Efficacy of fentanyl versus clonidine as an adjuvant to ropivacaine compared to ropivacaine for postoperative analgesia in caudal block for infraumblical pediatric surgeries: A prospective double-blinded randomized control study by T Krishna Prasad, J Balu Sankar, Dilip Kumar Govindan, K Soundarya Priyadharsini

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Analysis, identification and confirmation of synthetic opioids using chloroformate chemistry: Retrospective detection of fentanyl and acetylfentanyl in urine and plasma samples by EI-GC-MS and HR-LC-MS. by Carlos A Valdez, Roald N Leif, Todd H Corzett, Mark L Dreyer

“…The optimized protocol was successfully evaluated for its efficacy at detecting these species formed from fentanyl and acetylfentanyl when present at low and high levels in urine (fentanyl: 5 and 10 ng/mL and acetylfentanyl: 20 and 100 ng/mL) and plasma (fentanyl: 10 and 20 ng/mL and acetylfentanyl: 50 and 200 ng/mL), values that reflect levels reported in overdose victims. …”
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Relationship between the Use of Fentanyl-Based Intravenous Patient-Controlled Analgesia and Clinically Significant Events in Laparoscopic Gynecological Surgery: A Single-Center Retrospective Cohort Study by Miho Hamada, Chikashi Takeda, Li Dong, Akiko Hirotsu, Izumi Shizuya, Toshiyuki Mizota

“…Conclusion: The use of fentanyl-based ivPCA in laparoscopic gynecological surgery is associated with increased CSE.…”
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Expression of Concern: Association between Genetic Polymorphisms in Cav2.3 (R-type) Ca2+ Channels and Fentanyl Sensitivity in Patients Undergoing Painful Cosmetic Surgery

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Analgesic efficacy of a bilateral erector spinae plane block versus a fentanyl constant rate infusion in dogs undergoing hemilaminectomy: a retrospective cohort study by Inga Viilmann, Maja Drozdzynska, Enzo Vettorato

“…The aim of this study is to compare the analgesic efficacy of a bilateral ESPB with a fentanyl constant rate infusion (CRI) in dogs undergoing hemilaminectomy. …”
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Burden of opioid toxicity death in the fentanyl-dominant era for people who experience incarceration in Ontario, Canada, 2015–2020: a whole population retrospective cohort study by Dale Guenter, Tara Gomes, Ahmed M Bayoumi, Ruth Croxford, Fiona Kouyoumdjian, Susan J Bondy, Claire Bodkin, Leonora Regenstreif, Amanda Butler, Hanaya Akbari, Katherine E McLeod, Tharsan Kanagalingam, Lori A Kiefer, Aaron Michael Orkin, Akwasi Owusu-Bempah

“…Objectives To describe mortality due to opioid toxicity among people who experienced incarceration in Ontario between 2015 and 2020, during the fentanyl-dominant era.Design In this retrospective cohort study, we linked Ontario coronial data on opioid toxicity deaths between 2015 and 2020 with correctional data for adults incarcerated in Ontario provincial correctional facilities.Setting Ontario, Canada.Participants Whole population data.Main outcomes and measures The primary outcome was opioid toxicity death and the exposure was any incarceration in a provincial correctional facility between 2015 and 2020. …”
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Differential impact of fentanyl and morphine doses on ticagrelor-induced platelet inhibition in ST-segment elevation myocardial infarction: a subgroup analysis from the PERSEUS randomized trial by Dorian Garin, Sophie Degrauwe, Federico Carbone, Federico Carbone, Yazan Musayeb, Nathalie Lauriers, Marco Valgimigli, Juan F. Iglesias

Subjects: “…fentanyl…”
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Dexamethasone versus fentanyl as an adjuvant to ropivacaine in ilioinguinal and iliohypogastric nerve block for postoperative analgesia: A prospective randomized double-blind trial in lower-segment cesarean section by Gegal Pruthi, Mayank Gupta, K S Bharathi, Nidhi Singh, Dinesh Sood, Karamjot Singh, Praveen Kumar Choudhary, Priyanka Gupta

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Expression of Concern: Association between Genetic Polymorphisms in Cav2.3 (R-type) Ca2+ Channels and Fentanyl Sensitivity in Patients Undergoing Painful Cosmetic Surgery. by PLOS ONE Editors

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Effect of Fentanyl and Dexmedetomidine as Additives to 0.5% Ropivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block for Elective Upper Limb Surgeries: A Randomised Clinical Trial by M Umamaheshwar, KM Shwetha, Ramarao Bhogadi

“…Aim: To evaluate the block characteristics with addition of either fentanyl or dexmedetomidine to 0.5% ropivacaine for supraclavicular brachial block. …”
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Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data by Sabina Podlewska, Ryszard Bugno, Lucja Kudla, Andrzej J. Bojarski, Ryszard Przewlocki

“…In this study, a comprehensive molecular modeling protocol was developed to explain the observed activity profiles of selected µ opioid receptor agents: two G protein-biased µ opioid receptor agonists (PZM21 and SR-17018), unbiased morphine, and the β-arrestin-2-biased agonist, fentanyl. The study involved docking and molecular dynamics simulations carried out for three crystal structures of the target at a microsecond scale, followed by the statistical analysis of ligand–protein contacts. …”
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Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations by Dwaipayan Mukherjee, Michelle Collins, Douglas E. Dylla, Jatinder Kaur, Dimitri Semizarov, Anthony Martinez, Brian Conway, Tipu Khan, Nael M. Mostafa

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Once again... breakthrough cancer pain: an updated overview by Sebastiano Mercadante

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Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury by Adriana Franco-Acevedo, Raquel Echavarria, Bibiana Moreno-Carranza, Cesar-Ivan Ortiz, David Garcia, Ricardo Gonzalez-Gonzalez, Oscar-Kurt Bitzer-Quintero, Eliseo Portilla-De Buen, Zesergio Melo

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Perbandingan Efektivitas Kombinasi Fentanyl Patch 12,5 µg/jam dan 25 µg/jam dengan Ketorolak 30 mg Intravena pada Pascabedah Ortopedi Ekstremitas Bawah by Poppy Novita Rini, Mhd. Ihsan, Asmin Lubis

Subjects: “…Fentanyl patch…”
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Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids by Susan M. Cibulsky, Susan M. Cibulsky, Timo Wille, Timo Wille, Timo Wille, Renée Funk, Renée Funk, Danny Sokolowski, Danny Sokolowski, Christine Gagnon, Christine Gagnon, Marc Lafontaine, Marc Lafontaine, Carol Brevett, Rabih Jabbour, Jessica Cox, David R. Russell, David R. Russell, David A. Jett, David A. Jett, Jerry D. Thomas, Lewis S. Nelson

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Intranasal drug delivery in pediatric emergency departments: brief review and future outlook by Christopher Hugh McClean, Mohammad Hussein Alsabri, Sania Tahir, Rebecca Song, Christopher Chin

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Selected Political Criminal Poisonings in the Years 1978–2020: Detection and Treatment by Zuzanna Brunka, Jan Ryl, Piotr Brushtulli, Daria Gromala, Grzegorz Walczak, Sonia Zięba, Dorota Pieśniak, Jacek Sein Anand, Marek Wiergowski

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Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study by Matsuyuki Doi, Naoki Takahashi, Rumi Nojiri, Takehiko Hiraoka, Yusuke Kishimoto, Shinichi Inoue, Nobuyo Oya

Subjects: “…Fentanyl…”
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Associations with experience of non-fatal opioid overdose in British Columbia, Canada: a repeated cross sectional survey study by Max Ferguson, Paul Choisil, Jessica Lamb, Charlene Burmeister, Cheri Newman, Kurt Lock, Samuel Tobias, Lisa Liu, Jane A. Buxton

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