Delta-6 desaturase (Fads2) deficiency alters triacylglycerol/fatty acid cycling in murine white adipose tissue by Chenxuan Wang, Barbora Hucik, Ousseynou Sarr, Liam H. Brown, Kyle R.D. Wells, Keith R. Brunt, Manabu T. Nakamura, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch

Subjects: Get full text

Preclinical trials in Alzheimer’s disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice by Mahvish Faisal, Jana Aid, Bekzod Nodirov, Benjamin Lee, Miriam A. Hickey

“…5xFAD transgenic (TG) mice are used widely in AD preclinical trials; however, data on sample sizes are largely unaddressed. …”
Get full text

JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model by Erica Cecilia Priori, Clara Alice Musi, Arianna Giani, Luca Colnaghi, Ivana Milic, Andrew Devitt, Tiziana Borsello, Mariaelena Repici

“…To better elucidate this mechanism, we longitudinally studied 5xFAD mice at three selected time points representative of human AD symptom progression. …”
Get full text

Distribution in Different Organisms of Amino Acid Oxidases with FAD or a Quinone As Cofactor and Their Role as Antimicrobial Proteins in Marine Bacteria by Jonatan C. Campillo-Brocal, Patricia Lucas-Elío, Antonio Sanchez-Amat

“…Recently, a novel class of AAOs has been described that does not contain FAD as cofactor, but a quinone generated by post-translational modification of residues in the same protein. …”
Get full text

Patterns of changes in the fluorescence of nadh and fad coenzymes and their relationship in skeletal muscle in the early post-mortem period (an experimental study) by Anastasia S. Babkina, Dmitriy V. Sundukov, Arkady M. Golubev

Subjects: Get full text

Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model by Jinho Kim, ShinWoo Kang, Keun-A Chang

“…As expected, cx-DHED reversed memory impairment and reduced Aβ plaques and astrocyte overexpression in the brains of 5xFAD mice. Interestingly, cx-DHED reversed the abnormal expression of glucose transporters in the brains of 5xFAD mice. …”
Get full text

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice by Kathrin Gnoth, Stefanie Geissler, Julia Feldhaus, Nadine Taudte, Victoria Ilse, Sebastian Zürner, Sebastian Greiser, Ulf-Dietrich Braumann, Jens-Ulrich Rahfeld, Holger Cynis, Stephan Schilling

Subjects: Get full text

Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function by Yeonghoon Son, Hye-Jin Park, Ye Ji Jeong, Hyung-Do Choi, Nam Kim, Hae-June Lee

Subjects: “…5×fad; alzheimer’s disease; csf1r; long term exposure; microglial function; neuroinflammation; radiofrequency electromagnetic fields; therapeutic effect…”
Get full text

Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants by Conny Tanjung, Carla P. Harris, Hans Demmelmair, Sarah Dwitya, Zakiudin Munasir, Herawati Sudoyo, Marie Standl, Damayanti Rusli Sjarif, Berthold Koletzko

Subjects: Get full text

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice by Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann, Dan Frenkel

Subjects: Get full text

TMT-based quantitative proteomics analysis reveals the role of Notch signaling in FAdV-4-infected LMH cell by Yujuan Niu, Zhiyang Liu, Mengyu Wang, Ke Du, Kaihui Chang, Yonghe Ding

Subjects: Get full text

Therapeutic Effects of Aβ-Specific Regulatory T Cells in Alzheimer’s Disease: A Study in 5xFAD Mice by Seon-Young Park, Juwon Yang, Hyejin Yang, Inhee Cho, Jae Yoon Kim, Hyunsu Bae

“…Collectively, our results demonstrate that Aβ-specific Tregs can mitigate AD pathology in 5xFAD mice.…”
Get full text

Impact of FADS gene variation and dietary fatty acid exposure on biochemical and anthropomorphic phenotypes in a Hispanic/Latino cohort by Susan Sergeant, Brian A. Keith, Michael C. Seeds, Jimaree A. Legins, Caroline B. Young, Mara Z. Vitolins, Floyd H. Chilton, Floyd H. Chilton

Subjects: Get full text

Perceived Burdensomeness, Thwarted Belongingness and Fearlessness About Death in Italian university students: validation of the INQ-15 and the ACSS-FAD by S. Magliocca, D. Romano, F. Madeddu, P. Zeppegno, C.M. Gramaglia, R. Calati

“…ACSS-FAD and INQ-15 have been administered to a sample of 1,665 Italian university students. …”
Get full text

Insights into the Novel <i>FAD2</i> Gene Regulating Oleic Acid Accumulation in Peanut Seeds with Different Maturity by Shuzhen Zhao, Jie Sun, Jinbo Sun, Xiaoqian Zhang, Chuanzhi Zhao, Jiaowen Pan, Lei Hou, Ruizheng Tian, Xingjun Wang

Subjects: Get full text

Construction and Functional Evaluation of CRISPR/Cas9 Multiple Knockout Vectors of the <i>FAD2</i> Gene Family by Qi Zhang, Lu Liu, Zhifeng Xiao, Yuwei Sun, Yongjing Xi, Tingting Sun, Jiabao Wang, Piwu Wang

Subjects: “…<i>FAD2</i> gene family…”
Get full text

A socio-economic sustainability indicator for the Basque tropical tuna purse-seine fleet with a FAD fishing strategy by Arantza Murillas-Maza, Gala Moreno, Jefferson Murua

Subjects: Get full text

Depletion of gut microbiota resistance in 5×FAD mice enhances the therapeutic effect of mesenchymal stem cell-derived exosomes by Xuejia Hou, Hongyu Jiang, Te Liu, Jun Yan, Fuqiang Zhang, Xiaowen Zhang, Jingtong Zhao, Xupeng Mu, Jinlan Jiang

“…Methods: In this original research study, we used MSCs-exo to treat 5 ×FAD mice and fed them antibiotic cocktails for 1 week to detect cognitive ability and neuropathy. …”
Get full text

Functional Diversity of Homologous Oxidoreductases—Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction by Marta Hammerstad, Anne Kristine Rugtveit, Sondov Dahlen, Hilde Kristin Andersen, Hans-Petter Hersleth

“…Mutational studies and bioinformatics analyses confirmed the importance of the conserved FAD-stacking residues on the respective reaction rates, proposing a division of FNRs into four functionally unique sequence similarity clusters likely related to the nature of this residue.…”
Get full text

İnsan Sağlığına Nütrigenetik Bir Bakış: Yağ Asiti Desatüraz Enzimleri (FADS) Kodlayan Genlerde Tek Nükleotid Polimorfizmleri by Nuray Şengül, Leila Mehdizadeh Tapeh, Elif Kestir, Bakiye Nur Varlı, Simge Kaya, İsmail Hakkı Tekiner

Subjects: Get full text