FSF-GA: A Feature Selection Framework for Phenotype Prediction Using Genetic Algorithms by Mohammad Erfan Mowlaei, Xinghua Shi

“…These selected feature sets can be used to interpret the underlying genetic architecture that contributes to phenotypic variation.…”
Get full text

Naturalism in Architecture Creating a Culture of Resilience by Houssameldeen Bahgat El Refeie

“…The philosophy brought to mind techno-scientific images which drew out the concept of genetic architecture. These images tried to synchronize with the natural variables in order to achieve the concept of sustainable development. …”
Get full text

The genetic overlap between osteoporosis and craniosynostosis by Erika Kague, Carolina Medina-Gomez, Simeon A. Boyadjiev, Fernando Rivadeneira

“…In the past 15 years, genome-wide association studies (GWAS), have pinpointed hundreds of loci associated with bone mineral density (BMD), helping elucidate the underlying molecular mechanisms and genetic architecture of fracture risk. However, the challenge remains in pinpointing causative genes driving GWAS signals as a pivotal step to drawing the translational therapeutic roadmap. …”
Get full text

Genetic Risk Factors and Gene–Lifestyle Interactions in Gestational Diabetes by Tiina Jääskeläinen, Miira M. Klemetti

“…However, as of yet, GDM treatment protocols do not differentiate between these subtypes. Mapping the genetic architecture of GDM, as well as accurate phenotypic and genotypic definitions of GDM, could potentially help in the individualization of GDM treatment and assessment of long-term prognoses. …”
Get full text

Breeding for Higher Yields of Wheat and Rice through Modifying Nitrogen Metabolism by Pornpipat Kasemsap, Arnold J. Bloom

“…Gaps in our current understanding include (1) species differences among candidate genes in nitrogen metabolism pathways, (2) the extent to which relative abundance of these nitrogen forms across natural soil environments shape crop responses, and (3) natural variation and genetic architecture of nitrogen-mediated yield improvement. …”
Get full text

Genetic Cardiomyopathies: The Lesson Learned from hiPSCs by Ilaria My, Elisa Di Pasquale

“…A milestone in the research of genetically determined heart disease was the introduction of genomic technologies that provided unparalleled opportunities to explore the genetic architecture of cardiomyopathies, thanks to the generation of isogenic pairs. …”
Get full text

Comparison of analyses of the QTLMAS XIV common dataset. I: genomic selection by Pszczola Marcin, Strabel Tomasz, Wolc Anna, Mucha Sebastian, Szydlowski Maciej

“…<p>Abstract</p> <p>Background</p> <p>For the XIV QTLMAS workshop, a dataset for traits with complex genetic architecture has been simulated and released for analyses by participants. …”

Deciphering the transcriptomic regulation of heat stress responses in Nothofagus pumilio. by Maximiliano Estravis-Barcala, Katrin Heer, Paula Marchelli, Birgit Ziegenhagen, María Verónica Arana, Nicolás Bellora

“…Revealing the genetic architecture underlying the heat stress response is therefore crucial for the development of conservation strategies, and for breeding heat-resistant plant genotypes. …”
Get full text

Tuning parameters for polygenic risk score methods using GWAS summary statistics from training data by Wei Jiang, Ling Chen, Matthew J. Girgenti, Hongyu Zhao

“…Because directly using training data effects tends to overestimate the performance in the testing data, we adopt an empirical Bayes approach to shrinking the predicted performance in accordance with the genetic architecture of the disease. Extensive simulations and real data applications demonstrate PRStuning’s accuracy across PRS methods and parameters.…”
Get full text

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche. by Shu Ran, Yu-Fang Pei, Yong-Jun Liu, Lei Zhang, Ying-Ying Han, Rong Hai, Qing Tian, Yong Lin, Tie-Lin Yang, Yan-Fang Guo, Hui Shen, Inderpal S Thethi, Xue-Zhen Zhu, Hong-Wen Deng

“…Our findings may help improve the understanding of genetic architecture and pathophysiological mechanisms underlying both osteoporosis and AAM.…”
Get full text

Genomic architecture of migration timing in a long-distance migratory songbird by Evelien de Greef, Alexander Suh, Matt J. Thorstensen, Kira E. Delmore, Kevin C. Fraser

“…We examined the genetic architecture of migration timing in a long-distance migratory songbird (purple martin, Progne subis subis) by integrating genomic data with an extensive dataset of direct migratory tracks. …”
Get full text

Gene buddies: linked balanced polymorphisms reinforce each other even in the absence of epistasis by Jacob A. Tennessen

“…While these results may be intuitive, they have important implications for genetic architecture: clusters of mutually reinforcing genes may underlie phenotypic variation in natural populations, and such genes cannot be assumed to be functionally associated. …”
Get full text

Higher-order epistasis shapes natural variation in germ stem cell niche activity by Sarah R. Fausett, Asma Sandjak, Bénédicte Billard, Christian Braendle

“…These results provide first insights into the quantitative genetic architecture regulating an animal stem cell system.…”
Get full text

Crassulacean acid metabolism: a continuous or discrete trait? by Winter, K, Holtum, JAM, Smith, JAC

“…While questions remain concerning the adaptive significance of dark CO2 fixation in such species, plants with low-level CAM should prove valuable models for investigating the discrete changes in genetic architecture and gene expression that have enabled the evolutionary transition from C3 to CAM.…”

Analysis of quantitative trait loci that influence animal behavior. by Flint, J

“…In this article I review what that information has revealed about the genetic architecture of behavior. I show that most behaviors are influenced by QTL of small effect, each contributing to less than 10% of the variance of a behavioral trait. …”

Variation in heritability of tadpole growth: an experimental analysis. by Uller, T, Olsson, M, Ståhlberg, F

“…In the current study, we ask whether this process of divergence under natural selection has influenced the genetic architecture as visualised in estimates of heritability of growth rate at different temperature treatments under laboratory conditions. …”

Genetic diversity fuels gene discovery for tobacco and alcohol use by Saunders, GRB, Wang, X, Chen, F, Chen, Z, Hunter, DJ, Lin, K, Millwood, IY, Walters, RG

“…Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. …”

Quantitative variation in plasma angiotensin-I converting enzyme activity shows allelic heterogeneity in the ABO blood group locus. by Terao, C, Bayoumi, N, McKenzie, C, Zelenika, D, Muro, S, Mishima, M, Connell, J, Vickers, M, Lathrop, G, Farrall, M, Matsuda, F, Keavney, B

“…We sought to characterise the genetic architecture of plasma ACE at finer resolution in two populations. …”

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4 by Gilchrist, JJ, Rautanen, A, Fairfax, BP, Mills, TC, Naranbhai, V, Trochet, H, Pirinen, M, Muthumbi, E, Mwarumba, S, Njuguna, P, Mturi, N, Msefula, CL, Gondwe, EN, MacLennan, JM, Chapman, SJ, Molyneux, ME, Knight, JC, Spencer, CCA, Williams, TN, MacLennan, CA, Scott, JAG, Hill, AVS

“…These data implicate interleukin-12-dependent IFNγ-mediated immunity as a determinant of invasive NTS disease in African children, and highlight the shared genetic architecture of infectious and autoimmune disease.…”

Defining the role of common variation in the genomic and biological architecture of adult human height. by Wood, A, Esko, T, Yang, J, Vedantam, S, Pers, T, Gustafsson, S, Chu, A, Estrada, K, Luan, J, Kutalik, Z, Amin, N, Buchkovich, M, Croteau-Chonka, D, Day, F, Duan, Y, Fall, T, Fehrmann, R, Ferreira, T, Jackson, A, Karjalainen, J, Lo, K, Locke, A, Mägi, R, Mihailov, E, Porcu, E

“…Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.…”