Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT by Miriam Santer, Megan Lawrence, Sarah Pyne, Susanne Renz, Beth L Stuart, Tracey Sach, Matthew Ridd, Kim S Thomas, Jacqueline Nuttall, Natalia Permyakova, Zina Eminton, Nick Francis, Paul Little, Ingrid Muller, Irene Soulsby, Karen Thomas, Gareth Griffiths, Alison M Layton

“…The trial has strong external validity as it was pragmatic in design to reflect normal practice, and participants were broadly reflective of women who could be offered spironolactone in routine care (while acknowledging that women of non-white ethnicity were under-represented in this study). …”
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Effectiveness of septoplasty compared to medical management in adults with obstruction associated with a deviated nasal septum: the NAIROS RCT by Sean Carrie, Tony Fouweather, Tara Homer, James O’Hara, Nikki Rousseau, Leila Rooshenas, Alison Bray, Deborah D Stocken, Laura Ternent, Katherine Rennie, Emma Clark, Nichola Waugh, Alison J Steel, Jemima Dooley, Michael Drinnan, David Hamilton, Kelly Lloyd, Yemi Oluboyede, Caroline Wilson, Quentin Gardiner, Naveed Kara, Sadie Khwaja, Samuel Chee Leong, Sangeeta Maini, Jillian Morrison, Paul Nix, Janet A Wilson, M Dawn Teare

“…Contraindication to general anaesthesia. Immunocompromised. External bony deformity. Measurement of clinical outcomes Primary outcome The primary outcome was patient-reported assessment of nasal and general symptoms, using the SNOT-22 questionnaire, at 6 months (−2 weeks/+4 weeks). …”
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Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT by Rachel Adams, Rachel E Jordan, Alisha Maher, Peymane Adab, Timothy Barrett, Sheriden Bevan, Lucy Cooper, Ingrid DuRand, Florence Edwards, Pollyanna Hardy, Ciara Harris, Nicola R Heneghan, Kate Jolly, Sue Jowett, Tom Marshall, Margaret O’Hara, Christopher Poyner, Kiran Rai, Hugh Rickards, Ruth Riley, Natalie Ives, Steven Sadhra, Sarah Tearne, Gareth Walters, Elizabeth Sapey

“…Data were recorded either on Zoom or an encrypted recorder and transferred via secure file transfer to an external company for transcription. Interviews were transcribed intelligent/clean verbatim and anonymised. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…So long as the interaction allows service users to act intentionally, with understanding, and without external influences, professionals can respect an individual's autonomy.[48] The enhancement in service-user autonomy ultimately arises from the relationship and shared experience with the peer-support specialist.  …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…So long as the interaction allows service users to act intentionally, with understanding, and without external influences, professionals can respect an individual's autonomy.[48] The enhancement in service-user autonomy ultimately arises from the relationship and shared experience with the peer-support specialist.  …”
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Policies Affecting Pregnant Women with Substance Use Disorder by Colburn Yu

“…The Maternal Lifestyle Study (NCT00059540) was a prospective longitudinal observational study that compared the outcomes of newborns exposed to cocaine in-utero to those without.[24] One of its studies revealed one month old newborns with cocaine exposure had “lower arousal, poorer quality of movements and self-regulation, higher excitability, more hypertonia, and more nonoptimal reflexes.”[25] Another study showed that at one month old, heavy cocaine exposure affected neural transmission from the ear to the brain.[26] Long-term follow up from the study showed that at seven years old, children with high intrauterine cocaine exposure were more likely to have externalizing behavior problems such as aggressive behavior, temper tantrums, and destructive acts.[27] While I have witnessed this behavior in the teenage patient during my pediatrics rotation, not all newborns with intrauterine drug exposure are inevitably bound to have psychiatric and behavioral issues later in life. …”
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What is next for occupational cancer epidemiology? by Michelle C Turner

“…Although occupational exposure has previously not been emphasized, research in the internal and external occupational exposome is now beginning to emerge (28). …”
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