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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Published 2025“…Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. …”
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Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF‐1‐induced macrophage migration
Published 2016“…The colony‐stimulating factor‐1 receptor transduces colony‐stimulating factor‐1 signaling, and we have shown previously that phosphatidylinositol 3‐kinase p110δ is a critical mediator of colony‐stimulating factor‐1–stimulated motility through the colony‐stimulating factor‐1 receptor pY721 motif. …”
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Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity
Published 2013“…Colony stimulating factor‐1 (CSF‐1) stimulates mononuclear phagocytic cell survival, growth and differentiation into macrophages through activation and autophosphorylation of the CSF‐1 receptor (CSF‐1R). …”
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Human health risk, potentials of biomonitoring and phytoremediation of copper using Amaranthus viridis
Published 2024“…From a phytoremediation perspective, with most bioconcentration factor values> 1.0 and the transfer factor> 1.0, A. viridis is a very potential phytoextraction agent of Cu. …”
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Near Optimal Alphabet-Soundness Tradeoff PCPs
Published 2024“… (2) Bounded degree 2-CSP’s: under randomized reductions, for su ciently large > 0, it is NP-hard to approximate the value of 2-CSPs in which each variable appears in at most constraints within factor (1 − (1)) 2 , improving upon a recent result of [Lee-Manurangsi 2023]…”
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Tiny Pointers
Published 2024“…If a tiny pointer references an element in an array filled to load factor 1?1/k, then the optimal tiny-pointer size is ?…”
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PRMT5 controls the innate immune response
Published 2024“…It is known that PRMT5-mediated methylation of E2 promoter binding factor 1 (E2F1) not only supports cancer cell growth but also influences RNA splicing. …”
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Mechanistic insights into the HPF1/PARP1 complex
Published 2021“…While PARP1 was originally described to modify target substrates on glutamate and aspartate sites, it has become apparent in recent years that the presence of another protein, histone PARylation factor 1 (HPF1), switches its preference to serine target sites. …”
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Treatment of the textile wastewater using Malaysian Ganoderma lucidum mycelial pellets
Published 2024“…The optimal conditions of adsorption by GLMP were determined by variation effects of adsorbent concentration (0, 8.75, 12.5 and 25 g/L), pH (unadjusted 7.10 – 8.22, 4 and 6), and wastewater dilution factor (1:0, 1:4, and 2:3, v/v). This method was proved to be effective in both decolorization and chemical oxygen demand (COD) reduction, simultaneously. …”
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Establishment and optimization of induced pluripotent stem cell technologies
Published 2014“…Undifferentiated transcription factor 1 (UTF1) belongs to the core transcriptional network regulating pluripotency and its expression pattern during cell reprogramming and subsequent differentiation appears to be tightly connected to the pluripotent state. …”
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Estrogenic post-menopausal anti-osteoporotic mechanism of Achyranthes aspera L.: Phytochemicals and network pharmacology approaches
Published 2024“…The MeOH fraction was shown to upregulate the oestrogen marker genes trefoil factor 1 and progesterone receptor by 20.14–23.94 folds and 10.83–14.83 folds, respectively. …”
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Genome-wide mapping of Hif-1α binding sites in zebrafish
Published 2015“…To identify the dependency of these transcriptional changes on HIF, we undertook Chromatin Immunoprecipitation linked next generation sequencing (ChIP-seq) for the transcription factor Hypoxia Inducible Factor 1α (HIF-1α). We identified HIF-1α binding sites across the genome, with binding sites showing enrichment for an RCGTG motif, showing conservation with the mammalian hypoxia response element. …”
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Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification
Published 2022“…Abbreviations: ATP6V0B: ATPase H+ transporting V0 subunit b; ATP6V0C: ATPase H+ transporting V0 subunit c; ATP6V0E1: ATPase H+ transporting V0 subunit e1; ATP6V1H: ATPase H+ transporting V1 subunit H; CBZ: carbamazepine; CDI: C. difficile infection; CXCL: chemokine C-X-X motif ligand; IL: interleukin; LAMP1: lysosomal-associated membrane protein 1; LC3: microtubule-associated protein 1 light chain 3; LEF: lymphoid enhancer binding factor 1; MITF: melanocyte inducing transcription factor; NFKB: nuclear factor kappa B; PMA: phorbol 12-myristate 13-acetate; TcdA: Clostridial toxin A; TcdB: Clostridial toxin B; TFE3: transcription factor E3; TFEB: transcription factor EB.…”
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Masculinity among Indonesian militants
Published 2022“…The path into and out of extremism is influenced by various factors. One under-researched factor is the role of masculinity ─ how manhood and its accompanying sense of perceived responsibility drive individuals to resort to violence. …”
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Commentary -
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American foreign policy after 9/11 : a strategic turn towards unilateralism.
Published 2008“…The Bush administration's foreign policy represents a distinct strategic turn towards unilateralism, due to these factors: (1) American economic and military power (2) Psychological impact of the Al-Qaeda attacks on Sept 11, 2001 (3) The belief that in order to achieve its security, America needs to be free from the international rules, and also use military strength to reshape the world.…”
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Simplified test of universality in lattice QCD
Published 2013“…The determinant relations expected from universality considerations are found to be violated by a certain gauge field-dependent factor; i.e., we uncover a “universality anomaly.” …”
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Demographic factors and their correlations with loss aversion and framing effects.
Published 2012“…The purpose of this study was to understand more about the correlations between five demographic factors (i.e. level of income, level of education, age, race and gender) and individuals’ level of financial loss aversion. …”
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Final Year Project (FYP)