Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients by C.G. Barbosa, N.J. Goncalves-Santos, S.B. Souza-Ribeiro, J.P. Moura-Neto, D. Takahashi, D.O. Silva, A.F. Hurtado-Guerrero, M.G. Reis, M.S. Goncalves

Get full text

Effect of hydroxyurea on SP1, LIN28B, IGF2BP3, COL4A5, BCL2, gamma globin genes expression: an in vitro study by Akram Agha-Amini Fashami, Esmat Alemzadeh, Hossein Safarpour, Ebrahim Miri-Moghaddam

Get full text

The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease by John D. Belcher, Selvaraj Nataraja, Fuad Abdulla, Ping Zhang, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Maneet Singh, Shilpa Demes, Lyndsay Olson, Domi Stickens, Jeff Stanwix, Emer Clarke, Yongzhao Huang, Margaret Biddle, Gregory M. Vercellotti

Subjects: Get full text

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes by Martin H. Steinberg

Subjects: Get full text

Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease by Waseem Chauhan, Rahima Zennadi

Subjects: Get full text

Epigenetic modulations on the fetal hemoglobin induction by Najmaldin Saki, Mehrdad Noruzinia, Saeid Kaviani, Ali Dehghani Fard, Esmaeil Mortaz

“…The epigenetic modifications including DNA methylation and histon modification play an important role in γ-globin gene over-expression in mature stage of erythropoiesis. …”
Get full text

Efficacy of ruxolitinib as inducer of fetal hemoglobin in primary erythroid cultures from sickle cell and beta-thalassemia patients by Alice Pecoraro, Antonio Troia, Aurelio Maggio, Rosalba Di Marzo

“…In particular STAT3 is a repressor of gamma-globin gene. The decrease of STAT3 phosphorilation could derepress gamma-globin gene and reactivate its trascription. …”
Get full text

Characterisation of beta globin gene cluster deletions using multiplex-Gap-PCR and Multiplex Ligation-dependent Probe Amplification (MLPA) by Redzuwan, Yasmin Mohamad

“…These deletions occur at gamma-globin gene 1 (HBG1) and gamma-globin gene 2 (HBG2) in exon 3. …”
Get full text

Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene. by Plant, K, Dye, M, Lafaille, C, Proudfoot, N

“…The human gamma-globin genes form part of a 5-kb tandem duplication within the beta-globin gene cluster on chromosome 11. …”

A silent deletion in the beta-globin gene cluster. by Tate, V, Hill, A, Bowden, D, Sadler, JR, Weatherall, D, Clegg, J

“…A survey of the gamma-globin gene region of over 1000 normal individuals revealed a novel 2.5 kb deletion which removes the 5' end of the A gamma-globin gene. …”

Molecular Mechanisms of Hemoglobin F Induction by Najmaldin Saki, Ali Dehghani Fard, Majid Farshdousti Hagh, Mohammad Shahjahani, Saied Kaviani

“…During fetal life, HbF is the major hemoglobin but is largely substituted by adult hemoglobin (HbA, α2β2) following a globin expression switch after birth. Increased γ-globin expression can reduce the clinical severity of β-thalassemia and SCD. …”
Get full text

Hypoxia-Induced Alpha-Globin Expression in Syncytiotrophoblasts Mimics the Pattern Observed in Preeclamptic Placentas by Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson

“…Non-erythroid alpha-globin mRNA and protein, but not gamma-globin, were detected in syncytiotrophoblasts and stroma of PE placenta samples. …”
Get full text

Globin genes in Micronesia: origins and affinities of Pacific Island peoples. by O'Shaughnessy, D, Hill, A, Bowden, D, Weatherall, D, Clegg, J

“…DNA polymorphisms and copy-number variants of alpha-, zeta-, and gamma-globin genes have been studied in seven Micronesian island populations and have been compared with those in populations from Southeast Asia, Melanesia, and Polynesia. …”

Relative proteome quantification of alpha, beta, gamma and delta globin chains in early eluting peaks of Bio-Rad variant II® CE-HPLC of hemoglobin from healthy and beta-thalassemia... by Uday Younis Hussein Abdullah, Hishamshah M. Ibrahim, Haitham Muhammed Jassim, Mohamad Zaki Salleh, Teh Lay Kek, Mohd Nur Fakhruzzaman bin Noorizhab, Bin Alwi Zilfalil, Prapin Wilairat, Suthat Fucharoen

“…The objectives were to assess the relationship of the quantity of the free alpha, beta, delta and gamma globin chains with the phenotypic diversity of beta-thalassaemias (β-thal). …”
Get full text

Putative role of Bach1 gene in HbE/beta-thalassaemia patients by Lee, Tze Yan

“…Excess precipitated alpha chains and unstable beta globin chains cause Bach1 expression to increase whereas Bach1 is correlated indirectly with gamma globin chains to ameliorate the clinical severity of HbE/ beta thalassaemia. …”
Get full text

Induction of HBF by Mehran Karimi, Nader Cohan

“…So many studies have focused on explain the pathways that involved in the re-activation of &gamma;-globin gene expression. The HbF inducers are mainly includes chemotherapeutic agents (<em>e.g.…”
Get full text

Polynesian origins and affinities: globin gene variants in eastern Polynesia. by Hill, A, Gentile, B, Bonnardot, J, Roux, J, Weatherall, D, Clegg, J

“…Analysis of copy number variants of the duplicated alpha-, zeta-, and gamma-globin genes in eastern Polynesians revealed a high frequency of both triplicated-zeta-gene chromosomes and a specific alpha thalassemia deletion. …”

The use of monoclonal antibodies UCH beta and UCH gamma for the antenatal diagnosis of beta-thalassaemia. by Allen, C, Weereratne, H, Gale, R, Beverley, P, Huehns, E

“…Monoclonal antibodies for the beta-globin chain of human HbA (UCH beta) and the gamma-globin chain of human HbF (UCH gamma) have been made. …”

Chromosomes with one, two, three, and four fetal globin genes: molecular and hematologic analysis. by Hill, A, Bowden, D, Weatherall, D, Clegg, J

“…Analysis of DNA from 852 Island Melanesians has revealed a high frequency of single- and triple-gamma-globin genes in this population. Homozygotes for triple- and single-gamma genes have normal hematologic findings, normal hemoglobin F (HbF) levels, and when there is coexisting alpha thalassemia, appropriate levels of Bart's Hb (gamma 4) at birth. …”

Mapping sequences in loops of nuclear DNA by their progressive detachment from the nuclear cage. by Cook, P, Brazell, I

“…Equal weights of fragmented DNA are separated by gel electrophoresis, transferred to a filter and the relative amounts of the alpha, beta and gamma globin genes on the filter determined by hybridisation to the appropriate probes. …”