Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks by Paola Pizzo, Emy Basso, Riccardo Filadi, Elisa Greotti, Alessandro Leparulo, Diana Pendin, Nelly Redolfi, Michela Rossini, Nicola Vajente, Tullio Pozzan, Cristina Fasolato

“…Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimately responsible of amyloid-β (Aβ) formation. …”
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Effect of Different Types of Organic Manure on Oil and Fatty Acid Accumulation and Desaturase Gene Expression of Oilseed Flax in the Dry Areas of the Loess Plateau of China by Xingkang Ma, Yuhong Gao, Xingbang Ma, Bing Wu, Bin Yan, Yue Li, Yifan Wang, Peng Xu, Ming Wen, Haidi Wang, Yingze Wang, Lizhuo Guo

“…The 25 t ha⁻¹ sheep manure treatment was more conducive to the expression of <i>fad3a</i> and <i>fad3b</i> genes and promoted the accumulation of linolenic acid (LIN), and the LIN content increased by 0.64–3.90% compared with other treatments. …”
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In Silico Analysis of Fatty Acid Desaturases Structures in <i>Camelina sativa</i>, and Functional Evaluation of <i>Csafad7</i> and <i>Csafad8</i> on Seed Oil Formation and Seed Mor... by Nadia Raboanatahiry, Yongtai Yin, Kang Chen, Jianjie He, Longjiang Yu, Maoteng Li

“…It was revealed that the ω3-fatty acid desaturase could increase the C18:3 level at the expense of C18:2, but decreases in oil content and seed weight, and wrinkled phenotypes were observed in transgenic <i>CsaFAD7</i> lines, while no significant change was observed in transgenic <i>CsaFAD8</i> lines in comparison to the wild-type. …”
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Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase by Eszter Szabo, Eva Nemes-Nikodem, Krisztina Rubina Vass, Zsofia Zambo, Eszter Zrupko, Beata Torocsik, Oliver Ozohanics, Balint Nagy, Attila Ambrus

“…For the dimer interface variants G426E-, I445M-, and R447G-hLADH, enzyme activities and FAD loss were determined and compared against the previously published structural data.…”
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Low Temperature Affects Fatty Acids Profiling and Key Synthesis Genes Expression Patterns in <i>Zanthoxylum bungeanum</i> Maxim by Jieyun Tian, Lu Tian, Ming Chen, Yabing Chen, Anzhi Wei

“…Furthermore, fatty acid synthesis pathway genes fatty acyl-ACP thioesterase A (<i>FATA</i>), Delta (8)-fatty-acid desaturase 2 (<i>SLD2</i>), protein ECERIFERUM 3 (<i>CER3</i>), fatty acid desaturase 3 (<i>FAD3</i>) and fatty acid desaturase 5 (<i>FAD5</i>) played key roles in FG, and <i>SLD2</i>, <i>FAD5</i>, 3-oxoacyl-[acyl-carrier-protein] synthase I (<i>KAS I</i>), fatty acyl-ACP thioesterase B (<i>FATB</i>) and acetyl-CoA carboxylase (<i>ACC</i>) were the key genes responding to low temperature in FX. …”
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The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons by R. J. Elsworthy, J. A. Crowe, M. C. King, C. Dunleavy, E. Fisher, A. Ludlam, H. R. Parri, E. J. Hill, S. Aldred

“…Citalopram treatment reduced the Aβ1-42:40 ratio in control but not in fAD PSEN1 cells. ADAM10 activity was increased with Citalopram treatments in fAD PSEN1 cell lines, which was also seen for sAβPPα secretion. …”
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Biodegradation of Uric Acid by <i>Bacillus paramycoides</i>-YC02 by Xiaoyu Cao, Jingyuan Cai, Yu Zhang, Chao Liu, Meijie Song, Qianqian Xu, Yang Liu, Hai Yan

“…These enzymes play a crucial role in the metabolism pathway, converting vitamin B₂ to FAD and subsequently converting UA to 5-hydroxyisourate (HIU) with the assistance of FAD. …”
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The Chinese version of the family accommodation scale for obsessive-compulsive disorder self-rated: reliability, validity, factor structure, and mediating effect by Zhenhua Liao, Lijun Ding, Lijun Ding, Ciping You, Ying Chen, Wenchang Zhang

“…The FAS-SR, FAS-IR, FAD-12, and the patients’ symptom severity of Y-BOCS compulsion were used as tools for relatives. …”
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Safety and risk assessment of damaged multi-planar square hollow section (SHS) TT-, YT- and KT-joints by Sukumara Pillai, Vipin

“…Therefore, penalty factors of 1.2 and 1.1 for Pc load are recommended to move all the constructed Level 3C FAD curves above the standard Level 2A curve for cracked uni-planar and multi-planar SHS joints. …”
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TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosi... by Davidson, Y, Raby, S, Foulds, P, Robinson, A, Thompson, J, Sikkink, S, Yusuf, I, Amin, H, DuPlessis, D, Troakes, C, Al-Sarraj, S, Sloan, C, Esiri, M, Prasher, V, Allsop, D, Neary, D, Pickering-Brown, S, Snowden, J, Mann, D

“…They were present in 1/11 (9%) FAD, and 9/85 (10%) EOAD patients but were significantly more common (p = 0.003) in LOAD where 24/84 (29%) patients showed such changes. …”

Encyclopedia of lifestyle medicine and health / by Rippe, James M.

“…These three volumes sort out the science behind nightly news reports and magazine cover stories, helping the reader to discern sound, evidence-based advice from that which is merely fad. The volumes convey the latest research on lifestyle medicine, incorporating content from such areas as health psychology, communication, public policy and health promotion, and disease prevention, among others. …”

Molecular cloning and functional expression of delta 9-fatty acid desaturase from Antarctic Pseudomonas sp. A3 and Pseudomonas sp. A8 by Garba, Lawal

“…A8 were designated as PA3FAD9 and PA8FAD9, respectively each having an open reading frame of 1,185 bp coding for 394 amino acids with a predicted molecular weight of 45 kDa. …”
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Loreley El Jaber, <i>Un paí­s malsano. La conquista del espacio en las crónicas del Rí­o de la Plata (siglos XVI y XVII)</i> by Claudia Torre

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Il come ed il perché. A proposito della didattica della paleografia e della diplomatica by Giorgio Costamagna

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ДЕТСТВО В СВЕТЕ СОВРЕМЕННОГО СОЦИАЛЬНО-ОБЕСПЕЧИТЕЛЬНОГО ЗАКОНОДАТЕЛЬСТВА РЕСПУБЛИКИ КАЗАХСТАН by И. В. Межибовская

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Author Correction: Demonstration of Shor’s factoring algorithm for N = 21 on IBM quantum processors by Unathi Skosana, Mark Tame

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The Third Sector and the Argentine buisiness world by Luis Ulla

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Setka albo moje życie z „Kwartalnikiem” by Krzysztof Loska

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Occidentalismos léxicos en documentación notarial gaditana : entre el dialectalismo y la norma en testamentos del siglo XVIII by Margarita Fernández González

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P. Stabel, B. Blondé, A. Greve, International trade in the Low Countries (14th-16th centuries). Merchants, organisation, infrastructure. Proceedings of the international conferenc... by V. Enthoven

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