Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells by Remi Weber, Michael Weller, Michael Weller, Guido Reifenberger, Flavio Vasella, Flavio Vasella

“…Furthermore, the cell lines with MGMT promoter region methylation exhibited increased sensitivity to temozolomide, consistent with the impact of methylation on treatment outcomes in patients with glioblastoma. This precise epigenome-editing approach provides valuable insights into the functional relevance of MGMT promoter regional methylation and its potential for prognostic and predictive assessments, as well as epigenetic-targeted therapies.…”
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Environmental epigenetics in zebrafish by Vincenzo Cavalieri, Giovanni Spinelli

“…Abstract It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. …”
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Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data by Kohei Kashima, Tomoko Kawai, Riki Nishimura, Yuh Shiwa, Kevin Y. Urayama, Hiromi Kamura, Kazue Takeda, Saki Aoto, Atsushi Ito, Keiko Matsubara, Takeshi Nagamatsu, Tomoyuki Fujii, Isaku Omori, Mitsumasa Shimizu, Hironobu Hyodo, Koji Kugu, Kenji Matsumoto, Atsushi Shimizu, Akira Oka, Masashi Mizuguchi, Kazuhiko Nakabayashi, Kenichiro Hata, Naoto Takahashi

“…Gestational age (GA) is the most important prognostic factor for preterm infants, and numerous DNA methylation alterations associated with GA have been revealed by epigenome-wide association studies. However, in human preterm infants, whether the methylation changes relate to transcription in the fetal state and persist after birth remains to be elucidated. …”
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Extracellular Vesicles Orchestrate Immune and Tumor Interaction Networks by Kevin Ho Wai Yim, Ala’a Al Hrout, Simone Borgoni, Richard Chahwan

“…These responses can be equally mediated at the proteomic and epigenomic levels through surface markers or nucleic acid cargo signaling, respectively. …”
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Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors by Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer

“…ATAC sequencing showed that attachment cells share accessible intergenic chromatin areas with either tenocytes or chondrocytes. Epigenomic analysis revealed enhancer signatures for most of these regions. …”
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Symposium 19: Paternal diabetes and epigenetic changes in sperm by Evangelina Capobianco

“…The interest in the possibility that the environmental exposure of epigenome of germinal cells, such as methylation of DNA, post-traductional modification of histones and/or small non-coding RNAs can be transferred to the next generations affecting its metabolic health has increased in the lasts years1. …”
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Epigenetic Research in Stem Cell Bioengineering—Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials by Claudia Dompe, Krzysztof Janowicz, Greg Hutchings, Lisa Moncrieff, Maurycy Jankowski, Mariusz J. Nawrocki, Małgorzata Józkowiak, Paul Mozdziak, Jim Petitte, Jamil A. Shibli, Marta Dyszkiewicz-Konwińska, Małgorzata Bruska, Hanna Piotrowska-Kempisty, Bartosz Kempisty, Michał Nowicki

“…The epigenome denotes all the information related to gene expression that is not contained in the DNA sequence but rather results from chemical changes to histones and DNA. …”
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Genome-Wide Identification of Epigenetic Hotspots Potentially Related to Cardiovascular Risk in Adult Women after a Complicated Pregnancy. by Cees Oudejans, Ankie Poutsma, Omar Michel, Joyce Mulders, Allerdien Visser, Marie van Dijk, Tessa Nauta, Anouk Bokslag, Walter Paulus, Andreas de Haas, Pieter Koolwijk, Christianne J M de Groot

“…We sought to identify the nature of the epigenomic changes associated with the increased cardiovascular disease (CVD) risk in adult women following pre-eclampsia. …”
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Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease by Sabyasachi Maity, Kayla Farrell, Shaghayegh Navabpour, Sareesh Naduvil Narayanan, Timothy J. Jarome

“…Furthermore, alterations in the epigenome have been reported in neurodegenerative disorders, including Alzheimer’s disease. …”
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Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria by Qun Gao, Qun Gao, Shuwei Lu, Shuwei Lu, Yuwei Wang, Longgui He, Longgui He, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…In this review, we survey bacterial epigenomic studies and focus on the recent developments in the structure, function, and mechanism of several highly conserved bacterial DNA methylases. …”
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TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment by Ian C. MacArthur, Ian C. MacArthur, Ian C. MacArthur, Meelad M. Dawlaty, Meelad M. Dawlaty, Meelad M. Dawlaty

“…Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring interest in the function of this epigenetic mark in neurodevelopment and brain function. 5hmC is generated by oxidation of 5-methylcytosine (5mC), a process catalyzed by the ten–eleven translocation (TET) enzymes. 5hmC serves not only as an intermediate in DNA demethylation but also as a stable epigenetic mark. …”
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Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer by Shawn Ying Xuan Tan, Jieqiong Zhang, Jieqiong Zhang, Wee-Wei Tee, Wee-Wei Tee, Wee-Wei Tee

“…In this review, we provide an in-depth discussion of the interconnected crosstalk between epigenetics and inflammation, specifically how epigenetic mechanisms at different hierarchical levels of the genome control inflammatory gene transcription, which in turn enact changes within the cell’s epigenomic profile, especially in the context of inflammation-induced cancer.…”
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Studying Chromatin Epigenetics with Fluorescence Microscopy by Afanasii I. Stepanov, Zlata V. Besedovskaia, Maria A. Moshareva, Konstantin A. Lukyanov, Lidia V. Putlyaeva

“…Epigenetic modifications of histones (methylation, acetylation, phosphorylation, etc.) are of great importance in determining the functional state of chromatin. Changes in epigenome underlay all basic biological processes, such as cell division, differentiation, aging, and cancerous transformation. …”
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Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization. by Yasuhiro Yamauchi, Jonathan M Riel, Victor Ruthig, Monika A Ward

“…During its final phase, spermiogenesis, haploid round spermatids undergo cellular differentiation into spermatozoa, which involves extensive restructuring of cell morphology, DNA, and epigenome. Using mouse models with abrogated Y chromosome gene complements and Y-derived transgene we identified Y chromosome encoded Zfy2 as the gene responsible for sperm formation and function. …”
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DNA methylome, R-loop and clinical exome profiling of patients with sporadic amyotrophic lateral sclerosis by Orsolya Feró, Dóra Varga, Éva Nagy, Zsolt Karányi, Éva Sipos, József Engelhardt, Nóra Török, István Balogh, Borbála Vető, István Likó, Ábel Fóthi, Zoltán Szabó, Gábor Halmos, László Vécsei, Tamás Arányi, Lóránt Székvölgyi

“…Here, we present an integrative epigenomic study in blood samples from seven clinically characterised sporadic ALS patients to elucidate molecular factors associated with the disease. …”
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Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development by Natalie A. Trigg, David A. Skerrett-Byrne, Miguel J. Xavier, Wei Zhou, Amanda L. Anderson, Simone J. Stanger, Aimee L. Katen, Geoffry N. De Iuliis, Matthew D. Dun, Shaun D. Roman, Andrew L. Eamens, Brett Nixon

“…These data provide mechanistic links to account for how environmental insults can alter the sperm epigenome and compromise the transcriptomic profile of early embryos.…”
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Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells by Christopher D Todd, Özgen Deniz, Darren Taylor, Miguel R Branco

“…Here we tested a set of long terminal repeat TE families for roles as enhancers in mouse embryonic and trophoblast stem cells. Epigenomic and transcriptomic data suggested that a large number of TEs helped to establish tissue-specific gene expression programmes. …”
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The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease by Mustapha U. Imam, Maznah Ismail

“…This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. …”
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Is Life Unique? by David L. Abel

“…Life is largely directed by linear digital programming and by the Prescriptive Information (PI) instantiated particularly into physicodynamically indeterminate nucleotide sequencing. Epigenomic controls only compound the sophistication of these formalisms. …”
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Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. by Ryutaro Uchi, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Hidenari Hirata, Keishi Sugimachi, Genta Sawada, Takeshi Iwaya, Junji Kurashige, Yoshiaki Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Kenichi Chiba, Yuichi Shiraishi, Genta Nagae, Kenichi Yoshida, Yasunobu Nagata, Hiroshi Haeno, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Hisae Iinuma, Shin Sasaki, Satoshi Nagayama, Kazutaka Yamada, Shinichi Yachida, Mamoru Kato, Tatsuhiro Shibata, Eiji Oki, Hiroshi Saeki, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Shizuo Komune, Masaki Mori, Yutaka Suzuki, Ken Yamamoto, Hiroyuki Aburatani, Seishi Ogawa, Satoru Miyano, Koshi Mimori

“…To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. …”
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