<i>Cachrys</i> spp. from Southern Italy: Phytochemical Characterization and JAK/STAT Signaling Pathway Inhibition by Maria Rosaria Perri, Michele Pellegrino, Stefano Aquaro, Fabiola Cavaliere, Carmine Lupia, Dimitar Uzunov, Mariangela Marrelli, Filomena Conforti, Giancarlo Statti

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Different Seasonal Collections of <i>Ficus carica</i> L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes by Mariachiara Pucci, Manuela Mandrone, Ilaria Chiocchio, Eileen Mac Sweeney, Emanuela Tirelli, Daniela Uberti, Maurizio Memo, Ferruccio Poli, Andrea Mastinu, Giulia Abate

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Phytochemical Characterization, and Antioxidant and Antimicrobial Properties of Agitated Cultures of Three Rue Species: <i>Ruta chalepensis</i>, <i>Ruta corsica</i>, and <i>Ruta gr... by Agnieszka Szewczyk, Andreana Marino, Jessica Molinari, Halina Ekiert, Natalizia Miceli

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Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata by Chung, L.Y., Yap, K.F., Mustafa, Mohd Rais, Goh, S.H., Imiyabir, Z.

“…Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. …”
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Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice by Łukasz Kurach, Sylwia Kulczycka-Mamona, Joanna Kowalczyk, Krystyna Skalicka-Woźniak, Anna Boguszewska-Czubara, Nesrine El Sayed, Mitat Osmani, Karol Iwaniak, Barbara Budzyńska

“…The present study aimed to investigate the neuroprotective effects of xanthotoxin (furanocoumarin) and umbelliferone (simple coumarin) in lipopolysaccharide-induced cognitive dysfunction in mice. …”
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Isolation And Characterization Of Phenylalanine Ammonia Lyase (Pal) And Other Defence Response Genes From Oil Palm (Elaies Guineensis Jacq.) by Hwang, Siaw San

“…Phenylpropanoid metabolism is a plant specific pathway that leads to the production of secondary metabolites including isoflavonoid phytoalexins, lignin, flavonoid pigments and UV protectants such as furanocoumarin. Here, we report the isolation of several , different clones that are involved in the plant defense response by screening of oil palm zygotic embryo and suspension culture cDNA libraries.These clones include phenylalanine ammonia- lyase (PAL) (4-4A, II F I and 12B1), S-adenosylmethionine synthetase I (Adomet synthetase I) (11 AI), peroxidase (7 A2), chitinase III (4A3), calmodulin (3E2), and beta-ketoacyl-CoA synthase (KCS) (3G 1).…”
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Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential by Lutfun Nahar, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul, Satyajit D. Sarker

“…Dihydrofuranocoumarin, chalepin (<b>1</b>) and furanocoumarin, chalepensin (<b>2</b>) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant <i>Ruta chalepensis</i> L. …”
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An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa by Alice Nguvoko Kiyonga, Gyu Hwan Park, Hyun Su Kim, Young-Ger Suh, Tae Kon Kim, Kiwon Jung

“…In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of <i>Ostericum koreanum</i>. …”
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Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB by Ning An, Tao Yang, Xiao-Xia Zhang, Mei-xia Xu

“…Since bergamottin is a natural furanocoumarin showing the ability to inhibit the activation of NF-κB, in this study we aimed to determine the effect of bergamottin on ALI. …”
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Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549 Lung Adenocarcinoma Cells via Modulation of STAT3, NF-κB, and AP-1 Activation by Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree

“…Therefore, blocking the IL-17-induced oncogenic pathway is a new strategy for the treatment of lung cancer. Notopterol, a furanocoumarin, has demonstrated anti-tumor effects in several types of tumors. …”
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Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism by Yu Wang, Quan Zhou, Huihui Wang, Wei Song, Jianfeng Wang, Abdullah Al Mamun, Peiwu Geng, Yunfang Zhou, Shuanghu Wang

“…This work aimed to explore the mechanisms underlying the interaction of the active furanocoumarins in P. corylifolia on tofacitinib both in vivo and in vitro. …”
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Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition by Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Gautam Sethi, Kwang Seok Ahn

“…Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. …”
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Comparative analysis of metabolites and antioxidant potentials from different plant parts of Curcuma aeruginosa roxb by Sanimah Simoh, Sew, Yun Shin, Fazri Abd Rahim, Muhammad Aizuddin Ahmad, Alizah Zainal

“…The Principal Component Analysis (PCA) indicated that there was a clear distinction between rhizomes and other plant parts, i.e. stems, leaves, and adventitious roots that could be explained by relatively higher contents of terpenoids including curzerene, alpha-farnesen, furanocoumarin, velleral, germacrone cineole, borneol, beta- and gamma- elemene and methenolone. …”
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Ameliorative Effect of Imperatorin on <i>Dermatophagoides pteronyssinus</i>-Induced Allergic Asthma by Suppressing the Th2 Response in Mice by Chia-Chen Hsieh, Yan-Yan Ng, Wei-Sung Li, Chung-Yuh Tzeng, Tsai-Yi Hsu, Wan-Hsiang Huang, Jen-Chieh Tsai

“…Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. …”
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Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells by Wenhui Hao, Xuenong Zhang, Wenwen Zhao, Xiuping Chen

“…Psoralidin (PSO), a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties. …”
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Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links between Traditional Characters and the Skin Lipoperoxidation “Western” Model by Jose M. Prieto, Guillermo R. Schinella

“…The therapeutic value of the remaining drugs—with low antioxidant or anti-inflammatory activity—seems to be based on their actions on the Qi with the exception of furanocoumarin containing herbs—<i>A. dahurica</i> and <i>A. pubescens</i>—which “expel wind”. …”
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The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies by Miriam Rossi, Sandjida Aktar, Marissa Davis, Emily Hefter Feuss, Samara Roman-Holba, Kelly Wen, Christopher Gahn, Francesco Caruso

“…Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4). …”
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Flavonoids and Limonoids Profiles Variation in Leaves from Mandarin Cultivars and Its Relationship with Alternate Bearing by Cecilia Rodríguez Ceraolo, Valeria Vázquez, Ignacio Migues, María Verónica Cesio, Fernando Rivas, Horacio Heinzen

“…To investigate the changes during this transition, a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis of the leaf profiles of 20 compounds (17 polyphenols, two limonoids, and one furanocoumarin), in bearing and non-bearing branches arising from four different mandarin genotypes, was performed. …”
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Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction by Qingxia Shen, Wanyi Huang, Yueyang Qiu, Shuze Wang, Bin Zhang, Ningning Sun, Qing Zhou

“…Bergapten, a furanocoumarin naturally occurring in bergamot essential oil, has been demonstrated to have the potential to alleviate osteoarthritis-related symptoms via its anti-inflammatory activity. …”
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Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration by Ming-Cong Zheng, Wen-Ting Tang, Lu-Lu Yu, Xun-Jia Qian, Jie Ren, Jie-Jia Li, Wei-Wei Rong, Jun-Xu Li, Qing Zhu

“…Oxypeucedanin, a furanocoumarin extracted from many traditional Chinese herbal medicines, has a variety of pharmacological effects. …”
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