Genetics of type 2 diabetes. by Owen, K, McCarthy, M

“…Nevertheless, 2006 heralded identification of the most important type 2 diabetes susceptibility gene known so far, TCF7L2, and in 2007 large-scale genome-wide association studies are destined to provide novel insights into the genetic architecture and biology of type 2 diabetes.…”

Dissecting quantitative traits in mice. by Mott, R, Flint, J

“…When combined with newly acquired catalogs of sequence variation in inbred strains, the genetic architecture of these new populations makes it possible to dissect complex traits down to the level of single variants. …”

Genetic mouse models relevant to schizophrenia: Taking stock and looking forward by Harrison, P, Pritchett, D, Stumpenhorst, K, Betts, J, Nissen, W, Schweimer, J, Lane, T, Burnet, P, Lamsa, K, Sharp, T, Bannerman, D, Tunbridge, E

“…The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue. …”

Phenome‐wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers by Anwar Mulugeta, Amanda L. Lumsden, Iqbal Madakkatel, David Stacey, S. Hong Lee, Johanna Mäenpää, Martin K. Oehler, Elina Hyppönen

“…We conducted PheWAS and colocalization analyses for individual variants to identify evidence for shared genetic architecture. Results The OC‐GRS was associated with 10 diseases, and the clear cell OC‐GRS was associated with five diseases at the FDR threshold (p = 5.6 × 10−4). …”
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Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels by Nikolina Pleić, Mirjana Babić Leko, Ivana Gunjača, Thibaud Boutin, Vesela Torlak, Antonela Matana, Ante Punda, Ozren Polašek, Caroline Hayward, Tatijana Zemunik

“…Our results suggest that the genetic architecture of plasma Tg is not polygenic, but influenced by a few genes with major effects.…”
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Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect by Jeffrey T. Miller, Bryan W. Clark, Noah M. Reid, Sibel I. Karchner, Jennifer L. Roach, Mark E. Hahn, Diane Nacci, Andrew Whitehead

“…Abstract The genetic architecture of phenotypic traits can affect the mode and tempo of trait evolution. …”
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Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle by Mudasir Nazar, Xubin Lu, Ismail Mohamed Abdalla, Numan Ullah, Yongliang Fan, Zhi Chen, Abdelaziz Adam Idriss Arbab, Yongjiang Mao, Zhangping Yang

“…In the dairy industry, mammary system traits are economically important for dairy animals, and it is important to explain their fundamental genetic architecture in Holstein cattle. Good and stable mammary system-related teat traits are essential for producer profitability in animal fitness and in the safety of dairy production. …”
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Identification of Genomic Regions Associated with Fusarium Wilt Resistance in Cowpea by Junyang Dong, Yuqin Song, Baogen Wang, Xiaohua Wu, Ying Wang, Jian Wang, Zhongfu Lu, Yan Zhang, Guojing Li, Xinyi Wu, Huasen Wang

“…Understanding the genetic architecture of FW resistance is a prerequisite to combatting this disease and developing FW resistance varieties. …”
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Whole exome sequencing reveals genetic landscape associated with left ventricular outflow tract obstruction in Chinese Han population by Zilong Geng, Wenjuan Li, Ping Yang, Shasha Zhang, Shuo Wu, Junhao Xiong, Kun Sun, Dan Zhu, Sun Chen, Bing Zhang, Bing Zhang

“…These findings uncover the genetic architecture of LVOTO which advances the current understanding of LVOTO genetics.…”
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Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function by Wild, PS, Felix, JF, Schillert, A, Teumer, A, Chen, M-H, Leening, MJG, Völker, U, Großmann, V, Brody, JA, Irvin, MR, Shah, SJ, Pramana, S, Lieb, W, Schmidt, R, Stanton, AV, Malzahn, D, Smith, AV, Sundström, J, Minelli, C, Ruggiero, D, Lyytikäinen, L-P, Tiller, D, Smith, JG, Monnereau, C, Di Tullio, MR, Musani, SK, Morrison, AC, Pers, TH, Morley, M, Kleber, ME, Aragam, J, Benjamin, EJ, Bis, JC, Bisping, E, Broeckel, U, Cheng, S, Deckers, JW, Del Greco M, F, Edelmann, F, Fornage, M, Franke, L, Friedrich, N, Harris, TB, Hofer, E, Hofman, A, Huang, J, Hughes, AD, Kähönen, M, investigators, KNHI, Kruppa, J, Lackner, KJ, Lannfelt, L, Laskowski, R, Launer, LJ, Leosdottir, M, Lin, H, Lindgren, CM, Loley, C, MacRae, CA, Mascalzoni, D, Mayet, J, Medenwald, D, Morris, AP, Müller, C, Müller-Nurasyid, M, Nappo, S, Nilsson, PM, Nuding, S, Nutile, T, Peters, A, Pfeufer, A, Pietzner, D, Pramstaller, PP, Raitakari, OT, Rice, KM, Rivadeneira, F, Rotter, JI, Ruohonen, ST, Sacco, RL, Samdarshi, TE, Schmidt, H, Sharp, ASP, Shields, DC, Sorice, R, Sotoodehnia, N, Stricker, BH, Surendran, P, Thom, S, Töglhofer, AM, Uitterlinden, AG, Wachter, R, Völzke, H, Ziegler, A, Münzel, T, März, W, Cappola, TP, Hirschhorn, JN, Mitchell, GF, Smith, NL, Fox, ER, Dueker, ND, Jaddoe, VWV, Melander, O, Russ, M, Lehtimäki, T, Ciullo, M, Hicks, AA, Lind, L, Gudnason, V, Pieske, B, Barron, AJ, Zweiker, R, Schunkert, H, Ingelsson, E, Liu, K, Arnett, DK, Psaty, BM, Blankenberg, S, Larson, MG, Felix, SB, Franco, OH, Zeller, T, Vasan, RS, Dörr, M

“…Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. …”

The Dynamic Structure and Rapid Evolution of Human Centromeric Satellite DNA by Glennis A. Logsdon, Evan E. Eichler

“…We review how our understanding of the genetic architecture and epigenetic properties of human centromeric DNA have advanced as a result. …”
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Next generation sequencing technologies to explore the diversity of germplasm resources: Achievements and trends in tomato by Pasquale Tripodi

“…Progress in genomic technologies made possible the development of forefront methods for high-scale sequencing, providing comprehensive insight into the genetic architecture of germplasm resources. This review revisits next-generation sequencing strategies and applications to investigate the diversity of tomato, describing the common platforms used for SNP genotyping of large collections, de novo sequencing, and whole genome resequencing. …”
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Conservation Genetics of Crested Newt Species Triturus cristatus and T. carnifex within a Contact Zone in Central Europe: Impact of Interspecific Introgression and Gene Flow by Peter Mikulíček, Roland Kaiser, Andreas Maletzky

“…We used seven polymorphic microsatellite loci to evaluate genetic diversity and processes that may determine the genetic architecture of populations. Genetic diversity was moderate, pairwise FST-values were comparatively high showing significant genetic differentiation and limited gene flow. …”
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Impacts of Host Genotype and Grafting on Root, Rhizosphere, and Core Microbiomes in Theobroma cacao Seedlings by Jennifer Schmidt, Alana Firl, Taylor Crow, Ashley DuVal, Donald Livingstone

“…However, optimizing phytobiomes requires knowledge of the genetic architecture of host influence on the associated microbiome, and this knowledge is particularly lacking in perennial crops such as Theobroma cacao. …”
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Status and access to the Collaborative Cross population. by Welsh, C, Miller, DR, Manly, K, Wang, J, McMillan, L, Morahan, G, Mott, R, Iraqi, F, Threadgill, D, de Villena, F

“…Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. …”

Genetic variants in major depression. by Flint, J, Shifman, S, Munafo, M, Mott, R

“…Our own data indicate that the genetic architecture of affective illness is more complex than expected. …”

Mapping autism risk loci using genetic linkage and chromosomal rearrangements. by Szatmari, P, Paterson, A, Zwaigenbaum, L, Roberts, W, Brian, J, Liu, X, Vincent, J, Skaug, J, Thompson, A, Senman, L, Feuk, L, Qian, C, Bryson, SE, Jones, M, Marshall, C, Scherer, S, Vieland, V, Bartlett, C, Mangin, L, Goedken, R, Segre, A, Pericak-Vance, M, Cuccaro, M, Gilbert, JR, Wright, H

“…Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. …”

Finding the missing heritability of complex diseases. by Manolio, T, Collins, F, Cox, N, Goldstein, D, Hindorff, L, Hunter, D, McCarthy, M, Ramos, E, Cardon, L, Chakravarti, A, Cho, J, Guttmacher, A, Kong, A, Kruglyak, L, Mardis, E, Rotimi, C, Slatkin, M, Valle, D, Whittemore, A, Boehnke, M, Clark, A, Eichler, E, Gibson, G, Haines, J, Mackay, T

“…Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small increments in risk, and explain only a small proportion of familial clustering, leading many to question how the remaining, 'missing' heritability can be explained. …”

Genome-wide analysis identifies 12 loci influencing human reproductive behavior by Barban, N, Tropf, F, Mills, M, Eibich, P, Wagner, G, Prokopenko, I, Lindgren, C, Zondervan, K

“…The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. …”

Optimization of inclusive fitness. by Grafen, A

“…A very general genetic architecture is allowed, and there is arbitrary uncertainty. …”