Characterization of a male reproductive transcriptome for Peromyscus eremicus (Cactus mouse) by Lauren L. Kordonowy, Matthew D. MacManes

“…Well characterized genomic and transcriptomic data is intrinsic to explorations of the genetic architecture responsible for ecological adaptations. …”
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Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology by Sheldon D’Silva, Shreya Chakraborty, Bratati Kahali

“…Abstract Genome wide association studies (GWAS) have focused on elucidating the genetic architecture of complex traits by assessing single variant effects in additive genetic models, albeit explaining a fraction of the trait heritability. …”
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Whole exome sequencing study identifies candidate loss of function variants and locus heterogeneity in familial cholesteatoma. by Ryan Cardenas, Peter Prinsley, Carl Philpott, Mahmood F Bhutta, Emma Wilson, Daniel S Brewer, Barbara A Jennings

“…The number of candidate genes identified and the locus heterogeneity that we describe within and between multiply affected families suggest that the genetic architecture for familial cholesteatoma is complex.…”
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Substrate-specific effects of natural genetic variation on proteasome activity. by Mahlon A Collins, Randi Avery, Frank W Albert

“…Our results reveal the complex genetic architecture of proteasome activity and suggest that genetic influences on the proteasome may be an important source of variation in the many cellular and organismal traits shaped by protein degradation.…”
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Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data by Beretta Lorenzo, Santaniello Alessandro, van Riel Piet LCM, Coenen Marieke JH, Scorza Raffaella

“…<p>Abstract</p> <p>Background</p> <p>Epistasis is recognized as a fundamental part of the genetic architecture of individuals. Several computational approaches have been developed to model gene-gene interactions in case-control studies, however, none of them is suitable for time-dependent analysis. …”
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A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects by Urko M Marigorta, Greg eGibson

“…We conclude that a pervasive presence of gene-by-environment effects can remain hidden even though it contributes to the genetic architecture of complex traits.…”
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Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis. by Thomas J C Sauters, Cullen Roth, Debra Murray, Sheng Sun, Anna Floyd Averette, Chinaemerem U Onyishi, Robin C May, Joseph Heitman, Paul M Magwene

“…Our findings provide new perspectives on how microbial ecology shapes the genetic architecture of fungal virulence, and suggests the need for more nuanced models for the evolution of pathogenesis that account for the complexities of both microbe-microbe and microbe-host interactions.…”
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Inhibition of ethylene involved in resistance to E. turcicum in an exotic-derived double haploid maize population by Sarah Lipps, Alexander E. Lipka, Santiago Mideros, Tiffany Jamann

“…Northern corn leaf blight (NCLB) is an economically important disease of maize. While the genetic architecture of NCLB has been well characterized, the pathogen is known to overcome currently deployed resistance genes, and the role of hormones in resistance to NCLB is an area of active research. …”
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The condition‐dependence of male genital size and shape by Tanya M. Pennell, Manmohan D. Sharma, Andreas Sutter, Drew T. Wilson, Clarissa M. House, David J. Hosken

“…The differential effects of these treatments likely reflect underlying genetic architecture that has been shaped by past selection: inbreeding depression is only expected when traits have a history of directional selection, while diet impacts traits regardless of historical selection. …”
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Application of Bayesian genomic prediction methods to genome-wide association analyses by Anna Wolc, Jack C. M. Dekkers

“…Abstract Background Bayesian genomic prediction methods were developed to simultaneously fit all genotyped markers to a set of available phenotypes for prediction of breeding values for quantitative traits, allowing for differences in the genetic architecture (distribution of marker effects) of traits. …”
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Whole exome sequencing study identifies candidate loss of function variants and locus heterogeneity in familial cholesteatoma by Ryan Cardenas, Peter Prinsley, Carl Philpott, Mahmood F. Bhutta, Emma Wilson, Daniel S. Brewer, Barbara A. Jennings

“…The number of candidate genes identified and the locus heterogeneity that we describe within and between multiply affected families suggest that the genetic architecture for familial cholesteatoma is complex.…”
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The complementary roles of genome-wide approaches in identifying genes linked to an inherited risk of colorectal cancer by Olfat Ahmad, Asta Försti

“…In this review we aim to provide insights on the complementary roles played by different genomic approaches in allowing the current understanding of the genetic architecture of inherited CRC.…”
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A knowledge-based method for association studies on complex diseases. by Alireza Nazarian, Heike Sichtig, Alberto Riva

“…Analyzing the complexity underlying the genetic architecture of such traits may help develop more efficient diagnostic tests and therapeutic protocols. …”
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Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. by Corinne Berthonneche, Bastian Peter, Fanny Schüpfer, Pamela Hayoz, Zoltán Kutalik, Hugues Abriel, Thierry Pedrazzini, Jacques S Beckmann, Sven Bergmann, Fabienne Maurer

“…This indicates that cardiovascular phenotypes are unlikely to segregate according to global phylogeny, but rather be governed by smaller, local differences in the genetic architecture of the various strains.…”
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Deciphering the mechanism of anhydrobiosis in the entomopathogenic nematode Heterorhabditis indica through comparative transcriptomics. by Manimaran Balakumaran, Parameshwaran Chidambaranathan, Jagannadham Prasanth Tej Kumar J P, Anil Sirohi, Pradeep Kumar Jain, Kishore Gaikwad, Yuvaraj Iyyappan, Atmakuri Ramakrishna Rao, Sarika Sahu, Anil Dahuja, Sharad Mohan

“…It possesses tremendous genetic architecture to survive desiccation stress by undergoing anhydrobiosis to increase its lifespan-an attribute exploited in the formulation technology. …”
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Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region. by Javier de la Fuente, Andrew D Grotzinger, Riccardo E Marioni, Michel G Nivard, Elliot M Tucker-Drob

“…We apply our method to investigate the genetic architecture of AD using GWAX from UK Biobank and direct case-control GWAS from the International Genomics of Alzheimer's Project (IGAP). …”
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Genomics in Personalized Nutrition: Can You “Eat for Your Genes”? by Veronica A. Mullins, William Bresette, Laurel Johnstone, Brian Hallmark, Floyd H. Chilton

“…We review important issues such as dietary exposure and genetic architecture addressing the concepts of penetrance, pleiotropy, epistasis, polygenicity, and epigenetics. …”
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Haplotype-based genome-wide association study identifies loci and candidate genes for milk yield in Holsteins. by Zhenliang Chen, Yunqiu Yao, Peipei Ma, Qishan Wang, Yuchun Pan

“…Since milk yield is a highly important economic trait in dairy cattle, the genome-wide association study (GWAS) is vital to explain the genetic architecture underlying milk yield and to perform marker-assisted selection (MAS). …”
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Gene action for quantitative traits through Generation means analysis in sesame (Sesamum indicum) by JAWAHAR LAL JATOTH, KULDEEP SINGH DANGI, S SUDHEER KUMAR

“…It can be categorically stated that reciprocal recurrent selection or diallel selective mating system are the need of the hour to modify the genetic architecture of sesame for attaining higher yields with desirable oil content. …”
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Identification and Fine-Mapping of Quantitative Trait Loci Controlling Plant Height in Central European Winter Triticale (×<i>Triticosecale</i> Wittmack) by Johannes Trini, Hans Peter Maurer, Jan Eric Neuweiler, Tobias Würschum

“…In this study, we evaluated a panel of 846 diverse Central European triticale genotypes to dissect the genetic architecture underlying plant height by genome-wide association mapping. …”
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