Epigenome-wide DNA methylation in obsessive-compulsive disorder by Miriam A. Schiele, Jan Lipovsek, Pascal Schlosser, Michael Soutschek, Gerhard Schratt, Michael Zaudig, Götz Berberich, Anna Köttgen, Katharina Domschke

“…Abstract In adult patients with obsessive-compulsive disorder (OCD), altered DNA methylation has been discerned in several candidate genes, while DNA methylation on an epigenome-wide level has been investigated in only one Chinese study so far. …”
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Editorial: Epigenomics implication for economic traits in domestic animals by Chunfang Zhao, Chunfang Zhao, Bo Han, Guoqiang Yi, Sihua Jin, Zebin Zhang, Shenghe Li, Shenghe Li

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CRISPR-based epigenome editing for targeted gene regulation by Leong, Jonavan Jing

“…CRISPR-Cas system has been modified by fusing epigenetic modifiers to a “dead” Cas9 endonuclease (dCas9) to target epigenome using guide RNA as a docking tool. Fusion of repressive epigenetic factors to the dCas9 result in specific guide RNA-targeted repression of gene function (CRISPR interference). …”
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Advances and challenges in epigenomic single-cell sequencing applications by Philpott, M, Cribbs, AP, Brown Jr, T, Brown Sr, T, Oppermann, U

“…In the multi-omics era, many methods exist to investigate biological processes across the genome, transcriptome, epigenome, proteome and metabolome. Until recently, this was only possible for populations of cells or complex tissues, creating an averaging effect that may obscure direct correlations between multiple layers of data. …”

Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomics by Albert Stuart Reece, Albert Stuart Reece, Gary Kenneth Hulse, Gary Kenneth Hulse

“…Cannabis exposure phenocopies the elements of this process and reproduces DNA and chromatin breakages, reduces the DNA, RNA protein and histone synthesis, interferes with the epigenomic machinery controlling both DNA and histone modifications, induces general DNA hypomethylation, and epigenomically disrupts both the critical boundary elements and the cohesin motors that create chromatin loops. …”
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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity by Wahl, Simone, Drong, Alexander, Lehne, Benjamin, Loh, Marie, Scott, William R., Kunze, Sonja, Tsai, Pei-Chien, Ried, Janina S., Zhang, Weihua, Yang, Youwen, Tan, Sili, Fiorito, Giovanni, Franke, Lude, Guarrera, Simonetta, Kasela, Silva, Kriebel, Jennifer, Richmond, Rebecca C., Adamo, Marco, Afzal, Uzma, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Apperley, Jane F., Beekman, Marian, Bertazzi, Pier Alberto, Black, S. Lucas, Blancher, Christine, Bonder, Marc-Jan, Brosch, Mario, Carstensen-Kirberg, Maren, de Craen, Anton J. M., de Lusignan, Simon, Dehghan, Abbas, Elkalaawy, Mohamed, Fischer, Krista, Franco, Oscar H., Gaunt, Tom R., Hampe, Jochen, Hashemi, Majid, Isaacs, Aaron, Jenkinson, Andrew, Jha, Sujeet, Kato, Norihiro, Krogh, Vittorio, Laffan, Michael, Meisinger, Christa, Meitinger, Thomas, Mok, Zuan Yu, Motta, Valeria, Ng, Hong Kiat, Nikolakopoulou, Zacharoula, Nteliopoulos, Georgios, Panico, Salvatore, Pervjakova, Natalia, Prokisch, Holger, Rathmann, Wolfgang, Roden, Michael, Rota, Federica, Rozario, Michelle Ann, Sandling, Johanna K., Schafmayer, Clemens, Schramm, Katharina, Siebert, Reiner, Slagboom, P. Eline, Soininen, Pasi, Stolk, Lisette, Strauch, Konstantin, Tai, E-Shyong, Tarantini, Letizia, Thorand, Barbara, Tigchelaar, Ettje F., Tumino, Rosario, Uitterlinden, Andre G., van Duijn, Cornelia, Wickremasinghe, Ananda Rajitha, Wijmenga, Cisca, van Meurs, Joyce B. J., Vineis, Paolo, Yang, Tsun-Po, Yuan, Wei, Zhernakova, Alexandra, Batterham, Rachel L., Smith, George Davey, Deloukas, Panos, Heijmans, Bastiaan T., Herder, Christian, Hofman, Albert, Lindgren, Cecilia M., Milani, Lili, van der Harst, Pim, Peters, Annette, Illig, Thomas, Relton, Caroline L., Waldenberger, Melanie, Järvelin, Marjo-Riitta, Bollati, Valentina, Soong, Richie, Spector, Tim D., Scott, James, McCarthy, Mark I., Elliott, Paul, Bell, Jordana T., Matullo, Giuseppe, Gieger, Christian, Kooner, Jaspal S., Grallert, Harald, Chambers, John Campbell

Subjects: “…Epigenomics…”
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Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine by Gwen Lomberk, Nelson Dusetti, Juan Iovanna, Raul Urrutia

“…In pancreatic cancer, the epigenomic landscape can strongly impact the disease phenotype. …”
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Editorial: Application of epigenomics data to improve human and livestock health by Xiao Wang, Xiao Wang, Ying Yu, Lingzhao Fang, Zhimin Wang

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The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes by Amira Kohil, Maha Al-Asmakh, Maha Al-Asmakh, Maha Al-Asmakh, Mashael Al-Shafai, Mashael Al-Shafai, Annalisa Terranegra

“…In this mini review, we shed light on the influence of the diet-epigenome axis on the pathophysiology of T1DM.…”
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Interactive analysis of single-cell epigenomic landscapes with ChromSCape by Pacôme Prompsy, Pia Kirchmeier, Justine Marsolier, Marc Deloger, Nicolas Servant, Céline Vallot

“…Here, the authors present ChromSCape, a user-friendly interactive application that processes single-cell epigenomic data to assist the biological interpretation of chromatin landscapes within cell populations, as demonstrated in the context of cancer.…”
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Epigenome-wide association study of dietary fatty acid intake by Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R. Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T. Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen, Melanie Waldenberger

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Epigenomic insight of lingonberry and health-promoting traits during micropropagation by Arindam Sikdar, Umanath Sharma, Rajesh Barua, Abir U. Igamberdiev, Samir C. Debnath

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Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain by Chongyuan Luo, Madeline A. Lancaster, Rosa Castanon, Joseph R. Nery, Juergen A. Knoblich, Joseph R. Ecker

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Plant epigenome alterations: an emergent player in viroid-host interactions by Gustavo Gómez, Joan Marquez-Molins, German Martinez, Vicente Pallas

“…Here, we summarize the more relevant findings related to alteration of the host DNA methylome in response to viroid infection and discus the potential strategies which may be exploited by these non-conventional pathogenic RNAs to hijack and redesign the plant epigenome.…”
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Personalized and graph genomes reveal missing signal in epigenomic data by Cristian Groza, Tony Kwan, Nicole Soranzo, Tomi Pastinen, Guillaume Bourque

“…Abstract Background Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. …”
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Epigenome engineering in cancer: fairytale or a realistic path to the clinic? by Fahimeh eFalahi, Agustin eSgro, PILAR eBLANCAFORT

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Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study by Julie Mireille Joé Lepesant, Christoph Grunau, Céline Cosseau

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Connecting high-resolution 3D chromatin organization with epigenomics by Fan Feng, Yuan Yao, Xue Qing David Wang, Xiaotian Zhang, Jie Liu

“…Here the authors mapped 1D epigenomic profiles to fine-scale 3D chromatin structures with their deep learning model CAESAR. …”
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Editorial: Multi-omics, Epigenomics, and Computational Analysis of Neurodegenerative Disorders by Manoj Kumar Jaiswal

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Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges by Jun Ueda, Taiga Yamazaki, Hiroshi Funakoshi

Subjects: “…epigenome editing…”
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