Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised tr... by François Maltais, Leif Bjermer, Edward M. Kerwin, Paul W. Jones, Michael L. Watkins, Lee Tombs, Ian P. Naya, Isabelle H. Boucot, David A. Lipson, Chris Compton, Mitra Vahdati-Bolouri, Claus F. Vogelmeier

“…Methods The 24-week, double-blind, double-dummy, parallel-group Early MAXimisation of bronchodilation for improving COPD stability (EMAX) trial randomised patients at low exacerbation risk not receiving inhaled corticosteroids, to umeclidinium/vilanterol 62.5/25 μg once-daily, umeclidinium 62.5 μg once-daily or salmeterol 50 μg twice-daily. …”
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Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS... by Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello, Lorenzo Beretta

“…Results There were 29 subjects who completed the study; 7 subjects withdrew due to side-effects and 4 subjects were not compliant with the study procedures. As compared to dummy treatment, prucalopride was associated with more intestinal evacuations (p < 0.001), improvement of UCLA GIT constipation (-0.672 ± 0.112 vs 0.086 ± 0.115; p < 0.001), reflux (-0.409 ± 0.094 vs 0.01 ± 0.096; p < 0.005) and bloating (-0.418 ± 0.088 vs -0.084 ± 0.09; p = 0.01) scores. …”
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Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial by Adrian Richter, Julia Truthmann, Eva Hummers, Julia Freyer Martins Pereira, Ildikó Gágyor, Franziska Schuster, Amelie Witte, Susanne Böhm, Alexandra Greser, Petra Kamin, Sylvia Stracke, Marcus Dörr, Robin Bülow, Stefan Engeli, Jean François Chenot, Till Ittermann

“…Study design This pragmatic, prospective, double-blind, double-dummy, parallel-group, randomized, non-inferiority trial compares prednisolone with colchicine in terms of non-inferiority in patients with acute gout. …”
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Exploring genetic predictors of naltrexone treatment response in opioid use disorder by Е. A. Blokhina ., E. М. Krupitsky, А. O. Kibitov, V. Ya. Palatkin, T. S. Yaroslavtseva, Е. V. Verbitskaya, E. E. Zvartau

“…Purpose: The present study was aimed to evaluate the effect of the opioid receptors genes and dopamine system genes polymorphisms on the treatment outcomes of opioid dependence with implantable and oral naltrexone in randomized double blinded double dummy placebo controlled clinical trial. Methods: 306 patients with opioid dependence were randomized in 3 treatment groups (102 ss in each). …”
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Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage–related complications: The ACETatE (A low ChloriE hyperTonic solution... by Ofer Sadan, Kai Singbartl, Jacqueline Kraft, Joao McONeil Plancher, Alexander C. M. Greven, Prem Kandiah, Cederic Pimentel, C. L. Hall, Alexander Papangelou, William H. Asbury, John J. Hanfelt, Owen Samuels

“…Methods A low ChloridE hyperTonic solution for brain Edema (ACETatE) trial is a single-center, double-blinded, double-dummy, randomized pilot trial comparing bolus infusions of 23.4% NaCl and 16.4% NaCl/Na-acetate for the treatment of cerebral edema in patients with SAH. …”
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Genetic aspects for the behaviour of lactating sows towards humans by J. Kecman, J. Neu, N. Göres, B. Voß, F. Rosner, N. Kemper, H.H. Swalve

“…Sows were kept in individual indoor pens with movable farrowing crates in which the animals were restrained from 7 days antepartum (ap) to an average of 7 days postpartum (pp). The Dummy Arm Test (DAT; 1444 observations) was used to assess the sows’ reaction towards a stockperson handling the piglets around day 4 pp (closed crates). …”
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Opioids in patients with COPD and refractory dyspnea: literature review and design of a multicenter double blind study of low dosed morphine and fentanyl (MoreFoRCOPD) by Marlies van Dijk, Kris J. M. Mooren, Jan-Willem K. van den Berg, Wendy J. C. van Beurden-Moeskops, Roxane Heller-Baan, Sander M. de Hosson, Wai Yee Lam-Wong, Liesbeth Peters, Karin Pool, Huib A. M. Kerstjens

“…Methods We describe the design of a robust, multi-center, double blind, double-dummy, cross-over, randomized, placebo-controlled clinical trial with three study arms investigating transdermal fentanyl 12 mcg/h and morphine sustained-release 10 mg b.i.d. …”
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Non-comorbid Respiratory Factor and Work of Breathing in Pediatric COVID-19 Patient: How is Their Synergistic Correlation with the Level of Care? by Defi Efendi, Maria Dyah Kurniasari, Mega Hasanul Huda, Raudha Ilmi Farid, Yohanes Andy Rias, Yogi Prawira, Nina Dwi Putri, Ayuni Rizka Utami, Titik Ambar Asmarini, Pande Lilik Lestari, Pricilia Mais, Abram Babakal

“…The multivariate logistic regression was performed to test the adjusted odds ratios (AORs) with the 95% confidence intervals (CIs) of the association between WOB, non-comorbid respiratory, and level of care. Moreover, dummy variables (2x2) were made to analyze synergistic correlation of non-comorbid respiratory disease and WOB. …”
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Measurement of provider fidelity to immunization guidelines: a mixed-methods study on the feasibility of documenting patient refusals of the human papillomavirus vaccine by Rachel S. Chang, Jaimie Z. Shing, Jennifer C. Erves, Liping Du, Tatsuki Koyama, Stephen Deppen, Alyssa B. Rentuza, Caree McAfee, Christine Stroebel, Janet Cates, Lora Harnack, David Andrews, Robert Bramblett, Pamela C. Hull

“…Providers were instructed to document initial HPV vaccine refusals in the EHR's immunization forms and subsequent refusals using dummy procedure codes, for use in assessment and feedback reports. …”
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Efficacy and classification of Sesamum indicum linn seeds with Rosa damascena mill oil in uncomplicated pelvic inflammatory disease using machine learning by Sumbul, Arshiya Sultana, Md Belal Bin Heyat, Khaleequr Rahman, Faijan Akhtar, Saba Parveen, Mercedes Briones Urbano, Mercedes Briones Urbano, Mercedes Briones Urbano, Vivian Lipari, Vivian Lipari, Vivian Lipari, Isabel De la Torre Díez, Azmat Ali Khan, Abdul Malik

“…Additionally, we analyzed the data with machine learning.Materials and methods: We included 60 participants in a double-blind, double-dummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. …”
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The dependency of the prices of farm estates on arable land and forest land areas in Finland in the years 1961, 1962 and 1966 by Arvi Leponiemi

“…As general conclusions of the performed regression analysis it can be established that the increase of both agricultural and forest land areas increases the sales price less than proportionally (elasticity < 1) and that the area of arable land, the forest land and the dummy variables explain, in 1961, about 43 %, in 1962 29 % and in 1966 about 39 % of the changes of the sales prices of farm estates in the whole country. …”
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A randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5&nbsp;&micro;g compared with tiotropium 18&nbsp;&micro;g in patients with&nbsp;COPD by Feldman G, Maltais F, Khindri S, Vahdati-Bolouri M, Church A, Fahy WA, Trivedi R

“…Methods: This was a 12-week, multicenter, randomized, blinded, double-dummy, parallel-group, non-inferiority study. Patients were randomized 1:1 to UMEC 62.5&nbsp;&micro;g plus placebo or TIO 18&nbsp;&micro;g plus placebo. …”
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Comparison of Dry-Powder Inhaler and Pressurized Metered-Dose Inhaler Formulations of Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium in Patients with COPD... by Beeh KM, Kuna P, Corradi M, Viaud I, Guasconi A, Georges G

“…This study aimed to demonstrate non-inferiority of BDP/FF/G DPI vs pMDI for lung function.Methods: Multicenter, randomized, double-blind, double-dummy, active-controlled, three-way cross-over study in patients with COPD and post-bronchodilator forced expiratory volume in 1 second (FEV1) 30&ndash; 80% predicted. …”
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Extracorporeal Artificial Lungs: Co-Creating Future Technology &ndash; A Qualitative Analysis by Dormann J, Wendt S, Dreher M, Ansems K, Rolland C, Spillner J, Szafran A, Breuer T, Pison C, Verbelen T, Benstoem C

“…The aim of this study is to analyze patient acceptance about an extracorporeal artificial lung and to implement these findings into the development.Methods: In collaboration with a medical device developer, we presented a portable dummy oxygenator to patients with advanced lung disease, as potential end users. …”
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Estimação da digestibilidade dos carboidratos não-fibrosos em bovinos utilizando-se o conceito de entidade nutricional em condições brasileiras Estimation of nonfiber carbohydrates... by Edenio Detmann, Sebastião de Campos Valadares Filho, Lara Toledo Henriques, Douglas dos Santos Pina, Mário Fonseca Paulino, Rilene Ferreira Diniz Valadares, Mário Luiz Chizzotti, Karla Alves Magalhães

“…Tests for checking equality of models were conducted using a Dummy variable for comparing animal categories. The true digestibility coefficient did not differ between animal categories, and the estimated value was 0.9705. …”
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Indacaterol acetate/mometasone furoate provides sustained improvements in lung function compared with salmeterol xinafoate/fluticasone propionate in patients with moderate-to-very-... by Beeh KM, Kirsten AM, Tanase AM, Richard A, Cao W, Hederer B, Beier J, Kornmann O, van Zyl-Smit RN

“…Secondary objectives were to compare the efficacy of IND/MF (QMF149) vs Sal/Flu with respect to other lung function parameters, COPD exacerbations, symptoms and dyspnea, health status/health-related quality of life, and rescue medication use.Materials and methods: This was a 12-week multicenter, randomized, double-blind, double-dummy, parallel-group, Phase II study in patients with moderate-to-very-severe COPD, who were randomized (1:1) to IND/MF (QMF149) (150/160 &micro;g once daily; n=316) or Sal/Flu (50/500 &micro;g twice daily; n=313).Results: Over 90% of patients completed the study: 94.6% in the IND/MF (QMF149) group and 92.0% in the Sal/Flu group. …”
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The Effect and Safety Assessment of Metformin and DLBS3233 (A Bioactive Fraction of Lagerstroemia speciosa and Cinnamomum burmannii) on Improving Metabolic Parameters in Women with... by Hidayat ST, Mulyantoro I, Damas S, Tjandrawinata RR

“…DLBS3233 alone and in combination with metformin were evaluated for efficacy and safety in insulin-resistant women with polycystic ovary syndrome (PCOS).Methods: A randomized, double-blind, 3-arm, double-dummy, non-inferiority, and also a controlled clinical study was conducted at the Dr. …”
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Sublingual misoprostol versus intramuscular oxytocin for prevention of postpartum hemorrhage in Uganda: a double-blind randomized non-inferiority trial. by Esther C Atukunda, Mark J Siedner, Celestino Obua, Godfrey R Mugyenyi, Marc Twagirumukiza, Amon G Agaba

“…<h4>Methods and findings</h4>We performed a double-blind, double-dummy randomized controlled non-inferiority trial between 23 September 2012 and 9 September 2013 at Mbarara Regional Referral Hospital in Uganda. …”
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Development of an income-based hedonic monetization model for the assessment of aviation-related noise impacts by He, Qinxian, Ph. D. Massachusetts Institute of Technology

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Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries by Aknin, LB, Andretti, B, Goldszmidt, R, Helliwell, JF, Petherick, A, De Neve, J-E, Dunn, E, Fancourt, D, Goldberg, E, Jones, SP, Karadag, O, Karam, E, Layard, R, Saxena, S, Thornton, E, Whillans, A, Zaki, J

“…Using a combined dataset of country-level and individual-level data, we estimated linear regression models with country-fixed effects (ie, dummy variables representing the countries in our sample) and with individual and contextual covariates. …”