Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration. by Akiko Eguchi, Anny Mulya, Milos Lazic, Deepa Radhakrishnan, Michael P Berk, Davide Povero, Agnieszka Gornicka, Ariel E Feldstein

“…Here, we demonstrate that adipocyte-derived microparticles (MPs) are critical "find-me" signals for recruitment of monocytes and macrophages. …”
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Chemokines act as phosphatidylserine-bound "find-me" signals in apoptotic cell clearance. by Sergio M Pontejo, Philip M Murphy

“…Blebs released by apoptotic cells can deliver find-me signals; however, the mechanism is poorly understood. …”
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Exploding the necroptotic bubble by Liat Edry-Botzer, Motti Gerlic

“…In our recent publication (PLoS Biol. 15(6):e2002711), we describe similar ‘eat-me’ and ‘find-me’ signals present during necroptosis, challenging some of our common assumptions about regulated forms of lytic death.…”
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Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons by Guy C. Brown

“…After a stroke, neurons are stressed by ongoing ischemia, excitotoxicity and/or inflammation and are known to: (i) release “find-me” signals such as ATP, (ii) expose “eat-me” signals such as phosphatidylserine, and (iii) bind to opsonins, such as complement components C1q and C3b, inducing microglia to phagocytose such neurons. …”
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Efferocytosis of pathogen-infected cells by Karaji, N, Sattentau, Q

“…Dying cells are recognized by phagocytes through pathways initiated via "find me" signals, recognition via "eat me" signals and down-modulation of regulatory "don't eat me" signals. …”

Phagocytic Glial Cells in Brain Homeostasis by Rena Kono, Yuji Ikegaya, Ryuta Koyama

“…The intracellular signaling mechanisms that regulate microglial phagocytosis have been studied extensively, and several important factors, including molecules known as “find me” signals and “eat me” signals and receptors on microglia that are involved in phagocytosis, have been identified. …”
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Efferocytosis of Pathogen-Infected Cells by Niloofar Karaji, Quentin J. Sattentau

“…Dying cells are recognized by phagocytes through pathways initiated via “find me” signals, recognition via “eat me” signals and down-modulation of regulatory “don’t eat me” signals. …”
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CX3CL1(+) Microparticles Mediate the Chemoattraction of Alveolar Macrophages toward Apoptotic Acute Promyelocytic Leukemic Cells by Wen-Hui Tsai, Chung-Hung Shih, Shan-Yu Feng, I-Ting Li, Shao-Chi Chang, Yu-Chieh Lin, Hui-Chi Hsu

“…Background/Aims: During the resolution phase of inflammation, release of “find-me” signals by apoptotic cells is crucial in the chemoattraction of macrophages toward apoptotic cells for subsequent phagocytosis, in which microparticles derived from apoptotic cells (apo-MPs) are involved. …”
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Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro by Gerhard E. Grossmayer, Hildegard Keppeler, Sebastian Boeltz, Christina Janko, Christina Janko, Jürgen Rech, Martin Herrmann, Kirsten Lauber, Luis E. Muñoz

“…While dying, cells expose and release a plethora of eat-me and find-me signals to ensure their timely removal before entering the dangerous stage of secondary necrosis. …”
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Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis by Jennifer D Sokolowski, Jennifer D Sokolowski, Chloe N Chabanon-Hicks, Claudia Z Han, Daniel S Heffron, James W Mandell

“…This suggests fractalkine acts as a ‘find-me’ signal, recruiting microglial processes toward apoptotic cells to promote their clearance. …”
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Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases by Shehata Anwar, Vincent Pons, Serge Rivest

“…Its ligand, UDP, is a signaling molecule that can serve as an “find-me” signal when released in significant quantities by damaged/dying cells. …”
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ATP and Its Metabolite Adenosine as Regulators of Dendritic Cell Activity by Cinthia Silva-Vilches, Sabine Ring, Karsten Mahnke

“…Moreover, ATP and Ado production thereof acts as “find me” signal that guides cellular interactions of leukocytes during immune responses. …”
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The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity by Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon

“…Furthermore, raptinal also interfered with PANX1-regulated apoptotic processes including the release of the ‘find-me’ signal ATP, the formation of apoptotic cell-derived extracellular vesicles, as well as NLRP3 inflammasome activation. …”
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CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages by Wen-Hui Tsai, Shao-Chi Chang, Yu-Chieh Lin, Hui-Chi Hsu

“…During the resolution phase of acute lung injury, apoptotic cells release CX3CL1 as a “find-me” signal to attract alveolar macrophage transmigration toward apoptotic cells for phagocytosis. …”
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Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development by Wang-jun Yang, Rong-chang Cao, Wang Xiao, Xiao-lou Zhang, Hao Xu, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Jun-ling Zeng, Shu-ji Li, Min Luo, Yan-jiang Han, Xiao-bing Yang, Guo-dong Feng, Yu-heng Lu, Yuan-yuan Ni, Chan-gui Wu, Jun-jie Bai, Zi-qi Yuan, Jin Jin, Guo-wei Zhang

“…Our study indicates that the acinar Atp8b1/LPC pathway acts as an important “find-me” signal for macrophages and plays a protective role in CP, with Atp8b1 transcription promoted by the acinar cell-specific transcription factor Bhlha15. …”
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