Herbicide Diuron as endocrine disrupting chemicals (EDCs) through histopathalogical analysis in gonads of Javanese medaka (Oryzias javanicus, Bleeker 1854) by Kamarudin, Nur Amiera, Zulkifli, Syaizwan Zahmir, Azmai, Mohammad Noor Amal, Abdul Aziz, Fatin Zahidah, Ismail, Ahmad

“…In this study, Diuron caused histopathological alterations in gonads (ovary and testis) of Javanese medaka (Oryzias javanicus) by decreasing in gonadal staging and maturity of germ cells in oogenesis and spermatogenesis of female and male Javanese medaka. …”
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Parental High-Fat High-Sugar Diet Intake Programming Inflammatory and Oxidative Parameters of Reproductive Health in Male Offspring by Marcela Nascimento Sertorio, Helena César, Esther Alves de Souza, Laís Vales Mennitti, Aline Boveto Santamarina, Leonardo Mendes De Souza Mesquita, Andréa Jucá, Breno Picin Casagrande, Debora Estadella, Odair Aguiar, Luciana Pellegrini Pisani

“…Parental nutrition can impact the health of future generations, programming the offspring for the development of diseases. The developing germ cells of the offspring could be damaged by the maternal or the paternal environment. …”
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Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis by Raghuveer Kavarthapu, Rajakumar Anbazhagan, Ashish K. Sharma, Joseph Shiloach, Maria L. Dufau

“…GRTH/DDX25 is a testicular RNA helicase expressed in germ cells that plays a crucial role in completion of spermatogenesis. …”
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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans by J. Zimmer, L. Mueller, P. Frank-Herrmann, J. Rehnitz, J. E. Dietrich, M. Bettendorf, T. Strowitzki, M. Krivega

“…Abstract Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. …”
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Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis by Maryam Salem, Farnaz Khadivi, Parinaz Javanbakht, Sina Mojaverrostami, Mehdi Abbasi, Narjes Feizollahi, Yasaman Abbasi, Ehsan Heidarian, Farzane Rezaei Yazdi

“…Abstract The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. …”
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Transcriptome Sequencing and Comparative Analysis of Amphoteric ESCs and PGCs in Chicken (<i>Gallus gallus</i>) by Kai Jin, Jing Zhou, Qisheng Zuo, Jiuzhou Song, Yani Zhang, Guobing Chang, Guohong Chen, Bichun Li

“…Chicken (<i>Gallus gallus</i>) pluripotent embryonic stem cells (ESCs) and primordial germ cells (PGCs) can be broadly applied in the research of developmental and embryonic biology, but the difference between amphoteric ESCs and PGCs is still elusive. …”
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hnRNPU is required for spermatogonial stem cell pool establishment in mice by Yujiao Wen, Shumin Zhou, Yiqian Gui, Zeqing Li, Lisha Yin, Wenchao Xu, Shenglei Feng, Xixiang Ma, Shiming Gan, Mengneng Xiong, Juan Dong, Keren Cheng, Xiaoli Wang, Shuiqiao Yuan

“…Single-cell transcriptional analyses reveal that germ cells are in a mitotically quiescent state and lose their unique identity upon hnRNPU depletion. …”
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Generation of a Highly Biomimetic Organoid, Including Vasculature, Resembling the Native Immature Testis Tissue by Tat-Chuan Cham, Fahar Ibtisham, Mohammad Amin Fayaz, Ali Honaramooz

“…Surprisingly, our organoids also developed vascular structures; a phenomenon that has not been reported in any other culture system. In addition, germ cells do not decline over time, and Leydig cells release testosterone, hence providing a robust, tunable system for diverse basic and applied applications.…”
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Prospects for fertility preservation: the ovarian organ function reconstruction techniques for oogenesis, growth and maturation in vitro by Bai Hu, Bai Hu, Renjie Wang, Renjie Wang, Di Wu, Di Wu, Rui Long, Rui Long, Jinghan Ruan, Jinghan Ruan, Lei Jin, Ding Ma, Ding Ma, Chaoyang Sun, Chaoyang Sun, Shujie Liao, Shujie Liao

“…In vitro culture of oocytes in vitro Culture, female germ cells induction from pluripotent stem cells (PSC) in vitro, artificial ovary construction, and ovaria-related organoids construction have provided new solutions for fertility preservation, which will therefore maximize the potential for all patients undergoing fertility preservation. …”
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A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency by Baptiste Fouquet, Patrycja Pawlikowska, Sandrine Caburet, Celine Guigon, Marika Mäkinen, Laura Tanner, Marja Hietala, Kaja Urbanska, Laura Bellutti, Bérangère Legois, Bettina Bessieres, Alain Gougeon, Alexandra Benachi, Gabriel Livera, Filippo Rosselli, Reiner A Veitia, Micheline Misrahi

“…FANCM was more strongly expressed in human fetal germ cells than in somatic cells. FANCM protein was preferentially expressed along the chromosomes in pachytene cells, which undergo meiotic recombination. …”
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Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila by Marisa A. Rodrigues, Antoine Merckelbach, Esra Durmaz, Envel Kerdaffrec, Thomas Flatt

“…Here, we report that transgenic ablation of germ cells in late development or early adulthood in Drosophila melanogaster causes elevated baseline expression and increased induction of Toll and Imd immune genes upon bacterial infection, as compared to fertile flies with an intact germline. …”
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Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis by Cuie Chen, Yukiko M Yamashita

“…Depletion of alms1a in GSCs, but not in differentiating germ cells, results in rapid loss of centrosomes due to a failure in daughter centriole duplication, suggesting that Alms1a has a stem-cell-specific function in centrosome duplication. …”
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An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs by Long Xie, Zhenwen Huang, Meiyu Lan, Yaqi Cao, Lingling Sun, Lang Zhang, Erwei Zuo, Yangqing Lu

“…Here, we used site-specific integration of an EGFP fused to the OVAL gene by a rigid linker, (EAAAK)3, at the endogenous ovalbumin locus in chicken primordial germ cells to generate OVAL-E3-EGFP transgenic chickens, with transgenic chickens expressing CMV immediate enhancer/β-actin-driven EGFP (CAG-EGFP) as a non-secreted control. …”
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piRNN: deep learning algorithm for piRNA prediction by Kai Wang, Joshua Hoeksema, Chun Liang

“…Piwi-interacting RNAs (piRNAs) are the largest class of small non-coding RNAs discovered in germ cells. Identifying piRNAs from small RNA data is a challenging task due to the lack of conserved sequences and structural features of piRNAs. …”
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Elements of divergence in germline determination in closely related species by Shumpei Morita, Nathalie Oulhen, Stephany Foster, Gary M. Wessel

“…Differences in the primordial germ cells (PGCs) of two sea urchin species were examined here by stage-matched, integrated, single cell RNA-seq (scRNA-seq) datasets. …”
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Sexual function and fertility preservation in testicular cancer survivors by Shane Davis, Labeeqa Khizir, Benjamin Lichtbroun, Thomas Jang, Saum Ghodoussipour, Danielle Velez

“…While the standard recommendation for post pubertal patients is cryopreservation, prepubertal patients rely on experimental protocols for cryopreservation of germ cells with stem cell capabilities, with the hope that these cells will one day be stimulated to produce sperm. …”
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The functional diversity of Aurora kinases: a comprehensive review by Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister

“…Cellular distribution of AurB is ubiquitous, while AurC expression is mainly restricted to meiotically-active germ cells. In human tumors, all Aurora kinase members play oncogenic roles related to their mitotic activity and promote cancer cell survival and proliferation. …”
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Mutational signatures association with replication timing in normal cells reveals similarities and differences with matched cancer tissues by Adar Yaacov, Shai Rosenberg, Itamar Simon

“…The two ubiquitous signatures, SBS1 and SBS5, showed late and early bias, respectively, across multiple tissues and in mutations representing germ cells. We also performed a direct comparison with cancer samples in 4 matched tissue-cancer types. …”
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New players in the infertility of a mouse model of lysosomal storage disease: the hypothalamus-pituitary-gonadal axis. by Paola ePiomboni, Laura eGovernini, Martina eGori, Erica ePuggioni, Elvira eCostantino-Ceccarini, Alice eLuddi

“…In addition, galactosylceramidase catalyzes the hydrolysis of the terminal galactose from galactosyl-alkyl-acyl-glycerol, precursor of seminolipids, specifically expressed on the membrane of germ cells. Previous data reported by our group demonstrated that glycolipids play an important role in sperm maturation and differentiation. …”
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Role of Integrins in Sperm Activation and Fertilization by Veronika Merc, Michaela Frolikova, Katerina Komrskova

“…In addition to somatic cells, integrins have also been detected on germ cells and are known to play a crucial role in complex gamete-specific physiological events, resulting in sperm-oocyte fusion. …”
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