Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis by Lin, K, Pulit, SL, Van Rheenen, W, Shatunov, A, Dekker, AM, McLaughlin, RL, Diekstra, FP, Van Der Spek, RAA, Võsa, U, De Jong, S, Robinson, MR, Yang, J, Fogh, I, Van Doormaal, PT, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, Van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Rogelj, B, Vrabec, K, Ravnik-Glavač, M, Koritnik, B, Zidar, J, Leonardis, L, Grošelj, LD, Millecamps, S, Salachas, F, Meininger, V, De Carvalho, M, Pinto, S, Mora, JS, Rojas-García, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-Pazos, M, Lomen-Hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, AN, Tunca, C, Hamzeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-Blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Dürr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nöthen, MM, Amouyel, P, Tzourio, C, Dartigues, J-F, Uitterlinden, AG, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Blauw, HM, Van Der Kooi, AJ, De Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'Alfonso, S, Bertolin, C, Sorarù, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Registry, P, Slalom Group, Registry, S, Fals Sequencing Consortium, Slagen Consortium, Nnipps Study Group, Blair, I, Zhang, K, McCann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hübner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, Van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'H, P, Silani, V, Wray, NR, Visscher, PM, De Bakker, PIW, Van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-Chalabi, A, Van Den Berg, LH, Veldink, JH

“…To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). …”

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection by Schoech, AP, Jordan, DM, Loh, P-R, Gazal, S, O'Connor, LJ, Balick, DJ, Palamara, PF, Finucane, HK, Sunyaev, SR, Price, AL

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study by Guerreiro, R, Ross, OA, Kun-Rodrigues, C, Hernandez, DG, Orme, T, Eicher, JD, Shepherd, CE, Parkkinen, L, Darwent, L, Heckman, MG, Scholz, SW, Troncoso, JC, Pletnikova, O, Ansorge, O, Clarimon, J, Lleo, A, Morenas-Rodriguez, E, Clark, L, Honig, LS, Marder, K, Lemstra, A, Rogaeva, E, St George-Hyslop, P, Londos, E, Zetterberg, H, Barber, I, Braae, A, Brown, K, Morgan, K, Troakes, C, Al-Sarraj, S, Lashley, T, Holton, J, Compta, Y, Van Deerlin, V, Serrano, GE, Beach, TG, Lesage, S, Galasko, D, Masliah, E, Santana, I, Pastor, P, Diez-Fairen, M, Aguilar, M, Tienari, PJ, Myllykangas, L, Oinas, M, Revesz, T, Lees, A, Boeve, BF, Petersen, RC, Ferman, TJ, Escott-Price, V, Graff-Radford, N, Cairns, NJ, Morris, JC, Pickering-Brown, S, Mann, D, Halliday, GM, Hardy, J, Trojanowski, JQ, Dickson, DW, Singleton, A, Stone, DJ, Bras, J

Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report) by Fedko, IO, Hottenga, JJ, Helmer, Q, Mbarek, H, Huider, F, Amin, N, Beulens, JW, Bremmer, MA, Elders, PJ, Galesloot, TE, Kiemeney, LA, Van Loo, HM, Picavet, HSJ, Rutters, F, Van Der Spek, A, Van De Wiel, AM, Van Duijn, C, De Geus, EJC, Feskens, EJM, Hartman, CA, Oldehinkel, AJ, Smit, JH, Verschuren, WMM, Penninx, BWJH, Boomsma, DI, Bot, M

The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study by Foote, IF, Jacobs, BM, Mathlin, G, Watson, CJ, Bothongo, PLK, Waters, S, Dobson, R, Noyce, AJ, Bhui, KS, Korszun, A, Marshall, CR

“…Taken together, our findings suggest that there is extensive shared genetic architecture between AD modifiable risk factors, but this is largely independent of AD genetic pathways. …”

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation by Courtney J Smith, Nasa Sinnott-Armstrong, Anna Cichońska, Heli Julkunen, Eric B Fauman, Peter Würtz, Jonathan K Pritchard

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Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume’s Nutritional Composition and Protein Quality by Francisco A. Mendes, Susana T. Leitão, Verónica Correia, Elsa Mecha, Diego Rubiales, Maria Rosário Bronze, Maria Carlota Vaz Patto

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TeaGVD: A comprehensive database of genomic variations for uncovering the genetic architecture of metabolic traits in tea plants by Jie-Dan Chen, Wei-Zhong He, Si Chen, Qi-Yu Chen, Jian-Qiang Ma, Ji-Qiang Jin, Chun-Lei Ma, Doo-Gyung Moon, Sezai Ercisli, Ming-Zhe Yao, Liang Chen

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WHOLE GENOME SEQUENCING ANALYSIS IDENTIFIES GENETIC ARCHITECTURE UNDERLYING FEMALE PROTECTIVE EFFECT IN AUTISM SPECTRUM DISORDER by Hee Jeong Yoo, Soowhee Kim, Jungeun Ji, Hyeji Lee, Ganghee Lee, Da-Yea Song, Jung Woo Park, Eunha Kim, Junehawk Lee, Jung Kyoon Choi, Jeong Ho Lee, Eunjoon Kim, Donna Werling, Joon-Yong An

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Dissection of genetic architecture for tiller angle in rice (Oryza sativa. L) by multiple genome-wide association analyses by Muhammad Abdul Rehman Rashid, Rana Muhammad Atif, Yan Zhao, Farrukh Azeem, Hafiz Ghulam Muhu-Din Ahmed, Yinghua Pan, Danting Li, Yong Zhao, Zhanying Zhang, Hongliang Zhang, Jinjie Li, Zichao Li

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Author Correction: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits by Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gómez-Olivé, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, AWI-Gen study, H3Africa Consortium, Scott Hazelhurst, Michèle Ramsay

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Genetic architecture of adult-plant resistance to stripe rust in bread wheat (Triticum aestivum L.) association panel by Genet Atsbeha, Tilahun Mekonnen, Mulugeta Kebede, Teklehaimanot Haileselassie, Stephen B. Goodwin, Kassahun Tesfaye, Kassahun Tesfaye

“…Therefore, the present study targeted the genetic architecture of adult plant resistance to yellow rust in 178 wheat association panels. …”
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Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults by Xiayin Zhang, Shan Wang, Shunming Liu, Zijing Du, Guanrong Wu, Yingying Liang, Yu Huang, Xianwen Shang, Yijun Hu, Zhuoting Zhu, Wei Sun, Xueli Zhang, Honghua Yu

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Exploring the Genetic Architecture of Root-Related Traits in Mediterranean Bread Wheat Landraces by Genome-Wide Association Analysis by Rubén Rufo, Silvio Salvi, Conxita Royo, Jose Miguel Soriano

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Genetic architecture of salt tolerance in a Multi-Parent Advanced Generation Inter-Cross (MAGIC) cowpea population by Waltram Ravelombola, Ainong Shi, Bao-Lam Huynh, Jun Qin, Haizheng Xiong, Aurora Manley, Lingdi Dong, Dotun Olaoye, Gehendra Bhattarai, Bazgha Zia, Huda Alshaya, Ibtisam Alatawi

“…To the best of our knowledge, this study was one of the earliest reports using a MAGIC population to investigate the genetic architecture of salt tolerance in cowpea.…”
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LSO-076 Understanding the genetic architecture of SLE from the perspective of associations from 14 other autoimmune diseases by Wanling Yang, Yong-Fei Wang, Xiao Dang

Unraveling the Genetic Architecture for Low Temperature Germinability-Related Traits in Rice Using Genome-Wide Association Study by Caijing Li, Baoli Zou, Changsheng Lu, Guiting Song, Qiang Gao, Peng Wang, Guangliang Wu, Wei Jin, Hui Yin, Qin Cheng, Yanning Wang, Qi Zhong, Shiying Huang, Mengmeng Yang, Tao Huang, Haohua He, Jianmin Bian

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Using High-Throughput Phenotyping Analysis to Decipher the Phenotypic Components and Genetic Architecture of Maize Seedling Salt Tolerance by Shangjing Guo, Lujia Lv, Yanxin Zhao, Jinglu Wang, Xianju Lu, Minggang Zhang, Ronghuan Wang, Ying Zhang, Xinyu Guo

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Insights into the Genetic Architecture and Genomic Prediction of Powdery Mildew Resistance in Flax (<i>Linum usitatissimum</i> L.) by Frank M. You, Khalid Y. Rashid, Chunfang Zheng, Nadeem Khan, Pingchuan Li, Jin Xiao, Liqiang He, Zhen Yao, Sylvie Cloutier

“…To fully dissect the genetic architecture of PM resistance and identify QTL, a diverse flax core collection of 372 accessions augmented with an additional 75 breeding lines were sequenced, and PM resistance was evaluated in the field for eight years (2010–2017) in Morden, Manitoba, Canada. …”
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Genetic architecture of tuber-bound free amino acids in potato and effect of growing environment on the amino acid content by Jeewan Pandey, Dalton Thompson, Madhumita Joshi, Douglas C. Scheuring, Jeffrey W. Koym, Vijay Joshi, M. Isabel Vales

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