The genome sequence of the broad-bordered yellow underwing, Noctua fimbriata (Schreber, 1759) per Holland, PWH

“…We present a genome assembly from an individual female Noctua fimbriata (the broad-bordered yellow underwing; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 574 megabases in span. The complete assembly is scaffolded into 32 chromosomal pseudomolecules, with the W and Z sex chromosomes assembled.…”

Whole genome sequencing for the investigation of rare anaemias: challenges and real-world outcomes per Brierley, C, Babbs, C, McGowan, S, Downes, D, Sanchis-Juan, A, Aydinok, Y, Thakur, I, Connor, P, Tedgard, U, Bechensteen, A, Harvet, G, De La Fuente, J, Mettananda, S, Hendricks, M, Carey, P, Lausen, B, Ancliff, P, Qureshi, A, Louka, E, Okoli, S, Psaila, B, O'Sullivan, J, Mead, A, Mapeta, R, Megy, K, Ouwehand, W, Turro, E, Roberts, I, Layton, M, Roy, N

Whole genome sequencing coupled to imputation discovers genetic signals for anthropometric traits per Tachmazidou, I, Süveges, D, Min, J, Rayner, N, Southam, L, McCarthy, M, Lindgren, C, Morris, A, SpiroMeta consortium, GoT2D consortium, arcOGEN consortium, Understanding Society Scientific Group, UK10K consortium

“…We applied a hybrid whole genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of twelve anthropometric traits associated with height, body mass and fat distribution in up to 267,616 individuals. …”

Whole-genome sequencing of patients with rare diseases in a national health system per Turro, E, Astle, WJ, Megy, K, Bennett, DL, Ormondroyd, E, Roberts, I, Roy, NBA, Themistocleous, A, Watkins, H

“…Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. …”

Whole-genome sequencing identifies nosocomial transmission of extra-pulmonary M. tuberculosis per Walker, T, Crook, D, Peto, T, Conlon, C

“…We describe how whole-genome sequencing identified the nosocomial transmission of extra-pulmonary Mycobacterium tuberculosis infection on our Infectious Diseases unit in Oxford, UK…”

The complete genome sequence of Thermoproteus tenax: a physiologically versatile member of the Crenarchaeota. per Siebers, B, Zaparty, M, Raddatz, G, Tjaden, B, Albers, S, Bell, S, Blombach, F, Kletzin, A, Kyrpides, N, Lanz, C, Plagens, A, Rampp, M, Rosinus, A, von Jan, M, Makarova, K, Klenk, H, Schuster, S, Hensel, R

“…Here, we report on the complete genome sequence of the hyperthermophilic Crenarchaeum Thermoproteus tenax (strain Kra1, DSM 2078(T)) a type strain of the crenarchaeotal order Thermoproteales. …”

The genome sequence of the Ash-bark Knot-horn, Euzophera pinguis (Haworth, 1811) per Boyes, D, Holland, PWH

“…We present a genome assembly from an individual male Euzophera pinguis (the Ash-bark Knot-horn; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence is 464.7 megabases in span. Most of the assembly is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. …”

Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV) per McNaughton, AL, Roberts, HE, Bonsall, D, De Cesare, M, Mokaya, J, Lumley, SF, Golubchik, T, Piazza, P, Martin, J, De Lara, C, Brown, A, Ansari, MA, Bowden, R, Barnes, E, Matthews, P

Genomic sequence and variability in the RA-associated CRH region (8q13) per Fife, MS, Steer, S, Shah, C, Newton, J, Wordsworth, P, Milicic, A, Polley, A, Rosenthal, A, Thoren, G, Dix, K, Kokoris, M, Fisher, SA, Lewis, C, Lanchbury, J

Capsular typing method for Streptococcus agalactiae using whole genome sequence data per Sheppard, A, Vaughan, A, Jones, N, Turner, P, Turner, C, Efstratiou, A, Patel, D, MMM Informatics Group, Walker, A, Berkley, J, Crook, D, Seale, A

“…Here we report a whole genome sequencing-based method for GBS serotype assignment. …”

The genome sequence of the Black-tipped Ermine, Yponomeuta plumbella (Denis & Schiffermüller, 1775) per Boyes, D, Sims, I, Lees, D, Holland, PWH

“…We present a genome assembly from an individual male Yponomeuta plumbella (the Black-tipped Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence is 636.6 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. …”

Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing per Schuh, A, Dreau, H, Knight, SJL, Ridout, K, Mizani, T, Vavoulis, D, Colling, R, Antoniou, P, Kvikstad, EM, Pentony, MM, Hamblin, A, Protheroe, A, Parton, M, Shah, KA, Zsolt, O, Athanasou, N, Hassan, B, Flanagan, AM, Ahmed, A, Winter, S, Harris, A, Tomlinson, I, Popitsch, N, Church, DN, Taylor, JC

“…Here, we present the results of the first eight patients recruited into a clinical whole-genome sequencing (WGS) program in the United Kingdom. …”

Genome sequence of Phytomonas françai a Cassava (Manihot esculenta) latex parasite per Kelly, S, Butler, C, Jaskowska, E

“…Here we report the genome sequence of the cassava (Manihot esculenta) latex parasite Phytomonas françai. …”

Rapid whole-genome sequencing to inform COVID-19 outbreak response in Vietnam per Chau, NVV, Hong, NTT, Ngoc, NM, Anh, NT, Trieu, HT, Nhu, LNT, Yen, LM, Minh, NNQ, Phong, NT, Truong, NT, Huong, LTT, Tu, TNH, Hung, LM, Thanh, TT, Dung, NT, Dung, NT, Thwaites, G, Van Tan, L

Whole-genome sequencing reveals host factors underlying critical COVID-19 per Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, CA, Walker, S, Russell, CD, Malinauskas, T, Wu, Y, Millar, J, Shen, X, Elliott, KS, Griffiths, F, Oosthuyzen, W, Morrice, K, Keating, S, Wang, B, Rhodes, D, Klaric, L, Zechner, M, Parkinson, N, Siddiq, A, Goddard, P, Donovan, S, Maslove, D, Nichol, A, Semple, MG, Zainy, T, Maleady-Crowe, F, Todd, L, Salehi, S, Knight, J, Elgar, G, Chan, G, Arumugam, P, Patch, C, Rendon, A, Bentley, D, Kingsley, C, Kosmicki, JA, Horowitz, JE, Baras, A, Abecasis, GR, Ferreira, MAR, Justice, A, Mirshahi, T, Oetjens, M, Rader, DJ, Ritchie, MD, Verma, A, Horby, P, Ling, L, McAuley, D, Montgomery, H, Openshaw, PJM, Elliott, P, Walsh, T, Tenesa, A, Fawkes, A, Murphy, L, Rowan, K, Ponting, CP, Vitart, V, Wilson, JF, Yang, J, Bretherick, AD, Scott, RH, Hendry, SC, Moutsianas, L, Law, A, Caulfield, MJ, Baillie, JK

“…Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. …”

Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano per Wudarski, J, Simanov, D, Ustyantsev, K, de Mulder, K, Grelling, M, Grudniewska, M, Beltman, F, Glazenburg, L, Demircan, T, Wunderer, J, Qi, W, Vizoso, D, Weissert, P, Olivieri, D, Mouton, S, Guryev, V, Aboobaker, A, Schärer, L, Ladurner, P, Berezikov, E

“…The reported transgenesis method and annotated genome sequence will permit sophisticated genetic studies on stem cells and regeneration using M. lignano as a model organism.…”

Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. per Pizza, M, Scarlato, V, Masignani, V, Giuliani, M, Aricò, B, Comanducci, M, Jennings, G, Baldi, L, Bartolini, E, Capecchi, B, Galeotti, C, Luzzi, E, Manetti, R, Marchetti, E, Mora, M, Nuti, S, Ratti, G, Santini, L, Savino, S, Scarselli, M, Storni, E, Zuo, P, Broeker, M, Hundt, E, Knapp, B

“…To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. …”

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe per Hunt, M, Bradley, P, Lapierre, SG, Heys, S, Thomsit, M, Hall, MB, Malone, KM, Wintringer, P, Walker, TM, Cirillo, DM, Comas, I, Farhat, MR, Fowler, P, Gardy, J, Ismail, N, Kohl, TA, Mathys, V, Merker, M, Niemann, S, Omar, SV, Sintchenko, V, Smith, G, van Soolingen, D, Supply, P, Tahseen, S, Wilcox, M, Arandjelovic, I, Peto, TEA, Crook, DW, Iqbal, Z

“…We previously developed a software tool, Mykrobe predictor, which provided offline species identification and drug resistance predictions for M. tuberculosis from whole genome sequencing (WGS) data. Performance was insufficient to support the use of WGS as an alternative to conventional phenotype-based DST, due to mutation catalogue limitations. …”

Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children per French, CE, Delon, I, Dolling, H, Sanchis-Juan, A, Shamardina, O, Mégy, K, Abbs, S, Austin, T, Bowdin, S, Branco, RG, Firth, H, Tuna, S, Aitman, TJ, Ashford, S, Astle, WJ, Bennet, DL, Bleda, M, Carss, KJ, Chinnery, PF, Deevi, SVV, Fletcher, D, Gale, DP, Gräf, SF, Hu, F, James, R, Kasanicki, MA, Kingston, N, Koziell, AB, Allen, HL, Maher, ER, Markus, HS, Meacham, S, Morrell, NW, Penkett, CJ, Roberts, I, Smith, KGC, Stark, H, Stirrups, KE, Turro, E, Watkins, H, Williamson, C, Young, T, Bradley, JR, Ouwehand, WH, Raymond, FL, Agrawal, S, Armstrong, R, Beardsall, K, Belteki, G, Bohatschek, M, Broster, S, Campbell, R, Chaudhary, R, Costa, C, D’Amore, A, Fitzsimmons, A, Hague, J, Harley, J, Hoodbhoy, S, Kayani, R, Kelsall, W, Mehta, SG, O’Donnell, R, O’Hare, S, Ogilvy-Stuart, A, Papakostas, S, Park, SM, Parker, A, Pathan, N, Prapa, M, Sammut, A, Sandford, R, Schon, K, Singh, Y, Spike, K, Tavares, ALT, Wari-Pepple, D, Wong, HS, Woods, CG, Rowitch, DH, Raymond, FL

“…</p> <p><strong>Methods</strong> We performed trio whole genome sequence (WGS) analysis on a prospective cohort of families recruited in NICU and PICU at a single site in the UK. …”

Association studies in outbred mice in a new era of full-genome sequencing. per Yalcin, B, Flint, J