epigenome.…”
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Correction: Harnessing male germline epigenomics for the genetic improvement in cattle by Xiao Wang, Wenlong Li, Xia Feng, Jianbin Li, George E. Liu, Lingzhao Fang, Ying Yu

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TARGETING THE EPIGENOME IN LUNG CANCER: EXPANDING APPROACHES TO EPIGENETIC THERAPY by Marko eJakopovic, Anish eThomas, Sanjeeve eBalasubramaniam, David eSchrump, Giuseppe eGiaccone, Susan E. Bates

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Reprogramming of the Hevea brasiliensis Epigenome and Transcriptome in Response to Cold Stress by Xiao Tang, Xiao Tang, Yonglei Zhang, Hong-Mei Yuan, Jinling Zhai, Xi Huang

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Phthalate Exposure and Long-Term Epigenomic Consequences: A Review by Sudipta Dutta, Diana K. Haggerty, Daniel A. Rappolee, Daniel A. Rappolee, Douglas M. Ruden, Douglas M. Ruden

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Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts by Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer, Xander T. den Dekker, Wilfred F. J. van IJcken, Benjamin Nota, Alex E. Felice, Thamar B. van Dijk, Marieke von Lindern, Joseph Borg, Emile van den Akker, Sjaak Philipsen

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Does epigenome is influenced by allopollyploidisation during the evolution of Gossypium hirsutum by Priti Prasad, Samir V. Sawant

“…We are keen to understand whether the epigenome structure of A- and D-subgenomes are conserved or influenced by polyploidisation? …”
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Integrated genomic and epigenomic analysis of breast cancer brain metastasis. by Bodour Salhia, Jeff Kiefer, Julianna T D Ross, Raghu Metapally, Rae Anne Martinez, Kyle N Johnson, Danielle M DiPerna, Kimberly M Paquette, Sungwon Jung, Sara Nasser, Garrick Wallstrom, Waibhav Tembe, Angela Baker, John Carpten, Jim Resau, Timothy Ryken, Zita Sibenaller, Emanuel F Petricoin, Lance A Liotta, Ramesh K Ramanathan, Michael E Berens, Nhan L Tran

“…Hypomethylation and upregulation of KRT8 likely affects adhesion and permeability. Genomic and epigenomic profiling of breast brain metastasis has provided insight into the somatic events underlying this disease, which have potential in forming the basis of future therapeutic strategies.…”
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Distinct epigenomic and transcriptomic modifications associated with Wolbachia-mediated asexuality. by Xin Wu, Amelia R I Lindsey, Paramita Chatterjee, John H Werren, Richard Stouthamer, Soojin V Yi

“…It has been hypothesized that Wolbachia infection accompanies a modification of the host epigenome. However, to date, data on genome-wide epigenomic changes associated with Wolbachia are limited, and are often confounded by background genetic differences. …”
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NaviSE: superenhancer navigator integrating epigenomics signal algebra by Alex M. Ascensión, Mikel Arrospide-Elgarresta, Ander Izeta, Marcos J. Araúzo-Bravo

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Plant epigenomics—deciphering the mechanisms of epigenetic inheritance and plasticity in plants by Claudia Köhler, Nathan Springer

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Manipulating the Epigenome in Nuclear Transfer Cloning: Where, When and How by Kilian Simmet, Eckhard Wolf, Valeri Zakhartchenko

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Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex by Oliver Kaut, Ina Schmitt, Fabian Stahl, Holger Fröhlich, Per Hoffmann, Frank J. Gonzalez, Ullrich Wüllner

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Integrative Epigenomic Analysis of Transcriptional Regulation of Human CircRNAs by Xue-Cang Li, Zhi-Dong Tang, Li Peng, Yan-Yu Li, Feng-Cui Qian, Jian-Mei Zhao, Ling-Wen Ding, Xiao-Juan Du, Meng Li, Jian Zhang, Xue-Feng Bai, Jiang Zhu, Chen-Chen Feng, Qiu-Yu Wang, Jian Pan, Chun-Quan Li

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Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19 by Shreya Sarkar, Rwik Sen

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Using epigenomics to understand cellular responses to environmental influences in diseases by Julia J. Wattacheril, Srilakshmi Raj, David A. Knowles, John M. Greally

“…In this review, we have chosen to use the example of nonalcoholic fatty liver disease (NAFLD), a common, complex human disease with strong environmental and genetic influences. We describe how epigenomic approaches combined with emerging functional genetic and single-cell genomic techniques are poised to generate new insights into the pathogenesis of environmentally influenced human disease phenotypes exemplified by NAFLD.…”
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Editorial: Genomics and Epigenomics of Cancer Immunotherapy: Challenges and Clinical Implications by Malak Abedalthagafi

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Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. by Carlos Guerrero-Bosagna, Matthew Settles, Ben Lucker, Michael K Skinner

“…This study confirms that an environmental agent has the ability to induce epigenetic transgenerational changes in the sperm epigenome.…”
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3D‐Epigenomic Regulation of Gene Transcription in Hepatocellular Carcinoma by Yuliang Feng, Ping Wang, Liuyang Cai, Meixiao Zhan, Fan He, Jiahui Wang, Yong Li, Eva Gega, Wei Zhang, Wei Zhao, Yongjie Xin, Xudong Chen, Yijun Ruan, Ligong Lu

“…To investigate the underlying mechanisms, comprehensive 3D‐epigenomic analyses are performed in cellular models of THLE2 (a normal hepatocytes cell line) and HepG2 (a hepatocellular carcinoma cell line) using integrative approaches for chromatin topology, genomic and epigenomic variation, and transcriptional output. …”
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