Gregor Mendel's legacy in quantitative genetics. by Trudy F C Mackay, Robert R H Anholt

“…Gregor Mendel's discovery of the laws of segregation and independent assortment and his inference of the existence of non-mendelian interactions between loci remain at the heart of today's explorations of the genetic architecture of quantitative traits.…”
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Genetics: finding genes for schizophrenia. by Flint, J, Munafò, MR

“…New studies have substantially advanced our understanding of the genetic architecture of schizophrenia, but we are far from identifying the underlying mutations. …”

Single-Locus versus Multilocus Patterns of Local Adaptation to Climate in Eastern White Pine (Pinus strobus, Pinaceae). by Om P Rajora, Andrew J Eckert, John W R Zinck

“…However, little empirical work has focused on the relative contribution of single-locus versus multilocus effects to the genetic architecture of local adaptation in plants/forest trees. …”
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Mapping the Diverse and Inclusive Future of Parkinson’s Disease Genetics and Its Widespread Impact by Inas Elsayed, Alejandro Martinez-Carrasco, Mario Cornejo-Olivas, Sara Bandres-Ciga

“…As we move forward, shedding light on the genetic architecture contributing to PD in non-European populations is essential, and will provide novel insight into the generalized genetic map of the disease. …”
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CRISPR/Cas-Based Approaches to Study Schizophrenia and Other Neurodevelopmental Disorders by Artemiy O. Kurishev, Dmitry S. Karpov, Nonna I. Nadolinskaia, Anna V. Goncharenko, Vera E. Golimbet

“…Moreover, genomic association studies have revealed the complex genetic architecture of schizophrenia and other genetically determined mental disorders. …”
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Mosaic patterns of selection in genomic regions associated with diverse human traits. by Abin Abraham, Abigail L LaBella, John A Capra, Antonis Rokas

“…Natural selection shapes the genetic architecture of many human traits. However, the prevalence of different modes of selection on genomic regions associated with variation in traits remains poorly understood. …”
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Fine-mapping complex traits in heterogeneous stock rats by Baud, A

“…</p><p>I made some important observations about the nature of genetic architecture in rats, and how this compares to mice and humans. …”

Genome-wide association study of leprosy in Malawi and Mali by Gilchrist, JJ, Auckland, K, Parks, T, Mentzer, A, Band, G, Fairfax, B, Hill, A

“…More broadly, our data highlights the importance of defining the genetic architecture of disease across genetically diverse populations, and that disease insights derived from GWAS in one population may not translate to all affected populations.…”

Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population by Di Zhu, Yiqiang Zhao, Ran Zhang, Hanyu Wu, Gengyuan Cai, Zhenfang Wu, Yuzhe Wang, Xiaoxiang Hu

“…The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. …”
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Comparing modeling methods of genomic prediction for growth traits of a tropical timber species, Shorea macrophylla by Haruto Akutsu, Mohammad Na’iem, Widiyatno, Sapto Indrioko, Sawitri, Susilo Purnomo, Kentaro Uchiyama, Yoshihiko Tsumura, Naoki Tani, Naoki Tani

“…The GBLUP and RKHS methods gave the highest predictive ability for D7 and H7 with the sets of selected SNPs and showed that D7 has an additive genetic architecture while H7 has an epistatic genetic architecture. …”
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Adaptation of maize to temperate climates: mid-density genome-wide association genetics and diversity patterns reveal key genomic regions, with a major contribution of the Vgt2 (ZC... by Sophie Bouchet, Bertrand Servin, Pascal Bertin, Delphine Madur, Valérie Combes, Fabrice Dumas, Dominique Brunel, Jacques Laborde, Alain Charcosset, Stéphane Nicolas

“…To gain insight into the genetic architecture of this adaptive trait, we conducted a 50K SNP-based genome-wide association and diversity investigation on a panel of tropical and temperate American and European representatives. …”
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Improving the accuracy of whole genome prediction for complex traits using the results of genome wide association studies. by Zhe Zhang, Ulrike Ober, Malena Erbe, Hao Zhang, Ning Gao, Jinlong He, Jiaqi Li, Henner Simianer

“…Utilizing the whole genomic variation of complex traits to predict the yet-to-be observed phenotypes or unobserved genetic values via whole genome prediction (WGP) and to infer the underlying genetic architecture via genome wide association study (GWAS) is an interesting and fast developing area in the context of human disease studies as well as in animal and plant breeding. …”
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Genome-wide association study of quality traits and starch pasting properties of maize kernels by Xinmei Guo, Zhaopeng Ge, Ming Wang, Meiai Zhao, Yuhe Pei, Xiyun Song

“…The identified candidate genes will be useful for further understanding of the genetic architecture of starch pasting properties in maize. …”
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What Can Machine Learning Approaches in Genomics Tell Us about the Molecular Basis of Amyotrophic Lateral Sclerosis? by Christina Vasilopoulou, Andrew P. Morris, George Giannakopoulos, Stephanie Duguez, William Duddy

“…Lastly, it is suggested that future advances in the genomic and machine learning fields will bring about a better understanding of ALS genetic architecture, and enable improved personalized approaches to this and other devastating and complex diseases.…”
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Population Divergence along a Genetic Line of Least Resistance in the Tree Species <i>Eucalyptus globulus</i> by João Costa e Silva, Brad M. Potts, Peter A. Harrison

“…However, alternative scenarios, including selection aligning genetic architecture and population divergence, are discussed.…”
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Stability of genetic variance and covariance for reproductive characters in the face of climate change in a wild bird population. by Garant, D, Hadfield, J, Kruuk, L, Sheldon, B

“…Here we assess the impact of a changing climate on the genetic architecture underlying three reproductive traits in a wild bird population. …”

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data by Romagnoni, A, Jégou, S, Van Steen, K, Wainrib, G, Hugot, J, International Inflammatory Bowel Disease Genetics Consortium (Iibdgc)

“…Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. …”

Association genetics of acetophenone defence against spruce budworm in mature white spruce. by Lamara, M, Parent, GJ, Giguère, I, Beaulieu, J, Bousquet, J, MacKay, JJ

“…Here, we used diverse association genetics approaches to discover genes and their variants that may control the accumulation of acetophenones, and dissect the genetic architecture of these defence compounds against SBW in white spruce mature trees.…”

Elucidating combining ability, gene action and heterosis for yield and yield contributing traits in finger millet (Eleusine coracana L. Gaertn) by S. Divya1, K. Geetha1*, R. Siva kumar1, A. Nirmala Kumari2, P. T. Sharavanan2

“…In order to explore the genetic architecture of finger millet through combining ability studies, the present investigation was carried out using 20 hybrids which were produced using five lines and four testers in a Line x Tester mating design. …”
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Genome-wide association study of leprosy in Malawi and Mali. by James J Gilchrist, Kathryn Auckland, Tom Parks, Alexander J Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A Rockett, Ousmane B Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A Djimdé, Mahamadou A Thera, Ogobara K Doumbo, Samba Sow, Sian Floyd, Jörg M Pönnighaus, David K Warndorff, Amelia C Crampin, Paul E M Fine, Benjamin P Fairfax, Adrian V S Hill

“…More broadly, our data highlights the importance of defining the genetic architecture of disease across genetically diverse populations, and that disease insights derived from GWAS in one population may not translate to all affected populations.…”
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