Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…I then go on the report data from two bespoke experimental medicine clinical studies: The DECIMAL study (Defining Circadian Metabolism in MASLD) and the MIDNIGHT study (Metabolic Implications of Day and Night-shift working in NHS Healthcare Staff).…”

Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…<p><strong>Background:</strong> We report findings from an experimental medicine study of rationally designed prefusion stabilised native-like HIV envelope glycoprotein (Env) immunogens, representative of global circulating strains, delivered by sequential intramuscular injection.…”

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system by Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena

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Membrane vesicles of clostridioides difficile and other clostridial species by Goh, Shan, Inal, Jameel

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Regulation of cell migration by BMP signaling by Leong, Leslie Boon Hao

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Identifying novel neuromodulator targets of human cognition by Colwell, MJ

“…The research covered in Chapters 2–5 employs an experimental medicine approach, where healthy volunteers are used to model the cognitive effects of pharmacological interventions to assess their viability for clinical translation. …”