Genetic and Epigenetic Inheritance at Telomeres by Evan H. Lister-Shimauchi, Benjamin McCarthy, Michael Lippincott, Shawn Ahmed

“…Deficiency for telomerase or telomere-binding proteins in germ cells can result in shortened or lengthened chromosome termini that are transmitted to progeny. …”
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CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia by Kian-Yong Lee, Rebecca A Green, Edgar Gutierrez, J Sebastian Gomez-Cavazos, Irina Kolotuev, Shaohe Wang, Arshad Desai, Alex Groisman, Karen Oegema

“…Throughout metazoans, germ cells undergo incomplete cytokinesis to form syncytia connected by intercellular bridges. …”
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Dapagliflozin Mitigated Elevated Disomic and Diploid Sperm in a Mouse Model of Diabetes and Recover the Disrupted <i>Ogg1</i>, <i>Parp1</i>, and <i>P53</i> Gene Expression by Norah A. Albekairi, Mohammed A. Al-Hamamah, Ali A. Alshamrani, Mohamed S. M. Attia, Ahmed Nadeem, Mushtaq A. Ansari, Sheikh F. Ahmad, Saleh A. Bakheet, Sabry M. Attia

“…Furthermore, despite the increasing use of dapagliflozin for diabetes treatment, no data exists on its ability to affect aneuploidy levels in germ cells. Thus, our investigation aimed to evaluate the effects of diabetes on spontaneous sperm aneuploidy and whether treatment with dapagliflozin influences the frequency of aneuploidy in the sperm of an experimental diabetic animal model. …”
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Transcriptome profiling of histone writers/erasers enzymes across spermatogenesis, mature sperm and pre-cleavage embryo: Implications in paternal epigenome transitions and inherita... by Gastón Barbero, Maximiliano G. de Sousa Serro, Camila Perez Lujan, Alfredo D. Vitullo, Candela R. González, Betina González

“…Here, we curated male germ cells RNA-seq data and analyzed the expression profile of all known histone lysine writers and erasers enzymes across spermatogenesis, unraveling the developmental windows at which they are upregulated, and the specific activity related to canonical and non-canonical histone marks deposition and removal. …”
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Mastocytosis—A Review of Disease Spectrum with Imaging Correlation by Ahmed Elsaiey, Hagar S. Mahmoud, Corey T. Jensen, Sergio Klimkowski, Ahmed Taher, Humaira Chaudhry, Ajaykumar C. Morani, Vincenzo K. Wong, Usama I. Salem, Sarah M. Palmquist, Khaled M. Elsayes

“…Mastocytosis develops by activation mutation of the KIT surface receptor which is involved in the proliferation of a number of cell lines such as mast cells, germ cells, melanocytes, and hematopoietic cells. It manifests as two main categories: cutaneous mastocytosis and systemic mastocytosis. …”
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NEW EXPERIMENTAL PATHOGENETICALLY GROUNDED VARICOCELE MODE by M. A. Berdnikov, N. V. Antipov, Yu. K. Gulkov

“…There were phlebectasia, tunica media thinning, infl infi of the testicles with spermatogenous epithelium and mature germ cells necrobiosis, in some cases also arterial vessels proliferation and even spermatogenesis recovery.Conclusion. …”
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Genetic Regulation of Avian Testis Development by Martin Andres Estermann, Andrew Thomas Major, Craig Allen Smith

“…The paired testes of birds differentiate during embryogenesis, first marked by the development of pre-Sertoli cells in the gonadal primordium and their condensation into seminiferous cords. Germ cells become enclosed in these cords and enter mitotic arrest, while steroidogenic Leydig cells subsequently differentiate around the cords. …”
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Microscopic Features of Gonadally Inactive Testis of Khaki Campbell Duck (Anas platyrhynchos domesticus) in Bangladesh by Papia Khatun, Ziaul Haque, Shonkor Kumar Das

“…Most of the lumen of the seminiferous tubules was empty and all generation of germ cells were not present in most of the seminifeous tubules. …”
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Insulin-like signalling to the maternal germline controls progeny response to osmotic stress by Furuta, Tokiko, Webster, Amy K., Baugh, L. Ryan, Arur, Swathi, Burton, Nicholas O, Kaplan, Rebecca D., Horvitz, Howard Robert

“…In 1893 August Weismann proposed that information about the environment could not pass from somatic cells to germ cells, a hypothesis now known as the Weismann barrier. …”
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Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition by Maier, Nolan K, Ma, Jun, Lampson, Michael A, Cheeseman, Iain M

“…To generate haploid gametes, germ cells undergo two consecutive meiotic divisions requiring key changes to the cell division machinery. …”
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Conformational stability and activity of p73 require a second helix in the tetramerization domain. by Coutandin, D, Löhr, F, Niesen, F, Ikeya, T, Weber, T, Schäfer, B, Zielonka, E, Bullock, A, Yang, A, Güntert, P, Knapp, S, McKeon, F, Ou, H, Dötsch, V

“…p73 and p63, the two ancestral members of the p53 family, are involved in neurogenesis, epithelial stem cell maintenance and quality control of female germ cells. The highly conserved oligomerization domain (OD) of tumor suppressor p53 is essential for its biological functions, and its structure was believed to be the prototype for all three proteins. …”

C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma by Rivera, R.S., Nagatsuka, H., Gunduz, M., Cengiz, B., Gunduz, E., Siar, C.H., Tsujigiwa, H., Tamamura, R., Han, K.N., Nagai, N.

“…Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. …”
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A germline-targeted genetic screen for xrn-2 suppressors identifies a novel gene C34C12.2 in Caenorhabditis elegans by Ilkin Aygün, Alicja Rzepczak, Takashi S. Miki

“…The C34C12.2 protein is predominantly localized in the nucleolus of germ cells and shows a similarity to Saccharomyces cerevisiae Net1, which is involved in rDNA silencing. …”
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Human Endogenous Retrovirus-K (HML-2)-Related Genetic Variation: Human Genome Diversity and Disease by Wonseok Shin, Seyoung Mun, Kyudong Han

“…Originating from ancient exogenous retroviruses, these elements succeeded in infecting germ cells, enabling vertical transmission and existing as proviruses within the genome. …”
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Histological study of the effect of Piroxicam on testes of albino mice Mus musculus by Ali K. Obeys, Abdul Karim S. Mahood

“…In fifteenth day , mice were killed and testes tissue was prepared for light microscopic study .All animals exposed to drug were serve to have a depletion of germ cells, germinal cell necrorosis , especially in Spermatogonia and Leydig cells which had an abnormal fibroblast like appearance , abnormal space between neighboring Sertoli cells, thickness in seminiferous tubules basement membrane and wall arteries, therefore it is recommended that usage of this drug have harmful side effects on male fertility.…”
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CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. by Hui Tian, Timothy Billings, Petko M Petkov

“…We created two Cxxc1 conditional knockout mouse models to deplete CXXC1 generally in germ cells, and before the onset of meiosis. Surprisingly, male knockout mice were fertile, and the loss of CXXC1 in spermatocytes had no effect on PRDM9 hotspot trimethylation, double strand break formation or repair. …”
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Behavior and Functional Roles of CD34⁺ Mesenchymal Cells in Mammalian Testes by Shin-ichi Abe

“…Mammalian testes consist of seminiferous tubules within which Sertoli cells line up at the periphery and nurse germ cells, and of interstitia that harbor various cells such as peritubular myoid cells (PMCs), Leydig cells (LCs), vascular endothelial cells, immune cells such as macrophages, and mesenchymal (stromal) cells. …”
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Oocyte-granulosa-theca cell interactions during preantral follicular development by Orisaka Makoto, Tajima Kimihisa, Tsang Benjamin K, Kotsuji Fumikazu

“…Understanding the intraovarian mechanisms in the regulation of follicular growth and atresia during this stage may be of clinical significance in the selection of the best quality germ cells for assisted reproduction. In addition, since certain ovarian dysfunctions, such as polycystic ovarian syndrome and gonadotropin poor-responsiveness, are consequences of dysregulated follicle growth at this transitional stage, understanding the molecular and cellular mechanisms in the control of follicular development during the preantral-early antral transition may provide important insight into the pathophysiology and rational treatment of these conditions.…”
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Epigenetic Risks of Medically Assisted Reproduction by Romualdo Sciorio, Nady El Hajj

“…In the last decade, concerns were raised of a possible link between ART and increased incidence of imprinting disorders, as well as epigenetic alterations in the germ cells of infertile parents that are transmitted to the offspring following ART. …”
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Reproductive cycle of the Neotropical cichlid yellow peacock bass Cichla kelberi: A novel pattern of testicular development by Diógenes Henrique de Siqueira-Silva, Carlos Alberto Vicentini, Alexandre Ninhaus-Silveira, Rosicleire Veríssimo-Silveira

“…The present study describes the testicular maturation phases (associating the germ cells development and the morphological changes suffered by the germinal epithelium along the whole year), and the testicular morphology in the yellow peacock bass Cichla kelberi, relating it to other species. …”
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