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1861
Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks
Published 2020-09-01“…Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimately responsible of amyloid-β (Aβ) formation. …”
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1862
Effect of Different Types of Organic Manure on Oil and Fatty Acid Accumulation and Desaturase Gene Expression of Oilseed Flax in the Dry Areas of the Loess Plateau of China
Published 2024-02-01“…The 25 t ha<sup>−1</sup> sheep manure treatment was more conducive to the expression of <i>fad3a</i> and <i>fad3b</i> genes and promoted the accumulation of linolenic acid (LIN), and the LIN content increased by 0.64–3.90% compared with other treatments. …”
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1863
In Silico Analysis of Fatty Acid Desaturases Structures in <i>Camelina sativa</i>, and Functional Evaluation of <i>Csafad7</i> and <i>Csafad8</i> on Seed Oil Formation and Seed Mor...
Published 2021-10-01“…It was revealed that the ω3-fatty acid desaturase could increase the C18:3 level at the expense of C18:2, but decreases in oil content and seed weight, and wrinkled phenotypes were observed in transgenic <i>CsaFAD7</i> lines, while no significant change was observed in transgenic <i>CsaFAD8</i> lines in comparison to the wild-type. …”
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1864
Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase
Published 2023-06-01“…For the dimer interface variants G426E-, I445M-, and R447G-hLADH, enzyme activities and FAD loss were determined and compared against the previously published structural data.…”
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1865
Low Temperature Affects Fatty Acids Profiling and Key Synthesis Genes Expression Patterns in <i>Zanthoxylum bungeanum</i> Maxim
Published 2022-02-01“…Furthermore, fatty acid synthesis pathway genes fatty acyl-ACP thioesterase A (<i>FATA</i>), Delta (8)-fatty-acid desaturase 2 (<i>SLD2</i>), protein ECERIFERUM 3 (<i>CER3</i>), fatty acid desaturase 3 (<i>FAD3</i>) and fatty acid desaturase 5 (<i>FAD5</i>) played key roles in FG, and <i>SLD2</i>, <i>FAD5</i>, 3-oxoacyl-[acyl-carrier-protein] synthase I (<i>KAS I</i>), fatty acyl-ACP thioesterase B (<i>FATB</i>) and acetyl-CoA carboxylase (<i>ACC</i>) were the key genes responding to low temperature in FX. …”
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1866
The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons
Published 2022-07-01“…Citalopram treatment reduced the Aβ1-42:40 ratio in control but not in fAD PSEN1 cells. ADAM10 activity was increased with Citalopram treatments in fAD PSEN1 cell lines, which was also seen for sAβPPα secretion. …”
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1867
Biodegradation of Uric Acid by <i>Bacillus paramycoides</i>-YC02
Published 2023-08-01“…These enzymes play a crucial role in the metabolism pathway, converting vitamin B<sub>2</sub> to FAD and subsequently converting UA to 5-hydroxyisourate (HIU) with the assistance of FAD. …”
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1868
The Chinese version of the family accommodation scale for obsessive-compulsive disorder self-rated: reliability, validity, factor structure, and mediating effect
Published 2022-08-01“…The FAS-SR, FAS-IR, FAD-12, and the patients’ symptom severity of Y-BOCS compulsion were used as tools for relatives. …”
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1869
Safety and risk assessment of damaged multi-planar square hollow section (SHS) TT-, YT- and KT-joints
Published 2015“…Therefore, penalty factors of 1.2 and 1.1 for Pc load are recommended to move all the constructed Level 3C FAD curves above the standard Level 2A curve for cracked uni-planar and multi-planar SHS joints. …”
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Thesis -
1870
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosi...
Published 2011“…They were present in 1/11 (9%) FAD, and 9/85 (10%) EOAD patients but were significantly more common (p = 0.003) in LOAD where 24/84 (29%) patients showed such changes. …”
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1871
Encyclopedia of lifestyle medicine and health /
Published c201“…These three volumes sort out the science behind nightly news reports and magazine cover stories, helping the reader to discern sound, evidence-based advice from that which is merely fad. The volumes convey the latest research on lifestyle medicine, incorporating content from such areas as health psychology, communication, public policy and health promotion, and disease prevention, among others. …”
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1872
Molecular cloning and functional expression of delta 9-fatty acid desaturase from Antarctic Pseudomonas sp. A3 and Pseudomonas sp. A8
Published 2017“…A8 were designated as PA3FAD9 and PA8FAD9, respectively each having an open reading frame of 1,185 bp coding for 394 amino acids with a predicted molecular weight of 45 kDa. …”
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Thesis -
1873
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1874
Il come ed il perché. A proposito della didattica della paleografia e della diplomatica
Published 2017-05-01Get full text
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1875
ДЕТСТВО В СВЕТЕ СОВРЕМЕННОГО СОЦИАЛЬНО-ОБЕСПЕЧИТЕЛЬНОГО ЗАКОНОДАТЕЛЬСТВА РЕСПУБЛИКИ КАЗАХСТАН
Published 2016-02-01Get full text
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1876
Author Correction: Demonstration of Shor’s factoring algorithm for N = 21 on IBM quantum processors
Published 2023-03-01Get full text
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1880