Nutrigenomics in the context of evolution by Carsten Carlberg

“…In addition to genomic changes, also the programming of epigenomes in pre- and postnatal phases of life has an important contribution to the response to environmental changes. …”
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Alteration of Genomic Imprinting after Assisted Reproductive Technologies and Long-Term Health by Eguzkine Ochoa

“…Experimental evidence from animal studies suggests that ART can induce stress in the embryo and influence gene expression and DNA methylation. Human epigenome studies have generally revealed an enrichment of alterations in imprinted regions in children conceived by ART, but no global methylation alterations. …”
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Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications by H. Al Tbeishat

“…Many proteins of M. tuberculosis were found to affect the host’s epigenome. Nine proteins were exploited in this study to predict epitopes to develop an mRNA vaccine against tuberculosis. …”
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Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis by Shibata Darryl, Beart Robert W, Kim Jung

“…Therefore, life-long human stem cell histories are potentially written within and may be read from somatic cell epigenomes.</p>…”
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Race and ethnicity: Risk factors for fungal infections? by Jeffrey D Jenks, Chioma Inyang Aneke, Mohanad M Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl, George R Thompson

“…Risk factors may include genetic and immunologic differences such as aberrations in host immune response, host polymorphisms, and epigenomic factors stemming from environmental exposures and underlying social determinants of health. …”
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Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas by Sanghoon Lee, Hatice Ulku Osmanbeyoglu

“…Conclusions This study reveals the distinct epigenomic features of ILC and IDC and the active TFs driving cancer progression that may provide valuable information on patient prognosis.…”
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Differential DNA Methylation Regions in Adult Human Sperm following Adolescent Chemotherapy: Potential for Epigenetic Inheritance. by Margarett Shnorhavorian, Stephen M Schwartz, Barbara Stansfeld, Ingrid Sadler-Riggleman, Daniel Beck, Michael K Skinner

“…<h4>Conclusions</h4>This is the first observation in humans that an early life chemical exposure can permanently reprogram the spermatogenic stem cell epigenome. The germline (i.e., sperm) epimutations identified suggest chemotherapy has the potential to promote epigenetic inheritance to the next generation.…”
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In vitro analysis of integrated global high-resolution DNA methylation profiling with genomic imbalance and gene expression in osteosarcoma. by Bekim Sadikovic, Maisa Yoshimoto, Khaldoun Al-Romaih, Georges Maire, Maria Zielenska, Jeremy A Squire

“…Our objective was to develop an integrative approach for analysis of high-resolution epigenomic, genomic, and gene expression profiles in order to identify functional epi/genomic differences between OS cell lines and normal human osteoblasts. …”
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Race and ethnicity: Risk factors for fungal infections? by Jeffrey D. Jenks, Chioma Inyang Aneke, Mohanad M. Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl, George R. Thompson

“…Risk factors may include genetic and immunologic differences such as aberrations in host immune response, host polymorphisms, and epigenomic factors stemming from environmental exposures and underlying social determinants of health. …”
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PHF2 regulates sarcomeric gene transcription in myogenesis. by Taku Fukushima, Yuka Hasegawa, Sachi Kuse, Taiju Fujioka, Takeshi Nikawa, Satoru Masubuchi, Iori Sakakibara

“…Here, we focused on the epigenomic modification enzyme, PHF2, which demethylates histone 3 lysine 9 dimethyl (H3K9me2) during myogenesis. …”
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Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis. by Xiaokang Wang, Xiaokang Wang, Xudong Chen, Linhua Sun, Weiqiang Qian

“…Our study highlights the importance of the linker region of DRE2 in coordinating CIA-related protein interactions and identifies the canonical and non-canonical roles of DRE2 in maintaining genome stability, epigenomic patterns, and auxin response.…”
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A Comparative Analysis of Super-Enhancers and Broad H3K4me3 Domains in Pig, Human, and Mouse Tissues by Yanling Peng, Huifang Kang, Jing Luo, Yubo Zhang

“…In this study, by integrative computational analyses of epigenomic and transcriptomic data, we have characterized SEs and BDs in six pig tissues and analyzed their conservation in comparison with human and mouse tissues. …”
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Identification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutations. by Carlos Guerrero-Bosagna, Shelby Weeks, Michael K Skinner

“…The current study integrates previously described experimental epigenomic transgenerational data and web-based bioinformatic analyses to identify genomic features associated with these transgenerationally transmitted epimutations. …”
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The biochemistry and epigenetics of epilepsy: focus on adenosine and glycine by Detlev eBoison

“…New findings based on biochemical manipulation of the DNA methylome suggest that (i) epigenetic mechanisms play a functional role in epileptogenesis, and (ii) therapeutic reconstruction of the epigenome is an effective antiepileptogenic therapy.…”
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Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming by Maryam Moshref, Maria Questa, Veronica Lopez-Cervantes, Thomas K. Sears, Rachel L. Greathouse, Charles K. Crawford, Amir Kol

“…We hypothesized that inhibition of HDACs in canine fibroblasts would increase their reprogramming efficiency by altering the epigenomic landscape and enabling greater chromatin accessibility. …”
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The Pathologic and Genetic Characteristics of Extranodal NK/T-Cell Lymphoma by Hyunsung Kim, Young Hyeh Ko

“…EBV-encoded oncoproteins modulate the host-cell epigenetic machinery, reprogramming the viral and host epigenomes using host epigenetic modifiers. NGS analysis revealed the mutational landscape of ENKTL, predominantly involving the JAK–STAT pathway, epigenetic modifications, the RNA helicase family, the RAS/MAP kinase pathway, and tumor suppressors, which indicate an important role of these pathways and this group of genes in the lymphomagenesis of ENKTL. …”
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A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil. by Jing Zhang, Shenqiu Zhang, Qiong Shi, Thaddeus D Allen, Fengming You, Dun Yang

“…The synthetic lethal approach is attractive because it enables targeting of cancers harboring specific genomic or epigenomic alterations, the products of which may have proven refractory to direct targeting. …”
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Analyzing histone ChIP-seq data with a bin-based probability of being signal. by Vivian Hecht, Kevin Dong, Sreshtaa Rajesh, Polina Shpilker, Siddarth Wekhande, Noam Shoresh

“…Histone ChIP-seq is one of the primary methods for charting the cellular epigenomic landscape, the components of which play a critical regulatory role in gene expression. …”
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The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention by A. V. Kononov

“…Biopsy diagnosis of chronic gastritis combined with the evaluation of gene structure (genetic polymorphism) and epigenomic mechanisms (microRNA) allows the risk of gastric cancer to be ranked in a particular patient even with early precancerous changes in the gastric mucosa. …”
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Neurological impact of HIV/AIDS and substance use alters brain function and structure by James Haorah, Samikkannu Malaroviyam, Hemavathi Iyappan, Thangavel Samikkannu

“…This review includes an overview of post-translational modifications, alterations in microglia-specific biomarkers, and possible mechanistic pathways that may link epigenomic modifications to functional protein alterations in microglia. …”
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