Management of AML Beyond “3 + 7” in 2019 by Jonathan Canaani

“…To this end, it is expected that advances in genomic and epigenomic classification of AML will facilitate a rational and optimal choice of these novel agents for AML patients.…”
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Epigenetics and Colorectal Cancer Pathogenesis by Kebin Liu, Kankana Bardhan

“…Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. …”
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The genetic and epigenetic contributions to the development of nutritional rickets by Innocent Ogunmwonyi, Adewale Adebajo, Jeremy Mark Wilkinson

“…Additionally, the role of the epigenome in the development of rickets, although poorly understood, may be related to the effects of DNA methylation and non-coding RNAs on genes involved in bone metabolism. …”
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Data quality of whole genome bisulfite sequencing on Illumina platforms. by Amanda Raine, Ulrika Liljedahl, Jessica Nordlund

“…The powerful HiSeq X sequencers with their patterned flowcell technology and fast turnaround times are instrumental for many large-scale genomic and epigenomic studies. However, assessment of DNA methylation by sodium bisulfite treatment results in sequencing libraries of low diversity, which may impact data quality and yield. …”
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Environmentally induced epigenetic transgenerational inheritance of ovarian disease. by Eric Nilsson, Ginger Larsen, Mohan Manikkam, Carlos Guerrero-Bosagna, Marina I Savenkova, Michael K Skinner

“…The F3 generation granulosa cells were isolated and found to have a transgenerational effect on the transcriptome and epigenome (differential DNA methylation). Epigenetic biomarkers for environmental exposure and associated gene networks were identified. …”
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iPoLNG—An unsupervised model for the integrative analysis of single-cell multiomics data by Wenyu Zhang, Zhixiang Lin

“…Single-cell multiomics technologies, where the transcriptomic and epigenomic profiles are simultaneously measured in the same set of single cells, pose significant challenges for effective integrative analysis. …”
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Testicular histone hyperacetylation in mice by valproic acid administration affects the next generation by changes in sperm DNA methylation by Kazuya Sakai, Kenshiro Hara, Kentaro Tanemura

“…In this study, we focused on DNA methylation in mice treated with valproic acid (VPA), an inducer of epigenomic changes, and analyzed the treatment effects on the sperm from the next generation of mice. …”
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Leveraging functional annotations in genetic risk prediction for human complex diseases. by Yiming Hu, Qiongshi Lu, Ryan Powles, Xinwei Yao, Can Yang, Fang Fang, Xinran Xu, Hongyu Zhao

“…In this paper, we introduce AnnoPred, a principled framework that leverages diverse types of genomic and epigenomic functional annotations in genetic risk prediction for complex diseases. …”
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Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging by Ying Lyu, Yejing Ge

“…Particularly in the context of the skin epithelium, the epigenome and metabolome coordinately shape lineage plasticity and orchestrate stem cell function during aging. …”
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Pharmacological Manipulation of DNA Methylation in Adult Female Rats Normalizes Behavioral Consequences of Early-Life Maltreatment by Samantha M. Keller, Tiffany S. Doherty, Tania L. Roth

“…Therefore, we examined the possibility of rescuing the aberrant forced swim behavior in maltreated-adult females by administering an epigenome-modifying drug (zebularine) at a dose previously shown to normalize DNA methylation. …”
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Tumor heterogeneity of acute myeloid leukemia: insights from single-cell sequencing by AiLi Chen, ShaoYan Hu, Qian-Fei Wang

“…The recent development of single-cell sequencing (SCS) methods provides a powerful tool to allow analysis of genomes, transcriptomes, proteomes, and epigenomes at an individual cell level. The technologies applied in AML have broadened our understanding of AML heterogeneity and provided new insights for the development of novel therapeutic strategies. …”
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Genetic and Epigenetic Studies in Diabetic Kidney Disease by Harvest F. Gu

“…Current information from genetic and epigenetic studies of DKD and ESRD in patients with diabetes, including the approaches of genome-wide association study (GWAS) or epigenome-wide association study (EWAS) and candidate gene association analyses, are summarized. …”
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Chromatin as a sensor of metabolic changes during early development by David Pladevall-Morera, Jan J. Zylicz

“…Cellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. Indeed, some intermediates of metabolic reactions exert a non-canonical function by acting as co-factors, substrates or inhibitors of chromatin modifying enzymes. …”
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Contribution of genetic, epigenetic and transcriptomic differences to twin discordance in multiple sclerosis. by Handunnetthi, L, Handel, A, Ramagopalan, S

“…Evaluation of: Baranzini SE, Mudge J, van Velkinburgh JC et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. …”

Dilated cardiomyopathy: reconceptualization of the problem by T. G. Vaykhanskaya, L. N. Sivitskaya, T. V. Kurushko, O. D. Levdansky, N. G. Danilenko

“…Clinical manifestations depend not only on the malignancy and penetrance of the gene mutation, but also on a number of other causes — epigenomic factors, age, toxic effects, environmental aggressiveness, pregnancy, and the effects of other acquired diseases. …”
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Chromatin Dynamics and Transcriptional Control of Circadian Rhythms in <i>Arabidopsis</i> by Aida Maric, Paloma Mas

“…From the initial discovery more than 13 years ago of a parallelism between the oscillations in chromatin status and the transcriptional rhythms of an <i>Arabidopsis</i> clock gene, a number of studies have later expanded considerably our view on the circadian epigenome and transcriptome landscapes. Here, we describe the most recent identification of chromatin-related factors that are able to directly interact with <i>Arabidopsis</i> clock proteins to shape the transcriptional waveforms of circadian gene expression and clock outputs. …”
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The epigenetics of social adversity in early life: Implications for mental health outcomes by Patrick O. McGowan, Moshe Szyf

“…An organism's behavioral and physiological and social milieu influence and are influenced by the epigenome, which is composed predominantly of chromatin and the covalent modification of DNA by methylation. …”
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YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4 by Nana Chen, Gabriel Golczer, Subhoshree Ghose, Brian Lin, Adam Langenbucher, Jason Webb, Haymanti Bhanot, Nicholas B. Abt, Derrick Lin, Mark Varvares, Martin Sattler, Ann Marie Egloff, Richard Joh, Ravindra Uppaluri, Kevin S. Emerick, Michael S. Lawrence, Srinivas Vinod Saladi

“…Comprehensive proteomic and drug-screening studies across pan-cancer models confirm that FAT1-mutant HNSCC exhibits selective and higher sensitivity to BRD4 inhibition by JQ1. Epigenomic analysis reveals an active chromatin state in FAT1-mutant HNSCC cells that is driven by the YAP/TAZ transcriptional complex through recruitment of BRD4 to deposit active histone marks, thereby maintaining an oncogenic transcriptional state. …”
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Stabilization of hESCs in two distinct substates along the continuum of pluripotency by Chen Dekel, Robert Morey, Jacob Hanna, Louise C. Laurent, Dalit Ben-Yosef, Hadar Amir

“…Overall, we show that transcriptomic and epigenomic profiling can be used to place human pluripotent cultures along a developmental continuum and may inform their utility for clinical and research applications.…”
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Dynamic single-cell regulomes characterize human peripheral blood innate lymphoid cell subpopulations by Maryline Falquet, Ziyang Su, Tania Wyss, Giuseppe Ercolano, Sara Trabanelli, Camilla Jandus

“…Using single cell approaches, heightened heterogeneity of mouse ILCs has been appreciated, imprinted by tissue signals that shape their transcriptome and epigenome. Intra-subset diversity has also been observed in human ILCs. …”
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