Antioxidants in Fish Sperm and the Potential Role of Melatonin by Francisca Félix, Catarina C. V. Oliveira, Elsa Cabrita

“…Particularly in reproduction, germ cells lose antioxidant capacity with spermatogenesis, as spermatozoa are more prone to oxidative stress. …”
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Gap junctions mediate discrete regulatory steps during fly spermatogenesis. by Yanina-Yasmin Pesch, Vivien Dang, Michael John Fairchild, Fayeza Islam, Darius Camp, Priya Kaur, Christopher M Smendziuk, Anat Messenberg, Rosalyn Carr, Ciaran R McFarlane, Pierre-Yves Musso, Filip Van Petegem, Guy Tanentzapf

“…Gametogenesis requires coordinated signaling between germ cells and somatic cells. We previously showed that Gap junction (GJ)-mediated soma-germline communication is essential for fly spermatogenesis. …”
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Reconstitution and Transmission of Gut Microbiomes and Their Genes between Generations by Eugene Rosenberg, Ilana Zilber-Rosenberg

“…Microbiomes are transmitted between generations by a variety of different vertical and/or horizontal modes, including vegetative reproduction (vertical), via female germ cells (vertical), coprophagy and regurgitation (vertical and horizontal), physical contact starting at birth (vertical and horizontal), breast-feeding (vertical), and via the environment (horizontal). …”
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APRIL is overexpressed in cancer: link with tumor progression by Veyrune Jean-Luc, Moreaux Jérôme, De Vos John, Klein Bernard

“…</p> <p>Methods</p> <p>We compared the expression of <it>BAFF, APRIL, TACI and BAFF-R </it>gene expression in 40 human tumor types – brain, epithelial, lymphoid, germ cells – to that of their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray database.…”
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Infection of semen-producing organs by SIV during the acute and chronic stages of the disease. by Anna Le Tortorec, Roger Le Grand, Hélène Denis, Anne-Pascale Satie, Karim Mannioui, Pierre Roques, Anne Maillard, Sylvanne Daniels, Bernard Jégou, Nathalie Dejucq-Rainsford

“…Within the male genital tract, mostly T lymphocytes and a small number of germ cells harbour SIV antigens and RNA. In contrast to the other organs studied, the testis does not display an immune response to the infection. …”
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Niche formation and function in developing tissue: studies from the Drosophila ovary by Jian Jin, Ting Zhao

“…Given that vertebrate tissues are not suitable for large-scale forward genetics studies, the Drosophila ovary stands out as an excellent model for studying how multiple niche cell types and germ cells (GCs) are coordinately regulated in vivo. …”
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In vivo gene transfer into testis and sperm: Developments and future application by Coward, K, Kubota, H, Parrington, J

“…To be able to fully study the molecular mechanisms underlying spermatogenesis and fertilization, it is necessary to manipulate gene expression in male germ cells. Since there is still no reliable method of recapitulating spermatogenesis culture, the development of alternative transgenic approaches is paramount in the study of gene function in testis and sperm. …”

Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. by Robertson, E, Charatsi, I, Joyner, C, Koonce, C, Morgan, M, Islam, A, Paterson, C, Lejsek, E, Arnold, S, Kallies, A, Nutt, S, Bikoff, E

“…The zinc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during differentiation of B lymphocytes and regulates epigenetic changes required for specification of primordial germ cells. Blimp1 is dynamically expressed at diverse tissue sites in the developing mouse embryo, but its functional role remains unknown because Blimp1 mutant embryos arrest at E10.5 due to placental insufficiency. …”

High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner by Chambers, TJG, Morgan, MD, Heger, AH, Sharpe, RM, Drake, AJ

“…This suggests that nutrition may be able to modify genetic or epigenetic information carried by germ cells (GCs). To examine if a parental high fat diet (HFD) influences metabolic health in two generations of offspring, GC-eGFP Sprague Dawley rats were weaned onto HFD (45% fat) or Control Diet (CD; 10% fat). …”

Investigating mechanisms of premature ovarian insufficiency using a mouse model by Sheikh, S

“…Finally, reaggregated ovaries demonstrate that although DM germ cells retain the potential to develop follicles, DM somatic cells are imprinted with the POI phenotype. …”

The transcriptional basis of chromosome pairing. by Cook, P

“…Pairing between homologous chromosomes is essential for successful meiosis; generally only paired homologs recombine and segregate correctly into haploid germ cells. Homologs also pair in some somatic cells (e.g. in diploid and polytene cells of Drosophila). …”

Identification of a class of human cancer germline genes with transcriptional silencing refractory to the hypomethylating drug 5-aza-2'-deoxycytidine. by Almatrafi, A, Feichtinger, J, Vernon, E, Escobar, N, Wakeman, J, Larcombe, L, McFarlane, R

“…Bona fide germline genes have expression restricted to the germ cells of the gonads. Testis-specific germline development-associated genes can become activated in cancer cells and can potentially drive the oncogenic process and serve as therapeutic/biomarker targets; such germline genes are referred to as cancer/testis genes. …”

Testicular cells in hybrid water buffaloes (Bubalus bubalis) by Bongso, Tuan Ariffeen, Abdullah, Mohamad Hilmi, Basrur, P. K.

“…Histological examination of the hybrid testis revealed a large proportion of degenerating spermatocytes and abnormal spermatids in the process of spermiogenesis suggesting that the various synaptic associations leading to unbalanced gametes may be responsible for the degenerating germ cells in the hybrids. The unbalanced meiotic products will probably lead to selection against such spermatozoa or early embryos after fertilisation. …”
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Mesenchymal to Epithelial Transition Mediated by CDH1 Promotes Spontaneous Reprogramming of Male Germline Stem Cells to Pluripotency by Junhui An, Yu Zheng, Christina Tenenhaus Dann

“…Our results provide a mechanistic explanation for the spontaneous emergence of pluripotent cells from GSC cultures; namely, rare GSCs upregulate CDH1 and initiate MET, processes normally kept in check by ZEB1 and TGF-β signaling, thereby ensuring germ cells are protected from aberrant acquisition of pluripotency.…”
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Cell-type-specific mRNA transcription and degradation kinetics in zebrafish embryogenesis from metabolically labeled single-cell RNA-seq by Lior Fishman, Avani Modak, Gal Nechooshtan, Talya Razin, Florian Erhard, Aviv Regev, Jeffrey A. Farrell, Michal Rabani

“…They also identify cell-type-specific differences in degradation, namely selective retention of maternal transcripts within primordial germ cells and enveloping layer cells, two of the earliest specified cell types. …”
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Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds by Gabriela de Freitas Laiber Pascoal, Marina Vilar Geraldi, Mário Roberto Maróstica, Thomas Prates Ong

“…BFCs, such as ascorbic acid, α-tocopherol, polyunsaturated fatty acids, trace elements, carnitines, N-acetylcysteine, and coenzyme Q10, have been shown to improve male gametogenesis, modulate epigenetics of germ cells, and the epigenetic signature of the offspring, restoring offspring metabolic health induced by stressors during early life. …”
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scATAC-Seq reveals heterogeneity associated with spermatogonial differentiation in cultured male germline stem cells by Hoi Ching Suen, Alfred Chun Shui Luk, Jinyue Liao

“…Abstract Spermatogonial stem cells are the most primitive spermatogonia in testis, which can self-renew to maintain the stem cell pool or differentiate to give rise to germ cells including haploid spermatids. All-trans-retinoic acid (RA), a bioactive metabolite of vitamin A, plays a fundamental role in initiating spermatogonial differentiation. …”
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The Role of Mutant p63 in Female Fertility by Yi Luan, Pauline Xu, Seok-Yeong Yu, So-Youn Kim

“…TAp63 expression turns on in the nuclei of primordial germ cells in females and is maintained mainly in the oocyte nuclei of immature follicles. …”
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Impact of Host Telomere Length on HHV-6 Integration by Darren J. Wight, Giulia Aimola, Georg Beythien, Louis Flamand, Benedikt B. Kaufer

“…Both viruses can also integrate in germ cells and subsequently be inherited in children. …”
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Characteristics of spermatogenesis in infertile men with the AZFc region deletions by V. B. Chernykh, S. A. Rudneva, T. M. Sorokina, L. V. Shileyko, L. F. Kurilo, O. P. Ryzhkova, A. L. Chukhrova, A. V. Polyakov

“…Quantitative karyological analysis of immature germ cells from ejaculate sediment revealed from incomplete spermatogenesis arrest at prepaсhytene stages to complete spermatogenesis depletion. …”
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