Biobank data for studying the genetic architecture of osteoporosis and developing genetic risk scores by E. A. Sotnikova, A. V. Kiseleva, A. N. Meshkov, A. I. Ershova, A. A. Ivanova, M. A. Kolchina, V. A. Kutsenko, I. A. Skripnikova, O. M. Drapkina

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Age and diet shape the genetic architecture of body weight in diversity outbred mice by Kevin M Wright, Andrew G Deighan, Andrea Di Francesco, Adam Freund, Vladimir Jojic, Gary A Churchill, Anil Raj

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The OncoArray Consortium: a network for understanding the genetic architecture of common cancers by Amos, CI, Dennis, J, Wang, Z, Byun, J, Schumacher, FR, Gayther, SA, Casey, G, Hunter, DJ, Sellers, TA, Gruber, SB, Dunning, AM, Michailidou, K, Fachal, L, Doheny, K, Spurdle, AB, Li, Y, Xiao, X, Romm, J, Pugh, E, Coetzee, GA, Hazelett, DJ, Bojesen, SE, Caga-Anan, C, Haiman, CA, Kamal, A, Luccarini, C, Tessier, D, Vincent, D, Bacot, F, Van Den Berg, DJ, Nelson, S, Demetriades, S, Goldgar, DE, Couch, FJ, Forman, JL, Giles, GG, Conti, DV, Bickeböller, H, Risch, A, Waldenberger, M, Brüske-Hohlfeld, I, Hicks, BD, Ling, H, McGuffog, L, Lee, A, Kuchenbaecker, K, Soucy, P, Manz, J, Cunningham, JM, Butterbach, K, Kote-Jarai, Z, Kraft, P, Fitzgerald, L, Lindström, S, Adams, M, McKay, JD, Phelan, CM, Benlloch, S, Kelemen, LE, Brennan, P, Riggan, M, O'Mara, TA, Shen, H, Shi, Y, Thompson, DJ, Goodman, MT, Nielsen, SF, Berchuck, A, Laboissiere, S, Schmit, SL, Shelford, T, Edlund, CK, Taylor, JA, Field, JK, Park, SK, Offit, K, Thomassen, M, Schmutzler, R, Ottini, L, Hung, RJ, Marchini, J, Olama, A, Peters, U, Eeles, RA, Seldin, MF, Gillanders, E, Seminara, D, Antoniou, AC, Pharoah, PDP, Chenevix-Trench, G, Chanock, SJ, Simard, J, Easton, DF

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. by Jostins, L, Ripke, S, Weersma, R, Duerr, R, McGovern, D, Hui, K, Lee, J, Schumm, L, Sharma, Y, Anderson, C, Essers, J, Mitrovic, M, Ning, K, Cleynen, I, Theatre, E, Spain, S, Raychaudhuri, S, Goyette, P, Wei, Z, Abraham, C, Achkar, J, Ahmad, T, Amininejad, L, Ananthakrishnan, A, Andersen, V

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. by Panoutsopoulou, K, Southam, L, Elliott, K, Wrayner, N, Zhai, G, Beazley, C, Thorleifsson, G, Arden, N, Carr, A, Chapman, K, Deloukas, P, Doherty, M, McCaskie, A, Ollier, W, Ralston, S, Spector, T, Valdes, A, Wallis, G, Wilkinson, J, Arden, E, Battley, K, Blackburn, H, Blanco, F, Bumpstead, S, Cupples, L

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. by Panoutsopoulou, K, Southam, L, Elliott, K, Wrayner, N, Zhai, G, Beazley, C, Thorleifsson, G, Arden, N, Carr, A, Chapman, K, Deloukas, P, Doherty, M, McCaskie, A, Ollier, W, Ralston, S, Spector, T, Valdes, A, Wallis, G, Wilkinson, J, Arden, E, Battley, K, Blackburn, H, Blanco, F, Bumpstead, S, Cupples, L

Dengue and chikungunya virus loads in the mosquito Aedes aegypti are determined by distinct genetic architectures. by Mario Novelo, Heverton Lc Dutra, Hillery C Metz, Matthew J Jones, Leah T Sigle, Francesca D Frentiu, Scott L Allen, Stephen F Chenoweth, Elizabeth A McGraw

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Genetic Architecture Underlying the Metabolites of Chlorogenic Acid Biosynthesis in <i>Populus tomentosa</i> by Liangchen Yao, Peng Li, Qingzhang Du, Mingyang Quan, Lianzheng Li, Liang Xiao, Fangyuan Song, Wenjie Lu, Yuanyuan Fang, Deqiang Zhang

“…Here, we investigated the genetic architecture for CGA biosynthesis using a metabolite-based genome-wide association study (mGWAS) and expression quantitative trait nucleotide (eQTN) mapping in a population of 300 accessions of <i>Populus tomentosa</i>. …”
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A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders. by Anthony J Deo, Ramiro Costa, Lynn E DeLisi, Rob DeSalle, Fatemeh Haghighi

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Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease by Rubén Queiro, Pablo Coto, Leire González-Lara, Eliecer Coto

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Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank by Daniel Roelfs, Oleksandr Frei, Dennis van der Meer, Elleke Tissink, Alexey Shadrin, Dag Alnaes, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann

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The Genetic Architecture of Milling Quality in Spring Oat Lines of the Collaborative Oat Research Enterprise by Kathy Esvelt Klos, Belayneh A. Yimer, Catherine J. Howarth, Michael S. McMullen, Mark E. Sorrells, Nicholas A. Tinker, Weikai Yan, Aaron D. Beattie

“…The purpose of this study was to characterize the genetic architecture of traits related to milling quality by identifying quantitative trait loci (QTL) contributing to variation among a diverse collection of elite and foundational spring oat lines important to North American oat breeding programs. …”
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Deciphering the Genetic Architecture of Color Variation in Whole Grain Rice by Genome-Wide Association by Wenjun Wang, Xianjin Qiu, Ziqi Wang, Tianyi Xie, Wenqiang Sun, Jianlong Xu, Fan Zhang, Sibin Yu

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Genome-wide association study exploring the genetic architecture of eggshell speckles in laying hens by Xue Cheng, Xinghua Li, Mengyuan Yang, Chuanwei Zheng, Haiying Li, Lujiang Qu, Zhonghua Ning

“…Abstract Background Eggshell speckle phenotype is an important trait in poultry production because they affect eggshell quality. However, the genetic architecture of speckled eggshells remains unclear. …”
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Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods by Miikael Lehtimäki, Binisha H. Mishra, Coral Del-Val, Leo-Pekka Lyytikäinen, Mika Kähönen, C. Robert Cloninger, Olli T. Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimäki, Pashupati P. Mishra

“…Abstract Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. …”
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Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications. by Chantle Reiko Swichkow, Joshua S Bloom, Leonid Kruglyak

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Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits. by Ruth Johnson, Kathryn S Burch, Kangcheng Hou, Mario Paciuc, Bogdan Pasaniuc, Sriram Sankararaman

“…The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait. Although many previous studies have investigated polygenicity at a genome-wide scale, a detailed understanding of how polygenicity varies across genomic regions is currently lacking. …”
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Identification of the shared genetic architecture underlying seven autoimmune diseases with GWAS summary statistics by Yuping Wang, Yongli Yang, Xiaocan Jia, Chenyu Zhao, Chaojun Yang, Jingwen Fan, Nana Wang, Xuezhong Shi

Subjects: “…genetic architecture…”
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How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia by Merve Kasap, Donard S. Dwyer

“…Characterization of its genetic architecture may lead to a better understanding of the overall burden of risk variants and how they determine susceptibility to disease. …”
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The Genetic Architecture of the Chickens Dropping Moisture by Genetic Parameter Estimation and Genome-Wide Association by Tao Zhu, Tong-Yu Zhang, Junhui Wen, Xiaoyu Zhao, Yu Chen, Yaxiong Jia, Liang Wang, Xueze Lv, Weifang Yang, Zi Guan, Zhonghua Ning, Lujiang Qu

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