ADNP: In search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration by Illana eGozes, Yanina eIvashko-Pachima

“…Tauopathy, a major pathology in AD, is also found in ~45% of frontotemporal dementias (FTDs). Tau transcript, a product of a single gene, undergoes alternative splicing. …”
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Clinical features and multidisciplinary approaches to dementia care by Gr, JHG, Caspar S, MacDonald SWS

“…Four primary dementia classifications have been defined according to clinical and research criteria: 1) Alzheimer’s disease; 2) vascular dementias; 3) frontotemporal dementias; and 4) dementia with Lewy bodies/Parkinson’s disease dementia. …”
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Circulating miRNAs as Biomarkers for Neurodegenerative Disorders by Margherita Grasso, Paola Piscopo, Annamaria Confaloni, Michela A. Denti

“…Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementias (FTD), are considered distinct entities, however, there is increasing evidence of an overlap from the clinical, pathological and genetic points of view. …”
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Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle? by Maria Laura Passaro, Francesco Matarazzo, Gianmarco Abbadessa, Antonio Pezone, Antonio Porcellini, Fausto Tranfa, Michele Rinaldi, Ciro Costagliola

“…The extended spectrum of tauopathies includes conditions such as frontotemporal dementias, progressive supranuclear palsy, chronic traumatic encephalopathy, and Alzheimer’s disease. …”
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Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation by Yuxing Xia, Brach M. Bell, Benoit I. Giasson

“…The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed frontotemporal dementias. In all of these disorders, tau aggregates are enriched in post-translational modifications including acetylation, which has recently been identified at multiple sites. …”
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Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey by Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan, Tessa Grabinski

“…Additionally, tau is a central player in the pathogenesis of several diseases such as Alzheimer’s disease and several frontotemporal dementias. A critical variable to understanding tau in physiological and disease contexts is its normal localization within cells of the adult CNS. …”
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Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions by Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas

“…In contrast to the lentiform TDP-43 NIIs, which are observed in certain frontotemporal dementias and which are conditional upon GRN or VCP mutations, our data support the hypothesis that the presence of α-Syn NIIs in MSA is instead purely amyloid-strain-dependent.…”
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El neurólogo frente al dolor en la demencia by Luis Carlos Álvaro González

“…The consequence is the presence of hyperpathy and hyperalgesia. In the frontotemporal dementias, there is a reduction in pain expressivity. …”
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The neurologist facing pain in dementia by L.C. Álvaro González

“…Vascular dementias feature a cortico-subcortical deafferentation secondary to white matter lesions, resulting in a state of hyperpathy and hyperalgesia. In frontotemporal dementias, there is a reduction in pain expression linked to lesions in the orbitofrontal and anterior temporal areas, which are responsible for the emotional component of pain. …”
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