Recent natural selection causes adaptive evolution of an avian polygenic trait by Bosse, M, Spurgin, L, Laine, V, Cole, E, Firth, J, Gienapp, P, Gosler, A, McMahon, K, Poissant, J, Verhegen, I, Groenen, M, van Oers, K, Sheldon, B, Visser, M, Slate, J

“…We found that genomic regions under differential selection contained candidate genes for bill morphology, and used genetic architecture analyses to confirm that these genes, especially the collagen gene COL4A5, explained variation in bill length. …”

Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. by Turri, MG, Henderson, N, DeFries, J, Flint, J

“…We conclude that the genetic architecture of the selected strains is similar and relatively simple.…”

Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan by Shih-Pin Chen, Chia-Lin Hsu, Yen-Feng Wang, Fu-Chi Yang, Ting-Huei Chen, Jia-Hsin Huang, Li-Ling Hope Pan, Jong-Ling Fuh, Hsueh-Chen Chang, Yi-Lun Lee, Hung-Ching Chang, Ko-Han Lee, Yu-Chuan Chang, Cathy Shen-Jang Fann, Shuu-Jiun Wang

“…The objective of this study is to investigate the genetic architecture and susceptibility loci of cluster headache in Han Chinese resided in Taiwan. …”
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Genome‐Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants by Ahmed Salih, Maddalena Ardissino, Aaron Z. Wagen, Andrew Bard, Liliana Szabo, Mina Ryten, Steffen E. Petersen, André Altmann, Zahra Raisi‐Estabragh

“…We characterize the genetic architecture of adiposity‐adjusted PAT and identify causal associations between PAT and adverse cardiac magnetic resonance imaging measures of cardiac structure and function in 28 161 UK Biobank participants. …”
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Genome-wide association study for milk production and conformation traits in Canadian Alpine and Saanen dairy goats by Erin Massender, Hinayah R. Oliveira, Luiz F. Brito, Laurence Maignel, Mohsen Jafarikia, Christine F. Baes, Brian Sullivan, Flavio S. Schenkel

“…ABSTRACT: Increasing the productivity of Canadian dairy goats is critical to the competitiveness of the sector; however, little is known about the underlying genetic architecture of economically important traits in these populations. …”
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A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. by Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao

“…The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. …”
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Polygenic Risk Score and Risk Factors for Gestational Diabetes by Marija Majda Perišić, Klemo Vladimir, Sarah Karpov, Mario Štorga, Ali Mostashari, Raya Khanin

“…Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. …”
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A statistical design for testing transgenerational genomic imprinting in natural human populations. by Yao Li, Yunqian Guo, Jianxin Wang, Wei Hou, Myron N Chang, Duanping Liao, Rongling Wu

“…This new design, coupled with increasingly used genome-wide association studies, should have an immediate implication for studying the genetic architecture of complex traits in humans.…”
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Polymorphism of ACE, AGT, AGTR1 genes as genetic predictors of hypertension by A. Yu. Elkina, N. S. Akimova, Yu. G. Shvarts

“…The genetic architecture of blood pressure (BP) includes more than 30 genes, the polymorphic variants of which cause phenotypic heterogeneity of BP. …”
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Cyclophilin nomenclature problems, or, 'a visit from the sequence police' by Nebert Daniel W, Sophos Nickolas A, Vasiliou Vasilis, Nelson David R

“…As one genome after another becomes sequenced, it is imperative to consider the complexity of genes, genetic architecture, gene expression, gene-gene and gene-product interactions and evolutionary relatedness across species. …”
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Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding by Mohsen Yoosefzadeh Najafabadi, Mohsen Hesami, Istvan Rajcan

“…This type of inheritance can be influenced by several factors besides the genetic architecture of the plant and its breeding potential. …”
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Advanced searching for hypertrophic cardiomyopathy heritability in real practice tomorrow by Olga S. Chumakova, Natalia M. Baulina

“…As studies in recent decades have shown, the genetic architecture of HCM is quite complex both in the entire population and in each patient. …”
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A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes by Gennady Khvorykh, Andrey Khrunin, Ivan Filippenkov, Vasily Stavchansky, Lyudmila Dergunova, Svetlana Limborska

“…In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. …”
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Genes associated with ant social behavior show distinct transcriptional and evolutionary patterns by Alexander S Mikheyev, Timothy A Linksvayer

“…Our results indicate that the genetic architecture of social behavior includes both highly connected and conserved components as well as loosely connected and evolutionarily labile components.…”
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Cross-population selection signatures in Canchim composite beef cattle. by Igor Nelson Herculano Duarte, Ayrton Fernandes de Oliveira Bessa, Luciana Diniz Rola, Maria Victória Henrique Genuíno, Iasmin Marques Rocha, Cintia Righetti Marcondes, Luciana Correia de Almeida Regitano, Danísio Prado Munari, Donagh Pearse Berry, Marcos Eli Buzanskas

“…Identified genes were related to immunity, adaptation, morphology, as well as behavior, could give new perspectives for understanding the genetic architecture of Canchim. Some selection signatures identified genes that were recently introduced in Canchim, such as the loci related to the polled trait.…”
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Epigenetic association with environmental risk factors for mental disorders by S. Le Hellard

“…In the last decade, large genetic studies have began to unravel the genetic architecture of several of these disorders. While the mechanisms of action of environmental risk factors are still unclear. …”
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From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis by Fang, H, Chen, L, Knight, J

“…Roadblocks to progress exist, including little knowledge of the genetic architecture and regulatory mechanisms underlying associations, and the need to identify gene regulatory networks and assess target tractability. …”

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability by Palamara, P, Terhorst, J, Song, Y, Price, A

“…These results underscore the widespread effects of background selection on the genetic architecture of complex traits.…”

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. by Zeggini, E, Weedon, M, Lindgren, C, Frayling, T, Elliott, K, Lango, H, Timpson, N, Perry, JR, Rayner, N, Freathy, R, Barrett, J, Shields, B, Morris, A, Ellard, S, Groves, C, Harries, L, Marchini, J, Owen, K, Knight, B, Cardon, L, Walker, M, Hitman, G, Morris, A, Doney, A, McCarthy, M

“…Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. …”

Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. by Yalcin, B, Flint, J, Mott, R

“…We have developed a fast and economical strategy for dissecting the genetic architecture of quantitative trait loci at a molecular level. …”