The role of genetic modifiers, inflammation and CFTR in the pathogenesis of Cystic fibrosis related diabetes by Sana Hasan, Sarah Soltman, Colleen Wood, Scott M. Blackman

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Association of XmnI Polymorphism with Foetal Haemoglobin Level and Severity of Thalassaemia in Children: A Cross-sectional Study by Aditi Baruah, Kumari Naina, Arpita Gogoi, Pritanu Deb Baruah, Gautam Hazarika, Lucretia Hazarika

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MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey

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Editorial: Neuroimaging of Cognitive and Neuropsychiatric Symptoms in Movement Disorders by Frederic Sampedro, Frederic Sampedro, Frederic Sampedro, Estela Camara, Estela Camara, Jaime Kulisevsky, Jaime Kulisevsky, Jaime Kulisevsky

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The MRL Mitochondrial Genome Decreases Murine Muscular Dystrophy Severity by Jenan Holley-Cuthrell, Aqsa Iqbal, Ahlke Heydemann

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Genetic background influences tumour development in heterozygous Men1 knockout mice by Kate E Lines, Mahsa Javid, Anita A C Reed, Gerard V Walls, Mark Stevenson, Michelle Simon, Kreepa G Kooblall, Sian E Piret, Paul T Christie, Paul J Newey, Ann-Marie Mallon, Rajesh V Thakker

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Genetic modifiers of long‐term survival in sickle cell anemia by Ambroise Wonkam, Emile R. Chimusa, Khuthala Mnika, Gift Dineo Pule, Valentina Josiane Ngo Bitoungui, Nicola Mulder, Daniel Shriner, Charles N. Rotimi, Adebowale Adeyemo

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Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies by Yuwei Jiang, Lesley T. MacNeil

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Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels by Hung-Lin Chen, Junko Kasuya, Patrick Lansdon, Garrett Kaas, Hanxi Tang, Maggie Sodders, Toshihiro Kitamoto

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Natural variants suppress mutations in hundreds of essential genes by Leopold Parts, Amandine Batté, Maykel Lopes, Michael W Yuen, Meredith Laver, Bryan‐Joseph San Luis, Jia‐Xing Yue, Carles Pons, Elise Eray, Patrick Aloy, Gianni Liti, Jolanda van Leeuwen

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Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency by Antonino Montalbano, Lonny Juergensen, Ralph Roeth, Birgit Weiss, Maki Fukami, Susanne Fricke‐Otto, Gerhard Binder, Tsutomu Ogata, Eva Decker, Gudrun Nuernberg, David Hassel, Gudrun A Rappold

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Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis by Chunyu Li, Qianqian Wei, Yanbing Hou, Junyu Lin, Ruwei Ou, Lingyu Zhang, Qirui Jiang, Yi Xiao, Kuncheng Liu, Xueping Chen, TianMi Yang, Wei Song, Bi Zhao, Ying Wu, Huifang Shang

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Genetic Causes and Modifiers of Autism Spectrum Disorder by Lauren Rylaarsdam, Alicia Guemez-Gamboa

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Identification of recurrent genetic patterns from targeted sequencing panels with advanced data science: a case-study on sporadic and genetic neurodegenerative diseases by M. Tarozzi, A. Bartoletti-Stella, D. Dall’Olio, T. Matteuzzi, S. Baiardi, P. Parchi, G. Castellani, S. Capellari

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Investigating the effect of polygenic background on epilepsy phenotype in ‘monogenic’ familiesResearch in context by Karen L. Oliver, Ingrid E. Scheffer, Colin A. Ellis, Bronwyn E. Grinton, Samuel F. Berkovic, Melanie Bahlo, Zaid Afawi, Dina Amrom, Eva Andermann, Jocelyn F. Bautista, Susannah T. Bellows, Judith Bluvstein, Gregory D. Cascino, Seo-Kyung Chung, Patrick Cossette, Sarah W. Curtis, Norman Delanty, Orrin Devinsky, Dennis Dlugos, Michael P. Epstein, Catharine Freyer, Micheline Gravel, Rebekah V. Harris, Erin L. Heinzen, Olivia J. Henry, Heidi E. Kirsch, Robert C. Knowlton, Eric H. Kossoff, Rebecca Loeb, Daniel H. Lowenstein, Anthony G. Marson, Heather C. Mefford, Paul V. Motika, Terence J. O'Brien, Ruth Ottman, Juliann M. Paolicchi, Slave Petrovski, William O. Pickrell, Mark I. Rees, Lynette G. Sadleir, Jerry J. Shih, Rani K. Singh, Michael C. Smith, Philip E.M. Smith, Rhys H. Thomas, Judith Weisenberg, Peter Widdess-Walsh, Melodie R. Winawer

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High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts by Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu‐Wai‐Man, Pascal Reynier, Timothy Wai

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VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study by JUAN FRANCISCO CALDERÓN, ALONSO R PUGA, M. LUISA GUZMÁN, CARMEN PAZ ASTETE, MARTA ARRIAZA, MARIANA ARACENA, TERESA ARAVENA, PATRICIA SANZ, GABRIELA M REPETTO

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Phenotypic variability and the gender paradox in the R363C variant of Fabry disease by Alison C. Leslie, Jeanine Jarnes, Alia Ahmed, Sofia Shrestha, Jeffrey Wang, Chester B. Whitley, Nishitha R. Pillai

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Ascertainment of uninterrupted CAG repeat length and disease-modifying variants in fragment-based genetic testing for Huntington Disease by Hailey Findlay Black, Chris Kay, Jessica Dawson, Stephanie Bortnick, Kyla Javier, Qingwen Xia, Cheuk Hin Chau, Tess Leavitt, Larissa Arning, Huu Phuc Nguyen, Michael R. Hayden

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The complex landscape of DMD mutations: moving towards personalized medicine by Francesca Gatto, Silvia Benemei, Giulio Piluso, Luca Bello

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