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Gene-gene interactions in breast cancer susceptibility
Published 2012“…There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10 -4; ATM and BRCA1, P= 0.01; ATM and BRCA2, P= 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 × 10 =4; CHEK2 and BRCA1, P= 0.01; CHEK2 and BRCA2, P= 0.01). …”
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Gene-gene interactions in breast cancer susceptibility.
Published 2012“…There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10(-4); ATM and BRCA1, P= 0.01; ATM and BRCA2, P= 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 × 10(-4); CHEK2 and BRCA1, P= 0.01; CHEK2 and BRCA2, P= 0.01). …”
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Programmed gene rearrangements altering gene expression.
Published 1987“…Programmed gene rearrangements are used in nature to to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens). …”
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Screening-testing approaches for gene-gene and gene-environment interactions using independent statistics
Published 2013-12-01Get full text
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Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development
Published 2012-01-01“…This paper reviews and summarizes how gene-gene and gene-environment interactions affect IgE production and the development of atopic asthma in prenatal and childhood stages. …”
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Phytase Activity and Isolation of the Phytase Gene of Mitsuokella Jalaludinii
Published 2008Subjects: “…Genes…”
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Gene Association Classification for Autism Spectrum Disorder: Leveraging Gene Embedding and Differential Gene Expression Profiles to Identify Disease-Related Genes
Published 2023-08-01Subjects: “…gene associations…”
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Various microbial taxa couple arsenic transformation to nitrogen and carbon cycling in paddy soils
Published 2024-11-01Subjects: “…Arsenite oxidation genes…”
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Powerful Tukey's One Degree-of-Freedom Test for Detecting Gene-Gene and Gene-Environment Interactions
Published 2015-01-01“…This “missing heritability” problem has been partly attributed to the yet-to-be-identified gene-gene (G × G) and gene-environment (G × E) interactions. …”
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Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes
Published 2021-08-01Subjects: “…Gene gain…”
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Association, Haplotype, and Gene-Gene Interactions of the HPA Axis Genes with Suicidal Behaviour in Affective Disorders
Published 2013-01-01“…Therefore, we found it interesting to study polymorphisms of genes involved in the HPA axis (CRHR1, NR3C1, and AVPBR1). …”
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Effect of gene–gene and gene–environment interaction on the risk of first‐ever stroke and poststroke death
Published 2019-08-01Subjects: Get full text
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PrismEXP: gene annotation prediction from stratified gene-gene co-expression matrices
Published 2023-02-01Subjects: Get full text
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The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.
Published 2005“…We here report the cDNA sequences of 11 new rat Ly49 genes with full and three with incomplete open reading frames. …”
Journal article