PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders by Apostolia Topaloudi, Pritesh Jain, Melanie B. Martinez, Josephine K. Bryant, Grace Reynolds, Grace Reynolds, Zoi Zagoriti, George Lagoumintzis, Eleni Zamba-Papanicolaou, John Tzartos, Konstantinos Poulas, Kleopas A. Kleopa, Socrates Tzartos, Socrates Tzartos, Marianthi Georgitsi, Petros Drineas, Peristera Paschou

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Integration of multiple-omics data to reveal the shared genetic architecture of educational attainment, intelligence, cognitive performance, and Alzheimer’s disease by Fuxu Wang, Haoyan Wang, Ye Yuan, Bing Han, Shizheng Qiu, Yang Hu, Tianyi Zang

“…Growing evidence suggests the effect of educational attainment (EA) on Alzheimer’s disease (AD), but less is known about the shared genetic architecture between them. Here, leveraging genome-wide association studies (GWAS) for AD (N = 21,982/41,944), EA (N = 1,131,881), cognitive performance (N = 257,828), and intelligence (N = 78,308), we investigated their causal association with the linkage disequilibrium score (LDSC) and Mendelian randomization and their shared loci with the conjunctional false discovery rate (conjFDR), transcriptome-wide association studies (TWAS), and colocalization. …”
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Integrating genome-wide association studies and population genomics analysis reveals the genetic architecture of growth and backfat traits in pigs by Liangyu Shi, Liangyu Shi, Ligang Wang, Lingzhao Fang, Mianyan Li, Jingjing Tian, Lixian Wang, Fuping Zhao

“…In summary, the candidate genes will provide an insight into the understanding of the genetic architecture of growth-related traits and backfat thickness, and may have a potential use in the genomic breeding programs in pigs.…”
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The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study by Nagham Nafiz Hendi, Marlene Chakhtoura, Yasser Al-Sarraj, Dania Saleh Basha, Omar Albagha, Ghada El-Hajj Fuleihan, Georges Nemer

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Multi-locus genome-wide association studies reveal the genetic architecture of Fusarium head blight resistance in durum wheat by Jemanesh K. Haile, Demissew Sertse, Amidou N’Diaye, Valentyna Klymiuk, Krystalee Wiebe, Yuefeng Ruan, Harmeet S. Chawla, Maria-Antonia Henriquez, Lipu Wang, Hadley R. Kutcher, Barbara Steiner, Hermann Buerstmayr, Curtis J. Pozniak

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Study of genetic architecture of grain yield and quality traits through generation mean analysis in rice (Oryza sativa L.) by Ch. Sreelakshmi* and P. Ramesh Babu

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The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine by Lăcrămioara Ionela Butnariu, Eusebiu Vlad Gorduza, Laura Florea, Elena Țarcă, Ștefana Maria Moisă, Laura Mihaela Tradafir, Elena Cojocaru, Alina-Costina Luca, Laura Stătescu, Minerva Codruța Bădescu

“…The results of these studies showed that the genetic architecture of LEAD is extremely heterogeneous. …”
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Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma by Xikun Han, Zhaozhong Zhu, Qian Xiao, Jun Li, Xiumei Hong, Xiaobin Wang, Kohei Hasegawa, Carlos A. Camargo, Liming Liang

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Adaptation via pleiotropy and linkage: Association mapping reveals a complex genetic architecture within the stickleback Eda locus by Sophie L. Archambeault, Luis R. Bärtschi, Aurélie D. Merminod, Catherine L. Peichel

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Genetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA by Shengxin Fan, Pengtao Yuan, Shuaihao Li, Hongtai Li, Bin Zhai, Yuanfang Li, Hongyuan Zhang, Jinxin Gu, Hong Li, Yadong Tian, Xiangtao Kang, Yanhua Zhang, Guoxi Li

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Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis by Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen

“…Here, we characterize the genetic architecture of IBS, further, investigate its genetic overlap with psychiatric and gastrointestinal phenotypes, and identify novel genomic risk loci. …”
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Combination of meta‐analysis of QTL and GWAS to uncover the genetic architecture of seed yield and seed yield components in common bean by Paulo Izquierdo, James D. Kelly, Stephen E. Beebe, Karen Cichy

“…However, the complex genetic architecture and prevalent genotype by environment interactions for seed yield makes increasing genetic gains challenging. …”
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The shared genetic architecture of smoking behaviours and psychiatric disorders: evidence from a population-based longitudinal study in England by Olesya Ajnakina, Andrew Steptoe

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Assessing the Performance of Ridge Regression Method-6 in Genomic Evaluation of Discrete Threshold Traits with Additive and Dominance Genetic Architecture by Farhad Ghafouri-Kesbi

“…However, so far, this method has not been used in the genomic evaluation of threshold traits with additive and dominant genetic architecture, and its performance in this field is not known. …”
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Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture by Chia, R, Sabir, MS, Bandres-Ciga, S, Parkkinen, L, Ansorge, O

“…Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. …”

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression. by Kaisaki, P, Otto, G, Argoud, K, Collins, S, Wallis, R, Wilder, S, Yau, A, Hue, C, Calderari, S, Bihoreau, M, Cazier, J, Mott, R, Gauguier, D

Shared genetic architecture of hernias: a genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes by Ahmed, WU-R, Patel, MIA, Ng, M, McVeigh, J, Zondervan, K, Wiberg, A, Furniss, D

Genetic architecture of Al 3+ toxicity tolerance in rice F 2:3 populations determined through QTL mapping by Jahan, Nusrat, Javed, Muhammad Arshad, Khan, Anwar, Abd. Manan, Fazilah, Tabassum, Bushra

Genetic architecture of Al3+ toxicity tolerance in rice F2:3 populations determined through QTL mapping by Jahan, Nusrat, Javed, Muhammad Arshad, Khan, Anwar, Abd. Manan, Fazilah, Tabassum, Bushra

Tightly linked antagonistic‐effect loci underlie polygenic phenotypic variation in C. elegans by Max R. Bernstein, Stefan Zdraljevic, Erik C. Andersen, Matthew V. Rockman

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