Geochronological and thermometric evidence of unusually hot fluids in an Alpine fissure of Lauzière granite (Belledonne, Western Alps) by E. Janots, E. Janots, A. Grand'Homme, M. Bernet, D. Guillaume, E. Gnos, M.-C. Boiron, M. Rossi, A.-M. Seydoux-Guillaume, R. De Ascenção Guedes

“…<p>A multi-method investigation into Lauzière granite, located in the external Belledonne massif of the French Alps, reveals unusually hot hydrothermal conditions in vertical open fractures (Alpine-type clefts). The host-rock granite shows sub-vertical mylonitic microstructures and partial retrogression at temperatures of &lt;&thinsp;400&thinsp;<span class="inline-formula">^∘</span>C during Alpine tectonometamorphism. …”
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Gas hydrates distribution in the Shenhu Area, northern South China Sea: comparisons between the eight drilling sites with gas-hydrate petroleum system by M. SU, R. YANG, H. WANG, Z. SHA, J. LIANG, N. WU, S. QIAO, X. CONG

“…Gas chimneys and some small-scale faults (or micro-scale fractures) compose the migration pathways for gas bearing fluids. …”
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Characteristics, genetic mechanism and oil &amp; gas exploration significance of high-quality sandstone reservoirs deeper than 7000 m: A case study of the Bashijiqike Formation of... by Qinglu Zeng, Tao Mo, Jilong Zhao, Yongliang Tang, Ronghu Zhang, Jiufeng Xia, Chunlei Hu, Lingling Shi

“…Second, different from other ultra-deep fractured low-porosity sandstone reservoirs, this set of ultra-deep reservoir is a pore-type reservoir with porosity of 4–13%, permeability of 0.1–50.0 mD and better porosity and permeability correlation. …”
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A novel type of neural networks for feature engineering of geological data: Case studies of coal and gas hydrate-bearing sediments by Lishuai Jiang, Yang Zhao, Naser Golsanami, Lianjun Chen, Weichao Yan

“…The coal samples used in the experiments underwent nuclear magnetic resonance (NMR) measurements, and Scanning Electron Microscopy (SEM) imaging to investigate their original micro and macro fractures. Once done with these experiments, measurement of the rock mechanical properties, including tensile strength, was performed using a rock mechanical test system. …”
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Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China:... by Hongyi Li, Xianbiao Xie, Junqiang Yin, Jian Tu, Xiaoshuai Wang, Weihai Liu, Jiajun Zhang, Hongbo Li, Changye Zou, Yongqian Wang, Jingnan Shen, Gang Huang

“…Chemotherapy-related side effects were mild and well tolerated. Pathologic fractures (6.81%), loosening of instrumentation (6.00%,), surgical site infection (4.00%) and rejection of bone grafting (9.09%) developed in surgery patients. …”
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Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors by José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá

“…Thus, besides P2X7 and P2Y6 receptors activation, targeting NTPDase3 may represent a novel therapeutic strategy to increase bone mass and reduce the osteoporotic risk of fractures in Pm women.…”
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Emergency Providers’ Pain Management in Patients Transferred to Intensive Care Unit for Urgent Surgical Interventions by Quincy K. Tran, Tina Nguyen, Gurshawn Tuteja, Laura Tiffany, Ashley Aitken, Kevin Jones, Rebecca Duncan, Jeffrey Rea, Lewis Rubinson, Daniel Haase

“…Patients who had objective findings of long bone fractures were more likely to receive pain medication than those who did not, despite pain complaints. …”
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Omics Profiling of S2P Mutant Fibroblasts as a Mean to Unravel the Pathomechanism and Molecular Signatures of X-Linked MBTPS2 Osteogenesis Imperfecta by Pei Jin Lim, Pei Jin Lim, Severin Marfurt, Severin Marfurt, Uschi Lindert, Uschi Lindert, Lennart Opitz, Timothée Ndarugendamwo, Timothée Ndarugendamwo, Pakeerathan Srikanthan, Pakeerathan Srikanthan, Martin Poms, Martin Poms, Martin Hersberger, Martin Hersberger, Claus-Dieter Langhans, Dorothea Haas, Marianne Rohrbach, Marianne Rohrbach, Cecilia Giunta, Cecilia Giunta

“…Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by low bone density, bone fragility and recurrent fractures. The characterization of its heterogeneous genetic basis has allowed the identification of novel players in bone development. …”
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3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects... by Doris Baumgartner, Doris Baumgartner, Johannes Peter Schramel, Silvio Kau, Ewald Unger, Gunpreet Oberoi, Christian Peham, Matthias Eberspächer-Schweda

“…No material defects pre- or post-failure testing were found in the printed mandibles and screws. Plate fractures were most often observed in similar locations, depending on the design. …”
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Congenital heart defects and intensity of oil and gas well site activities in early pregnancy by Lisa M. McKenzie, William Allshouse, Stephen Daniels

“…Keywords: Congenital heart defects, Birth outcomes, Oil and natural gas development, Case control study, Environmental exposure, Hydraulic fracturing…”
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Beneficios de un programa de reeducación vesical en ancianos hospitalizados by Silvia del Rey Contreras, Montserrat García González, Mª Luisa Rodriguez de Prada, Juan José Baztán Cortés

“…Hospital Cruz Roja (Madrid, España) Fecha del Trabajo: 12/01/2006 Palabra Clave: Incontinencia urinaria en ancianos, reeducación vesical, valoración geriátrica, accidente cerebrovascular, fractura de cadera Key Words: Urinary incontinence, vesicle re-education, geriatric valuation, cerebrovascular disease, hip fracture…”
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A material balance based practical analysis method to improve the dynamic reserve evaluation reliability of ultra-deep gas reservoirs with ultra-high pressure by Hedong Sun, Wen Cao, Jun Li, Wei Jia, Yuanjie Li, Yan Wu, Songbai Zhu, Xiaotao Fu, Min Yang, Guangren Meng

“…Ultra-deep major gas fields are typically characterized by high and ultra-high pressure, tight matrix and developed fractures, so the reserve estimation is of higher uncertainty. …”
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Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis by Rui Lin, Bilian Xu, Zhiqiang Ye, Yin Gao, Haiping Fang, Jintong Song, Dahong Liang, Lingna Liu, Zilong Hu, Min Zhang, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Yanzhi Liu

“…Background: Osteopenia and fragile fractures are diabetes-associated complications. Many hypoglycemic drugs have effects on bone metabolism. …”
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Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta by Pei Jin Lim, Giulio Marcionelli, Pakeerathan Srikanthan, Timothée Ndarugendamwo, Jason Pinner, Jason Pinner, Marianne Rohrbach, Cecilia Giunta

“…Patients with OI typically present with reduced bone mass, tendency for recurrent fractures, short stature and bowing deformities of the long bones. …”
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HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice by Chao Ma, Juan Gao, Jun Liang, Weixiang Dai, Zhenfei Wang, Mengjiao Xia, Tao Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, Kerong Dai, Guangwang Liu

“…Abstract Background Senile osteoporosis can cause bone fragility and increased risk for fractures and has been one of the most prevalent and severe diseases affecting the elderly population worldwidely. …”
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Microscopic pore structure characteristics and controlling factors of marine shale: a case study of Lower Cambrian shales in the Southeastern Guizhou, Upper Yangtze Platform, South... by Ruyue Wang, Ruyue Wang, Ruyue Wang, Ruyue Wang, Ruyue Wang, Yuejiao Liu, Zhi Li, Zhi Li, Zhi Li, Dahai Wang, Dahai Wang, Dahai Wang, Guanping Wang, Guanping Wang, Guanping Wang, Fuqiang Lai, Zhihao Li, Zhihao Li, Zhihao Li, Jianhua He

“…In contrast, shales under unfavorable preservation conditions appear dense, with excessively developed fractures increasing both average pore size and local permeability. …”
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Feedbacks between the formation of secondary minerals and the infiltration of fluids into the regolith of granitic rocks in different climatic zones (Chilean Coastal Cordillera) by F. J. Hampl, F. Schiperski, C. Schwerdhelm, N. Stroncik, C. Bryce, F. von Blanckenburg, F. von Blanckenburg, T. Neumann

“…The most important is weathering-induced fracturing (WIF) by Fe(II) oxidation in biotite and precipitation of Fe(III) oxyhydroxides and by the swelling of interstratified smectitic clay minerals that promotes the formation of fluid pathways. …”
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Characteristics and Predictors of Radiographic Local Failure in Patients With Spinal Metastases Treated With Palliative Conventional Radiation Therapy by Jie Jane Chen, MD, Adam J. Sullivan, PhD, Diana D. Shi, MD, Monica S. Krishnan, MD, Lauren M. Hertan, MD, MS, Claudia S. Roldan, BA, Mai Anh Huynh, MD, PhD, Alexander Spektor, MD, PhD, M. Mohsin Fareed, MD, Tai Chung Lam, MD, Tracy A. Balboni, MD, MPH

“…Of those with LF, 51.4% had new compression fractures, 39.2% were admitted for pain control, and 35.1% received reirradiation; median time from radiation therapy (RT) to each of these events was 3.0, 5.7, and 9.2 months, respectively. …”
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Effect of Calcium Fortified Foods on Health Outcomes: A Systematic Review and Meta-Analysis by Gabriela Cormick, Ana Pilar Betran, Iris Beatriz Romero, Maria Sol Cormick, José M. Belizán, Ariel Bardach, Agustín Ciapponi

“…The largest cost savings (43%) reported from calcium fortification programs came from prevented hip fractures in older women from Germany. Our study highlights that calcium fortification leads to a higher calcium intake, small benefits in children’s height and bone health and also important evidence gaps for other outcomes and populations that could be solved with high quality experimental or quasi-experimental studies in relevant groups, especially as some evidence of calcium supplementation show controversial results on the bone health benefit on older adults.…”
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Clinical outcomes and treatment patterns in REASSURE: planned interim analysis of a real-world observational study of radium-223 in metastatic castration-resistant prostate cancerR... by Celestia S. Higano, Daniel J. George, Neal D. Shore, Oliver Sartor, Kurt Miller, Peter S. Conti, Cora N. Sternberg, Fred Saad, Juan Pablo Sade, Joaquim Bellmunt, Matthew R. Smith, Kumari Chandrawansa, Per Sandström, Frank Verholen, Bertrand Tombal

“…Seventy (5%) patients had fractures. Interpretation: REASSURE offers insight into radium-223 use in global real-world clinical practice with currently available therapies. …”
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