Autoantibodies to the NY-ESO-1 Tumor Antigen in Metastatic Melanoma: Sialylation of the Fc Region of Immunoglobulin G Induces Differential Expression Signatures of Inflammatory Mol... by Martin Oaks, Nathaniel Rein, John O. Richards, James Shaffer

“…Conclusions: Our findings support the concept that alternate glycoforms of IgG induce differing functional programs of dendritic cell differentiation and maturation. …”
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Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF by Irina Larionova, Irina Larionova, Irina Larionova, Artem Kiselev, Elena Kazakova, Elena Kazakova, Tengfei Liu, Marina Patysheva, Marina Patysheva, Pavel Iamshchikov, Pavel Iamshchikov, Quan Liu, Dieuwertje M. Mossel, Vladimir Riabov, Militsa Rakina, Militsa Rakina, Alexey Sergushichev, Natalia Bezgodova, Sergei Vtorushin, Nikolai Litviakov, Nikolai Litviakov, Evgeny Denisov, Philipp Koshkin, Denis Pyankov, Matvei Tsyganov, Marina Ibragimova, Nadezhda Cherdyntseva, Nadezhda Cherdyntseva, Nadezhda Cherdyntseva, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska

“…In cohort of patients with breast cancer, the effect of platinum therapy on the transcriptome of TAMs was validated, and differential expression of regulators of endocytosis was identified.ResultsHere we show that chemotherapeutic agent cisplatin can initiate detrimental transcriptional and functional programs in TAMs, without significant impairment of their viability. …”
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DCA for Sparse Quadratic Kernel-Free Least Squares Semi-Supervised Support Vector Machine by Jun Sun, Wentao Qu

“…One important method for solving the nonconvex problem is the DC (difference of convex function) programming. Therefore, we first approximate the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mo>ℓ</mo><mn>0</mn></msub></semantics></math></inline-formula> norm by a polyhedral DC function. …”
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Interaction of production areas of settlements with regional settlement systems at the municipal level of territorial planning by N. G. Yushkova

“…However, the planning of the territory of this level is able to reduce the acuteness of contradictions between short-term and long-term prospects of regional development, as well as to ensure the accuracy of linking the formed objects of different sizes with non-typical functional programs.Materials and methods. The methodological basis was provided by general scientific methods (system approach, system-structural analysis, comparative analysis, theoretical modelling) and special interdisciplinary methods (methods of graph-analytical modelling), scientific literature, data from official sites of statistical bodies and municipalities, open cartographic sources, urban planning documents of territorial planning.Results. …”
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La salud ambiental en el modelo de gestión sanitaria andaluza Environmental health policy in the Andalussian health management system by I. Marín Rodríguez

“…This paper, which was presented at the VI National Congress of Environmental Health, describes the structure, functions, programs and activities developed in the Environmental Health area in Andalussia.…”
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Bayesian computational models for inferring preferences by Evans, Owain Rhys

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The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis by Mariola Molina-García, David Fraguas, Ángel del Rey-Mejías, Gisela Mezquida, Ana M. Sánchez-Torres, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Álvaro Andreu-Bernabeu, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Anna Mané, Manuel Cuesta, Elena de la Serna, Beatriz Payá, Iñaki Zorrilla, Celso Arango, Miquel Bernardo, Marta Rapado-Castro, Mara Parellada

“…Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.…”
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Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb by Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira

“…Currently, despite diet supplementation, effective therapeutical solutions to prevent the deleterious cardiac offspring function programming by an obesogenic womb are lacking. In this review, we discuss the mechanisms by which an obesogenic intrauterine environment could program the offspring’s cardiovascular metabolism in a sex-divergent way, with a special focus on cardiac mitochondrial function, and debate possible strategies to implement during MO pregnancy that could ameliorate, revert, or even prevent deleterious effects of MO on the offspring’s cardiovascular system. …”
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CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate by Gürkan Bal, Jean Schneikert, Zhuoran Li, Kristin Franke, Shiva Raj Tripathi, Torsten Zuberbier, Magda Babina

“…KIT represents the cells‘ crucial receptor tyrosine kinase, which orchestrates proliferation, survival, and functional programs throughout the lifespan. cAMP response element binding protein (CREB), an evolutionarily well-conserved transcription factor (TF), regulates multiple cellular programs, but its function in MCs is poorly understood. …”
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Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies by Alberto Visioli, Nadia Trivieri, Gandino Mencarelli, Fabrizio Giani, Massimiliano Copetti, Orazio Palumbo, Riccardo Pracella, Maria Grazia Cariglia, Chiara Barile, Luigi Mischitelli, Amata Amy Soriano, Pietro Palumbo, Federico Legnani, Francesco DiMeco, Leonardo Gorgoglione, Graziano Pesole, Angelo L. Vescovi, Elena Binda

“…Results Here, distinct biomarker signatures together with aberrant functional programs were shown to stratify GBM patients as well as their sibling GSCs population into TCGA clusters. …”
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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy by Qiang Lu, Dongquan Kou, Shenghan Lou, Milad Ashrafizadeh, Amir Reza Aref, Israel Canadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan, Peng Han

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Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life by Érica Kássia Sousa-Vidal, Guilherme Henrique, Renata Elen Costa da Silva, Caroline Serrano-Nascimento, Caroline Serrano-Nascimento, Caroline Serrano-Nascimento

“…This study aimed to investigate the impact of intrauterine exposure to DEHP on the HPT axis function programming of the offspring animals during adulthood.MethodsPregnant Wistar rats were orally treated with corn oil or corn oil supplemented with DEHP (0.48 or 4.8 mg/kg/day) throughout the gestational period. …”
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Computing spaces in type theory by Doré, M

“…Using the example of the powerset, we show how both mathematical <em>definitions</em> and <em>programs</em> can be expressed and related with one another in type theory. We show how a functional program implementing the powerset can be shown to satisfy the mathematical definition of the powerset, thereby allowing for using interchangeably the program and its mathematical specification.…”

3560 Using Research Performance Progress Report data to Explore CTSI-Stakeholder Engagement through Network Analysis by Elizabeth Wayman, Eric P. Rubinstein, Camille Anne Martina, Ann Marie Dozier

“…The first were CTSI internal functions/programs, i.e. the entities that submitted RPPR sections and formed an interconnected sub-network. …”
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Safe food for infants: An EU-China project to enhance the control of safety risks raised by microbial and chemical hazards all along the infant food chains by Erwan Engel, Gilles Rivière, Diana Kemmer, Oliver Deusch, Norbert Fuchsbauer, Steven Biesterveld, Evangelia Krystalli, Marion Bondoux, Guang Li, Weikang Yang, Jianbo Hou, Ying Liang, Hua Yang, Weihuan Fang, Massimo Pettoello-Mantovani, Brian Flynn, Kalliopi Rantsiou, Bart Van der Burg, Sara Bover-Cid, Marcel H. Zwietering

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Nitrosyl-Heme and Heme Iron Intake from Processed Meats in Subjects from the EPIC-Spain Cohort by Lucía Rizzolo-Brime, Andreu Farran-Codina, Ricard Bou, Leila Luján-Barroso, Jose Ramón Quirós, Pilar Amiano, María José Sánchez, Miguel Rodríguez-Barranco, Marcela Guevara, Conchi Moreno-Iribas, Alba Gasque, María-Dolores Chirlaque, Sandra M. Colorado-Yohar, José María Huerta Castaño, Antonio Agudo, Paula Jakszyn

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Tumor-Derived cGAMP Regulates Activation of the Vasculature by Marco Campisi, Marco Campisi, Shriram K. Sundararaman, Shriram K. Sundararaman, Sarah E. Shelton, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Elena Ivanova, Israel Cañadas, Israel Cañadas, Tatsuya Osaki, Tatsuya Osaki, Sharon Wei Ling Lee, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Roger D. Kamm, Shunsuke Kitajima, Shunsuke Kitajima, David A. Barbie, David A. Barbie

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