Genetic architecture of the structural connectome by Michael Wainberg, Natalie J. Forde, Salim Mansour, Isabel Kerrebijn, Sarah E. Medland, Colin Hawco, Shreejoy J. Tripathy

Get full text

The genetic architecture of psychophysiological phenotypes. by Munafò, MR, Flint, J

The genetic architecture of hypertrophic cardiomyopathy by Harper, AR

“…</p> <p>Here, the genetic architecture of HCM is further evaluated, under a central hypothesis that the genetic aetiology of HCM extends beyond known rare variant contributions. …”

Genetic architecture of intrinsic antibiotic susceptibility. by Hany S Girgis, Alison K Hottes, Saeed Tavazoie

Get full text

The genetic architecture of type 2 diabetes by Altshuler, David

“…The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. …”
Get full text
Get full text

Dissecting the genetic architecture of human personality by Munafò, MR, Flint, J

Genetic architecture of circulating lipid levels. by Demirkan, A, Amin, N, Isaacs, A, Jarvelin, MR, Whitfield, J, Wichmann, H, Kyvik, K, Rudan, I, Gieger, C, Hicks, A, Johansson, Å, Hottenga, J, Smith, J, Wild, S, Pedersen, N, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A, Hofman, A, Witteman, J, Montgomery, G, Pietiläinen, K, Rantanen, T, Kaprio, J

“…These results suggest that the genetic architecture of circulating lipids involves a number of undiscovered variants with very small effects, and that increasing GWAS sample sizes will enable the identification of novel variants that regulate lipid levels.…”

The genetic architecture of carpal tunnel syndrome by Wiberg, A

“…I have provided evidence for a robust genetic architecture underlying CTS and have identified several biologically plausible candidate genes that contribute to its pathophysiology. …”

The genetic architecture of type 2 diabetes. by Fuchsberger, C, Flannick, J, Teslovich, TM, Mahajan, A, Agarwala, V, Gaulton, KJ, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, DJ, Rivas, MA, Perry, JRB, Sim, X, Blackwell, TW, Robertson, NR, Rayner, NW, Cingolani, P, Locke, AE, Tajes, JF, Highland, HM, Dupuis, J, Chines, PS, Lindgren, CM, Hartl, C, Jackson, AU, Chen, H, Huyghe, JR, van de Bunt, M, Pearson, RD, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, HM, Gamazon, ER, Lee, J, Chen, Y, Scott, RA, Below, JE, Chen, P, Huang, J, Go, MJ, Stitzel, ML, Pasko, D, Parker, SCJ, Varga, TV, Green, T, Beer, NL, Day-Williams, AG, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, MK, Kim, B-J, Kim, Y, Kim, YJ, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, TJ, Nagai, Y, Wang, X, Welch, RP, Yoon, J, Zhang, W, Barzilai, N, Voight, BF, Han, B-G, Jenkinson, CP, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, MCY, Palmer, ND, Balkau, B, Stančáková, A, Abboud, HE, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, JD, Neale, BM, Purcell, S, Butterworth, AS, Howson, JMM, Lee, HM, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, VKL, Park, KS, Saleheen, D, So, WY, Tam, CHT, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, JE, Rybin, D, Farook, VS, Fowler, SP, Freedman, BI, Griswold, M, Hale, DE, Hicks, PJ, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, WY, Liu, J, van der Schouw, YT, Loh, M, Musani, SK, Puppala, S, Scott, WR, Yengo, L, Tan, S-T, Taylor, HA, Thameem, F, Wilson, G, Wong, TY, Njølstad, PR, Levy, JC, Mangino, M, Bonnycastle, LL, Schwarzmayr, T, Fadista, J, Surdulescu, GL, Herder, C, Groves, CJ, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, HA, Doney, ASF, Kinnunen, L, Esko, T, Farmer, AJ, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, ME, Jørgensen, T, Ladenvall, C, Justesen, JM, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, AH, Stirrups, K, Wood, AR, Mihailov, E, Blancher, C, Carneiro, MO, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, de Angelis, MH, Deloukas, P, Gjesing, AP, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, FB, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, SP, Palmer, CNA, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, RM, Syvänen, A-C, Bergman, RN, Bharadwaj, D, Bottinger, EP, Cho, YS, Chandak, GR, Chan, JCN, Chia, KS, Daly, MJ, Ebrahim, SB, Langenberg, C, Elliott, P, Jablonski, KA, Lehman, DM, Jia, W, Ma, RCW, Pollin, TI, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, YY, Zeggini, E, Loos, RJF, Small, KS, Ried, JS, DeFronzo, RA, Grallert, H, Glaser, B, Metspalu, A, Wareham, NJ, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, HK, Illig, T, Franks, PW, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, KR, Gloyn, AL, Strauch, K, Tuomi, T, Kooner, JS, Lee, J-Y, Park, T, Donnelly, P, Morris, AD, Hattersley, AT, Bowden, DW, Collins, FS, Atzmon, G, Chambers, JC, Spector, TD, Laakso, M, Strom, TM, Bell, GI, Blangero, J, Duggirala, R, Tai, ES, McVean, G, Hanis, CL, Wilson, JG, Seielstad, M, Frayling, TM, Meigs, JB, Cox, NJ, Sladek, R, Lander, ES, Gabriel, S, Burtt, NP, Mohlke, KL, Meitinger, T, Groop, L, Abecasis, G, Florez, JC, Scott, LJ, Morris, AP, Kang, HM, Boehnke, M, Altshuler, D, McCarthy, MI

“…The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. …”

Genetic architecture of circulating lipid levels by Demirkan, A, Amin, N, Isaacs, A, Jarvelin, M, Whitfield, J, Wichmann, H, Kyvik, K, Rudan, I, Gieger, C, Hicks, A, Johansson, A, Hottenga, J, Smith, J, Wild, S, Pedersen, N, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A, Hofman, A, Witteman, J, Montgomery, G, Pietiläinen, K, Rantanen, T, Kaprio, J

“…These results suggest that the genetic architecture of circulating lipids involves a number of undiscovered variants with very small effects, and that increasing GWAS sample sizes will enable the identification of novel variants that regulate lipid levels. © 2011 Macmillan Publishers Limited All rights reserved.…”

Dissecting the genetic architecture of human personality. by Munafò, MR, Flint, J

“…At the same time, evidence from other fields indicates that the genetic architecture of personality is likely to consist of the combined effect of many hundreds, if not thousands, of small effect loci.…”

The genetic architecture of type 2 diabetes by McCarthy, D, Mahajan, A, Gaulton, K, Moutsianas, L, Rivas, M, Perry, J, Robertson, N, Rayner, N, Tajes, J, Lindgren, C, Beer, N, van de Bunt, M, Pearson, R, Kumar, A, Chen, Y, Ferreira, T, Horikoshi, M, Levy, J, Groves, C, Ingelsson, E, Neville, M, Farmer, A, Karpe, F, Blancher, C, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Owen, K, Gloyn, A, Donnelly, P, McVean, G, Morris, A, McCarthy, M

“…The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. …”

Mapping the human genetic architecture of COVID-19 by Hajar Fauzan, Ahmad

Get full text

The genetic architecture of multimodal human brain age by Junhao Wen, Bingxin Zhao, Zhijian Yang, Guray Erus, Ioanna Skampardoni, Elizabeth Mamourian, Yuhan Cui, Gyujoon Hwang, Jingxuan Bao, Aleix Boquet-Pujadas, Zhen Zhou, Yogasudha Veturi, Marylyn D. Ritchie, Haochang Shou, Paul M. Thompson, Li Shen, Arthur W. Toga, Christos Davatzikos

“…This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). …”
Get full text

Genetic architecture of fresh-market tomato yield by Prashant Bhandari, Juhee Kim, Tong Geon Lee

Get full text

Genetic architecture promotes the evolution and maintenance of cooperation. by Antoine Frénoy, François Taddei, Dusan Misevic

“…Effectively, cooperation evolved to be protected and robust to mutations through entangled genetic architecture. Our results confirm the importance of second-order selection on evolutionary outcomes, uncover an important genetic mechanism for the evolution and maintenance of cooperation, and suggest promising methods for preventing gene loss in synthetically engineered organisms.…”
Get full text

The genetic architecture of climatic adaptation of tropical cattle. by Laercio R Porto-Neto, Antonio Reverter, Kishore C Prayaga, Eva K F Chan, David J Johnston, Rachel J Hawken, Geoffry Fordyce, Jose Fernando Garcia, Tad S Sonstegard, Sunduimijid Bolormaa, Michael E Goddard, Heather M Burrow, John M Henshall, Sigrid A Lehnert, William Barendse

“…We explored the genetic architecture of ten traits of tropical cattle production using genome wide association studies of 4,662 animals varying from 0% to 100% indicine. …”
Get full text

The genetic architecture of local adaptation in a cline by Laroche, Fabien, Lenormand, Thomas

“…We find that clustering of local-adaptation genes is pervasive within clines during both the establishment phase of local adaptation and the subsequent “reconfiguration” phase where different genetic architectures compete with each other. We also show that changing the fitness function relating trait to fitness has a strong impact on the overall evolutionary dynamics and resulting architecture. …”
Get full text

What is the genetic architecture of major psychiatric disorders? by W. Hennah, M. Gennarelli

Get full text

Genetic architecture of artemisinin-resistant Plasmodium falciparum by Miotto, O, Amato, R, Ashley, EA, MacInnis, B, Almagro-Garcia, J, Amaratunga, C, Lim, P, Mead, D, Oyola, SO, Dhorda, M, Imwong, M, Woodrow, C, Manske, M, Stalker, J, Drury, E, Campino, S, Amenga-Etego, L, Thanh, T-NN, Tran, HT, Ringwald, P, Bethell, D, Nosten, F, Phyo, A, Pukrittayakamee, S, Chotivanich, K, Chuor, CM, Nguon, C, Suon, S, Sreng, S, Newton, PN, Mayxay, M, Khanthavong, M, Hongvanthong, B, Htut, Y, Han, KT, Kyaw, MP, Faiz, MA, Fanello, CI, Onyamboko, M, Mokuolu, OA, Jacob, CG, Takala-Harrison, S, Plowe, CV, Day, NJ, Dondorp, AM, Spencer, CCA, McVean, G, Fairhurst, RM, White, NJ, Kwiatkowski, DP