Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The role of epigenetic factors in the implementation of environmental effects in cognitive characteristics is revealed. Considering the epigenome significance, several studies were focused on the design of substances affecting methylation and histone modification, which can be used for the treatment of cognitive disorders. …”
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ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure by Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, William T. Goldsmith, Andrya J. Durr, Garrett K. Fink, Timothy R. Nurkiewicz, John M. Hollander

“…The purpose of this study was to determine whether maternal ENM inhalation exposure influences progeny cardiac development and epigenomic remodeling. Results Pregnant FVB dams were exposed to nano-TiO2 aerosols with a mass concentration of 12.09 ± 0.26 mg/m3 starting at gestational day five (GD 5), for 6 h over 6 non-consecutive days. …”
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Transcriptional checkpoint response SET in motion: role for miR-106b-5p and H3K36me3 in regulating E2F-dependent transcription by Van Bijsterveldt, L

“…Furthermore, I identified a role for miRNAs in controlling the epigenome in response to external stresses, such as via the miR-7704-KDM6B axis, and further confirmed the regulation of SETD2-dependent H3K36me3 by miR-106b-5p, thereby providing a functional link between miRNAs and regulation of cell cycle progression.…”

Immunohistochemical Expression of Five Protein Combinations Revealed as Prognostic Markers in Asian Oral Cancer by Hui-Ching Wang, Hui-Ching Wang, Chien-Jung Chiang, Ta-Chih Liu, Chun-Chieh Wu, Yi-Ting Chen, Jan-Gowth Chang, Jan-Gowth Chang, Jan-Gowth Chang, Jan-Gowth Chang, Jan-Gowth Chang, Grace S. Shieh, Grace S. Shieh, Grace S. Shieh, Grace S. Shieh

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DNA methylation signatures associated with prognosis of gastric cancer by Jin Dai, Akihiro Nishi, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Wen-Qing Li, Kai-Feng Pan

“…We aimed to identify DNA methylation biomarkers associated with multiple prognostic outcomes of GC in an epigenome-wide association study. Methods Based on the Cancer Genome Atlas (TCGA), DNA methylation loci associated with OS (n = 381), disease-specific survival (DSS, n = 372), and progression-free interval (PFI, n = 383) were discovered in training set subjects (false discovery rates < 0.05) randomly selected for each prognostic outcome and were then validated in remaining subjects (P-values < 0.05). …”
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Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs by Jenny van Dongen, Gonneke Willemsen, BIOS Consortium, Eco JC de Geus, Dorret I Boomsma, Michael C Neale

“…Background: Smoking-associated DNA methylation levels identified through epigenome-wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms, but the contribution of a shared genetic predisposition to smoking and DNA methylation levels is typically not accounted for. …”
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Evolution and conservation of polycomb repressive complex 1 core components and putative associated factors in the green lineage by Yong Huang, Ling Jiang, Bo-Yu Liu, Cheng-Fang Tan, Dong-Hong Chen, Wen-Hui Shen, Ying Ruan

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Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food by Adelheid Soubry, Susan K. Murphy, Susan K. Murphy, Greet Vansant, Yang He, Thomas M. Price, Cathrine Hoyo

“…Changes at the level of the epigenome have been suggested to underlie these observations. …”
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PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical St... by Bao Sun, Bao Sun, Lin Cheng, Lin Cheng, Yan Xiong, Yan Xiong, Lei Hu, Zhiying Luo, Zhiying Luo, Maosong Zhou, Ji Li, Hongfu Xie, Fazhong He, Fazhong He, Xiaoqing Yuan, Xiaoqing Yuan, Xiaoping Chen, Xiaoping Chen, Hong-Hao Zhou, Hong-Hao Zhou, Zhaoqian Liu, Zhaoqian Liu, Xiang Chen, Xiang Chen, Wei Zhang, Wei Zhang

“…Secondly, whether the identified disease-associated changes of epigenome precede disease onset, or result from the disease progression, needs further investigation. …”
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Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human <i>FUT2</i> and <i>GLA</i> Genes—In Vitro Studies by Jerzy Wiater, Marcin Samiec, Kamil Wartalski, Zdzisław Smorąg, Jacek Jura, Ryszard Słomski, Maria Skrzyszowska, Marek Romek

“…The latter is due to be focused on determining epigenomic reprogrammability of single- or double-transgenic cell nuclei inherited from adult cutaneous keratinocytes in porcine nuclear-transferred oocytes and corresponding cloned embryos. …”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Large-scale studies have revealed abnormal cancer epigenomes caused by mutations and structural alterations of chromatin modifiers, aberrant DNA methylation, and histone modification signatures. …”
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Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity by Yu, Vanessa, Yong, Fiona, Marta, Angellica, Khadayate, Sanjay, Osakwe, Adrien, Bhattacharya, Supriyo, Varghese, Sneha S., Chabosseau, Pauline, Tabibi, Sayed M., Chen, Keran, Georgiadou, Eleni, Parveen, Nazia, Suleiman, Mara, Stamoulis, Zoe, Marselli, Lorella, De Luca, Carmela, Tesi, Marta, Ostinelli, Giada, Delgadillo-Silva, Luis, Wu, Xiwei, Hatanaka, Yuki, Montoya, Alex, Elliott, James, Patel, Bhavik, Demchenko, Nikita, Whilding, Chad, Hajkova, Petra, Shliaha, Pavel, Kramer, Holger, Ali, Yusuf, Marchetti, Piero, Sladek, Robert, Dhawan, Sangeeta, Withers, Dominic J., Rutter, Guy A., Millership, Steven J.

“…Changes at the level of the epigenome provide one such possibility, which we explore here by focusing on the imprinted gene Nnat (encoding neuronatin [NNAT]), which is required for normal insulin synthesis and secretion. …”
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Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study by John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Joseph E. Tonna, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella

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Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function by Scott L. Weiss, MD, MSCE, Kyle Bittinger, PhD, Jung-Jin Lee, PhD, Elliot S. Friedman, PhD, Lisa M. Mattei, PhD, Kathryn Graham, BS, Donglan Zhang, BS, Jeny Bush, RNC, Fran Balamuth, MD, PhD, MSCE, Francis X. McGowan, Jr, MD, Frederic D. Bushman, PhD, Robert N. Baldassano, MD, Gary D. Wu, MD, Douglas C. Wallace, PhD, Ronald G. Collman, MD

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Distinct sex-specific DNA methylation differences in Alzheimer’s disease by Tiago C. Silva, Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Achintya Varma, X. Steven Chen, Eden R. Martin, Lily Wang

“…Methods We studied sex-specific DNA methylation differences in the blood samples of AD subjects compared to cognitively normal subjects, by performing sex-specific meta-analyses of two large blood-based epigenome-wide association studies (ADNI and AIBL), which included DNA methylation data for a total of 1284 whole blood samples (632 females and 652 males). …”
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Microcell-Mediated Chromosome Transfer Identifies EPB41L3 as a Functional Suppressor of Epithelial Ovarian Cancers by Dimitra Dafou, Barbara Grun, John Sinclair, Kate Lawrenson, Elizabeth C. Benjamin, Estrid Hogdall, Susanne Kruger-Kjaer, Lise Christensen, Heidi M. Sowter, Ahmed Al-Attar, Richard Edmondson, Stephen Darby, Andrew Berchuck, Peter W. Laird, C. Leigh Pearce, Susan J. Ramus, Ian J. Jacobs, Simon A. Gayther

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Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases by Marjan Huizing, Tal Yardeni, Federico Fuentes, May C.V. Malicdan, Petcharat Leoyklang, Alexander Volkov, Benjamin Dekel, Emily Brede, Jodi Blake, Alva Powell, Harish Chatrathi, Yair Anikster, Nuria Carrillo, William A. Gahl, Jeffrey B. Kopp

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Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer by Xu Liang, Sophie Vacher, Anais Boulai, Virginie Bernard, Sylvain Baulande, Mylene Bohec, Ivan Bièche, Florence Lerebours, Céline Callens

“…After grouping 91 genes on 10 signaling pathways, we found that the DNA repair pathway for the triple-negative breast cancer (TNBC) subgroup, the RTK/RAS/MAPK and cell cycle pathways for the HR–/HER2+ subgroup, the DNA repair, RTK/RAS/MAPK, and NOTCH pathways for the HR+/HER2– subgroup, and the DNA repair, epigenome, and diverse pathways for the HR+/HER2+ subgroup were all significantly differently altered between IBC and non-IBC. …”
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EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer by Jianfeng Chen, Jing Han Hong, Yulin Huang, Shini Liu, Jiaxin Yin, Peng Deng, Yichen Sun, Zhaoliang Yu, Xian Zeng, Rong Xiao, Jason Yongsheng Chan, Peiyong Guan, Yali Wang, Peili Wang, Lizhen Liu, Shijun Wen, Qiang Yu, Choon Kiat Ong, Bin-Tean Teh, Ying Xiong, Jing Tan

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Biological Function of Long Non-coding RNA (LncRNA) Xist by Wenlun Wang, Lu Min, Xinyuan Qiu, Xiaomin Wu, Chuanyang Liu, Jiaxin Ma, Dongyi Zhang, Lingyun Zhu

“…A range of evidence has suggested that lncRNAs function as key regulators in crucial cellular functions, including proliferation, differentiation, apoptosis, migration, and invasion, by regulating the expression level of target genes via epigenomic, transcriptional, or post-transcriptional approaches (Cao et al., 2018). …”
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