Testicular histone hyperacetylation in mice by valproic acid administration affects the next generation by changes in sperm DNA methylation. by Kazuya Sakai, Kenshiro Hara, Kentaro Tanemura

“…In this study, we focused on DNA methylation in mice treated with valproic acid (VPA), an inducer of epigenomic changes, and analyzed the treatment effects on the sperm from the next generation of mice. …”
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Pigment Epithelia of the Eye: Cell-Type Conversion in Regeneration and Disease by Eleonora N. Grigoryan

“…Being predetermined onto- and phylogenetically, it includes a species-specific molecular context, differential expression of transcription factors, signaling pathways, and epigenomic changes. The accumulated knowledge regarding the mechanisms of PECs phenotypic switching allows the development of approaches to specified conversion for many purposes: obtaining cells for transplantation, creating conditions to stimulate natural regeneration of the retina and the lens, blocking undesirable conversions associated with eye pathology, and finding molecular markers of pathology to be targets of therapy.…”
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A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. by Hang Yin, Sarah Sweeney, Debasish Raha, Michael Snyder, Haifan Lin

“…These features, likely conserved among diverse epigenomes, reveal general strategies for chromatin modifications.…”
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Imprinted Genes Impact Upon Beta Cell Function in the Current (and Potentially Next) Generation by Chelsie Villanueva-Hayes, Steven J. Millership

“…Imprinted loci, therefore, represent an excellent opportunity with which to assess epigenomic changes in beta cells due to the diet in both the current and next generation.…”
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Application of Single-Cell Multi-Omics in Dissecting Cancer Cell Plasticity and Tumor Heterogeneity by Deshen Pan, Deshui Jia

“…Recently, advance in single-cell technologies has provided an unprecedented resolution to uncover the intra-tumoral heterogeneity by profiling the transcriptomes, genomes, proteomes and epigenomes of the cellular components and also their spatial distribution, which greatly accelerated the process of basic and translational cancer research. …”
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Epigenetics and its role in effecting agronomical traits by Chainika Gupta, Romesh K. Salgotra

“…Epigenetic modifications, in addition to DNA sequence variation, improve breeding by giving useful markers. Also, it takes epigenome diversity into account to predict plant performance and increase crop production. …”
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Maternal Methyl Supplemented Diets and Effects on Offspring Health by Rachel J. O'Neill, Paul B. Vrana, Cheryl S. Rosenfeld

“…Further studies are needed to explore the comprehensive effects maternal MS diets have on the offspring epigenome and subsequent overall health.…”
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Drosophila functional elements are embedded in structurally constrained sequences. by Ephraim Kenigsberg, Amos Tanay

“…These data suggest that current gaps in our understanding of genome function and evolutionary dynamics are explicable by a model of sparse sequence elements directly encoding for function, embedded into structural sequences that help to define the local and global epigenomic context of such functional elements.…”
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Current advances of targeting epigenetic modifications in neuroendocrine prostate cancer by Wen-Chi Cheng, Hung-Jung Wang

“…Recent evidences suggest that this cellular reprogramming or the lineage plasticity is driven by dysregulation of the epigenome and transcriptional networks. Aberrant DNA methylation and altered expression of epigenetic modifiers, such as enhancer of zeste-homolog 2, transcription factors, histone demethylases, are hallmarks of NEPC. …”
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Cellular computation and cognition by W. Tecumseh Fitch

“…Neurons are eukaryotic cells that store information not only in synapses, but also in their dendritic structure and connectivity, as well as genetic “marking” in the epigenome of each individual cell. Each neuron computes a complex nonlinear function of its inputs, roughly equivalent in processing capacity to an entire 1990s-era neural network model. …”
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Epigenetic Diabetic Vascular Complications by Ali Ahmadzadeh-Amiri, Ahmad Ahmadzadeh-Amiri

“…Application and development of high technology sequencing combined with more sensitive and advanced methodologies for epigenome studying help to determine specific epigenetic events that stimulate gene responses in patients with diabetes mellitus.…”
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Epigenetics in Sepsis: Understanding Its Role in Endothelial Dysfunction, Immunosuppression, and Potential Therapeutics by Deborah Cross, Ruth Drury, Jennifer Hill, Andrew J. Pollard

“…Whilst therapeutic modulation of the epigenome is still in its infancy, there is substantial evidence from animal models that this approach could reap benefits. …”
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Epigenetic therapy and dermatologic disease: moving beyond CTCL by Joshua S. Mervis, Jean S. McGee

“…While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. …”
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Integration of multi-omics technologies for crop improvement: Status and prospects by Ru Zhang, Cuiping Zhang, Chengyu Yu, Jungang Dong, Jihong Hu

“…Using a large amount of omics-level data from the functional genome, transcriptome, proteome, epigenome, metabolome, and microbiome, clarifying the interaction between gene and phenotype formation will become possible. …”
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Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. by Carmen J Marsit, Matthew A Maccani, James F Padbury, Barry M Lester

“…There is growing evidence that the intrauterine environment can impact the neurodevelopment of the fetus through alterations in the functional epigenome of the placenta. In the placenta, the HSD11B2 gene encoding the 11-beta hydroxysteroid dehydrogenase enzyme, which is responsible for the inactivation of maternal cortisol, is regulated by DNA methylation, and has been shown to be susceptible to stressors from the maternal environment.We examined the association between DNA methylation of the HSD11B2 promoter region in the placenta of 185 healthy newborn infants and infant and maternal characteristics, as well as the association between this epigenetic variability and newborn neurobehavioral outcome assessed with the NICU Network Neurobehavioral Scales. …”
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Novel insights into the role of acetyl-CoA producing enzymes in epigenetic regulation by Marta Russo, Francesco Pileri, Serena Ghisletti

“…This reprogramming is essential for the production of metabolites required for chromatin modifications, such as acetyl-CoA, and regulate their usage and availability impacting the macrophage epigenome. One of the most transcriptionally induced proinflammatory mediator is nitric oxide (NO), which has been shown to inhibit key metabolic enzymes involved in the production of these metabolites. …”
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Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy by Chen Chen, Zehua Wang, Yanru Qin

“…Numerous evidences also indicate epigenome is sensitive to cancer metabolism. Conversely, epigenetic dysfunction is certified to alter metabolic enzymes leading to tumorigenesis. …”
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Epigenetics of Hepatic Insulin Resistance by Hannah Maude, Claudia Sanchez-Cabanillas, Inês Cebola

“…Work from recent years has demonstrated that the epigenome may constitute an interface where different signals may converge to promote IR gene expression programs. …”
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Mouse models of human GWAS hits for Obesity and Diabetes in the post Genomic era: Time for reevaluation by Laber, S, Cox, R

“…By contrast, genome-wide comparative analysis of the mouse and human epigenome across tissues has highlighted the presence of cis-regulatory divergence (9, 10). …”

Suberoylanilide Hydroxamic Acid (SAHA) Is a Driver Molecule of Neuroplasticity: Implication for Neurological Diseases by Lucia Verrillo, Rosita Di Palma, Alberto de Bellis, Denise Drongitis, Maria Giuseppina Miano

“…This is mainly achieved through the promotion of changes in the epigenome. One of the epi-drivers priming this process is suberoylanilide hydroxamic acid (SAHA or Vorinostat), a pan-histone deacetylase inhibitor that modulates and promotes neuroplasticity in healthy and disease conditions. …”
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