Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase by Andreea Zubaș, Alina Ghinet, Amaury Farce, Joëlle Dubois, Elena Bîcu

Subjects: Get full text

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice by Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury, Joseph R. Mazzulli, Robert Vassar

Subjects: Get full text

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase by Anna Hagemann, Philipp Klemens Altrogge, Miriam Caroline Alice Kehrenberg, Daniel Diehl, Dominik Jung, Lea Weber, Hagen Sjard Bachmann

Subjects: “…farnesyltransferase…”
Get full text

Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle by Harumasa Nakazawa, Lai Ping Wong, Laura Shelton, Ruslan Sadreyev, Masao Kaneki

Subjects: Get full text

Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines by Ali Abdollahi, Davoud Asgari, Simin Sharifi, Soodabeh Davaran, Saeed Ghasemi, Javid Shahbazi Mojarrad

Subjects: “…Farnesyltransferase inhibitor…”
Get full text

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni by Alexandra Probst, Thi N. Nguyen, Nelly El-Sakkary, Danielle Skinner, Brian M. Suzuki, Frederick S. Buckner, Michael H. Gelb, Conor R. Caffrey, Anjan Debnath

Subjects: Get full text

Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover by Foo, Mattheus Xing Rong, Ong, Peh Fern, Yap, Zi Xuan, Maric, Martina, Bong, Christopher Jue Shi, Dröge, Peter, Burke, Brian, Dreesen, Oliver

Subjects: Get full text

Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B by Jacquie L. Harper, Iman M. Khalil, Lisa Shaw, Marie-Lise Bourguet-Kondracki, Joëlle Dubois, Alexis Valentin, David Barker, Brent R. Copp

Subjects: Get full text

Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties by Anna Hagemann, Sandro Tasillo, Aykut Aydin, Miriam Caroline Alice Kehrenberg, Hagen Sjard Bachmann

Subjects: “…Human Farnesyltransferase…”
Get full text

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice by Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö, Ling Li

Subjects: Get full text

Discovery of new targets for antimalarial chemotherapy by Grellier P., Depoix D., Schrével J., Florent I.

Subjects: Get full text

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) by Gajewski Thomas F, Salama April KS, Niedzwiecki Donna, Johnson Jeffrey, Linette Gerald, Bucher Cynthia, Blaskovich Michelle A, Sebti Said M, Haluska Frank

Subjects: Get full text

Biocatalytic production of the antibiotic aurachin D in Escherichia coli by Sebastian Kruth, Lina Schibajew, Markus Nett

Subjects: Get full text

Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells by Shilei Xu, Shilei Xu, Sebastian Dolff, Nils Mülling, Hagen S. Bachmann, Yang Dai, Monika Lindemann, Ming Sun, Oliver Witzke, Andreas Kribben, Benjamin Wilde

Subjects: Get full text

New indazole-indolizine-triazine hybrid molecules with farnesyltransferase inhibitory activity by Liliana Ciurlă-Lucescu, Elena Bîcu, Dalila Belei, Alina Ghinet

Subjects: Get full text

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria by Shao H. Yang, Sandy Y. Chang, Douglas A. Andres, H. Peter Spielmann, Stephen G. Young, Loren G. Fong

Subjects: Get full text

Relative Contributions of Prenylation and Postprenylation Processing in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Pathogenesis by Shannon K. Esher, Kyla S. Ost, Lukasz Kozubowski, Dong-Hoon Yang, Min Su Kim, Yong-Sun Bahn, J. Andrew Alspaugh, Connie B. Nichols

Subjects: Get full text

Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells by Noriyuki Egawa, Tomokazu Tanaka, Shohei Matsufuji, Kohei Yamada, Kotaro Ito, Hiroshi Kitagawa, Keiichiro Okuyama, Yoshihiko Kitajima, Hirokazu Noshiro

Subjects: “…farnesyltransferase inhibitor…”
Get full text

Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases[S] by Shao H. Yang, Sandy Y. Chang, Yiping Tu, Gregory W. Lawson, Martin O. Bergo, Loren G. Fong, Stephen G. Young

Subjects: “…protein farnesyltransferase…”
Get full text

Incorporation of Perillyl Alcohol into Lipid-Based Nanocarriers Enhances the Antiproliferative Activity in Malignant Glioma Cells by Tarek A. Ahmed, Alshaimaa M. Almehmady, Waleed S. Alharbi, Abdullah A. Alshehri, Fahad A. Almughem, Reem M. Altamimi, Manal A. Alshabibi, Abdelsattar M. Omar, Khalid M. El-Say

Subjects: Get full text