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<i>Cachrys</i> spp. from Southern Italy: Phytochemical Characterization and JAK/STAT Signaling Pathway Inhibition
Published 2022-10-01Subjects: Get full text
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Different Seasonal Collections of <i>Ficus carica</i> L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes
Published 2022-07-01Subjects: Get full text
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Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata
Published 2008“…Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. …”
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Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice
Published 2021-02-01“…The present study aimed to investigate the neuroprotective effects of xanthotoxin (furanocoumarin) and umbelliferone (simple coumarin) in lipopolysaccharide-induced cognitive dysfunction in mice. …”
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Isolation And Characterization Of Phenylalanine Ammonia Lyase (Pal) And Other Defence Response Genes From Oil Palm (Elaies Guineensis Jacq.)
Published 2002“…Phenylpropanoid metabolism is a plant specific pathway that leads to the production of secondary metabolites including isoflavonoid phytoalexins, lignin, flavonoid pigments and UV protectants such as furanocoumarin. Here, we report the isolation of several , different clones that are involved in the plant defense response by screening of oil palm zygotic embryo and suspension culture cDNA libraries.These clones include phenylalanine ammonia- lyase (PAL) (4-4A, II F I and 12B1), S-adenosylmethionine synthetase I (Adomet synthetase I) (11 AI), peroxidase (7 A2), chitinase III (4A3), calmodulin (3E2), and beta-ketoacyl-CoA synthase (KCS) (3G 1).…”
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Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential
Published 2021-03-01“…Dihydrofuranocoumarin, chalepin (<b>1</b>) and furanocoumarin, chalepensin (<b>2</b>) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant <i>Ruta chalepensis</i> L. …”
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An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
Published 2021-10-01“…In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of <i>Ostericum koreanum</i>. …”
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Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
Published 2021-10-01“…Since bergamottin is a natural furanocoumarin showing the ability to inhibit the activation of NF-κB, in this study we aimed to determine the effect of bergamottin on ALI. …”
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Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549 Lung Adenocarcinoma Cells via Modulation of STAT3, NF-κB, and AP-1 Activation
Published 2023-10-01“…Therefore, blocking the IL-17-induced oncogenic pathway is a new strategy for the treatment of lung cancer. Notopterol, a furanocoumarin, has demonstrated anti-tumor effects in several types of tumors. …”
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Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism
Published 2024-04-01“…This work aimed to explore the mechanisms underlying the interaction of the active furanocoumarins in P. corylifolia on tofacitinib both in vivo and in vitro. …”
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Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition
Published 2018-07-01“…Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. …”
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Comparative analysis of metabolites and antioxidant potentials from different plant parts of Curcuma aeruginosa roxb
Published 2018“…The Principal Component Analysis (PCA) indicated that there was a clear distinction between rhizomes and other plant parts, i.e. stems, leaves, and adventitious roots that could be explained by relatively higher contents of terpenoids including curzerene, alpha-farnesen, furanocoumarin, velleral, germacrone cineole, borneol, beta- and gamma- elemene and methenolone. …”
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Ameliorative Effect of Imperatorin on <i>Dermatophagoides pteronyssinus</i>-Induced Allergic Asthma by Suppressing the Th2 Response in Mice
Published 2022-10-01“…Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. …”
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Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells
Published 2014-09-01“…Psoralidin (PSO), a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties. …”
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Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links between Traditional Characters and the Skin Lipoperoxidation “Western” Model
Published 2022-03-01“…The therapeutic value of the remaining drugs—with low antioxidant or anti-inflammatory activity—seems to be based on their actions on the Qi with the exception of furanocoumarin containing herbs—<i>A. dahurica</i> and <i>A. pubescens</i>—which “expel wind”. …”
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The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies
Published 2020-07-01“…Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4). …”
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Flavonoids and Limonoids Profiles Variation in Leaves from Mandarin Cultivars and Its Relationship with Alternate Bearing
Published 2022-01-01“…To investigate the changes during this transition, a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis of the leaf profiles of 20 compounds (17 polyphenols, two limonoids, and one furanocoumarin), in bearing and non-bearing branches arising from four different mandarin genotypes, was performed. …”
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Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction
Published 2023-11-01“…Bergapten, a furanocoumarin naturally occurring in bergamot essential oil, has been demonstrated to have the potential to alleviate osteoarthritis-related symptoms via its anti-inflammatory activity. …”
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Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration
Published 2022-06-01“…Oxypeucedanin, a furanocoumarin extracted from many traditional Chinese herbal medicines, has a variety of pharmacological effects. …”
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