Forward genetic analysis of mammalian immunity by Siggs, O, Owen Siggs

“…</p> <p>These findings uncover new entry points for the understanding of mammalian immunity, and highlight the value of mouse forward genetics in the understanding of mammalian phenomena in general.…”

Exploring hematopoiesis in zebrafish using forward genetic screening by Hyemin Song, Unbeom Shin, Uijeong Nam, Yoonsung Lee

“…Recent advances in mutant gene mapping have further expanded the scope of forward genetic screening, facilitating the identification of previously unknown genes and pathways relevant to hematopoiesis. …”
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Investigating the genetic basis of sleep using forward genetics by Guillaumin, M

“…This project has focused on the Sleepy6 mouse line which was obtained via a forward genetics sleep screen. This model has a mutation in synaptobrevin 2, which results in a decreased sleep duration. …”

NOVEL LYMPHOCYTE DEFICIENCIES REVEALED BY MOUSE FORWARD GENETICS by Siggs, O, Bull, K, Beutler, B, Cornall, R

ACIDES: on-line monitoring of forward genetic screens for protein engineering by Takahiro Nemoto, Tommaso Ocari, Arthur Planul, Muge Tekinsoy, Emilia A. Zin, Deniz Dalkara, Ulisse Ferrari

“…Abstract Forward genetic screens of mutated variants are a versatile strategy for protein engineering and investigation, which has been successfully applied to various studies like directed evolution (DE) and deep mutational scanning (DMS). …”
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Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella by Hongtao Zhang, Lei Zhang, Ganglin Ren, Hongbin Si, Xingju Song, Xianyong Liu, Xun Suo, Dandan Hu

“…In this study, strains of E. tenella resistant to 250 mg/kg monensin were generated and characterized. Forward genetic approaches based on pooled genome sequencing, including experimental evolution and linkage group selection, were used to locate candidate targets responsible for resistance to monensin and diclazuril in E. tenella. …”
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‘There and Back Again’—Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension by Emilia M. Swietlik, Matina Prapa, Jennifer M. Martin, Divya Pandya, Kathryn Auckland, Nicholas W. Morrell, Stefan Gräf

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Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii. by Marc-Jan Gubbels, Margaret Lehmann, Mani Muthalagi, Maria E Jerome, Carrie F Brooks, Tomasz Szatanek, Jayme Flynn, Ben Parrot, Josh Radke, Boris Striepen, Michael W White

“…Here we describe a forward genetic dissection of the apicomplexan cell cycle using the Toxoplasma model. …”
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Forward Genetic Screens as Tools to Investigate Role and Mechanisms of EMT in Cancer by Ákos Gasparics, Attila Sebe

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Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy by Anton D. Shevlyakov, Tatiana O. Kolesnikova, Murilo S. de Abreu, Elena V. Petersen, Konstantin B. Yenkoyan, Konstantin A. Demin, Allan V. Kalueff

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Applications of forward genetic screens to LncRNAs, cancer immunotherapy, and cellular engineering by Joung, Julia.

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Mapping of signalling pathways using a FACS-based forward genetic approach by De Zan, E

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Finding New Components of the Mammalian Immune System by Bruce Beutler

Subjects: “…Forward genetics…”
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KDM5A mutations identified in autism spectrum disorder using forward genetics by Lauretta El Hayek, Islam Oguz Tuncay, Nadine Nijem, Jamie Russell, Sara Ludwig, Kiran Kaur, Xiaohong Li, Priscilla Anderton, Miao Tang, Amanda Gerard, Anja Heinze, Pia Zacher, Hessa S Alsaif, Aboulfazl Rad, Kazem Hassanpour, Mohammad Reza Abbaszadegan, Camerun Washington, Barbara R DuPont, Raymond J Louie, CAUSES Study, Madeline Couse, Maha Faden, R Curtis Rogers, Rami Abou Jamra, Ellen R Elias, Reza Maroofian, Henry Houlden, Anna Lehman, Bruce Beutler, Maria H Chahrour

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A large-scale forward genetic screen for maize mutants with altered lignocellulosic properties by Shaogan Wang, Stefan Robertz, Merve Seven, Florian Kraemer, Benjamin M. Kuhn, Lifeng Liu, China Lunde, Markus Pauly, Markus Pauly, Vicente Ramírez, Vicente Ramírez

“…Here, we describe a large-scale forward genetic approach resulting in the identification of a collection of chemically mutagenized maize mutants with diverse alterations in their cell wall attributes such as crystalline cellulose content or hemicellulose composition. …”
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Probing the cohesin loading reaction using forward genetics and quantitative ChIP-sequencing by Petela, N

Soybean Protein and Oil Variants Identified through a Forward Genetic Screen for Seed Composition by Karen Hudson

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A Forward Genetic Screen in Sclerotinia sclerotiorum Revealed the Transcriptional Regulation of Its Sclerotial Melanization Pathway by Yan Xu, Kevin Ao, Lei Tian, Yilan Qiu, Xingchuan Huang, Xueru Liu, Ryan Hoy, Yishan Zhang, Khalid Youssef Rashid, Shitou Xia, Xin Li

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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations by Bull, K, Rimmer, A, Siggs, O, Miosge, L, Roots, C, Enders, A, Bertram, E, Crockford, T, Whittle, B, Potter, P, Simon, M, Mallon, A, Brown, S, Beutler, B, Goodnow, C, Lunter, G, Cornall, R

“…Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. …”

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. by Arnold, C, Pirie, E, Dosenovic, P, McInerney, G, Xia, Y, Wang, N, Li, X, Siggs, O, Karlsson Hedestam, G, Beutler, B